HRP20031066B1 - Crystalline anticholinergic, method for its production, and use thereof in the production of a drug - Google Patents
Crystalline anticholinergic, method for its production, and use thereof in the production of a drugInfo
- Publication number
- HRP20031066B1 HRP20031066B1 HR20031066A HRP20031066A HRP20031066B1 HR P20031066 B1 HRP20031066 B1 HR P20031066B1 HR 20031066 A HR20031066 A HR 20031066A HR P20031066 A HRP20031066 A HR P20031066A HR P20031066 B1 HRP20031066 B1 HR P20031066B1
- Authority
- HR
- Croatia
- Prior art keywords
- production
- drug
- crystalline
- anticholinergic
- crystalline anticholinergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10129710 | 2001-06-22 | ||
| DE10215436 | 2002-04-08 | ||
| PCT/EP2002/006291 WO2003000265A1 (de) | 2001-06-22 | 2002-06-08 | Kristallines anticholinergikum, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20031066A2 HRP20031066A2 (en) | 2004-04-30 |
| HRP20031066B1 true HRP20031066B1 (en) | 2011-10-31 |
Family
ID=26009556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20031066A HRP20031066B1 (en) | 2001-06-22 | 2002-06-08 | Crystalline anticholinergic, method for its production, and use thereof in the production of a drug |
Country Status (37)
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| US20050038004A1 (en) * | 2003-07-31 | 2005-02-17 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| CA2544352C (en) * | 2003-11-03 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Crystalline anhydrate with anticholinergic effect |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| SI2422786T1 (sl) | 2004-04-22 | 2014-12-31 | Boehringer Ingelheim International Gmbh | Nove farmacevtske kombinacije za zdravljenje respiratornih obolenj |
| DE102004024454A1 (de) | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| DE602004020337D1 (de) | 2004-08-11 | 2009-05-14 | Boehringer Ingelheim Pharma | Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege |
| US20060079544A1 (en) * | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
| DE102004048389A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
| CA2605688A1 (en) | 2005-04-28 | 2006-11-02 | Boehringer Ingelheim International Gmbh | Compounds for treating inflammatory diseases |
| CN101203513A (zh) * | 2005-05-02 | 2008-06-18 | 贝林格尔·英格海姆国际有限公司 | 噻托溴铵的晶型 |
| KR20080012932A (ko) | 2005-05-02 | 2008-02-12 | 베링거 인겔하임 인터내셔날 게엠베하 | 티오트로퓸 브로마이드의 신규한 결정형 |
| DE102005030733A1 (de) | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| PL1917253T3 (pl) | 2005-08-15 | 2015-06-30 | Boehringer Ingelheim Int | Sposób wytwarzania betamimetyków |
| US20070086957A1 (en) * | 2005-10-10 | 2007-04-19 | Thierry Bouyssou | Combination of medicaments for the treatment of respiratory diseases |
| US7423146B2 (en) | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
| EP2123650B1 (en) * | 2005-12-19 | 2012-04-04 | Sicor, Inc. | Novel form of tiotropium bromide and process for preparation thereof |
| US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
| CN100999521B (zh) * | 2006-01-13 | 2010-12-08 | 江苏正大天晴药业股份有限公司 | 结晶性抗胆碱药噻托溴铵 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| DK1874781T3 (da) | 2006-04-19 | 2009-11-02 | Boehringer Ingelheim Int | Dihydrothienopyrimidiner til behandling af inflammatoriske sygdomme |
| WO2008017637A1 (de) | 2006-08-07 | 2008-02-14 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen zur behandlung von atemwegserkrankungen |
| UY30550A1 (es) | 2006-08-22 | 2008-03-31 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos |
| GB0716026D0 (en) | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| PL2215092T3 (pl) | 2007-10-19 | 2012-07-31 | Boehringer Ingelheim Int | Podstawione piperydyno-dihydrotienopirymidyny |
| EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
| PL2379525T3 (pl) | 2008-12-19 | 2016-01-29 | Centrexion Therapeutics Corp | Cykliczne pirymidyno-4-karboksamidy jako antagoniści receptora CCR2 do leczenia stanów zapalnych, astmy oraz COPD |
| EP2403851B1 (en) | 2009-03-06 | 2015-06-17 | Mahmut Bilgic | New crystalline forms of tiotropium bromide |
| CA2782464C (en) | 2009-12-17 | 2016-11-29 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists |
| WO2011073155A1 (en) | 2009-12-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Novel antagonists for ccr2 and uses thereof |
| AU2011209274B8 (en) | 2010-01-29 | 2015-08-13 | Boehringer Ingelheim International Gmbh | Substituted naphthyridines and their use as Syk kinase inhibitors |
| US8877745B2 (en) | 2010-05-12 | 2014-11-04 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569295B1 (en) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| US8841313B2 (en) | 2010-05-17 | 2014-09-23 | Boehringer Ingelheim International Gmbh | CCR2 antagonists and uses thereof |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| WO2011151251A1 (en) | 2010-06-01 | 2011-12-08 | Boehringer Ingelheim International Gmbh | New ccr2 antagonists |
| TR201007108A2 (tr) * | 2010-08-25 | 2012-03-21 | B�Lg�� Mahmut | Yeni tiotropyum bromür kristali ve üretim yöntemi.@ |
| EP2668177B1 (en) | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
| TR201101897A2 (tr) | 2011-02-28 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür içeren kristal madde |
| TR201102068A2 (tr) | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür içeren kristal maddeler |
| TR201111589A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür susuz kristal formu. |
| JP5786257B2 (ja) | 2011-06-16 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の選択的ｃｃｒ２拮抗薬 |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| CA2843022C (en) | 2011-07-26 | 2019-09-24 | Boehringer Ingelheim International Gmbh | Substituted quinolines and their use as medicaments |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| CN106905314A (zh) | 2011-11-25 | 2017-06-30 | 阿德弗里奥药品有限责任公司 | 用于制备取代的5‑氟‑1h‑吡唑并吡啶类化合物的方法 |
| CZ304368B6 (cs) | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| PT106142B (pt) * | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
| EA025960B1 (ru) | 2012-11-05 | 2017-02-28 | Зентива, К.С. | Стабилизация сольватов тиотропия |
| CN104341412A (zh) * | 2013-07-29 | 2015-02-11 | 天津金耀集团有限公司 | 一种无水噻托溴铵结晶的制备方法 |
| EA032097B1 (ru) | 2014-03-19 | 2019-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Гетероарильные ингибиторы syk |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| RS60737B1 (sr) | 2014-10-21 | 2020-09-30 | Ariad Pharma Inc | Kristalni oblici 5-hloro-n4-[-2-(dimetilfosforil)fenil]-n2-{2-metoksi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidin-2,4-diamina |
| EP3414243A1 (en) * | 2016-02-11 | 2018-12-19 | Sima Patent Ve Lisanslama Hizmetleri Ltd. STI | Crystalline form of tiotropium bromide anhydrate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0418716A1 (de) * | 1989-09-16 | 1991-03-27 | Boehringer Ingelheim Kg | Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen |
| WO2002030928A1 (de) * | 2000-10-12 | 2002-04-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
| WO2002051840A1 (de) * | 2000-12-22 | 2002-07-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur herstellung des anticholinergikums tiotropiumbromid |
-
2002
- 2002-06-08 PT PT02743165T patent/PT1401445E/pt unknown
- 2002-06-08 KR KR1020097004823A patent/KR101011353B1/ko not_active Expired - Lifetime
- 2002-06-08 CZ CZ20040120A patent/CZ302786B6/cs not_active IP Right Cessation
- 2002-06-08 SK SK52-2004A patent/SK287262B6/sk unknown
- 2002-06-08 MX MXPA03011718A patent/MXPA03011718A/es active IP Right Grant
- 2002-06-08 CN CN02812303A patent/CN100586948C/zh not_active Expired - Lifetime
- 2002-06-08 HR HR20031066A patent/HRP20031066B1/xx not_active IP Right Cessation
- 2002-06-08 SI SI200230431T patent/SI1401445T1/sl unknown
- 2002-06-08 IL IL15923802A patent/IL159238A0/xx unknown
- 2002-06-08 NZ NZ530690A patent/NZ530690A/en not_active IP Right Cessation
- 2002-06-08 PL PL364489A patent/PL208137B1/pl unknown
- 2002-06-08 JP JP2003506910A patent/JP2005504015A/ja active Pending
- 2002-06-08 WO PCT/EP2002/006291 patent/WO2003000265A1/de active Application Filing
- 2002-06-08 RS YUP-997/03A patent/RS50441B/sr unknown
- 2002-06-08 AT AT02743165T patent/ATE337006T1/de active
- 2002-06-08 DE DE50207943T patent/DE50207943D1/de not_active Expired - Lifetime
- 2002-06-08 KR KR1020037016769A patent/KR100971616B1/ko not_active Expired - Lifetime
- 2002-06-08 ME MEP-2008-620A patent/ME00412B/me unknown
- 2002-06-08 HU HU0400333A patent/HUP0400333A3/hu unknown
- 2002-06-08 EP EP02743165A patent/EP1401445B1/de not_active Expired - Lifetime
- 2002-06-08 DK DK02743165T patent/DK1401445T3/da active
- 2002-06-08 EE EEP200400029A patent/EE05316B1/xx unknown
- 2002-06-08 EA EA200301293A patent/EA005813B1/ru not_active IP Right Cessation
- 2002-06-08 CA CA2450961A patent/CA2450961C/en not_active Expired - Fee Related
- 2002-06-08 AU AU2002345016A patent/AU2002345016B2/en not_active Expired
- 2002-06-08 BR BR0210537-3A patent/BR0210537A/pt not_active Application Discontinuation
- 2002-06-08 ES ES02743165T patent/ES2271280T3/es not_active Expired - Lifetime
- 2002-06-19 EG EG2002060698A patent/EG24851A/xx active
- 2002-06-19 TW TW095100968A patent/TW200617007A/zh unknown
- 2002-06-19 TW TW091113373A patent/TWI261589B/zh not_active IP Right Cessation
- 2002-06-20 UY UY27342A patent/UY27342A1/es not_active Application Discontinuation
- 2002-06-20 MY MYPI20022316A patent/MY122779A/en unknown
- 2002-06-21 PE PE2002000538A patent/PE20030130A1/es active IP Right Grant
- 2002-06-21 AR ARP020102337A patent/AR037491A1/es not_active Application Discontinuation
- 2002-06-21 PE PE2007000660A patent/PE20081305A1/es not_active Application Discontinuation
- 2002-08-19 SA SA2230255A patent/SA02230255B1/ar unknown
-
2003
- 2003-12-08 IL IL159238A patent/IL159238A/en active IP Right Grant
- 2003-12-12 BG BG108440A patent/BG66303B1/bg unknown
- 2003-12-19 NO NO20035696A patent/NO334301B1/no not_active IP Right Cessation
-
2004
- 2004-01-20 CO CO04003764A patent/CO5550423A2/es not_active Application Discontinuation
-
2006
- 2006-09-20 CY CY20061101339T patent/CY1105223T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0418716A1 (de) * | 1989-09-16 | 1991-03-27 | Boehringer Ingelheim Kg | Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen |
| WO2002030928A1 (de) * | 2000-10-12 | 2002-04-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
| WO2002051840A1 (de) * | 2000-12-22 | 2002-07-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur herstellung des anticholinergikums tiotropiumbromid |
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