HRP20030436B1 - Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as a medicament, and pharmaceutical preparations containing these compounds - Google Patents

Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as a medicament, and pharmaceutical preparations containing these compounds

Info

Publication number
HRP20030436B1
HRP20030436B1 HR20030436A HRP20030436A HRP20030436B1 HR P20030436 B1 HRP20030436 B1 HR P20030436B1 HR 20030436 A HR20030436 A HR 20030436A HR P20030436 A HRP20030436 A HR P20030436A HR P20030436 B1 HRP20030436 B1 HR P20030436B1
Authority
HR
Croatia
Prior art keywords
carbon atoms
alkyl
substituted
phenyl
compounds
Prior art date
Application number
HR20030436A
Other languages
English (en)
Croatian (hr)
Inventor
Peukert Stefan
Brendel Joachim
Hemmerle Horst
Kleemann Heinz-Werner
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of HRP20030436A2 publication Critical patent/HRP20030436A2/hr
Publication of HRP20030436B1 publication Critical patent/HRP20030436B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20030436A 2000-11-30 2003-05-29 Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as a medicament, and pharmaceutical preparations containing these compounds HRP20030436B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10059418A DE10059418A1 (de) 2000-11-30 2000-11-30 Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013294 WO2002044137A1 (fr) 2000-11-30 2001-11-17 Composes bisaryle substitues en ortho et meta, leur procede de fabrication, leur utilisation comme medicaments, et preparations pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
HRP20030436A2 HRP20030436A2 (en) 2005-04-30
HRP20030436B1 true HRP20030436B1 (en) 2006-04-30

Family

ID=7665215

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030436A HRP20030436B1 (en) 2000-11-30 2003-05-29 Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as a medicament, and pharmaceutical preparations containing these compounds

Country Status (29)

Country Link
US (2) US6605625B2 (fr)
EP (1) EP1339675B1 (fr)
JP (1) JP4051283B2 (fr)
KR (1) KR100968056B1 (fr)
CN (1) CN1290825C (fr)
AR (1) AR031430A1 (fr)
AT (1) ATE289292T1 (fr)
AU (2) AU2793102A (fr)
BR (1) BR0115769A (fr)
CA (1) CA2430273C (fr)
CZ (1) CZ301631B6 (fr)
DE (2) DE10059418A1 (fr)
EE (1) EE05240B1 (fr)
ES (1) ES2236341T3 (fr)
HK (1) HK1061231A1 (fr)
HR (1) HRP20030436B1 (fr)
HU (1) HUP0303317A3 (fr)
IL (2) IL156097A0 (fr)
MX (1) MXPA03004386A (fr)
NO (1) NO328599B1 (fr)
NZ (1) NZ526177A (fr)
PL (1) PL206245B1 (fr)
PT (1) PT1339675E (fr)
RS (1) RS50403B (fr)
RU (1) RU2278858C2 (fr)
SK (1) SK286708B6 (fr)
TW (1) TWI254039B (fr)
WO (1) WO2002044137A1 (fr)
ZA (1) ZA200303893B (fr)

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GB0124938D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
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GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
ES2263058T3 (es) 2002-08-19 2006-12-01 Glaxo Group Limited Derivados de pirimidina como inhibidores selectivos de cox-2.
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
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WO2004054977A1 (fr) * 2002-12-13 2004-07-01 Cytopia Pty Ltd Inhibiteurs de kinase a base de nicotinamide
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GB0308185D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
US20050054673A1 (en) * 2003-09-08 2005-03-10 Aventis Pharma Deutschland Gmbh Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias
DE10341233A1 (de) * 2003-09-08 2005-03-24 Aventis Pharma Deutschland Gmbh Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
CA2539479C (fr) * 2003-09-23 2010-07-06 Merck & Co., Inc. Inhibiteurs des canaux potassiques a l'isoquinoleine
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EP1725236A4 (fr) * 2004-03-11 2009-05-13 Glaxo Group Ltd Nouveaux antagonistes du recepteur de l'acetylcholine muscarinique m3
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US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
WO2006014877A2 (fr) * 2004-07-29 2006-02-09 Merck & Co., Inc. Inhibiteurs de canaux potassiques
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US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0512429D0 (en) * 2005-06-17 2005-07-27 Smithkline Beecham Corp Novel compound
CA2615440A1 (fr) * 2005-07-22 2007-02-08 Merck & Co., Inc. Inhibiteurs des canaux potassiques
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
JP5161871B2 (ja) * 2006-04-27 2013-03-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｔａｓｋ−１およびｔａｓｋ−３イオンチャンネルの阻害剤
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
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GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
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Also Published As

Publication number Publication date
ZA200303893B (en) 2004-04-15
KR20030062364A (ko) 2003-07-23
RS37603A (en) 2006-12-15
US6924392B2 (en) 2005-08-02
PL362700A1 (en) 2004-11-02
IL156097A0 (en) 2003-12-23
HUP0303317A2 (hu) 2004-01-28
RS50403B (sr) 2009-12-31
PT1339675E (pt) 2005-04-29
SK286708B6 (sk) 2009-03-05
IL156097A (en) 2010-11-30
AU2002227931B2 (en) 2006-07-13
AR031430A1 (es) 2003-09-24
JP2004514707A (ja) 2004-05-20
HRP20030436A2 (en) 2005-04-30
CA2430273C (fr) 2010-02-09
ES2236341T3 (es) 2005-07-16
PL206245B1 (pl) 2010-07-30
US6605625B2 (en) 2003-08-12
EP1339675A1 (fr) 2003-09-03
NZ526177A (en) 2004-11-26
US20030013719A1 (en) 2003-01-16
NO20032438L (no) 2003-07-09
US20030225099A1 (en) 2003-12-04
CN1494527A (zh) 2004-05-05
NO328599B1 (no) 2010-03-29
AU2793102A (en) 2002-06-11
BR0115769A (pt) 2004-01-13
MXPA03004386A (es) 2003-09-04
TWI254039B (en) 2006-05-01
RU2278858C2 (ru) 2006-06-27
JP4051283B2 (ja) 2008-02-20
SK6532003A3 (en) 2003-12-02
NO20032438D0 (no) 2003-05-28
DE50105386D1 (de) 2005-03-24
EE200300183A (et) 2003-06-16
CZ301631B6 (cs) 2010-05-05
EE05240B1 (et) 2009-12-15
CA2430273A1 (fr) 2002-06-06
ATE289292T1 (de) 2005-03-15
HUP0303317A3 (en) 2010-04-28
DE10059418A1 (de) 2002-06-20
WO2002044137A1 (fr) 2002-06-06
CZ20031502A3 (cs) 2003-08-13
HK1061231A1 (en) 2004-09-10
EP1339675B1 (fr) 2005-02-16
KR100968056B1 (ko) 2010-07-08
CN1290825C (zh) 2006-12-20

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