SK286708B6 - Orto- a meta-substituované bisarylové zlúčeniny, ich použitie ako liečiv a farmaceutické prostriedky, ktoré ich obsahujú - Google Patents

Orto- a meta-substituované bisarylové zlúčeniny, ich použitie ako liečiv a farmaceutické prostriedky, ktoré ich obsahujú Download PDF

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Publication number
SK286708B6
SK286708B6 SK653-2003A SK6532003A SK286708B6 SK 286708 B6 SK286708 B6 SK 286708B6 SK 6532003 A SK6532003 A SK 6532003A SK 286708 B6 SK286708 B6 SK 286708B6
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SK
Slovakia
Prior art keywords
groups
carbon atoms
group
atoms
alkyl
Prior art date
Application number
SK653-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK6532003A3 (en
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of SK6532003A3 publication Critical patent/SK6532003A3/sk
Publication of SK286708B6 publication Critical patent/SK286708B6/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK653-2003A 2000-11-30 2001-11-17 Orto- a meta-substituované bisarylové zlúčeniny, ich použitie ako liečiv a farmaceutické prostriedky, ktoré ich obsahujú SK286708B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10059418A DE10059418A1 (de) 2000-11-30 2000-11-30 Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013294 WO2002044137A1 (fr) 2000-11-30 2001-11-17 Composes bisaryle substitues en ortho et meta, leur procede de fabrication, leur utilisation comme medicaments, et preparations pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
SK6532003A3 SK6532003A3 (en) 2003-12-02
SK286708B6 true SK286708B6 (sk) 2009-03-05

Family

ID=7665215

Family Applications (1)

Application Number Title Priority Date Filing Date
SK653-2003A SK286708B6 (sk) 2000-11-30 2001-11-17 Orto- a meta-substituované bisarylové zlúčeniny, ich použitie ako liečiv a farmaceutické prostriedky, ktoré ich obsahujú

Country Status (29)

Country Link
US (2) US6605625B2 (fr)
EP (1) EP1339675B1 (fr)
JP (1) JP4051283B2 (fr)
KR (1) KR100968056B1 (fr)
CN (1) CN1290825C (fr)
AR (1) AR031430A1 (fr)
AT (1) ATE289292T1 (fr)
AU (2) AU2793102A (fr)
BR (1) BR0115769A (fr)
CA (1) CA2430273C (fr)
CZ (1) CZ301631B6 (fr)
DE (2) DE10059418A1 (fr)
EE (1) EE05240B1 (fr)
ES (1) ES2236341T3 (fr)
HK (1) HK1061231A1 (fr)
HR (1) HRP20030436B1 (fr)
HU (1) HUP0303317A3 (fr)
IL (2) IL156097A0 (fr)
MX (1) MXPA03004386A (fr)
NO (1) NO328599B1 (fr)
NZ (1) NZ526177A (fr)
PL (1) PL206245B1 (fr)
PT (1) PT1339675E (fr)
RS (1) RS50403B (fr)
RU (1) RU2278858C2 (fr)
SK (1) SK286708B6 (fr)
TW (1) TWI254039B (fr)
WO (1) WO2002044137A1 (fr)
ZA (1) ZA200303893B (fr)

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GB0124934D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
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GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
ES2263058T3 (es) 2002-08-19 2006-12-01 Glaxo Group Limited Derivados de pirimidina como inhibidores selectivos de cox-2.
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
AU2003291839B2 (en) * 2002-12-13 2009-01-22 Ym Biosciences Australia Pty Ltd Nicotinamide-based kinase inhibitors
WO2004054977A1 (fr) * 2002-12-13 2004-07-01 Cytopia Pty Ltd Inhibiteurs de kinase a base de nicotinamide
JP4896518B2 (ja) * 2002-12-13 2012-03-14 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド ニコチンアミド系キナーゼ阻害薬
GB0308185D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
US20050054673A1 (en) * 2003-09-08 2005-03-10 Aventis Pharma Deutschland Gmbh Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias
DE10341233A1 (de) * 2003-09-08 2005-03-24 Aventis Pharma Deutschland Gmbh Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
CA2539479C (fr) * 2003-09-23 2010-07-06 Merck & Co., Inc. Inhibiteurs des canaux potassiques a l'isoquinoleine
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EP1725236A4 (fr) * 2004-03-11 2009-05-13 Glaxo Group Ltd Nouveaux antagonistes du recepteur de l'acetylcholine muscarinique m3
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
WO2006014877A2 (fr) * 2004-07-29 2006-02-09 Merck & Co., Inc. Inhibiteurs de canaux potassiques
US20080051416A1 (en) * 2004-10-05 2008-02-28 Smithkline Beecham Corporation Novel Compounds
US7932247B2 (en) 2004-11-15 2011-04-26 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0512429D0 (en) * 2005-06-17 2005-07-27 Smithkline Beecham Corp Novel compound
CA2615440A1 (fr) * 2005-07-22 2007-02-08 Merck & Co., Inc. Inhibiteurs des canaux potassiques
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
JP5161871B2 (ja) * 2006-04-27 2013-03-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Task−1およびtask−3イオンチャンネルの阻害剤
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
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Also Published As

Publication number Publication date
HRP20030436B1 (en) 2006-04-30
ZA200303893B (en) 2004-04-15
KR20030062364A (ko) 2003-07-23
RS37603A (en) 2006-12-15
US6924392B2 (en) 2005-08-02
PL362700A1 (en) 2004-11-02
IL156097A0 (en) 2003-12-23
HUP0303317A2 (hu) 2004-01-28
RS50403B (sr) 2009-12-31
PT1339675E (pt) 2005-04-29
IL156097A (en) 2010-11-30
AU2002227931B2 (en) 2006-07-13
AR031430A1 (es) 2003-09-24
JP2004514707A (ja) 2004-05-20
HRP20030436A2 (en) 2005-04-30
CA2430273C (fr) 2010-02-09
ES2236341T3 (es) 2005-07-16
PL206245B1 (pl) 2010-07-30
US6605625B2 (en) 2003-08-12
EP1339675A1 (fr) 2003-09-03
NZ526177A (en) 2004-11-26
US20030013719A1 (en) 2003-01-16
NO20032438L (no) 2003-07-09
US20030225099A1 (en) 2003-12-04
CN1494527A (zh) 2004-05-05
NO328599B1 (no) 2010-03-29
AU2793102A (en) 2002-06-11
BR0115769A (pt) 2004-01-13
MXPA03004386A (es) 2003-09-04
TWI254039B (en) 2006-05-01
RU2278858C2 (ru) 2006-06-27
JP4051283B2 (ja) 2008-02-20
SK6532003A3 (en) 2003-12-02
NO20032438D0 (no) 2003-05-28
DE50105386D1 (de) 2005-03-24
EE200300183A (et) 2003-06-16
CZ301631B6 (cs) 2010-05-05
EE05240B1 (et) 2009-12-15
CA2430273A1 (fr) 2002-06-06
ATE289292T1 (de) 2005-03-15
HUP0303317A3 (en) 2010-04-28
DE10059418A1 (de) 2002-06-20
WO2002044137A1 (fr) 2002-06-06
CZ20031502A3 (cs) 2003-08-13
HK1061231A1 (en) 2004-09-10
EP1339675B1 (fr) 2005-02-16
KR100968056B1 (ko) 2010-07-08
CN1290825C (zh) 2006-12-20

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20111117