HRP20030381B1 - 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A - Google Patents
3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE AInfo
- Publication number
- HRP20030381B1 HRP20030381B1 HR20030381A HRP20030381A HRP20030381B1 HR P20030381 B1 HRP20030381 B1 HR P20030381B1 HR 20030381 A HR20030381 A HR 20030381A HR P20030381 A HRP20030381 A HR P20030381A HR P20030381 B1 HRP20030381 B1 HR P20030381B1
- Authority
- HR
- Croatia
- Prior art keywords
- meaning
- individual
- group
- hydrogen
- aza
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001033 ether group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20030381A HRP20030381B1 (en) | 2003-05-14 | 2003-05-14 | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A |
| ES04732143T ES2274453T3 (es) | 2003-05-14 | 2004-05-11 | Nuevos derivados 3-decladinosil 9a-n-carbamoilicos y 9a-n-tiocarbamoilicos de 9-desoxo-9-dihidro-9a-aza-9a-homoeritromicina a. |
| YUP-2005/0837A RS20050837A (en) | 2003-05-14 | 2004-05-11 | NEW 3-DECLADINOSYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A- HOMOERYTHROMYCIN A NEW 3- DECLADINOSYL 9A-N-CARBAMOYL AND -A- N-THIOCARBAMOYL DERIVATIVES OF 9- DEOX-9-DIHYDRO-9A-AZA-9A- HOMOERYTHROMYCIN A |
| JP2006530610A JP2007501268A (ja) | 2003-05-14 | 2004-05-11 | 新規な９−デオキソ−９−ジヒドロ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの３−デクラジノシル９ａ−Ｎ−カルバモイル及び９ａ−Ｎ−チオカルバモイル誘導体 |
| PCT/HR2004/000014 WO2004101591A1 (en) | 2003-05-14 | 2004-05-11 | NEW 3-DECLADINOSYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A-HOMOERYTHROMYCIN A |
| DE602004003054T DE602004003054T2 (de) | 2003-05-14 | 2004-05-11 | Neue 3-decladinosyl-9a-n-carbamoyl- und 9a-n-thiocarbamoylderivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a |
| PL04732143T PL1631575T3 (pl) | 2003-05-14 | 2004-05-11 | Nowe 3-dekladinozylo-9a-N-karbamoilowe i 9a-N-tiokarbamoilowe pochodne 9-deokso-9-dihydro-9a-aza-9a homoerytromycyny A |
| DK04732143T DK1631575T3 (da) | 2003-05-14 | 2004-05-11 | Nye 3-decladinosyl-9a-N-carbamoyl- og 9a-N-thiocarbamoylderivater af 9-deox-9-dihydro-9a-AZA-9A-homoerythromycin A |
| US10/557,025 US20070066544A1 (en) | 2003-05-14 | 2004-05-11 | 3-Decladinosyl 9a-n-carbamoyl and 9a-n-thiocarbamoyl derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a |
| PT04732143T PT1631575E (pt) | 2003-05-14 | 2004-05-11 | NOVOS DERIVADOS 3- DECLADINOSIL 9ª-N-CARBAMOIL E 9ª-N- TIOCARBAMOIL DE 9-DESOXI-9-DI-HIDRO-9ª-AZA-9ª-HOMOERITROMICINA |
| CA002525143A CA2525143A1 (en) | 2003-05-14 | 2004-05-11 | New 3-decladinosyl 9a-n-carbamoyl and 9a-n-thiocarbamoyl derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a |
| AT04732143T ATE344270T1 (de) | 2003-05-14 | 2004-05-11 | Neue 3-decladinosyl-9a-n-carbamoyl- und 9a-n- thiocarbamoylderivate von 9-deoxo-9-dihydro-9a- aza-9a-homoerythromycin a |
| EP04732143A EP1631575B1 (en) | 2003-05-14 | 2004-05-11 | NEW 3-DECLADINOSYL 9a-N -CARBAMOYL AND 9a-N -THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A-HOMOERYTHROMYCIN A |
| CNB2004800130438A CN100345860C (zh) | 2003-05-14 | 2004-05-11 | 新的9－脱氧－9－二氢－9A－氮杂－9A－高红霉素A的3－去红霉糖基9a－N－氨基甲酰基和9a－N－硫代氨基甲酰基衍生物 |
| SI200430155T SI1631575T1 (sl) | 2003-05-14 | 2004-05-11 | NOVI 3-DEKLADINOZIL 9a-N-KARBAMOILNI IN 9a-N-TIOKARBAMOILNI DERIVATI 9-DEOKS-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A |
| CL200401026A CL2004001026A1 (es) | 2003-05-14 | 2004-05-13 | COMPUESTOS DERIVADOS DE 3-DECLADINOSILO DE 9a-N-CARBAMOIL Y 9a-N-TIOCARBAMOIL-9-DEOXO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A; Y PROCEDIMIENTO DE PREPARACION, UTILES COMO AGENTES ANTIBACTERIANOS. |
| ARP040101631A AR044320A1 (es) | 2003-05-14 | 2004-05-14 | Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a |
| IS8109A IS8109A (is) | 2003-05-14 | 2005-10-31 | Nýjar 3-dekladínósýl 9a-N-karbamóýl og 9a-N-þíókarbamóýl afleiður af 9-deoxó-9-díhýdró-9a-asa-9a-hómóerýþrómýsíni A |
| HK06112660A HK1092156A1 (en) | 2003-05-14 | 2006-11-17 | New 3-decladinosyl 9A-N-carbamoyl and 9A-N-thiocarbamoyl derivatives of 9-deox-9-di-hydro-9A-aza-9A homoerythromycin a |
| CY20071100033T CY1107321T1 (el) | 2003-05-14 | 2007-01-10 | Νεα 3-δεκλαδινοσυλ-9α-ν-καρβaμοϋλικα και 9α-ν-θειοκαρβαμοϋλικα παραγωγα της 9-δεσοξο-9-διυδρο-9α-αζα-9α-ομοepυθρομυκινης |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20030381A HRP20030381B1 (en) | 2003-05-14 | 2003-05-14 | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20030381A2 HRP20030381A2 (en) | 2005-02-28 |
| HRP20030381B1 true HRP20030381B1 (en) | 2007-05-31 |
Family
ID=33446264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030381A HRP20030381B1 (en) | 2003-05-14 | 2003-05-14 | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20070066544A1 (is) |
| EP (1) | EP1631575B1 (is) |
| JP (1) | JP2007501268A (is) |
| CN (1) | CN100345860C (is) |
| AR (1) | AR044320A1 (is) |
| AT (1) | ATE344270T1 (is) |
| CA (1) | CA2525143A1 (is) |
| CL (1) | CL2004001026A1 (is) |
| CY (1) | CY1107321T1 (is) |
| DE (1) | DE602004003054T2 (is) |
| DK (1) | DK1631575T3 (is) |
| ES (1) | ES2274453T3 (is) |
| HK (1) | HK1092156A1 (is) |
| HR (1) | HRP20030381B1 (is) |
| IS (1) | IS8109A (is) |
| PL (1) | PL1631575T3 (is) |
| PT (1) | PT1631575E (is) |
| RS (1) | RS20050837A (is) |
| SI (1) | SI1631575T1 (is) |
| WO (1) | WO2004101591A1 (is) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080200403A1 (en) * | 2005-01-14 | 2008-08-21 | Glaxosmithkline | 9A-Carbamoyl and Thiocarbamoyl Azalides with Anti-Inflammatory Activity |
| ATE429921T1 (de) * | 2005-01-14 | 2009-05-15 | Glaxosmithkline Zagreb | 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung |
| EP2988597B1 (en) | 2013-04-04 | 2022-06-08 | President and Fellows of Harvard College | Macrolides and methods of their preparation and use |
| CN104119413B (zh) * | 2014-07-29 | 2016-08-24 | 华中农业大学 | 一种土拉霉素残留标示物的合成方法 |
| JP2017531663A (ja) | 2014-10-08 | 2017-10-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | １４員ケトライドならびにそれらの調製および使用の方法 |
| EP3273969A4 (en) | 2015-03-25 | 2018-11-21 | President and Fellows of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
| GB201608236D0 (en) | 2016-05-11 | 2016-06-22 | Fidelta D O O | Seco macrolide compounds |
| CN113573779A (zh) * | 2018-11-19 | 2021-10-29 | 齐卡尼治疗股份有限公司 | C10-亚烷基取代的13元大环内酯及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43116B (en) * | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
| HRP931480B1 (en) * | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
| HRP990130B1 (en) * | 1999-05-03 | 2004-06-30 | Pliva D D | HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A |
| US20020115621A1 (en) * | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| HRP20010146B1 (en) * | 2001-02-28 | 2005-10-31 | Pliva D.D. | 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A |
| US6933283B2 (en) * | 2002-04-25 | 2005-08-23 | Abbott Laboratories | 11-deoxy azalide antibacterials |
-
2003
- 2003-05-14 HR HR20030381A patent/HRP20030381B1/xx not_active IP Right Cessation
-
2004
- 2004-05-11 PT PT04732143T patent/PT1631575E/pt unknown
- 2004-05-11 CN CNB2004800130438A patent/CN100345860C/zh not_active Expired - Fee Related
- 2004-05-11 SI SI200430155T patent/SI1631575T1/sl unknown
- 2004-05-11 CA CA002525143A patent/CA2525143A1/en not_active Abandoned
- 2004-05-11 ES ES04732143T patent/ES2274453T3/es not_active Expired - Lifetime
- 2004-05-11 RS YUP-2005/0837A patent/RS20050837A/sr unknown
- 2004-05-11 PL PL04732143T patent/PL1631575T3/pl unknown
- 2004-05-11 DK DK04732143T patent/DK1631575T3/da active
- 2004-05-11 WO PCT/HR2004/000014 patent/WO2004101591A1/en active Application Filing
- 2004-05-11 EP EP04732143A patent/EP1631575B1/en not_active Expired - Lifetime
- 2004-05-11 US US10/557,025 patent/US20070066544A1/en not_active Abandoned
- 2004-05-11 AT AT04732143T patent/ATE344270T1/de not_active IP Right Cessation
- 2004-05-11 DE DE602004003054T patent/DE602004003054T2/de not_active Expired - Lifetime
- 2004-05-11 JP JP2006530610A patent/JP2007501268A/ja active Pending
- 2004-05-13 CL CL200401026A patent/CL2004001026A1/es unknown
- 2004-05-14 AR ARP040101631A patent/AR044320A1/es not_active Application Discontinuation
-
2005
- 2005-10-31 IS IS8109A patent/IS8109A/is unknown
-
2006
- 2006-11-17 HK HK06112660A patent/HK1092156A1/xx not_active IP Right Cessation
-
2007
- 2007-01-10 CY CY20071100033T patent/CY1107321T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1631575A1 (en) | 2006-03-08 |
| DK1631575T3 (da) | 2007-02-26 |
| DE602004003054T2 (de) | 2007-06-06 |
| ATE344270T1 (de) | 2006-11-15 |
| HRP20030381A2 (en) | 2005-02-28 |
| WO2004101591A1 (en) | 2004-11-25 |
| ES2274453T3 (es) | 2007-05-16 |
| IS8109A (is) | 2005-10-31 |
| HK1092156A1 (en) | 2007-02-02 |
| CY1107321T1 (el) | 2012-11-21 |
| CN1788013A (zh) | 2006-06-14 |
| SI1631575T1 (sl) | 2007-04-30 |
| PT1631575E (pt) | 2007-01-31 |
| CA2525143A1 (en) | 2004-11-25 |
| PL1631575T3 (pl) | 2007-03-30 |
| JP2007501268A (ja) | 2007-01-25 |
| US20070066544A1 (en) | 2007-03-22 |
| DE602004003054D1 (de) | 2006-12-14 |
| AR044320A1 (es) | 2005-09-07 |
| CN100345860C (zh) | 2007-10-31 |
| EP1631575B1 (en) | 2006-11-02 |
| CL2004001026A1 (es) | 2005-04-22 |
| RS20050837A (en) | 2007-12-31 |
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Legal Events
| Date | Code | Title | Description |
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| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O., |
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| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080421 Year of fee payment: 6 |
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| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20090515 |