HRP20030331A2 - Pyrimidine-2,4,6-trione metalloproteinase inhibitors - Google Patents
Pyrimidine-2,4,6-trione metalloproteinase inhibitors Download PDFInfo
- Publication number
- HRP20030331A2 HRP20030331A2 HR20030331A HRP20030331A HRP20030331A2 HR P20030331 A2 HRP20030331 A2 HR P20030331A2 HR 20030331 A HR20030331 A HR 20030331A HR P20030331 A HRP20030331 A HR P20030331A HR P20030331 A2 HRP20030331 A2 HR P20030331A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- phenoxy
- group
- diseases
- heteroaryl
- Prior art date
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- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 title description 12
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 239
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 112
- -1 hydroxy, amino Chemical group 0.000 claims description 99
- 125000001424 substituent group Chemical group 0.000 claims description 70
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- 238000000034 method Methods 0.000 claims description 41
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- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 39
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 39
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- 239000001257 hydrogen Substances 0.000 claims description 36
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 27
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- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 19
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- VDBIMEBUTGEHGU-UHFFFAOYSA-N 5-(2-ethoxyethyl)-5-[4-[4-(1,3-oxazol-5-yl)phenoxy]phenoxy]-1,3-diazinane-2,4,6-trione Chemical compound C=1C=C(OC=2C=CC(=CC=2)C=2OC=NC=2)C=CC=1OC1(CCOCC)C(=O)NC(=O)NC1=O VDBIMEBUTGEHGU-UHFFFAOYSA-N 0.000 claims description 2
- LNEQEABJJGGNEB-UHFFFAOYSA-N 5-(2-ethoxyethyl)-5-[4-[4-(1,3-thiazol-2-yl)phenoxy]phenoxy]-1,3-diazinane-2,4,6-trione Chemical compound C=1C=C(OC=2C=CC(=CC=2)C=2SC=CN=2)C=CC=1OC1(CCOCC)C(=O)NC(=O)NC1=O LNEQEABJJGGNEB-UHFFFAOYSA-N 0.000 claims description 2
- PVQVZBZVLHMJTB-UHFFFAOYSA-N 5-(2-ethoxyethyl)-5-[4-[4-(1-methylpyrazol-3-yl)phenoxy]phenoxy]-1,3-diazinane-2,4,6-trione Chemical compound C=1C=C(OC=2C=CC(=CC=2)C2=NN(C)C=C2)C=CC=1OC1(CCOCC)C(=O)NC(=O)NC1=O PVQVZBZVLHMJTB-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US24331400P | 2000-10-26 | 2000-10-26 | |
PCT/IB2001/001953 WO2002034726A2 (en) | 2000-10-26 | 2001-10-17 | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
Publications (1)
Publication Number | Publication Date |
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HRP20030331A2 true HRP20030331A2 (en) | 2003-06-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20030331A HRP20030331A2 (en) | 2000-10-26 | 2003-04-28 | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
Country Status (36)
Country | Link |
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US (2) | US6706723B2 (xx) |
EP (1) | EP1332136A2 (xx) |
JP (1) | JP2004512327A (xx) |
KR (1) | KR20030061825A (xx) |
CN (1) | CN1714084A (xx) |
AP (1) | AP2001002319A0 (xx) |
AR (1) | AR035362A1 (xx) |
AU (1) | AU2002210800A1 (xx) |
BG (1) | BG107651A (xx) |
BR (1) | BR0114917A (xx) |
CA (1) | CA2425280A1 (xx) |
CR (1) | CR6939A (xx) |
CZ (1) | CZ20031069A3 (xx) |
EA (1) | EA200300409A1 (xx) |
EC (1) | ECSP034568A (xx) |
EE (1) | EE200300195A (xx) |
GT (1) | GT200100214A (xx) |
HN (1) | HN2001000243A (xx) |
HR (1) | HRP20030331A2 (xx) |
HU (1) | HUP0302337A3 (xx) |
IL (1) | IL154946A0 (xx) |
IS (1) | IS6749A (xx) |
MA (1) | MA26956A1 (xx) |
MX (1) | MXPA03003734A (xx) |
NO (1) | NO20031852L (xx) |
NZ (1) | NZ524774A (xx) |
OA (1) | OA12528A (xx) |
PA (1) | PA8531501A1 (xx) |
PE (1) | PE20020585A1 (xx) |
PL (1) | PL362919A1 (xx) |
SK (1) | SK4872003A3 (xx) |
SV (1) | SV2003000704A (xx) |
TN (1) | TNSN01150A1 (xx) |
UY (1) | UY26981A1 (xx) |
WO (1) | WO2002034726A2 (xx) |
ZA (1) | ZA200302192B (xx) |
Families Citing this family (50)
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ES2287110T3 (es) * | 2000-04-11 | 2007-12-16 | Sankyo Company, Limited | Composicion farmaceutica estabilizada que contiene un bloqueador de calcio consistente en azelnidipina. |
CA2425280A1 (en) * | 2000-10-26 | 2002-05-02 | Pfizer Products Inc. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
WO2002064571A1 (en) | 2001-02-14 | 2002-08-22 | Warner-Lambert Company Llc | Pyrimidine matrix metalloproteinase inhibitors |
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
EP1368327B1 (en) | 2001-02-14 | 2004-10-20 | Warner-Lambert Company LLC | Benzo thiadiazine matrix metalloproteinase inhibitors |
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
BR0213233A (pt) | 2001-10-12 | 2005-01-04 | Warner Lambert Co | Alcinos inibidores de metaloproteinase de matriz |
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
US6936620B2 (en) | 2001-12-20 | 2005-08-30 | Bristol Myers Squibb Company | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases |
WO2003053941A2 (en) * | 2001-12-20 | 2003-07-03 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-alpha converting enzyme (tace) and/or matrix metalloproteinases |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
AU2003219410A1 (en) | 2002-04-26 | 2003-11-10 | Pfizer Products Inc. | Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors |
NI200300045A (es) | 2002-04-26 | 2005-07-08 | Pfizer Prod Inc | Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa. |
CA2483500A1 (en) * | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | Pyrimidine-2, 4, 6-trione metallo-proteinase inhibitors |
AU2003216660A1 (en) * | 2002-04-26 | 2003-11-10 | Pfizer Products Inc. | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
EP1553949B1 (en) | 2002-08-13 | 2007-04-18 | Warner-Lambert Company LLC | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors |
WO2004014909A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
AU2003253176A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Monocyclic derivatives as matrix metalloproteinase inhibitors |
EP1537090A1 (en) | 2002-08-13 | 2005-06-08 | Warner-Lambert Company Llc | Chromone derivatives as matrix metalloproteinase inhibitors |
AU2003250466A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
AU2003249477A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
MXPA05001786A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz. |
WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
AU2003250470A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
GB0223249D0 (en) * | 2002-10-08 | 2002-11-13 | Amersham Plc | Improved imaging agents |
WO2004084903A1 (en) * | 2003-03-27 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis |
WO2004084902A1 (en) * | 2003-03-28 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment of chronic wounds |
ES2537514T3 (es) | 2003-04-04 | 2015-06-09 | Incyte Corporation | Composiciones, métodos y kits relacionados con la escisión de HER-2 |
CN100558362C (zh) * | 2004-04-01 | 2009-11-11 | 霍夫曼-拉罗奇有限公司 | 三氧嘧啶治疗和预防支气管炎症疾病的应用 |
ATE493973T1 (de) | 2004-06-04 | 2011-01-15 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
EP2427438B1 (en) | 2009-05-05 | 2016-10-12 | Cambria Pharmaceuticals, Inc. | Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis |
RU2400233C1 (ru) | 2009-07-07 | 2010-09-27 | Общество с ограниченной ответственностью "Вирфарм" | Способ лечения заболеваний печени различного генеза |
KR101301533B1 (ko) * | 2010-02-09 | 2013-09-04 | 한미사이언스 주식회사 | 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체 |
KR101893756B1 (ko) | 2011-03-14 | 2018-09-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 류코트리엔 생성의 벤조디옥산 억제제 |
WO2013012844A1 (en) * | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
AR091315A1 (es) | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
MX2014010563A (es) | 2012-03-06 | 2014-12-05 | Boehringer Ingelheim Int | Benzodioxanos en combinacion con otros activos para inhibir la produccion de leucotrieno. |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
RU2644250C2 (ru) * | 2012-09-14 | 2018-02-08 | Элизабет ЛЕВИНА | Лекарственное средство с активностью против грамположительных бактерий, микобактерий и грибов |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
EP3022193B1 (en) | 2013-07-15 | 2017-04-26 | Boehringer Ingelheim International GmbH | Inhibitors of leukotriene production |
US9573957B2 (en) | 2013-07-15 | 2017-02-21 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
WO2020039092A2 (en) * | 2018-08-24 | 2020-02-27 | Xeniopro GmbH | Novel aromatic molecules |
AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
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DE19548624A1 (de) | 1995-12-23 | 1997-06-26 | Boehringer Mannheim Gmbh | Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
CA2294259A1 (en) * | 1997-06-21 | 1998-12-30 | Roche Diagnostics Gmbh | Barbituric acid derivatives with antimetastatic and antitumor activity |
DE19726427A1 (de) | 1997-06-23 | 1998-12-24 | Boehringer Mannheim Gmbh | Pyrimidin-2,4,6-trion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US6265578B1 (en) | 1999-02-12 | 2001-07-24 | Hoffmann-La Roche Inc. | Pyrimidine-2,4,6-triones |
HN2000000137A (es) * | 1999-08-12 | 2001-02-02 | Pfizer Prod Inc | Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas |
CA2425280A1 (en) * | 2000-10-26 | 2002-05-02 | Pfizer Products Inc. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
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- 2001-10-17 CZ CZ20031069A patent/CZ20031069A3/cs unknown
- 2001-10-17 WO PCT/IB2001/001953 patent/WO2002034726A2/en not_active Application Discontinuation
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- 2001-10-17 KR KR10-2003-7005756A patent/KR20030061825A/ko not_active Application Discontinuation
- 2001-10-17 EE EEP200300195A patent/EE200300195A/xx unknown
- 2001-10-17 HU HU0302337A patent/HUP0302337A3/hu unknown
- 2001-10-17 AU AU2002210800A patent/AU2002210800A1/en not_active Abandoned
- 2001-10-17 NZ NZ524774A patent/NZ524774A/en unknown
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- 2001-10-23 UY UY26981A patent/UY26981A1/es not_active Application Discontinuation
- 2001-10-24 HN HN2001000243A patent/HN2001000243A/es unknown
- 2001-10-24 AR ARP010104976A patent/AR035362A1/es unknown
- 2001-10-24 PE PE2001001051A patent/PE20020585A1/es not_active Application Discontinuation
- 2001-10-25 TN TNTNSN01150A patent/TNSN01150A1/fr unknown
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2003
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