HRP20010595B1 - Thioamide derivatives - Google Patents
Thioamide derivativesInfo
- Publication number
- HRP20010595B1 HRP20010595B1 HR20010595A HRP20010595A HRP20010595B1 HR P20010595 B1 HRP20010595 B1 HR P20010595B1 HR 20010595 A HR20010595 A HR 20010595A HR P20010595 A HRP20010595 A HR P20010595A HR P20010595 B1 HRP20010595 B1 HR P20010595B1
- Authority
- HR
- Croatia
- Prior art keywords
- 6alkyl
- aryl
- formula
- group
- alkyl
- Prior art date
Links
- 150000003556 thioamides Chemical class 0.000 title 1
- -1 perfluoro C1-6alkyl Chemical group 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Gyroscopes (AREA)
- Liquid Crystal Substances (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12047599P | 1999-02-18 | 1999-02-18 | |
PCT/EP2000/001058 WO2000048994A1 (en) | 1999-02-18 | 2000-02-10 | Thioamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20010595A2 HRP20010595A2 (en) | 2002-08-31 |
HRP20010595B1 true HRP20010595B1 (en) | 2006-02-28 |
Family
ID=22390545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20010595A HRP20010595B1 (en) | 1999-02-18 | 2001-08-10 | Thioamide derivatives |
Country Status (29)
Country | Link |
---|---|
US (6) | US6288267B1 (id) |
EP (1) | EP1154993B1 (id) |
JP (1) | JP2002537286A (id) |
KR (1) | KR100649819B1 (id) |
CN (1) | CN1213025C (id) |
AT (1) | ATE278664T1 (id) |
AU (1) | AU773388B2 (id) |
BR (1) | BR0008280A (id) |
CA (1) | CA2362831C (id) |
CZ (1) | CZ20012980A3 (id) |
DE (1) | DE60014588T2 (id) |
DK (1) | DK1154993T3 (id) |
ES (1) | ES2228458T3 (id) |
HK (1) | HK1044330A1 (id) |
HR (1) | HRP20010595B1 (id) |
HU (1) | HUP0200155A3 (id) |
ID (1) | ID30129A (id) |
IL (2) | IL144636A0 (id) |
MA (1) | MA26769A1 (id) |
NO (1) | NO20014018D0 (id) |
NZ (1) | NZ513254A (id) |
PL (1) | PL349461A1 (id) |
PT (1) | PT1154993E (id) |
RU (1) | RU2245874C2 (id) |
SI (1) | SI1154993T1 (id) |
TR (1) | TR200102399T2 (id) |
WO (1) | WO2000048994A1 (id) |
YU (1) | YU58701A (id) |
ZA (1) | ZA200106180B (id) |
Families Citing this family (35)
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US6939855B2 (en) | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
US6680195B1 (en) * | 1997-11-26 | 2004-01-20 | Inhibitex, Inc. | Extracellular matrix-binding proteins from staphylococcus aureus |
US6521626B1 (en) * | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
US6380387B1 (en) | 1999-12-06 | 2002-04-30 | Hoffmann-La Roche Inc. | 4-Pyrimidinyl-n-acyl-l phenylalanines |
US6388084B1 (en) | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
EP2267045B1 (en) * | 2000-01-26 | 2015-07-15 | Mitsui Chemicals, Inc. | Olefin polymer of very low polydispersity and process for preparing the same |
EP1270547A4 (en) | 2000-03-23 | 2005-07-13 | Ajinomoto Kk | NEW PHENYL ALANIDE DERIVATIVES |
US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
ES2252310T3 (es) * | 2000-09-14 | 2006-05-16 | Grunenthal Gmbh | Beta-tioaminoacidos. |
US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20090297611A1 (en) * | 2003-07-31 | 2009-12-03 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20050069227A1 (en) * | 2003-09-29 | 2005-03-31 | Mark Steele | Flexible package having integrated slit member |
US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
AR047537A1 (es) * | 2004-02-10 | 2006-01-25 | Janssen Pharmaceutica Nv | Piridazinonaureas como antagonistas de integrinas |
KR20070004676A (ko) * | 2004-02-10 | 2007-01-09 | 얀센 파마슈티카 엔.브이. | 알파4 인테그린의 길항제로서의 피리다지논 |
AU2005222074B2 (en) * | 2004-03-10 | 2011-02-17 | Merck Sharp & Dohme Corp. | VLA-4 antagonists |
US7776891B2 (en) * | 2004-08-16 | 2010-08-17 | Merck Sharp & Dohme Corp. | VLA-4 antagonists |
US7641325B2 (en) * | 2004-10-04 | 2010-01-05 | Kodak Graphic Communications Group Canada | Non-conductive fluid droplet characterizing apparatus and method |
WO2006081986A1 (en) * | 2005-02-07 | 2006-08-10 | F.Hoffmann-La Roche Ag | Bambuterol and integrin inhibitor combination |
WO2006094640A2 (en) * | 2005-03-04 | 2006-09-14 | F.Hoffmann-La Roche Ag | Roflumilast and integrin inhibitor combination and method of treatment |
CZ297581B6 (cs) * | 2005-05-26 | 2007-01-10 | Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Antimykotické a antimykobakteriální thiosalicylanilidy a způsob jejich přípravy |
AU2006337137B2 (en) * | 2005-12-29 | 2012-06-14 | Tersera Therapeutics Llc | Multicyclic amino acid derivatives and methods of their use |
CA2714335A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
KR101811965B1 (ko) * | 2007-11-07 | 2017-12-22 | 셀덱스 쎄라퓨틱스, 인크. | 인간 수지상 및 상피 세포 205(dec-205)에 결합하는 항체 |
KR20110008086A (ko) | 2008-04-11 | 2011-01-25 | 메리맥 파마슈티컬즈, 인크. | 인간 혈청 알부민 링커 및 그 콘쥬게이트 |
US8927694B2 (en) | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
US8343706B2 (en) | 2010-01-25 | 2013-01-01 | International Business Machines Corporation | Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same |
EP2769223A1 (en) | 2011-10-17 | 2014-08-27 | Westfälische Wilhelms-Universität Münster | Assessment of pml risk and methods based thereon |
US9345766B2 (en) | 2012-08-30 | 2016-05-24 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-ERBB3 agents |
EP3873897B1 (en) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases |
EP3873900A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
WO2020092375A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
CN114222730B (zh) | 2019-08-14 | 2024-09-10 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
CN113683499B (zh) * | 2021-09-10 | 2024-01-30 | 上海皓鸿生物医药科技有限公司 | 一种制备杜韦利西布中间体的方法 |
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BE584914A (id) | 1958-11-24 | |||
US3527793A (en) | 1967-08-18 | 1970-09-08 | Bristol Myers Co | Phenylglycine derivatives |
IT1190378B (it) | 1985-06-21 | 1988-02-16 | Isf Spa | Derivati pirrolidonici |
US5039805A (en) | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
US5463116A (en) | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
DE69524598T2 (de) | 1994-06-20 | 2002-07-11 | Takeda Chemical Industries, Ltd. | Kondensierte imidazolderivate, ihre herstellung und verwendung |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
US5804595A (en) | 1995-12-05 | 1998-09-08 | Regents Of The University Of Minnesota | Kappa opioid receptor agonists |
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WO1997036859A1 (en) * | 1996-03-29 | 1997-10-09 | G.D. Searle & Co. | Para-substituted phenylpropanoic acid derivatives as integrin antagonists |
DE69706407T2 (de) | 1996-03-29 | 2002-05-29 | G.D. Searle & Co., Chicago | META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN |
DE19654483A1 (de) | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanin-Derivate |
JP2002512625A (ja) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
ATE249421T1 (de) * | 1997-06-23 | 2003-09-15 | Tanabe Seiyaku Co | Inhibitoren der alpha4-beta1 vermittelten zelladhäsion |
CN1265674A (zh) * | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 能抑制由vla-4介导的白细胞粘连的4-氨基苯基丙氨酸化合物 |
JP2001512139A (ja) * | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4が介在する白血球接着を阻害するスルホニル化ジペプチド化合物 |
EP0994895A1 (en) * | 1997-07-31 | 2000-04-26 | Elan Pharmaceuticals, Inc. | Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 |
US6229011B1 (en) * | 1997-08-22 | 2001-05-08 | Hoffman-La Roche Inc. | N-aroylphenylalanine derivative VCAM-1 inhibitors |
JP3555876B2 (ja) * | 1997-08-22 | 2004-08-18 | エフ.ホフマン−ラ ロシュ アーゲー | N−アロイルフェニルアラニン誘導体 |
CN1276785A (zh) | 1997-08-22 | 2000-12-13 | 霍夫曼-拉罗奇有限公司 | N-烷酰基苯丙氨酸衍生物 |
HUP0101701A3 (en) * | 1997-12-23 | 2003-02-28 | Aventis Pharma Ltd West Mallin | Substituted betha-alanines and pharmaceutical compositions comprising them |
AU3260399A (en) | 1998-02-26 | 1999-09-15 | Celltech Therapeutics Limited | Phenylalanine derivatives as inhibitors of alpha4 integrins |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
-
2000
- 2000-02-10 BR BR0008280-5A patent/BR0008280A/pt not_active Application Discontinuation
- 2000-02-10 AT AT00903680T patent/ATE278664T1/de not_active IP Right Cessation
- 2000-02-10 CZ CZ20012980A patent/CZ20012980A3/cs unknown
- 2000-02-10 ID IDW00200101770A patent/ID30129A/id unknown
- 2000-02-10 WO PCT/EP2000/001058 patent/WO2000048994A1/en active IP Right Grant
- 2000-02-10 RU RU2001124596/04A patent/RU2245874C2/ru not_active IP Right Cessation
- 2000-02-10 KR KR1020017010495A patent/KR100649819B1/ko not_active IP Right Cessation
- 2000-02-10 ES ES00903680T patent/ES2228458T3/es not_active Expired - Lifetime
- 2000-02-10 PL PL00349461A patent/PL349461A1/xx not_active Application Discontinuation
- 2000-02-10 AU AU25475/00A patent/AU773388B2/en not_active Ceased
- 2000-02-10 TR TR2001/02399T patent/TR200102399T2/xx unknown
- 2000-02-10 JP JP2000599735A patent/JP2002537286A/ja active Pending
- 2000-02-10 DK DK00903680T patent/DK1154993T3/da active
- 2000-02-10 EP EP00903680A patent/EP1154993B1/en not_active Expired - Lifetime
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- 2000-02-10 IL IL14463600A patent/IL144636A0/xx active IP Right Grant
- 2000-02-10 DE DE60014588T patent/DE60014588T2/de not_active Expired - Lifetime
- 2000-02-10 HU HU0200155A patent/HUP0200155A3/hu unknown
- 2000-02-10 YU YU58701A patent/YU58701A/sh unknown
- 2000-02-10 NZ NZ513254A patent/NZ513254A/en unknown
- 2000-02-17 US US09/505,903 patent/US6288267B1/en not_active Expired - Fee Related
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2001
- 2001-03-20 US US09/812,325 patent/US20020028933A1/en not_active Abandoned
- 2001-05-23 US US09/863,579 patent/US6458844B2/en not_active Expired - Fee Related
- 2001-05-23 US US09/863,567 patent/US6479666B2/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,032 patent/US6426348B1/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,104 patent/US6423728B1/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106180A patent/ZA200106180B/en unknown
- 2001-07-30 IL IL144636A patent/IL144636A/en not_active IP Right Cessation
- 2001-08-08 MA MA26290A patent/MA26769A1/fr unknown
- 2001-08-10 HR HR20010595A patent/HRP20010595B1/xx not_active IP Right Cessation
- 2001-08-17 NO NO20014018A patent/NO20014018D0/no not_active Application Discontinuation
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2002
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