HRP20010005A2 - N-benzodioxanylmethyl-1-piperidyl-methylamine compounds having affinity for 5-ht receptors - Google Patents
N-benzodioxanylmethyl-1-piperidyl-methylamine compounds having affinity for 5-ht receptors Download PDFInfo
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- HRP20010005A2 HRP20010005A2 HR20010005A HRP20010005A HRP20010005A2 HR P20010005 A2 HRP20010005 A2 HR P20010005A2 HR 20010005 A HR20010005 A HR 20010005A HR P20010005 A HRP20010005 A HR P20010005A HR P20010005 A2 HRP20010005 A2 HR P20010005A2
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- JHMFOOYHJDKJTB-ZETCQYMHSA-N [(3s)-6-(trifluoromethyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methanol Chemical compound C1=C(C(F)(F)F)C=C2O[C@@H](CO)COC2=C1 JHMFOOYHJDKJTB-ZETCQYMHSA-N 0.000 description 1
- PBOYJAITSSDOFN-UHFFFAOYSA-N [1-(2-methoxyphenyl)piperidin-4-yl]methanamine Chemical compound COC1=CC=CC=C1N1CCC(CN)CC1 PBOYJAITSSDOFN-UHFFFAOYSA-N 0.000 description 1
- LHMXZQRNBUJIEX-UHFFFAOYSA-N [1-(4-fluoro-2-methoxyphenyl)piperidin-4-yl]methanamine Chemical compound COC1=CC(F)=CC=C1N1CCC(CN)CC1 LHMXZQRNBUJIEX-UHFFFAOYSA-N 0.000 description 1
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- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
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- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
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- 229910052736 halogen Inorganic materials 0.000 description 1
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- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
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- 150000003840 hydrochlorides Chemical class 0.000 description 1
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- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
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- QHLRKDSRGUZHSH-SFHVURJKSA-N n-[[(3s)-6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-1-[1-(2-methoxyphenyl)piperidin-4-yl]methanamine Chemical compound COC1=CC=CC=C1N1CCC(CNC[C@@H]2OC3=CC(Cl)=CC=C3OC2)CC1 QHLRKDSRGUZHSH-SFHVURJKSA-N 0.000 description 1
- BCXCABRDBBWWGY-UHFFFAOYSA-N n-benzyl-n-methylprop-2-yn-1-amine;hydrochloride Chemical compound Cl.C#CCN(C)CC1=CC=CC=C1 BCXCABRDBBWWGY-UHFFFAOYSA-N 0.000 description 1
- 208000015706 neuroendocrine disease Diseases 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000004958 nuclear spectroscopy Methods 0.000 description 1
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- 235000019809 paraffin wax Nutrition 0.000 description 1
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- 229960004239 pargyline hydrochloride Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- 239000002831 pharmacologic agent Substances 0.000 description 1
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 description 1
- 229960001999 phentolamine Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
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- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- 239000000758 substrate Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9811879.7A GB9811879D0 (en) | 1998-06-03 | 1998-06-03 | Therapeutic agents |
| PCT/EP1999/003648 WO1999062902A1 (en) | 1998-06-03 | 1999-05-26 | N-benzodioxanylmethyl-1-piperidyl-methylamine compounds having affinity for 5-ht receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010005A2 true HRP20010005A2 (en) | 2001-12-31 |
Family
ID=10833098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010005A HRP20010005A2 (en) | 1998-06-03 | 2001-01-02 | N-benzodioxanylmethyl-1-piperidyl-methylamine compounds having affinity for 5-ht receptors |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1087964A1 (pt) |
| JP (1) | JP2002517392A (pt) |
| KR (1) | KR20010052526A (pt) |
| CN (1) | CN1304408A (pt) |
| AR (1) | AR018622A1 (pt) |
| AU (1) | AU4369599A (pt) |
| BG (1) | BG104988A (pt) |
| BR (1) | BR9910927A (pt) |
| CA (1) | CA2333756A1 (pt) |
| CO (1) | CO5021190A1 (pt) |
| GB (1) | GB9811879D0 (pt) |
| HR (1) | HRP20010005A2 (pt) |
| HU (1) | HUP0102233A2 (pt) |
| ID (1) | ID27067A (pt) |
| IL (1) | IL139552A0 (pt) |
| NO (1) | NO20006041D0 (pt) |
| PL (1) | PL344594A1 (pt) |
| SK (1) | SK17602000A3 (pt) |
| TR (1) | TR200003569T2 (pt) |
| WO (1) | WO1999062902A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9915616D0 (en) * | 1999-07-05 | 1999-09-01 | Knoll Ag | Therapeutic agents |
| GB0007376D0 (en) * | 2000-03-28 | 2000-05-17 | Knoll Ag | Therapeutic agents |
| HUP0302016A2 (hu) * | 2000-05-12 | 2003-09-29 | Solvay Pharmaceuticals B.V. | Piperazin és piperidinvegyületek, ezeket tartalmazó gyógyászati készítmények, eljárás elżállításukra és alkalmazásuk |
| JP2003532676A (ja) * | 2000-05-12 | 2003-11-05 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | ＣＮＳ障害を治療するための組合せられたドーパミンＤ２、５−ＨＴ１Ａおよびαアドレノレセプターアゴニスト作用、を有する化合物の使用 |
| CA2597616A1 (en) | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2681325B1 (fr) * | 1991-09-16 | 1993-12-17 | Fabre Medicament Pierre | Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique. |
| FR2701479B1 (fr) * | 1993-02-11 | 1995-05-12 | Pf Medicament | Nouveaux dérivés hétérocycliques de l'aminométhyl-4 pipéridine, leur préparation et leur application en thérapeutique. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| GB9514380D0 (en) * | 1995-07-13 | 1995-09-13 | Knoll Ag | Therapeutic agents |
-
1998
- 1998-06-03 GB GBGB9811879.7A patent/GB9811879D0/en not_active Ceased
-
1999
- 1999-05-26 CN CN99806908A patent/CN1304408A/zh active Pending
- 1999-05-26 TR TR2000/03569T patent/TR200003569T2/xx unknown
- 1999-05-26 JP JP2000552113A patent/JP2002517392A/ja active Pending
- 1999-05-26 KR KR1020007013670A patent/KR20010052526A/ko not_active Application Discontinuation
- 1999-05-26 CA CA002333756A patent/CA2333756A1/en not_active Abandoned
- 1999-05-26 IL IL13955299A patent/IL139552A0/xx unknown
- 1999-05-26 AU AU43695/99A patent/AU4369599A/en not_active Abandoned
- 1999-05-26 EP EP99926434A patent/EP1087964A1/en not_active Ceased
- 1999-05-26 SK SK1760-2000A patent/SK17602000A3/sk unknown
- 1999-05-26 WO PCT/EP1999/003648 patent/WO1999062902A1/en not_active Application Discontinuation
- 1999-05-26 ID IDW20002519A patent/ID27067A/id unknown
- 1999-05-26 PL PL99344594A patent/PL344594A1/xx not_active Application Discontinuation
- 1999-05-26 HU HU0102233A patent/HUP0102233A2/hu unknown
- 1999-05-26 BR BR9910927-1A patent/BR9910927A/pt not_active IP Right Cessation
- 1999-06-03 AR ARP990102619A patent/AR018622A1/es not_active Application Discontinuation
- 1999-06-03 CO CO99035020A patent/CO5021190A1/es unknown
-
2000
- 2000-11-27 BG BG104988A patent/BG104988A/bg unknown
- 2000-11-29 NO NO20006041A patent/NO20006041D0/no not_active Application Discontinuation
-
2001
- 2001-01-02 HR HR20010005A patent/HRP20010005A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010052526A (ko) | 2001-06-25 |
| GB9811879D0 (en) | 1998-07-29 |
| WO1999062902A1 (en) | 1999-12-09 |
| NO20006041L (no) | 2000-11-29 |
| BR9910927A (pt) | 2001-02-20 |
| BG104988A (bg) | 2001-11-30 |
| EP1087964A1 (en) | 2001-04-04 |
| HUP0102233A2 (hu) | 2002-05-29 |
| TR200003569T2 (tr) | 2001-04-20 |
| ID27067A (id) | 2001-02-22 |
| JP2002517392A (ja) | 2002-06-18 |
| AR018622A1 (es) | 2001-11-28 |
| SK17602000A3 (sk) | 2001-08-06 |
| IL139552A0 (en) | 2002-02-10 |
| CN1304408A (zh) | 2001-07-18 |
| CO5021190A1 (es) | 2001-03-27 |
| CA2333756A1 (en) | 1999-12-09 |
| NO20006041D0 (no) | 2000-11-29 |
| PL344594A1 (en) | 2001-11-05 |
| AU4369599A (en) | 1999-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| OBST | Application withdrawn |