HK48693A - (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid,2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofuranyl)acetic acid and esters thereof - Google Patents

(rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid,2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofuranyl)acetic acid and esters thereof

Info

Publication number
HK48693A
HK48693A HK486/93A HK48693A HK48693A HK 48693 A HK48693 A HK 48693A HK 486/93 A HK486/93 A HK 486/93A HK 48693 A HK48693 A HK 48693A HK 48693 A HK48693 A HK 48693A
Authority
HK
Hong Kong
Prior art keywords
trimethylbenzofuranyl
dihydro
acetic acid
acyloxy
hydroxy
Prior art date
Application number
HK486/93A
Other languages
English (en)
Inventor
Mario Brufani
Stefano Ceccarelli
Patrizia Giannetti
Agnese Paesano
Romolo Scuri
Sergio Zanarella
Original Assignee
Foscama Biomed Chim Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foscama Biomed Chim Farma filed Critical Foscama Biomed Chim Farma
Publication of HK48693A publication Critical patent/HK48693A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
HK486/93A 1988-08-01 1993-05-20 (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid,2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofuranyl)acetic acid and esters thereof HK48693A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821603A IT1229482B (it) 1988-08-01 1988-08-01 Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.

Publications (1)

Publication Number Publication Date
HK48693A true HK48693A (en) 1993-05-27

Family

ID=11184201

Family Applications (1)

Application Number Title Priority Date Filing Date
HK486/93A HK48693A (en) 1988-08-01 1993-05-20 (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid,2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofuranyl)acetic acid and esters thereof

Country Status (15)

Country Link
US (2) US4999350A (zh)
JP (1) JPH0278675A (zh)
KR (1) KR0129526B1 (zh)
CN (1) CN1034574C (zh)
BE (1) BE1003255A5 (zh)
CA (1) CA1324134C (zh)
CH (1) CH679583A5 (zh)
DE (1) DE3925496A1 (zh)
ES (1) ES2014188A6 (zh)
FR (1) FR2634766A1 (zh)
GB (1) GB2221463B (zh)
HK (1) HK48693A (zh)
IT (1) IT1229482B (zh)
SE (1) SE469652B (zh)
SG (1) SG26693G (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231341B (it) * 1989-08-18 1991-11-28 Foscama Biomed Chim Farma 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.
IT1239946B (it) * 1990-03-12 1993-11-27 Biomedica Foscama Industria Chimicofarmaceutica Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici
US5240956A (en) * 1990-11-07 1993-08-31 Cortech, Inc. Ester inhibitors
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
JP3246741B2 (ja) * 1992-04-06 2002-01-15 メレルダウファーマス−ティカルズ インコーポレイテッド ２，３−ジヒドロベンゾフラノールの新規な誘導体及びその製法
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
TW393475B (en) * 1992-10-16 2000-06-11 Chugai Pharmaceutical Co Ltd 4-alkoxyl-2,6-di-t-butyl phenol derivatives
IT1289494B1 (it) * 1996-12-20 1998-10-15 Biomedica Foscana Ind Chimico Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione
IT1320131B1 (it) * 2000-12-21 2003-11-18 Foscama Biomed Chim Farma Uso degli acidi 5-idrossi e 5-acilossi-2,3-diidro-4,6,7-trimetil-2-benzofuranacetici e loro esteri come cicatrizzanti delle lesioni

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6065063A (ja) * 1983-09-20 1985-04-13 Matsunaga Kagaku Kogyo Kk 難燃化剤
US4537903A (en) * 1983-10-12 1985-08-27 Merck & Co., Inc. Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents
US4918092A (en) * 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
CA1281325C (en) * 1984-06-20 1991-03-12 Patrice C. Belanger Benzofuran derivatives
JPS6388173A (ja) * 1986-09-30 1988-04-19 Kuraray Co Ltd ２，３−ジヒドロベンゾフラン誘導体
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
JP2855340B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 ２―置換クマラン誘導体

Also Published As

Publication number Publication date
SE8902603L (sv) 1990-02-02
FR2634766A1 (fr) 1990-02-02
GB2221463B (en) 1992-03-25
KR900003145A (ko) 1990-03-23
DE3925496C2 (zh) 1992-04-30
KR0129526B1 (ko) 1998-04-09
GB8917515D0 (en) 1989-09-13
CN1042354A (zh) 1990-05-23
IT1229482B (it) 1991-09-03
ES2014188A6 (es) 1990-06-16
CN1034574C (zh) 1997-04-16
US5041568A (en) 1991-08-20
CH679583A5 (zh) 1992-03-13
IT8821603A0 (it) 1988-08-01
SG26693G (en) 1993-05-21
JPH0278675A (ja) 1990-03-19
FR2634766B1 (zh) 1994-08-19
SE8902603D0 (sv) 1989-07-26
CA1324134C (en) 1993-11-09
DE3925496A1 (de) 1990-02-22
GB2221463A (en) 1990-02-07
SE469652B (sv) 1993-08-16
US4999350A (en) 1991-03-12
BE1003255A5 (fr) 1992-02-11

Similar Documents

Publication Publication Date Title
AU1906188A (en) Herbicidal fluorophenoxyphenoxyalkanoic acids and derivatives thereof
AU1388388A (en) Benzoic acid derivatives and use thereof
NZ222233A (en) 1,5-diphenylpyrazole derivatives and use as safeners for 2-phenoxypropionic acid ester herbicides
AU1501892A (en) Acylamino acid esters and processes for the preparation thereof
AU2669688A (en) 1,7-annelated indolecarboxylic acid esters and amides
AU8202087A (en) 2beta-substituted-methylpenicillanic acid derivatives, and salts and esters thereof
GB2217710B (en) Pyridone carboxylic acid derivative
AU6874591A (en) Pesticidal pyrimidinyl benzoic acids and esters
AU641903B2 (en) Carboxylic acid derivatives
GB2221463B (en) (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid,2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofuranyl)acetic acid and esters thereof
AU2850492A (en) Novel aminoalkanephosphinic acids and salts thereof
IL105427A0 (en) 4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenylacetic acid and derivatives thereof
EP0498883A4 (en) 3-substituted and 3,3-disubstituted 4-oxoretinoic acids and their esters
ZA911398B (en) Carboxylic acid derivatives
AU564013B2 (en) 1,8-bridged 4-quinolone-3-carboxylic acids and derivatives
AU5882186A (en) 3-(substituted)propenylaminothiazol-ylcephalosporanic acids and esters thereof
ZA913132B (en) Carboxylic acid derivatives
AU2733788A (en) Heterocyclic oxophthalazinyl acetic acids
AU554260B2 (en) 3,5-bis(trifluoromethyl) phenoxy carboxylic acids and derivatives
AU3608089A (en) Quinolonecarboxylic acids
ZA899942B (en) Carboxylic acid derivatives
HU9301754D0 (en) Substituted benzothiazolyl-phenyl acetic acid derivatives and quinooxalyl-methoxi ones
AU1998088A (en) Aminopolycarboxylic acids and derivatives thereof
AU4065993A (en) Saturated, monocarboxylic acids, the preparation thereof, and derivatives therefrom
ZA908298B (en) Optically active thiazetoquinoline-3-carboxylic acid compound,method for preparation thereof,and a pharmaceutical composition comprising the same

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040801