HK130797A - Novel magnetic resonance imaging agents - Google Patents
Novel magnetic resonance imaging agentsInfo
- Publication number
- HK130797A HK130797A HK130797A HK130797A HK130797A HK 130797 A HK130797 A HK 130797A HK 130797 A HK130797 A HK 130797A HK 130797 A HK130797 A HK 130797A HK 130797 A HK130797 A HK 130797A
- Authority
- HK
- Hong Kong
- Prior art keywords
- imaging agents
- groups
- magnetic resonance
- resonance imaging
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Iron (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Magnetic Heads (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/221,425 US5130120A (en) | 1988-07-19 | 1988-07-19 | Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI agents |
US07/377,491 US5137711A (en) | 1988-07-19 | 1989-07-13 | Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents |
PCT/US1989/003104 WO1990001024A1 (en) | 1988-07-19 | 1989-07-19 | Novel magnetic resonance imaging agents |
Publications (1)
Publication Number | Publication Date |
---|---|
HK130797A true HK130797A (en) | 1997-09-26 |
Family
ID=26915778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK130797A HK130797A (en) | 1988-07-19 | 1997-06-26 | Novel magnetic resonance imaging agents |
Country Status (10)
Country | Link |
---|---|
US (1) | US5137711A (nl) |
EP (1) | EP0425571B2 (nl) |
JP (2) | JPH082855B2 (nl) |
AT (1) | ATE142614T1 (nl) |
CA (1) | CA1339821C (nl) |
DE (2) | DE68927173T3 (nl) |
HK (1) | HK130797A (nl) |
NL (1) | NL300299I2 (nl) |
SG (1) | SG49063A1 (nl) |
WO (1) | WO1990001024A1 (nl) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743196A (en) * | 1985-06-10 | 1988-05-10 | Chugai Ro Co., Ltd. | Continuous annealing furnace for a strip |
IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
US5567411A (en) * | 1986-11-10 | 1996-10-22 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group |
US5252317A (en) * | 1986-11-10 | 1993-10-12 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid |
GB9007965D0 (en) * | 1990-04-09 | 1990-06-06 | Nycomed As | Compounds |
US5399340A (en) * | 1987-09-24 | 1995-03-21 | Schering Aktiengesellschaft | Use of amide complex compounds |
US5384108A (en) * | 1989-04-24 | 1995-01-24 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
US5695739A (en) * | 1989-06-30 | 1997-12-09 | Schering Aktiengesellschaft | Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production |
US6039931A (en) * | 1989-06-30 | 2000-03-21 | Schering Aktiengesellschaft | Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production |
CA2065415A1 (en) * | 1989-09-05 | 1991-03-06 | Raghavan Rajagopalan | Magnetic resonance imaging agents |
DE4011684A1 (de) | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5843399A (en) * | 1990-04-06 | 1998-12-01 | Schering Aktiengesellschaft | DTPA monoamides for MRI |
GB9007967D0 (en) * | 1990-04-09 | 1990-06-06 | Nycomed As | Compounds |
FR2663544B1 (fr) * | 1990-06-26 | 1994-05-06 | Medgenix Group Sa | Agent de contraste pour l'imagerie par rmn et agents chelateurs comportant des structures peptidiques. |
US5077037A (en) * | 1990-08-03 | 1991-12-31 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
US5162109A (en) * | 1990-09-13 | 1992-11-10 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
CA2096543A1 (en) * | 1990-11-21 | 1992-05-22 | Raghavan Rajagopalan | Alkoxyamide derivatized chelates for mri |
US5310539A (en) * | 1991-04-15 | 1994-05-10 | Board Of Regents, The University Of Texas System | Melanin-based agents for image enhancement |
US5208375A (en) * | 1991-07-02 | 1993-05-04 | Mallinckrodt Medical, Inc. | Compositions for magnetic resonance imaging |
US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
US5508388A (en) * | 1992-07-16 | 1996-04-16 | Mallinckrodt Medical, Inc. | Process for manufacturing DTPA-bis amide magnetic resonance imaging |
WO1994008630A1 (en) * | 1992-10-13 | 1994-04-28 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
ES2140469T3 (es) * | 1992-10-14 | 2000-03-01 | Nycomed Imaging As | Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes. |
US5817292A (en) * | 1992-10-14 | 1998-10-06 | Nycomed Imaging As | MR imaging compositions and methods |
US5756688A (en) * | 1992-10-14 | 1998-05-26 | Sterling Winthrop Inc. | MR imaging compositions and methods |
DE69312951T2 (de) * | 1992-10-14 | 1997-12-11 | Nycomed Imaging As | Chelatpolymere |
US5730968A (en) * | 1994-03-31 | 1998-03-24 | Sterling Winthrop Inc. | Segmented chelating polymers as imaging and therapeutic agents |
US5571498A (en) * | 1994-06-02 | 1996-11-05 | Hemagen/Pfc | Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI). |
US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
DE19507819A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
DE19507822B4 (de) * | 1995-02-21 | 2006-07-20 | Schering Ag | Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
US6020373A (en) * | 1995-10-20 | 2000-02-01 | Eastern Virginia Medical School | Chelate derivatives as protectors against tissue injury |
US5888476A (en) * | 1996-11-13 | 1999-03-30 | Mallinckrodt Medical, Inc. | Magnetic resonance blood pool agents |
US6224935B1 (en) | 1999-01-28 | 2001-05-01 | Cornell Research Foundation, Inc. | Ordered arrays via metal-initiated self-assembly of ligand containing dendrimers and bridging ligands |
FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
CN101384272B (zh) * | 2005-12-20 | 2013-05-01 | 杜克大学 | 用于递送具有增强的药理性质的活性剂的方法和组合物 |
US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
EP2926825A1 (en) | 2008-06-27 | 2015-10-07 | Duke University | Therapeutic agents comprising elastin-like peptides |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
DE3129906C3 (de) † | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
DE3324236A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner |
CA1242643A (en) * | 1983-08-12 | 1988-10-04 | Eric T. Fossel | Nmr imaging utilizing chemical shift reagents |
US4687658A (en) * | 1984-10-04 | 1987-08-18 | Salutar, Inc. | Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging |
US4687659A (en) * | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
US4826673A (en) * | 1985-01-09 | 1989-05-02 | Mallinckrodt, Inc. | Methods and compositions for enhancing magnetic resonance imaging |
EP0250358A3 (en) * | 1986-06-20 | 1988-10-05 | Schering Aktiengesellschaft | Novel complex compounds |
IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
DE3640708C2 (de) † | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
-
1989
- 1989-07-13 US US07/377,491 patent/US5137711A/en not_active Expired - Lifetime
- 1989-07-19 JP JP1508230A patent/JPH082855B2/ja not_active Expired - Fee Related
- 1989-07-19 CA CA000606161A patent/CA1339821C/en not_active Expired - Lifetime
- 1989-07-19 WO PCT/US1989/003104 patent/WO1990001024A1/en active IP Right Grant
- 1989-07-19 DE DE68927173T patent/DE68927173T3/de not_active Expired - Lifetime
- 1989-07-19 SG SG1996005703A patent/SG49063A1/en unknown
- 1989-07-19 DE DE122007000068C patent/DE122007000068I2/de active Active
- 1989-07-19 AT AT89908787T patent/ATE142614T1/de active
- 1989-07-19 EP EP89908787A patent/EP0425571B2/en not_active Expired - Lifetime
-
1995
- 1995-07-11 JP JP7197116A patent/JP2815556B2/ja not_active Expired - Fee Related
-
1997
- 1997-06-26 HK HK130797A patent/HK130797A/xx not_active IP Right Cessation
-
2007
- 2007-10-18 NL NL300299C patent/NL300299I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
JPH082855B2 (ja) | 1996-01-17 |
US5137711A (en) | 1992-08-11 |
CA1339821C (en) | 1998-04-14 |
DE68927173T3 (de) | 2001-01-11 |
EP0425571B1 (en) | 1996-09-11 |
AU650615B2 (en) | 1994-06-30 |
DE122007000068I2 (de) | 2009-01-02 |
JPH0920785A (ja) | 1997-01-21 |
ATE142614T1 (de) | 1996-09-15 |
JP2815556B2 (ja) | 1998-10-27 |
NL300299I2 (nl) | 2008-02-01 |
DE122007000068I1 (de) | 2008-02-14 |
SG49063A1 (en) | 1998-05-18 |
JPH04507084A (ja) | 1992-12-10 |
EP0425571A1 (en) | 1991-05-08 |
DE68927173D1 (de) | 1996-10-17 |
WO1990001024A1 (en) | 1990-02-08 |
EP0425571B2 (en) | 2000-09-20 |
NL300299I1 (nl) | 2007-12-03 |
AU3988589A (en) | 1990-02-19 |
DE68927173T2 (de) | 1997-01-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20090718 |