HK1258766A1 - 岩藻糖基化抗體的分離方法 - Google Patents

岩藻糖基化抗體的分離方法

Info

Publication number
HK1258766A1
HK1258766A1 HK19101095.1A HK19101095A HK1258766A1 HK 1258766 A1 HK1258766 A1 HK 1258766A1 HK 19101095 A HK19101095 A HK 19101095A HK 1258766 A1 HK1258766 A1 HK 1258766A1
Authority
HK
Hong Kong
Prior art keywords
separation method
fucosylated antibodies
fucosylated
antibodies
separation
Prior art date
Application number
HK19101095.1A
Other languages
English (en)
Inventor
Anne Freimoser-Grundschober
Christiane Jaeger
Peter Sondermann
Pablo Umana
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of HK1258766A1 publication Critical patent/HK1258766A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK19101095.1A 2011-10-19 2014-12-23 岩藻糖基化抗體的分離方法 HK1258766A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11185798 2011-10-19

Publications (1)

Publication Number Publication Date
HK1258766A1 true HK1258766A1 (zh) 2019-11-22

Family

ID=47019025

Family Applications (2)

Application Number Title Priority Date Filing Date
HK19101095.1A HK1258766A1 (zh) 2011-10-19 2014-12-23 岩藻糖基化抗體的分離方法
HK14112853.5A HK1199272A1 (zh) 2011-10-19 2014-12-23 岩藻糖基化抗體的分離方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK14112853.5A HK1199272A1 (zh) 2011-10-19 2014-12-23 岩藻糖基化抗體的分離方法

Country Status (12)

Country Link
US (2) US9994610B2 (zh)
EP (1) EP2768845B1 (zh)
JP (2) JP6356605B2 (zh)
KR (1) KR20140077178A (zh)
CN (2) CN103890002A (zh)
BR (1) BR112014009178A2 (zh)
CA (1) CA2851053A1 (zh)
ES (1) ES2619677T3 (zh)
HK (2) HK1258766A1 (zh)
MX (1) MX355048B (zh)
RU (1) RU2650873C2 (zh)
WO (1) WO2013057078A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
SG174804A1 (zh) 2006-09-13 2011-10-28 Abbott Lab
SG10201702951RA (en) 2008-10-20 2017-06-29 Abbvie Inc Viral inactivation during purification of antibodies
AU2009347206C1 (en) 2008-10-20 2016-12-08 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
CN103827134A (zh) 2011-07-20 2014-05-28 泽普泰恩股份有限公司 多肽分离方法
JP6451119B2 (ja) * 2014-07-17 2019-01-16 東ソー株式会社 抗体依存性細胞傷害活性の強さに基づき抗体を分離する方法
US20180319838A1 (en) * 2015-11-04 2018-11-08 Biogen Ma Inc. Conjugation methods for modifying or immobilizing proteins
SG11202003765RA (en) * 2017-04-06 2020-05-28 Flodesign Sonics Inc Acoustic perfusion devices
EP3993887B1 (en) * 2019-07-03 2023-07-26 Merck Patent GmbH Glycoform purification
US20230236194A1 (en) * 2019-07-12 2023-07-27 National University Corporation Hokkaido University Development of blood fibrosis marker for non-alcoholic steatohepatitis
GB202204016D0 (en) * 2022-03-22 2022-05-04 Ucl Business Plc Affinity chromatography ligands for antibody glycovariant separation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007089A1 (en) * 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
DK2180007T4 (da) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
EP1006183A1 (en) * 1998-12-03 2000-06-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Recombinant soluble Fc receptors
NZ592087A (en) 2001-08-03 2012-11-30 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
KR101292000B1 (ko) 2003-01-22 2013-08-01 로슈 글리카트 아게 융합 구성체와 Ｆｃ 수용체 결합 친화도 및 이펙터 기능이증가된 항체를 생성하기 위한 이의 용도
CN101098890B (zh) * 2004-11-12 2012-07-18 赞科股份有限公司 对FcRn的结合被改变的Fc变体
US7699979B2 (en) * 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
KR101247836B1 (ko) * 2005-06-17 2013-03-28 와이어쓰 엘엘씨 항 ａ 베타 항체의 정제 방법
WO2010048313A2 (en) * 2008-10-22 2010-04-29 Biogen Idec Ma Inc. Recombinant fcrn and variants thereof for purification of fc-containing fusion proteins
WO2011039150A1 (en) 2009-10-02 2011-04-07 Roche Glycart Ag A-fucosylation detection in antibodies
CN103827134A (zh) * 2011-07-20 2014-05-28 泽普泰恩股份有限公司 多肽分离方法

Also Published As

Publication number Publication date
US9994610B2 (en) 2018-06-12
EP2768845B1 (en) 2017-01-18
US20140255399A1 (en) 2014-09-11
CN108314729A (zh) 2018-07-24
JP2014530829A (ja) 2014-11-20
WO2013057078A1 (en) 2013-04-25
MX355048B (es) 2018-04-03
EP2768845A1 (en) 2014-08-27
RU2014118552A (ru) 2015-11-27
JP2018184406A (ja) 2018-11-22
RU2650873C2 (ru) 2018-04-17
HK1199272A1 (zh) 2015-06-26
MX2014004604A (es) 2014-05-27
US20180265544A1 (en) 2018-09-20
CA2851053A1 (en) 2013-04-25
JP6356605B2 (ja) 2018-07-11
CN103890002A (zh) 2014-06-25
KR20140077178A (ko) 2014-06-23
BR112014009178A2 (pt) 2018-09-04
ES2619677T3 (es) 2017-06-26

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