HK1258447A1 - 非選擇性代謝型谷氨酸受體激活劑用於治療注意缺陷病症和22q綜合症 - Google Patents

非選擇性代謝型谷氨酸受體激活劑用於治療注意缺陷病症和22q綜合症

Info

Publication number
HK1258447A1
HK1258447A1 HK19100752.7A HK19100752A HK1258447A1 HK 1258447 A1 HK1258447 A1 HK 1258447A1 HK 19100752 A HK19100752 A HK 19100752A HK 1258447 A1 HK1258447 A1 HK 1258447A1
Authority
HK
Hong Kong
Prior art keywords
syndrome
treatment
attention deficit
glutamate receptor
metabotropic glutamate
Prior art date
Application number
HK19100752.7A
Other languages
English (en)
Inventor
Hakon Hakonarson
Charlly Kao
Original Assignee
Childrens Hospital Philadelphia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital Philadelphia filed Critical Childrens Hospital Philadelphia
Publication of HK1258447A1 publication Critical patent/HK1258447A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK19100752.7A 2015-09-08 2019-01-16 非選擇性代謝型谷氨酸受體激活劑用於治療注意缺陷病症和22q綜合症 HK1258447A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562215633P 2015-09-08 2015-09-08
US201562215673P 2015-09-08 2015-09-08
US201562215636P 2015-09-08 2015-09-08
US201562215628P 2015-09-08 2015-09-08
PCT/US2016/050559 WO2017044491A1 (en) 2015-09-08 2016-09-07 Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22q syndrome

Publications (1)

Publication Number Publication Date
HK1258447A1 true HK1258447A1 (zh) 2019-11-15

Family

ID=56943962

Family Applications (4)

Application Number Title Priority Date Filing Date
HK19100753.6A HK1258448A1 (zh) 2015-09-08 2019-01-16 診斷和治療行為障礙的方法
HK19100752.7A HK1258447A1 (zh) 2015-09-08 2019-01-16 非選擇性代謝型谷氨酸受體激活劑用於治療注意缺陷病症和22q綜合症
HK19100745.7A HK1258373A1 (zh) 2015-09-08 2019-01-16 診斷和治療圖雷特多綜合症的方法
HK19100751.8A HK1258446A1 (zh) 2015-09-08 2019-01-16 診斷和治療焦慮症的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK19100753.6A HK1258448A1 (zh) 2015-09-08 2019-01-16 診斷和治療行為障礙的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK19100745.7A HK1258373A1 (zh) 2015-09-08 2019-01-16 診斷和治療圖雷特多綜合症的方法
HK19100751.8A HK1258446A1 (zh) 2015-09-08 2019-01-16 診斷和治療焦慮症的方法

Country Status (13)

Country Link
US (12) US11179378B2 (zh)
EP (11) EP3347013B1 (zh)
JP (8) JP7152306B2 (zh)
CN (7) CN115919852A (zh)
AU (8) AU2016318775B2 (zh)
CA (5) CA3225374A1 (zh)
DK (4) DK3347014T3 (zh)
ES (7) ES2976071T3 (zh)
HK (4) HK1258448A1 (zh)
IL (10) IL303605A (zh)
PL (3) PL3964213T3 (zh)
SG (1) SG10202012842SA (zh)
WO (4) WO2017044491A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2686300T3 (es) 2010-08-24 2018-10-17 The Children's Hospital Of Philadelphia Asociación de variaciones genéticas raras recurrentes con el trastorno por déficit de atención e hiperactividad (TDAH) y procedimientos de uso de las mismas para el diagnóstico y tratamiento del mismo
IL303605A (en) 2015-09-08 2023-08-01 Childrens Hospital Philadelphia Methods for diagnosis and treatment of Tourette syndrome
US20200143922A1 (en) * 2016-06-03 2020-05-07 Yale University Methods and apparatus for predicting depression treatment outcomes
WO2018048868A1 (en) * 2016-09-07 2018-03-15 The Children's Hospital Of Philadelphia Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder
WO2018195184A1 (en) 2017-04-19 2018-10-25 Aevi Genomics Medicine, Inc. Methods of diagnosing and treating adhd in biomarker positive subjects
WO2018209328A1 (en) * 2017-05-11 2018-11-15 Miwa Julie M Compositions and methods for treating lynx2 disorders
CN107483425B (zh) * 2017-08-08 2020-12-18 北京盛华安信息技术有限公司 基于攻击链的复合攻击检测方法
SG11202006813TA (en) 2018-01-18 2020-08-28 Childrens Hospital Philadelphia Fasoracetam crystalline forms
WO2019143824A1 (en) 2018-01-18 2019-07-25 Aevi Genomic Medicine, Inc. Solid forms of fasoracetam
KR102250063B1 (ko) * 2019-06-14 2021-05-12 한국생명공학연구원 뚜렛증후군의 원인 유전자를 동정하는 방법
CN110955751A (zh) * 2019-11-13 2020-04-03 广州供电局有限公司 工作票文本去重方法、装置、系统及计算机存储介质
EP4213855A4 (en) * 2020-09-21 2024-10-23 Reveragen Biopharma Inc TREATMENT OF NF-KB-MEDIATED DISEASES
WO2022065518A1 (ja) * 2020-09-23 2022-03-31 国立大学法人京都大学 神経突起伸長促進剤
KR20240112047A (ko) * 2023-01-11 2024-07-18 차의과학대학교 산학협력단 불안장애를 진단하기 위한 바이오마커 및 이의 용도
CN117594119B (zh) * 2024-01-17 2024-05-10 北京大学第六医院 用于预测帕罗西汀或其药用盐对抑郁或焦虑症患者疗效的装置

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004523557A (ja) * 2001-02-23 2004-08-05 ジョンズ・ホプキンス・ユニバーシティ チック、振せん、および関連疾患の治療
US20050233321A1 (en) 2001-12-20 2005-10-20 Hess John W Identification of novel polymorphic sites in the human mglur8 gene and uses thereof
US20070244152A1 (en) 2004-03-25 2007-10-18 Lowy Martin T Use of an Nk3 Antagonist for the Treatment of Bipolar Disorders
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007104035A1 (en) 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TW200819458A (en) 2006-06-23 2008-05-01 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators
US20100120628A1 (en) 2007-02-06 2010-05-13 Genizon Biosciences Inc. Genemap of the human genes associated with adhd
EP2149047A4 (en) 2007-04-30 2010-05-19 Univ Ohio State Res Found POLYMORPHISMS IN GENES WITH INFLUENCE ON DOPAMINTRANSPORTER DISEASES AND ITS APPLICATIONS
US20090176740A1 (en) 2007-11-30 2009-07-09 Phillips Ii Dauglas James Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine
US9783851B2 (en) 2008-02-20 2017-10-10 The Children's Hospital Of Philadelphia Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatment of autism
WO2010057132A1 (en) 2008-11-14 2010-05-20 The Children's Hospital Of Philadelphia Genetic alterations associated with schizophrenia and methods of use thereof for the diagnosis and treatment of the same
CA2766246C (en) 2008-11-14 2020-03-10 Hakon Hakonarson Genetic variants underlying human cognition and methods of use thereof as diagnostic and therapeutic targets
EP2470527A4 (en) 2009-08-20 2013-02-27 Merck Sharp & Dohme BENZOTRIAZOLE D ETHER DERIVATIVES
US8714471B2 (en) * 2010-07-29 2014-05-06 Brady Worldwide, Inc. Friction core brake
ES2686300T3 (es) * 2010-08-24 2018-10-17 The Children's Hospital Of Philadelphia Asociación de variaciones genéticas raras recurrentes con el trastorno por déficit de atención e hiperactividad (TDAH) y procedimientos de uso de las mismas para el diagnóstico y tratamiento del mismo
US20130225623A1 (en) 2010-10-27 2013-08-29 Mount Sinai School Of Medicine Methods of Treating Psychiatric or Neurological Disorders with MGLUR Antagonists
WO2013006857A1 (en) 2011-07-07 2013-01-10 The Children's Hospital Of Philadelphia Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatment of autism
WO2016022324A1 (en) 2014-05-30 2016-02-11 The Children's Hospital Of Philadelphia Genetic alterations associated with autism and autistic phenotype and methods of diagnosing and treating autism
US20130143867A1 (en) * 2011-12-02 2013-06-06 Sychroneuron Inc. Acamprosate formulations, methods of using the same, and combinations comprising the same
EP3878442A1 (en) * 2012-08-23 2021-09-15 Stuart L. Weg Anxiolytic composition comprising ketamine, formulation and method of use
US9346239B2 (en) 2012-09-26 2016-05-24 Eastman Kodak Company Method for providing patterns of functional materials
WO2014152965A2 (en) 2013-03-14 2014-09-25 The Children's Hospital Of Philadelphia Schizophrenia-associated genetic loci identified in genome wide association studies and use thereof as novel therapeutic targets
US11219617B2 (en) 2014-05-30 2022-01-11 The Children's Hospital Of Philadelphia Methods of diagnosing and treating autism
KR102232583B1 (ko) 2015-01-08 2021-03-26 삼성전자주식회사 전자장치 및 전자장치의 웹 재현 방법
AU2016278053A1 (en) 2015-06-15 2018-01-04 The Children's Hospital Of Philadelphia Methods of diagnosing and treating autism
IL303605A (en) 2015-09-08 2023-08-01 Childrens Hospital Philadelphia Methods for diagnosis and treatment of Tourette syndrome

Also Published As

Publication number Publication date
WO2017044502A1 (en) 2017-03-16
US11179378B2 (en) 2021-11-23
US11298347B2 (en) 2022-04-12
JP2018526396A (ja) 2018-09-13
CN108495630A (zh) 2018-09-04
ES2898932T3 (es) 2022-03-09
US20220117953A1 (en) 2022-04-21
IL257785B (en) 2022-04-01
EP3922249B1 (en) 2024-02-28
AU2016318780A1 (en) 2018-04-12
US20170087141A1 (en) 2017-03-30
DK3347015T3 (da) 2021-12-06
US11806341B2 (en) 2023-11-07
DK3347013T3 (da) 2022-04-04
ES2909329T3 (es) 2022-05-06
US9884057B2 (en) 2018-02-06
EP3977996A1 (en) 2022-04-06
EP4410288A1 (en) 2024-08-07
US20200306237A1 (en) 2020-10-01
IL257747B (en) 2022-04-01
HK1258446A1 (zh) 2019-11-15
DK3347014T3 (da) 2021-12-06
JP2023051937A (ja) 2023-04-11
IL290994A (en) 2022-05-01
EP3347014B1 (en) 2021-10-20
IL290992B1 (en) 2023-03-01
CA3225374A1 (en) 2017-03-16
PL3977996T3 (pl) 2024-07-01
AU2016318786B2 (en) 2022-04-07
IL290985A (en) 2022-05-01
IL290993B2 (en) 2023-11-01
IL290992A (en) 2022-05-01
US11173153B2 (en) 2021-11-16
AU2022204324B2 (en) 2024-08-29
EP3347015B1 (en) 2021-10-20
US20170105985A1 (en) 2017-04-20
DK3347016T3 (da) 2021-07-12
EP3347015A1 (en) 2018-07-18
EP3347016A1 (en) 2018-07-18
CN115919852A (zh) 2023-04-07
ES2981632T3 (es) 2024-10-09
IL257744A (en) 2018-06-28
AU2022203039A1 (en) 2022-05-26
US20170087139A1 (en) 2017-03-30
WO2017044497A1 (en) 2017-03-16
EP4342493A3 (en) 2024-07-03
AU2016318775B2 (en) 2022-02-10
WO2017044503A1 (en) 2017-03-16
CA2997191A1 (en) 2017-03-16
ES2876898T3 (es) 2021-11-15
IL300474A (en) 2023-04-01
EP3922249A1 (en) 2021-12-15
JP2018526395A (ja) 2018-09-13
CN108348517A (zh) 2018-07-31
ES2897953T3 (es) 2022-03-03
EP3964213B1 (en) 2024-03-13
CN108601776A (zh) 2018-09-28
EP3347014A1 (en) 2018-07-18
US20240100036A1 (en) 2024-03-28
JP7027308B2 (ja) 2022-03-01
US20170087140A1 (en) 2017-03-30
HK1258448A1 (zh) 2019-11-15
EP3347013A1 (en) 2018-07-18
IL257744B (en) 2022-04-01
AU2022205142A1 (en) 2022-07-28
EP3977996B1 (en) 2024-03-13
IL257785A (en) 2018-06-28
IL257746B (en) 2022-04-01
ES2980894T3 (es) 2024-10-03
IL257746A (en) 2018-06-28
CA2997189A1 (en) 2017-03-16
JP7152306B2 (ja) 2022-10-12
US10869861B2 (en) 2020-12-22
US20210205288A1 (en) 2021-07-08
EP4410289A1 (en) 2024-08-07
AU2022204324A1 (en) 2022-07-07
CN108348518A (zh) 2018-07-31
EP3347013B1 (en) 2022-02-16
JP2023011558A (ja) 2023-01-24
SG10202012842SA (en) 2021-01-28
AU2016318780B2 (en) 2022-04-07
JP7281280B2 (ja) 2023-05-25
JP2018526398A (ja) 2018-09-13
IL257747A (en) 2018-06-28
IL290993A (en) 2022-05-01
JP2018526394A (ja) 2018-09-13
JP7532465B2 (ja) 2024-08-13
US12121514B2 (en) 2024-10-22
EP4342493A2 (en) 2024-03-27
JP7281279B2 (ja) 2023-05-25
AU2022204355A1 (en) 2022-07-14
AU2016318775A1 (en) 2018-04-12
AU2022205142B2 (en) 2024-08-29
US11806340B2 (en) 2023-11-07
AU2016318785A1 (en) 2018-04-12
JP2022078104A (ja) 2022-05-24
EP3347016B1 (en) 2021-04-28
JP2023036671A (ja) 2023-03-14
AU2016318785B2 (en) 2022-04-14
AU2016318786A1 (en) 2018-04-12
CN108348517B (zh) 2021-11-05
EP3964213A1 (en) 2022-03-09
IL290992B2 (en) 2023-07-01
IL290993B1 (en) 2023-07-01
IL303605A (en) 2023-08-01
CA2997187A1 (en) 2017-03-16
US20220117954A1 (en) 2022-04-21
HK1258373A1 (zh) 2019-11-08
CN116919961A (zh) 2023-10-24
US20220296582A1 (en) 2022-09-22
EP4023222A1 (en) 2022-07-06
US20180110767A1 (en) 2018-04-26
CN116919962A (zh) 2023-10-24
ES2976071T3 (es) 2024-07-22
PL3964213T3 (pl) 2024-07-08
WO2017044491A1 (en) 2017-03-16
CA2997188A1 (en) 2017-03-16
US20240075022A1 (en) 2024-03-07
AU2022204355B2 (en) 2024-08-29
CA2997187C (en) 2024-02-20
PL3922249T3 (pl) 2024-07-29
AU2022203039B2 (en) 2024-08-22

Similar Documents

Publication Publication Date Title
IL290992B1 (en) Non-selective metabotropic glutamate receptor activators for the treatment of ADHD and 22q syndrome
IL273679A (en) Medical pad systems and methods
DK3386484T3 (da) Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler
GB2537970B (en) Shade adjustment notification system and method
IL248757A0 (en) Controllable drug delivery system and method of use
GB201802952D0 (en) Itinerary generation and adjustment system
IL249189A0 (en) Combined treatment of antibodies against human cd40 and antibodies against human pd-l1
HK1215119A1 (zh) 治療產品遞送系統和配對方法
HK1212791A1 (zh) 可動態組合和調整的個人工作系統
HUE052709T2 (hu) Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására
PT3160964T (pt) Moduladores dos receptores de arilo e métodos de fabrico e utilização dos mesmos
IL252011B (en) Methods and compositions especially for the treatment of attention deficit disorder
DK3113782T3 (da) Lægemiddelleveringssystemer og fremgangsmåder til behandling af blærekræft med gemcitabin
FI20146023A (fi) Hammas- ja kielituki
IL267205A (en) Inhibited waxy starches and methods of using them
PL3000407T3 (pl) Urządzenia i sposoby do stabilizacji elementów mocujących po rozmieszczeniu
ZA201702403B (en) Sphingosine-1-phospate receptor modulators for treatment of cardiopulmonary disorders
SG11201608498WA (en) System and method for generating flame effect
IL249894A0 (en) Targeted medical nanoparticles and methods for their preparation and use
HK1259078A1 (zh) 合成的鞘脂類分子、藥物、它們的合成方法及治療方法
SI3370733T1 (sl) Postopek za aktivacijo CD40 in blokada imunske nadzorne točke
IL264165A (en) Inhibited starches, coagulation retarders and methods of using them
PL3288483T3 (pl) System kotwienia i pozycjonowania czaszkowego
GB201411150D0 (en) Novel aptamers and therapeutic uses thereof
GB2531711B (en) Authentication system and method of authentication