HK1256307A1 - 用小分子混合物將人神經膠質細胞化學重編程為神經元 - Google Patents

用小分子混合物將人神經膠質細胞化學重編程為神經元

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Publication number
HK1256307A1
HK1256307A1 HK18115373.5A HK18115373A HK1256307A1 HK 1256307 A1 HK1256307 A1 HK 1256307A1 HK 18115373 A HK18115373 A HK 18115373A HK 1256307 A1 HK1256307 A1 HK 1256307A1
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HK
Hong Kong
Prior art keywords
neurons
small molecule
glial cells
human glial
chemical reprogramming
Prior art date
Application number
HK18115373.5A
Other languages
English (en)
Inventor
Gong Chen
Lei Zhang
Jiuchao Yin
Ningxin Ma
Original Assignee
Penn State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Res Found filed Critical Penn State Res Found
Publication of HK1256307A1 publication Critical patent/HK1256307A1/zh

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK18115373.5A 2015-12-04 2018-11-30 用小分子混合物將人神經膠質細胞化學重編程為神經元 HK1256307A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562263353P 2015-12-04 2015-12-04
PCT/US2016/064553 WO2017096123A1 (en) 2015-12-04 2016-12-02 Chemical reprogramming of human glial cells into neurons with small molecule cocktail

Publications (1)

Publication Number Publication Date
HK1256307A1 true HK1256307A1 (zh) 2019-09-20

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HK18115373.5A HK1256307A1 (zh) 2015-12-04 2018-11-30 用小分子混合物將人神經膠質細胞化學重編程為神經元

Country Status (10)

Country Link
US (2) US9885015B2 (zh)
EP (2) EP3795147B1 (zh)
JP (1) JP6951336B2 (zh)
KR (2) KR102444438B1 (zh)
CN (2) CN108430582B (zh)
AU (1) AU2016364845B2 (zh)
CA (1) CA3007116A1 (zh)
HK (1) HK1256307A1 (zh)
SG (1) SG11201804440XA (zh)
WO (1) WO2017096123A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201800001168A1 (it) * 2018-01-17 2019-07-17 Fond Per Listituto Oncologico Di Ricerca Ior Nuovi farmaci senolitici inibitori alk
AU2020257262A1 (en) * 2019-04-18 2021-11-18 Brown University Neurogenesis
EP4065091A4 (en) * 2019-11-25 2023-11-29 The Penn State Research Foundation COMPOSITION AND METHOD FOR CONVERTING HUMAN GLIA CELLS INTO NEURONS
WO2021195706A1 (en) * 2020-03-31 2021-10-07 Children's Medical Research Institute New dynamin inhibitors and uses
WO2022095057A1 (zh) * 2020-11-09 2022-05-12 深圳先进技术研究院 一种医药组合物及其医药用途
CN113244236B (zh) * 2021-06-01 2023-02-03 上海市第一人民医院 色瑞替尼在制备治疗甲状腺相关眼病的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2379149A1 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic pyrrolidines and piperidines, and related compositions and methods
GB0316882D0 (en) * 2003-07-18 2003-08-20 Consejo Superior Investigacion Reversible immortalization of OEG from human olfactory bulbs as a tool to promote spinal cord regeneration
JP2009538279A (ja) 2006-03-09 2009-11-05 ユニバーシティー オブ ロチェスター 末梢および神経の炎症性クロストーク
CN101732255A (zh) 2010-01-07 2010-06-16 同济大学 一种氟比洛芬脂质体及其制备方法
EP2577318B1 (en) 2010-05-25 2019-06-26 Memorial Sloan-Kettering Cancer Center Method of nociceptor differentiantion of human embryonic stem cells and uses thereof
CN114601937A (zh) * 2012-07-19 2022-06-10 宾夕法尼亚州研究基金会 再生用于在神经系统中治疗疾病和损伤的功能性神经元
EP3881857A1 (en) * 2016-02-18 2021-09-22 The Penn State Research Foundation Generating gabaergic neurons in brains
WO2020263639A1 (en) * 2019-06-28 2020-12-30 The Penn State Research Foundation Methods and materials for treating huntington's disease

Also Published As

Publication number Publication date
SG11201804440XA (en) 2018-06-28
KR102102837B1 (ko) 2020-04-22
CN111184739B (zh) 2022-06-24
EP3383495A1 (en) 2018-10-10
KR102444438B1 (ko) 2022-09-19
EP3795147A1 (en) 2021-03-24
JP2018535988A (ja) 2018-12-06
CN108430582A (zh) 2018-08-21
CA3007116A1 (en) 2017-06-08
EP3383495B1 (en) 2021-01-20
CN108430582B (zh) 2020-02-21
US20170159013A1 (en) 2017-06-08
EP3795147B1 (en) 2023-08-30
EP3383495A4 (en) 2019-09-04
US20180148688A1 (en) 2018-05-31
CN111184739A (zh) 2020-05-22
US9885015B2 (en) 2018-02-06
KR20180081824A (ko) 2018-07-17
US10253293B2 (en) 2019-04-09
AU2016364845A1 (en) 2018-06-21
JP6951336B2 (ja) 2021-10-20
KR20200043503A (ko) 2020-04-27
WO2017096123A1 (en) 2017-06-08
AU2016364845B2 (en) 2022-07-28

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