HK1255145B - 地佐辛類似物 - Google Patents

地佐辛類似物

Info

Publication number
HK1255145B
HK1255145B HK18114230.1A HK18114230A HK1255145B HK 1255145 B HK1255145 B HK 1255145B HK 18114230 A HK18114230 A HK 18114230A HK 1255145 B HK1255145 B HK 1255145B
Authority
HK
Hong Kong
Prior art keywords
dezocine
analogue
dezocine analogue
Prior art date
Application number
HK18114230.1A
Other languages
English (en)
Inventor
張楊
伍文韜
李志祥
楊廣文
方勇波
張濤
谷偉
陳曙輝
王非
黎健
Original Assignee
山東丹紅制藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 山東丹紅制藥有限公司 filed Critical 山東丹紅制藥有限公司
Publication of HK1255145B publication Critical patent/HK1255145B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/16—Eight-membered rings
    • C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK18114230.1A 2016-01-04 2018-11-07 地佐辛類似物 HK1255145B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610003868 2016-01-04
PCT/CN2017/070126 WO2017118375A1 (zh) 2016-01-04 2017-01-04 地佐辛类似物

Publications (1)

Publication Number Publication Date
HK1255145B true HK1255145B (zh) 2020-04-09

Family

ID=59273706

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114230.1A HK1255145B (zh) 2016-01-04 2018-11-07 地佐辛類似物

Country Status (7)

Country Link
US (1) US10414718B2 (zh)
EP (1) EP3401306B1 (zh)
JP (1) JP6605157B2 (zh)
CN (2) CN108602757B (zh)
ES (1) ES2836429T3 (zh)
HK (1) HK1255145B (zh)
WO (1) WO2017118375A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6983910B2 (ja) 2017-07-03 2021-12-17 山東丹紅制薬有限公司Shandong Danhong Pharmaceutical Co., Ltd. デゾシン類似体塩酸塩の結晶形及び非晶質
JP6850371B2 (ja) * 2017-07-04 2021-03-31 シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． デゾシン類似体エステルを含む徐放懸濁液およびその製造方法
CN108299173B (zh) * 2018-01-26 2021-01-12 扬子江药业集团有限公司 一种地佐辛关键中间体的不对称合成方法
US20210087156A1 (en) * 2018-04-24 2021-03-25 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Pharmaceutically acceptable salts of benzodicycloalkane derivative, polymorphic substance thereof, and application thereof
CN115490581A (zh) * 2021-06-18 2022-12-20 扬子江药业集团江苏海慈生物药业有限公司 一种阿片类重要中间体有关物质及其制备方法及用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976693A (en) * 1970-12-03 1976-08-24 American Home Products Corporation Benzobicycloalkanone oximes
US3836670A (en) * 1971-11-19 1974-09-17 American Home Prod Benzobicycloalkane amines for inducing analgesia
ZA717697B (en) 1970-12-03 1973-06-27 American Home Prod Benzobicycloalkane amines
US3931328A (en) * 1972-06-14 1976-01-06 American Home Products Corporation Benzobicycloalkane ketones
US4001331A (en) * 1972-06-14 1977-01-04 American Home Products Corporation Benzobicycloalkane
US3937736A (en) * 1972-06-14 1976-02-10 American Home Products Corporation Benzobicycloalkane amines
US3957872A (en) * 1972-06-14 1976-05-18 American Home Products Corporation Benzobicycloalkane amine n-oxides and the salts thereof
US4001326A (en) * 1972-06-14 1977-01-04 American Home Products Corporation Benzobicycloalkane imines
US3869512A (en) * 1973-02-20 1975-03-04 American Home Prod Dibenzobicycloalkane amines and related compounds
US3976696A (en) * 1973-12-03 1976-08-24 American Home Products Corporation Benzobicycloalkane amines
US3979434A (en) * 1973-12-03 1976-09-07 American Home Products Corporation Benzobicycloalkane amines
US4049701A (en) * 1975-02-26 1977-09-20 American Home Products Corporation Benzobicycloalkane amines
US4034041A (en) * 1975-03-13 1977-07-05 American Home Products Corporation 1,3-Bridged amino tetralins
AU2009249069A1 (en) * 2008-05-20 2009-11-26 Neurogesx, Inc. Carbonate prodrugs and methods of using the same
JP2013523599A (ja) * 2009-04-02 2013-06-17 シャイア エルエルシー 新規なオピオイドのジカルボン酸結合アミノ酸及びペプチドプロドラッグ並びにその用途
CN102503840B (zh) * 2011-12-15 2013-06-19 扬子江药业集团江苏海慈生物药业有限公司 一种地佐辛的制备方法
CN108698980B (zh) * 2016-11-17 2021-05-07 上海海雁医药科技有限公司 苯并二环烷烃衍生物、其制法及其用途
JP6983910B2 (ja) * 2017-07-03 2021-12-17 山東丹紅制薬有限公司Shandong Danhong Pharmaceutical Co., Ltd. デゾシン類似体塩酸塩の結晶形及び非晶質

Also Published As

Publication number Publication date
JP2019502754A (ja) 2019-01-31
CN110054568A (zh) 2019-07-26
CN108602757A (zh) 2018-09-28
WO2017118375A1 (zh) 2017-07-13
CN110054568B (zh) 2020-01-14
JP6605157B2 (ja) 2019-11-13
CN108602757B (zh) 2019-07-05
EP3401306A4 (en) 2019-03-13
US10414718B2 (en) 2019-09-17
EP3401306B1 (en) 2020-09-30
EP3401306A1 (en) 2018-11-14
ES2836429T3 (es) 2021-06-25
US20190010114A1 (en) 2019-01-10

Similar Documents

Publication Publication Date Title
DK3512547T3 (en) Anti-pd-1-antistoffer
AU201616678S (en) Cylindres
DK3504696T3 (en) Optisk kommunikativt batteristyringssystem
DK3482386T3 (en) Patientsimulator
DK3438253T3 (en) Phytasemutant
DK3270751T3 (en) Foodprocessor
DK3538786T3 (en) Friktionsmateriale
PL3238827T3 (pl) Młynek do kości
HK1255145B (zh) 地佐辛類似物
DK3440392T3 (en) Styreapparat
LT3225858T (lt) Medsraigtis
GB201703128D0 (en) Kraftfahrzeugkarosserie
LT3249244T (lt) Medsraigis
DK3468998T3 (en) Anti-tnfrsf25-antistoffer
AU201710564S (en) Bookrack
DK3430092T3 (en) Coatingsystem
PL3426937T3 (pl) Śruba
AU201713059S (en) SUNSHADE - square
GB201703902D0 (en) Screwdriver
AU201713060S (en) SUNSHADE - triangle
AU5499P (en) T15-1218 Bituminaria bituminosa
AU2016376V (en) NinbellaPurple Alyogyne huegelii
AU2016362V (en) JCU9 Desmanthus pernambucanus
AU2016359V (en) JCU6 Desmanthus bicornutus
AU2016360V (en) JCU7 Desmanthus leptophyllus