HK1254976A1 - 造血幹細胞和抗癌免疫檢查點抑制劑的組合療法 - Google Patents
造血幹細胞和抗癌免疫檢查點抑制劑的組合療法Info
- Publication number
- HK1254976A1 HK1254976A1 HK18114083.9A HK18114083A HK1254976A1 HK 1254976 A1 HK1254976 A1 HK 1254976A1 HK 18114083 A HK18114083 A HK 18114083A HK 1254976 A1 HK1254976 A1 HK 1254976A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cells
- hematopoietic stem
- immune checkpoint
- against cancer
- checkpoint inhibitors
- Prior art date
Links
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 title 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 title 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 title 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4636—Immune checkpoint inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/47—Brain; Nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562199916P | 2015-07-31 | 2015-07-31 | |
US201662296866P | 2016-02-18 | 2016-02-18 | |
US201662296849P | 2016-02-18 | 2016-02-18 | |
US201662296826P | 2016-02-18 | 2016-02-18 | |
PCT/US2016/044718 WO2017023753A1 (en) | 2015-07-31 | 2016-07-29 | Hematopoietic stem cells in combinatorial therapy with immune checkpoint inhibitors against cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1254976A1 true HK1254976A1 (zh) | 2019-08-02 |
Family
ID=57943813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18114083.9A HK1254976A1 (zh) | 2015-07-31 | 2018-11-05 | 造血幹細胞和抗癌免疫檢查點抑制劑的組合療法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US10660954B2 (zh) |
EP (1) | EP3328896A4 (zh) |
JP (2) | JP7062290B2 (zh) |
KR (1) | KR20180029079A (zh) |
AU (2) | AU2016303489B2 (zh) |
CA (1) | CA2994241A1 (zh) |
HK (1) | HK1254976A1 (zh) |
WO (1) | WO2017023753A1 (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10660954B2 (en) | 2015-07-31 | 2020-05-26 | University Of Florida Research Foundation, Incorporated | Hematopoietic stem cells in combinatorial therapy with immune checkpoint inhibitors against cancer |
WO2017219029A2 (en) | 2016-06-17 | 2017-12-21 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+cells |
US10799555B2 (en) | 2016-09-15 | 2020-10-13 | Leidos, Inc. | PD-1 peptide inhibitors |
JP7114095B2 (ja) | 2016-12-21 | 2022-08-08 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | Ccr2+造血幹細胞は養子細胞療法におけるt細胞活性化を媒介する |
MX2019008205A (es) | 2017-01-20 | 2020-01-23 | Magenta Therapeutics Inc | Composiciones y metodos para el agotamiento de células cd137+. |
US10300090B2 (en) | 2017-03-15 | 2019-05-28 | Orca Biosystems, Inc. | Compositions of hematopoietic stem cell transplants |
US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
US11033622B2 (en) | 2017-05-25 | 2021-06-15 | Leidos, Inc. | PD-1 and CTLA-4 dual inhibitor peptides |
EP3687505A1 (en) | 2017-09-26 | 2020-08-05 | Tesaro Inc. | Niraparib formulations |
JP7330196B2 (ja) * | 2018-01-18 | 2023-08-21 | ユートロピクス ファーマシューティカルズ, インコーポレイテッド | がん薬物応答性を予測する方法 |
JP2021513524A (ja) * | 2018-02-05 | 2021-05-27 | テサロ, インコーポレイテッド | 小児用ニラパリブ製剤および小児向け処置方法 |
WO2019157158A2 (en) | 2018-02-08 | 2019-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for allogenic hematopoietic stem cell transplantation |
TWI723354B (zh) | 2018-03-21 | 2021-04-01 | 中國醫藥大學 | 用於癌症治療之工程化幹細胞 |
US20210236694A1 (en) * | 2018-05-03 | 2021-08-05 | The Johns Hopkins University | Induction of anti-tumoral immune microenvironments |
US11697799B2 (en) | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
EP4054591A1 (en) * | 2019-11-04 | 2022-09-14 | Astrazeneca AB | Combination therapy for treating cancer |
JP2023521671A (ja) * | 2020-04-03 | 2023-05-25 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | Covid-19感染症に対する幹細胞免疫調節療法 |
WO2021247789A1 (en) | 2020-06-04 | 2021-12-09 | Leidos, Inc. | Immunomodulatory compounds |
EP4181675A4 (en) | 2020-07-18 | 2024-04-24 | Ossium Health, Inc. | PERMEATION OF WHOLE VERTEBRAL BODY WITH CRYOPROTECTIVE USING VACUUM-ASSISTED DIFFUSION |
EP4225444A1 (en) | 2020-10-12 | 2023-08-16 | Leidos, Inc. | Immunomodulatory peptides |
EP4228406A1 (en) | 2020-10-14 | 2023-08-23 | Ossium Health, Inc. | Systems and methods for extraction and cryopreservation of bone marrow |
CN117279650A (zh) | 2020-12-18 | 2023-12-22 | 奥瑟姆健康公司 | 细胞治疗方法 |
CN114788877B (zh) * | 2022-03-24 | 2023-11-24 | 苏州大学 | 一种基因工程化造血干细胞给药系统及其制备方法和应用 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
EP2829609A1 (en) | 1999-08-24 | 2015-01-28 | E. R. Squibb & Sons, L.L.C. | Human CTLA-4 antibodies and their uses |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
WO2001054732A1 (en) | 2000-01-27 | 2001-08-02 | Genetics Institute, Llc. | Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof |
SI2206517T1 (sl) | 2002-07-03 | 2023-12-29 | Ono Pharmaceutical Co., Ltd. | Imunopotencirni sestavki,ki obsegajo protitelesa proti PD-L1 |
DK1558648T3 (da) | 2002-10-17 | 2012-04-23 | Genmab As | Humane monoklonale antistoffer mod cd20 |
WO2006116181A2 (en) | 2005-04-25 | 2006-11-02 | Trustees Of Dartmouth College | Regulatory t cell mediator proteins and uses thereof |
US7960434B2 (en) | 2006-05-19 | 2011-06-14 | University Of South Florida | Small molecule inhibitors of STAT3 with anti-tumor activity |
KR101523391B1 (ko) | 2006-12-27 | 2015-05-27 | 에모리 유니버시티 | 감염 및 종양 치료를 위한 조성물 및 방법 |
PL2170959T3 (pl) | 2007-06-18 | 2014-03-31 | Merck Sharp & Dohme | Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1 |
WO2009114725A2 (en) * | 2008-03-12 | 2009-09-17 | Children's Hospital Medical Center | Mobilization of hematopoietic stem cells |
KR20110050529A (ko) | 2008-08-25 | 2011-05-13 | 앰플리뮨, 인크. | Pd-1 길항제의 조성물 및 사용 방법 |
KR101924874B1 (ko) | 2008-09-26 | 2018-12-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도 |
CN102231984A (zh) | 2008-10-01 | 2011-11-02 | 北卡罗来纳大学查珀尔希尔分校 | 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗化疗化合物的造血防护 |
US8475790B2 (en) | 2008-10-06 | 2013-07-02 | Bristol-Myers Squibb Company | Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases |
JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Pd−l1/pd−l2の同時阻害 |
CA2794483C (en) | 2010-03-26 | 2020-07-07 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
WO2013043569A1 (en) | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
CN104159911A (zh) | 2012-03-07 | 2014-11-19 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的模拟肽化合物 |
EA037351B8 (ru) | 2012-05-15 | 2021-04-29 | Бристол-Майерс Сквибб Компани | Способ лечения злокачественных опухолей с использованием комбинации антител против pd-1 и ctla-4 |
KR102129636B1 (ko) | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
CA2877533C (en) | 2012-06-22 | 2022-08-16 | The Trustees Of Dartmouth College | Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders |
US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
CN105246507B (zh) | 2012-09-07 | 2019-01-25 | 达特茅斯大学理事会 | 用于诊断和治疗癌症的vista调节剂 |
US10570204B2 (en) * | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
RS63295B1 (sr) | 2013-12-24 | 2022-06-30 | Janssen Pharmaceutica Nv | Anti-vista antitela i fragmenti |
US11123426B2 (en) | 2014-06-11 | 2021-09-21 | The Trustees Of Dartmouth College | Use of vista agonists and antagonists to suppress or enhance humoral immunity |
US10660954B2 (en) | 2015-07-31 | 2020-05-26 | University Of Florida Research Foundation, Incorporated | Hematopoietic stem cells in combinatorial therapy with immune checkpoint inhibitors against cancer |
-
2016
- 2016-07-29 US US15/748,284 patent/US10660954B2/en active Active
- 2016-07-29 AU AU2016303489A patent/AU2016303489B2/en active Active
- 2016-07-29 EP EP16833610.5A patent/EP3328896A4/en active Pending
- 2016-07-29 KR KR1020187005904A patent/KR20180029079A/ko not_active Application Discontinuation
- 2016-07-29 CA CA2994241A patent/CA2994241A1/en active Pending
- 2016-07-29 JP JP2018504814A patent/JP7062290B2/ja active Active
- 2016-07-29 WO PCT/US2016/044718 patent/WO2017023753A1/en unknown
-
2018
- 2018-11-05 HK HK18114083.9A patent/HK1254976A1/zh unknown
-
2020
- 2020-04-13 US US16/847,484 patent/US11904016B2/en active Active
-
2021
- 2021-11-15 JP JP2021185556A patent/JP2022033776A/ja active Pending
-
2023
- 2023-05-16 AU AU2023203038A patent/AU2023203038A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2018522901A (ja) | 2018-08-16 |
CA2994241A1 (en) | 2017-02-09 |
JP7062290B2 (ja) | 2022-05-06 |
JP2022033776A (ja) | 2022-03-02 |
KR20180029079A (ko) | 2018-03-19 |
EP3328896A4 (en) | 2019-08-07 |
US20210008200A1 (en) | 2021-01-14 |
US10660954B2 (en) | 2020-05-26 |
US20180214544A1 (en) | 2018-08-02 |
US11904016B2 (en) | 2024-02-20 |
EP3328896A1 (en) | 2018-06-06 |
AU2016303489B2 (en) | 2023-02-16 |
AU2016303489A1 (en) | 2018-02-15 |
AU2023203038A1 (en) | 2023-06-08 |
WO2017023753A1 (en) | 2017-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1254976A1 (zh) | 造血幹細胞和抗癌免疫檢查點抑制劑的組合療法 | |
IL286282A (en) | Use of palinabolin in combination with immune checkpoint inhibitors | |
HK1243005A1 (zh) | 抗lilrb抗體及其在檢測和治療癌症中的用途 | |
IL251774A0 (en) | Methods and preparations for dosing in stress cell therapy | |
IL256687B (en) | Isolated tau-binding antibody and its use in treatment and diagnosis | |
SG10201912978PA (en) | Methods for improving the efficacy and expansion of immune cells | |
HUE043847T2 (hu) | Hialuronán-lebontó enzimmel és egy immun checkpoint inhibitorral végzett kombinációs terápia | |
IL259479B (en) | Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor | |
IL256467B (en) | A control block and a whole-cell microbacterium for the treatment of cancer | |
GB201510758D0 (en) | Novel TNFa structure for use in therapy | |
PL3303778T3 (pl) | Ulepszenia w magazynowaniu energi | |
HK1249852A1 (zh) | 與癌症藥物的聯合治療中的nk-92細胞 | |
HK1246165A1 (zh) | 細胞內atp增強劑 | |
GB201510292D0 (en) | Improvements in Dosimetry Techniques for Radiotherapy | |
IL246607B (en) | Improved cellular preparations and methods for cancer treatment | |
SG11201704916TA (en) | Pyrazolopyridinamines as mknk1 and mknk2 inhibitors | |
GB201510288D0 (en) | Improvements in dosimetry techniques for radiotherapy | |
GB201613078D0 (en) | Stem cells and cancer | |
IL252118A0 (en) | Analytical methods and arrays for their use | |
HK1252514A1 (zh) | 包含與抗體組合施予的ido抑制劑的腫瘤治療劑 | |
GB201521304D0 (en) | Tokenisation in cardholder - not - present transactions | |
IL266116A (en) | Anti-bag3 antibodies in combination with inhibitors of immune check-point for therapeutic use | |
GB201410226D0 (en) | Methods and arrays for use in the same | |
GB201511419D0 (en) | The use of bioinformatic data in autolobous cell therapies | |
GB201511158D0 (en) | Cell modification and application in therapy |