HK1251449A1 - 用於治疗2型糖尿病的交联聚二烯丙基胺共聚物 - Google Patents

用於治疗2型糖尿病的交联聚二烯丙基胺共聚物 Download PDF

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Publication number
HK1251449A1
HK1251449A1 HK18104883.2A HK18104883A HK1251449A1 HK 1251449 A1 HK1251449 A1 HK 1251449A1 HK 18104883 A HK18104883 A HK 18104883A HK 1251449 A1 HK1251449 A1 HK 1251449A1
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HK
Hong Kong
Prior art keywords
copolymers
diabetes
type
crosslinked
treatment
Prior art date
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HK18104883.2A
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English (en)
Chinese (zh)
Inventor
Pradeep K. Dhal
Robert J. Miller
Steven C. Polomoscanik
Philip Just Larsen
Thomas Huebschle
Thorsten Schmidt
Ian Davison
Peter Mcdonnell
Chinyere AGBUGBA
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Genzyme Corporation
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Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of HK1251449A1 publication Critical patent/HK1251449A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C08F226/04—Diallylamine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/08—Epoxidation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0025—Crosslinking or vulcanising agents; including accelerators
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1515—Three-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C08F26/04—Diallylamine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Epoxy Resins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18104883.2A 2014-12-18 2015-12-16 用於治疗2型糖尿病的交联聚二烯丙基胺共聚物 HK1251449A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462093751P 2014-12-18 2014-12-18
US62/093,751 2014-12-18
PCT/US2015/066006 WO2016100456A2 (en) 2014-12-18 2015-12-16 Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes

Publications (1)

Publication Number Publication Date
HK1251449A1 true HK1251449A1 (zh) 2019-02-01

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Country Status (27)

Country Link
US (1) US11267924B2 (enExample)
EP (1) EP3233090A2 (enExample)
JP (2) JP6866293B2 (enExample)
KR (1) KR20170096008A (enExample)
CN (1) CN107250189A (enExample)
AR (1) AR103175A1 (enExample)
AU (1) AU2015362590A1 (enExample)
BR (1) BR112017012794A2 (enExample)
CA (1) CA2971204A1 (enExample)
CL (1) CL2017001579A1 (enExample)
CO (1) CO2017007119A2 (enExample)
CR (1) CR20170323A (enExample)
DO (1) DOP2017000140A (enExample)
EA (1) EA201791380A1 (enExample)
EC (1) ECSP17045972A (enExample)
GT (1) GT201700133A (enExample)
HK (1) HK1251449A1 (enExample)
IL (1) IL252899A0 (enExample)
MA (2) MA41202A (enExample)
MX (1) MX2017007966A (enExample)
PE (1) PE20171510A1 (enExample)
PH (1) PH12017501120A1 (enExample)
SG (1) SG11201704840RA (enExample)
TN (1) TN2017000253A1 (enExample)
TW (1) TW201636030A (enExample)
UY (1) UY36457A (enExample)
WO (1) WO2016100456A2 (enExample)

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Publication number Priority date Publication date Assignee Title
TWI784968B (zh) 2016-09-09 2022-12-01 丹麥商西蘭製藥公司 澱粉素類似物
US10479865B2 (en) * 2017-11-01 2019-11-19 Strides Shasun Limited Process for the preparation of sevelamer carbonate
US12295369B2 (en) 2019-08-07 2025-05-13 Solventum Intellectual Properties Company Articles containing a crosslinked guanidinyl-containing polymer and uses thereof
AU2020348451A1 (en) * 2019-09-20 2022-04-21 Glyscend, Inc. Substituted phenyl boronic acid containing polymers and methods of use
US20240254267A1 (en) * 2021-03-01 2024-08-01 Renosis, Inc. Crosslinked poly (allylamine) polymer pharmaceutical compositions

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EA201791380A1 (ru) 2018-03-30
CR20170323A (es) 2017-08-22
CL2017001579A1 (es) 2018-03-23
SG11201704840RA (en) 2017-07-28
GT201700133A (es) 2019-09-17
WO2016100456A3 (en) 2016-08-18
PE20171510A1 (es) 2017-10-20
AU2015362590A1 (en) 2017-08-03
IL252899A0 (en) 2017-08-31
CO2017007119A2 (es) 2017-08-18
JP2021063229A (ja) 2021-04-22
JP2018501358A (ja) 2018-01-18
BR112017012794A2 (pt) 2018-01-02
CN107250189A (zh) 2017-10-13
TW201636030A (zh) 2016-10-16
TN2017000253A1 (en) 2018-10-19
UY36457A (es) 2016-07-29
US11267924B2 (en) 2022-03-08
EP3233090A2 (en) 2017-10-25
MA41202A (fr) 2017-10-24
MA40697A1 (fr) 2018-01-31
PH12017501120A1 (en) 2018-01-08
AR103175A1 (es) 2017-04-19
ECSP17045972A (es) 2017-11-30
MX2017007966A (es) 2018-03-15
WO2016100456A2 (en) 2016-06-23
JP6866293B2 (ja) 2021-05-12
KR20170096008A (ko) 2017-08-23
US20160177019A1 (en) 2016-06-23
CA2971204A1 (en) 2016-06-23
DOP2017000140A (es) 2017-07-31

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