HK1250784A1 - 一次性生物测定盒及盒内执行多个测定步骤和流体输送的方法 - Google Patents

一次性生物测定盒及盒内执行多个测定步骤和流体输送的方法 Download PDF

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Publication number
HK1250784A1
HK1250784A1 HK18110185.4A HK18110185A HK1250784A1 HK 1250784 A1 HK1250784 A1 HK 1250784A1 HK 18110185 A HK18110185 A HK 18110185A HK 1250784 A1 HK1250784 A1 HK 1250784A1
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HK
Hong Kong
Prior art keywords
cartridge
pores
substrate
disposable
fluid transfer
Prior art date
Application number
HK18110185.4A
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English (en)
Chinese (zh)
Inventor
Alexandre Izmailov
David Englert
Paul Smith
Original Assignee
Angle Europe Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angle Europe Limited filed Critical Angle Europe Limited
Publication of HK1250784A1 publication Critical patent/HK1250784A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Plasma & Fusion (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
HK18110185.4A 2015-04-09 2016-04-11 一次性生物测定盒及盒内执行多个测定步骤和流体输送的方法 HK1250784A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562145330P 2015-04-09 2015-04-09
US62/145,330 2015-04-09
US201562165347P 2015-05-22 2015-05-22
US62/165,347 2015-05-22
PCT/CA2016/050414 WO2016161524A1 (en) 2015-04-09 2016-04-11 Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK42021023917.4A Division HK40033655A (en) 2015-04-09 2018-08-08 Porous substrate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK42021023917.4A Addition HK40033655A (en) 2015-04-09 2018-08-08 Porous substrate

Publications (1)

Publication Number Publication Date
HK1250784A1 true HK1250784A1 (zh) 2019-01-11

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HK18110185.4A HK1250784A1 (zh) 2015-04-09 2016-04-11 一次性生物测定盒及盒内执行多个测定步骤和流体输送的方法

Country Status (7)

Country Link
US (5) US10946375B2 (https=)
EP (2) EP3683578A1 (https=)
JP (2) JP6787924B2 (https=)
CN (2) CN107615064B (https=)
CA (3) CA3162780A1 (https=)
HK (1) HK1250784A1 (https=)
WO (1) WO2016161524A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106872684B (zh) * 2017-03-27 2018-11-02 厦门先明生物技术有限公司 集成试剂组并行处理反应装置
CN114471758B (zh) 2017-05-11 2023-10-17 芯易诊有限公司 样品分析系统
AU2021358962B2 (en) * 2020-10-07 2025-01-30 Massachusetts Institute Of Technology Microfluidic cell culture devices
CN114015552B (zh) * 2021-11-04 2022-06-07 贵州医科大学附属医院 一种用于鉴定人骨髓间充质干细胞的试剂盒
DE102024202811A1 (de) 2024-03-25 2025-09-25 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und mikrofluidisches Verfahren zur Verflüssigung von Trockenreagenzien, insbesondere für einen Nachweis von Krankheitserregern

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
DE4202454C1 (https=) 1992-01-29 1993-07-29 Siemens Ag, 8000 Muenchen, De
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US5423581A (en) * 1993-03-31 1995-06-13 Salyers; Marshall L. Low carryover fitting and method for coupling tubing to a device using the same
ATE424927T1 (de) * 1993-10-28 2009-03-15 Houston Advanced Res Ct Mikrofabriziertes poröses durchflussgerät zur diskreten bestimmung von bindungsreaktionen
DE4435107C1 (de) * 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturisierter Fluß-Thermocycler
US5882496A (en) 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
PT1050588E (pt) 1997-07-11 2005-04-29 Pamgene Bv Metodo para a producao de um dispositivo que permite efectuar um ensaio, utilizacao de uma membrana para fabricar o referido dispositivo, estojo que compreende o referido dispositivo e metodo para a deteccao de um analito utilizando tal dispositivo
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
EP1125129A1 (en) 1998-10-13 2001-08-22 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
GB9907665D0 (en) 1999-04-01 1999-05-26 Cambridge Molecular Tech Fluidic devices
DE19919903A1 (de) * 1999-04-30 2000-11-02 Nft Nano Filtertechnik Gmbh Verfahren zur Herstellung eines Filters
KR20020021810A (ko) 1999-08-11 2002-03-22 야마모토 카즈모토 분석용 카트리지 및 송액 제어 장치
US6383748B1 (en) 1999-09-14 2002-05-07 Pamgene B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
JP3715148B2 (ja) * 1999-09-17 2005-11-09 富士写真フイルム株式会社 高密度マクロアレイ
EP1202803A2 (en) 1999-12-22 2002-05-08 Gene Logic, Inc. Flow-through chip cartridge, chip holder, system & method thereof
US6770322B1 (en) * 2000-03-03 2004-08-03 Ysi Incorporated Method of making a platform for use in a sensor in a microfluidic device
US7470546B2 (en) * 2000-05-31 2008-12-30 Infineon Technologies Ag Method and arrangement for taking up a first medium, which is present in a first phase, into a capillary device
US7163660B2 (en) 2000-05-31 2007-01-16 Infineon Technologies Ag Arrangement for taking up liquid analytes
US6716629B2 (en) * 2000-10-10 2004-04-06 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US6886409B2 (en) 2001-03-13 2005-05-03 Pamgene International B.V. System for controlling the flow of a fluid through a substrate
US6418968B1 (en) 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
US20030062657A1 (en) * 2001-07-31 2003-04-03 Massachusetts Institute Of Technology On-chip membrane maker
US7166443B2 (en) * 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
JP2003166910A (ja) 2001-11-30 2003-06-13 Asahi Kasei Corp 送液機構及び該送液機構を備える分析装置
US20050241477A1 (en) * 2002-03-05 2005-11-03 Mundschau Michael V Hydrogen transport membranes
DE10217568A1 (de) * 2002-04-19 2003-11-13 Infineon Technologies Ag Wellenleiter in porösen Substraten
US20040042930A1 (en) 2002-08-30 2004-03-04 Clemens Charles E. Reaction chamber with capillary lock for fluid positioning and retention
US6806543B2 (en) * 2002-09-12 2004-10-19 Intel Corporation Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molecule detection
US7279134B2 (en) * 2002-09-17 2007-10-09 Intel Corporation Microfluidic devices with porous membranes for molecular sieving, metering, and separations
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
JP4027218B2 (ja) 2002-12-13 2007-12-26 キヤノン株式会社 濾過膜の製造方法
JP4795626B2 (ja) 2003-03-04 2011-10-19 紀夫 寺前 多孔体膜並びに薄膜の作製方法
GB0311902D0 (en) * 2003-05-22 2003-06-25 Cambridge Life Sciences Assay method and apparatus
US20040265171A1 (en) 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
JP4683633B2 (ja) 2004-11-09 2011-05-18 キヤノン株式会社 液体の分析システムおよびカートリッジ
JP4623716B2 (ja) 2004-11-25 2011-02-02 旭化成株式会社 核酸検出用カートリッジ及び核酸検出方法
WO2006132324A1 (ja) * 2005-06-10 2006-12-14 Olympus Corporation 反応容器およびそれを用いる反応装置
CN101213023A (zh) 2005-06-30 2008-07-02 皇家飞利浦电子股份有限公司 流体分析装置和方法
JP2007097444A (ja) 2005-09-30 2007-04-19 Bussan Nanotech Research Institute Inc 検査用チップ
JP4231869B2 (ja) * 2005-12-09 2009-03-04 シャープ株式会社 バイオケミカルセンサ及び測定装置
WO2009024773A1 (en) * 2007-08-17 2009-02-26 Diagnostics For The Real World, Ltd Device, system and method for processing a sample
EP2070594A1 (en) 2007-12-14 2009-06-17 Koninklijke Philips Electronics N.V. Microfluidic device and method of making the same and sensor incorporating the same
JP5152198B2 (ja) * 2007-12-19 2013-02-27 株式会社島津製作所 分注デバイス
EP2304445B1 (en) 2008-07-09 2020-06-10 Micropoint Bioscience Inc Analytical cartridge with fluid flow control
CA2768779A1 (en) * 2009-07-20 2011-01-27 Siloam Biosciences, Inc. Microfluidic assay platforms
US8512588B2 (en) * 2010-08-13 2013-08-20 Lawrence Livermore National Security, Llc Method of fabricating a scalable nanoporous membrane filter
BR112013007516A2 (pt) * 2010-10-01 2020-10-06 3M Innovative Properties Company monitor portátil para indicação de final de vida útil
US9182326B2 (en) 2011-03-24 2015-11-10 Boehringer Ingelheim Microparts Gmbh Device and method for filtering blood
US20130032235A1 (en) * 2011-08-02 2013-02-07 Teledyne Dalsa Semiconductor, Inc. Integrated microfluidic check valve and device including such a check valve
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
GB2516675A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
WO2016149837A1 (en) 2015-03-25 2016-09-29 Axela Inc. Solid phase nucleic acid target capture and replication using strand displacing polymerases

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CA3162752A1 (en) 2016-10-13
JP2018517891A (ja) 2018-07-05
US20210237050A1 (en) 2021-08-05
CA2981990A1 (en) 2016-10-13
EP3281009A4 (en) 2018-11-14
JP6787924B2 (ja) 2020-11-18
US11305274B2 (en) 2022-04-19
WO2016161524A1 (en) 2016-10-13
CN110665557B (zh) 2022-08-23
CN107615064A (zh) 2018-01-19
CA3162780A1 (en) 2016-10-13
CN110665557A (zh) 2020-01-10
EP3683578A1 (en) 2020-07-22
JP2019164140A (ja) 2019-09-26
EP3281009A1 (en) 2018-02-14
US20220226810A1 (en) 2022-07-21
US20230001407A1 (en) 2023-01-05
JP7123848B2 (ja) 2022-08-23
CN107615064B (zh) 2020-02-28
US20190054460A1 (en) 2019-02-21
US20180117582A1 (en) 2018-05-03
US10946375B2 (en) 2021-03-16

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