HK1250020A1 - 用於吡咯连接的二价化合物的化学合成的方法及其组合物 - Google Patents

用於吡咯连接的二价化合物的化学合成的方法及其组合物 Download PDF

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Publication number
HK1250020A1
HK1250020A1 HK18109533.5A HK18109533A HK1250020A1 HK 1250020 A1 HK1250020 A1 HK 1250020A1 HK 18109533 A HK18109533 A HK 18109533A HK 1250020 A1 HK1250020 A1 HK 1250020A1
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HK
Hong Kong
Prior art keywords
pyrrole
compositions
methods
chemical synthesis
bivalent compounds
Prior art date
Application number
HK18109533.5A
Other languages
English (en)
Chinese (zh)
Inventor
John CRAN
Original Assignee
Avekshan Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avekshan Llc filed Critical Avekshan Llc
Publication of HK1250020A1 publication Critical patent/HK1250020A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK18109533.5A 2015-03-18 2016-03-18 用於吡咯连接的二价化合物的化学合成的方法及其组合物 HK1250020A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562134758P 2015-03-18 2015-03-18
US62/134,758 2015-03-18
PCT/US2016/023107 WO2016149608A1 (en) 2015-03-18 2016-03-18 Methods for the chemical synthesis of pyrrole-linked bivalent compounds, and compositions thereof

Publications (1)

Publication Number Publication Date
HK1250020A1 true HK1250020A1 (zh) 2018-11-23

Family

ID=56919959

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109533.5A HK1250020A1 (zh) 2015-03-18 2016-03-18 用於吡咯连接的二价化合物的化学合成的方法及其组合物

Country Status (8)

Country Link
US (2) US10253034B2 (enExample)
EP (1) EP3270916A4 (enExample)
JP (1) JP2018510218A (enExample)
CN (1) CN107613973A (enExample)
CA (1) CA2978097A1 (enExample)
HK (1) HK1250020A1 (enExample)
IL (1) IL254454B (enExample)
WO (1) WO2016149608A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510218A (ja) * 2015-03-18 2018-04-12 アヴェクシャン エルエルシー ピロールで結合している二価の化合物の化学合成方法、及びその組成物
US10703762B2 (en) 2015-08-28 2020-07-07 Idemitsu Kosan Co., Ltd. Compound, material for organic electroluminescence device, organic electroluminescence device and electronic apparatus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
JPH03193782A (ja) * 1989-12-25 1991-08-23 Toray Ind Inc ｎｏｒ―ＢＮＩの製造法
DE10218582A1 (de) 2002-04-26 2003-11-06 Bayer Ag Zimtsäureamide
US10226428B2 (en) 2003-09-19 2019-03-12 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US9623023B2 (en) 2012-10-22 2017-04-18 The Florida State University Research Foundation, Incorporated Class of non-stimulant treatment and ADHD and related disorders
JP2018510218A (ja) * 2015-03-18 2018-04-12 アヴェクシャン エルエルシー ピロールで結合している二価の化合物の化学合成方法、及びその組成物

Also Published As

Publication number Publication date
IL254454B (en) 2020-08-31
US10654862B2 (en) 2020-05-19
EP3270916A1 (en) 2018-01-24
JP2018510218A (ja) 2018-04-12
EP3270916A4 (en) 2018-11-21
US20190161491A1 (en) 2019-05-30
WO2016149608A1 (en) 2016-09-22
US10253034B2 (en) 2019-04-09
CN107613973A (zh) 2018-01-19
IL254454A0 (en) 2017-11-30
US20180072747A1 (en) 2018-03-15
CA2978097A1 (en) 2016-09-22

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HK1250020A1 (zh) 用於吡咯连接的二价化合物的化学合成的方法及其组合物