JP2018510218A - ピロールで結合している二価の化合物の化学合成方法、及びその組成物 - Google Patents

ピロールで結合している二価の化合物の化学合成方法、及びその組成物 Download PDF

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Publication number
JP2018510218A
JP2018510218A JP2018500267A JP2018500267A JP2018510218A JP 2018510218 A JP2018510218 A JP 2018510218A JP 2018500267 A JP2018500267 A JP 2018500267A JP 2018500267 A JP2018500267 A JP 2018500267A JP 2018510218 A JP2018510218 A JP 2018510218A
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formula
compound
salt
reaction
norbni
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JP2018510218A5 (enExample
Inventor
ジョン クラン
ジョン クラン
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アヴェクシャン エルエルシー
アヴェクシャン エルエルシー
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Publication of JP2018510218A5 publication Critical patent/JP2018510218A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2018500267A 2015-03-18 2016-03-18 ピロールで結合している二価の化合物の化学合成方法、及びその組成物 Pending JP2018510218A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562134758P 2015-03-18 2015-03-18
US62/134,758 2015-03-18
PCT/US2016/023107 WO2016149608A1 (en) 2015-03-18 2016-03-18 Methods for the chemical synthesis of pyrrole-linked bivalent compounds, and compositions thereof

Publications (2)

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JP2018510218A true JP2018510218A (ja) 2018-04-12
JP2018510218A5 JP2018510218A5 (enExample) 2019-04-25

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JP2018500267A Pending JP2018510218A (ja) 2015-03-18 2016-03-18 ピロールで結合している二価の化合物の化学合成方法、及びその組成物

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US (2) US10253034B2 (enExample)
EP (1) EP3270916A4 (enExample)
JP (1) JP2018510218A (enExample)
CN (1) CN107613973A (enExample)
CA (1) CA2978097A1 (enExample)
HK (1) HK1250020A1 (enExample)
IL (1) IL254454B (enExample)
WO (1) WO2016149608A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510218A (ja) * 2015-03-18 2018-04-12 アヴェクシャン エルエルシー ピロールで結合している二価の化合物の化学合成方法、及びその組成物
US10703762B2 (en) 2015-08-28 2020-07-07 Idemitsu Kosan Co., Ltd. Compound, material for organic electroluminescence device, organic electroluminescence device and electronic apparatus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
JPH03193782A (ja) * 1989-12-25 1991-08-23 Toray Ind Inc ｎｏｒ―ＢＮＩの製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10218582A1 (de) 2002-04-26 2003-11-06 Bayer Ag Zimtsäureamide
US10226428B2 (en) 2003-09-19 2019-03-12 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US9623023B2 (en) 2012-10-22 2017-04-18 The Florida State University Research Foundation, Incorporated Class of non-stimulant treatment and ADHD and related disorders
JP2018510218A (ja) * 2015-03-18 2018-04-12 アヴェクシャン エルエルシー ピロールで結合している二価の化合物の化学合成方法、及びその組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
JPH03193782A (ja) * 1989-12-25 1991-08-23 Toray Ind Inc ｎｏｒ―ＢＮＩの製造法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
PORTOGHESE, P. S. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, JPN6020008158, 1987, pages 238 - 239, ISSN: 0004380322 *
PORTOGHESE, P. S. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, JPN6020008157, 1988, pages 836 - 841, ISSN: 0004380321 *
SCHMIDHAMMER, H. ET AL., LIEBIGS ANNALEN DER CHEMIE, JPN6020008167, 1994, pages 445 - 447, ISSN: 0004380325 *
ZHOU, C. ET AL., CHEMICAL COMMUNICATIONS, vol. 50, JPN6020008165, 2014, pages 3085 - 3088, ISSN: 0004380324 *
社団法人 日本化学会, 実験化学ガイドブック, JPN7020000597, 15 June 1984 (1984-06-15), pages 141 - 142, ISSN: 0004380323 *

Also Published As

Publication number Publication date
IL254454B (en) 2020-08-31
US10654862B2 (en) 2020-05-19
EP3270916A1 (en) 2018-01-24
EP3270916A4 (en) 2018-11-21
US20190161491A1 (en) 2019-05-30
WO2016149608A1 (en) 2016-09-22
US10253034B2 (en) 2019-04-09
CN107613973A (zh) 2018-01-19
IL254454A0 (en) 2017-11-30
HK1250020A1 (zh) 2018-11-23
US20180072747A1 (en) 2018-03-15
CA2978097A1 (en) 2016-09-22

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