IL254454B - Chemical synthesis methods of bivalent compounds related to pyrrole and their preparations - Google Patents

Chemical synthesis methods of bivalent compounds related to pyrrole and their preparations

Info

Publication number
IL254454B
IL254454B IL254454A IL25445417A IL254454B IL 254454 B IL254454 B IL 254454B IL 254454 A IL254454 A IL 254454A IL 25445417 A IL25445417 A IL 25445417A IL 254454 B IL254454 B IL 254454B
Authority
IL
Israel
Prior art keywords
pyrrole
compositions
methods
chemical synthesis
bivalent compounds
Prior art date
Application number
IL254454A
Other languages
English (en)
Hebrew (he)
Other versions
IL254454A0 (en
Inventor
John Cran
Original Assignee
Avekshan Llc
John Cran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avekshan Llc, John Cran filed Critical Avekshan Llc
Publication of IL254454A0 publication Critical patent/IL254454A0/en
Publication of IL254454B publication Critical patent/IL254454B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL254454A 2015-03-18 2017-09-12 Chemical synthesis methods of bivalent compounds related to pyrrole and their preparations IL254454B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562134758P 2015-03-18 2015-03-18
PCT/US2016/023107 WO2016149608A1 (en) 2015-03-18 2016-03-18 Methods for the chemical synthesis of pyrrole-linked bivalent compounds, and compositions thereof

Publications (2)

Publication Number Publication Date
IL254454A0 IL254454A0 (en) 2017-11-30
IL254454B true IL254454B (en) 2020-08-31

Family

ID=56919959

Family Applications (1)

Application Number Title Priority Date Filing Date
IL254454A IL254454B (en) 2015-03-18 2017-09-12 Chemical synthesis methods of bivalent compounds related to pyrrole and their preparations

Country Status (8)

Country Link
US (2) US10253034B2 (enExample)
EP (1) EP3270916A4 (enExample)
JP (1) JP2018510218A (enExample)
CN (1) CN107613973A (enExample)
CA (1) CA2978097A1 (enExample)
HK (1) HK1250020A1 (enExample)
IL (1) IL254454B (enExample)
WO (1) WO2016149608A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510218A (ja) * 2015-03-18 2018-04-12 アヴェクシャン エルエルシー ピロールで結合している二価の化合物の化学合成方法、及びその組成物
US10703762B2 (en) 2015-08-28 2020-07-07 Idemitsu Kosan Co., Ltd. Compound, material for organic electroluminescence device, organic electroluminescence device and electronic apparatus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
JPH03193782A (ja) * 1989-12-25 1991-08-23 Toray Ind Inc ｎｏｒ―ＢＮＩの製造法
DE10218582A1 (de) 2002-04-26 2003-11-06 Bayer Ag Zimtsäureamide
US10226428B2 (en) 2003-09-19 2019-03-12 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US9623023B2 (en) 2012-10-22 2017-04-18 The Florida State University Research Foundation, Incorporated Class of non-stimulant treatment and ADHD and related disorders
JP2018510218A (ja) * 2015-03-18 2018-04-12 アヴェクシャン エルエルシー ピロールで結合している二価の化合物の化学合成方法、及びその組成物

Also Published As

Publication number Publication date
US10654862B2 (en) 2020-05-19
EP3270916A1 (en) 2018-01-24
JP2018510218A (ja) 2018-04-12
EP3270916A4 (en) 2018-11-21
US20190161491A1 (en) 2019-05-30
WO2016149608A1 (en) 2016-09-22
US10253034B2 (en) 2019-04-09
CN107613973A (zh) 2018-01-19
IL254454A0 (en) 2017-11-30
HK1250020A1 (zh) 2018-11-23
US20180072747A1 (en) 2018-03-15
CA2978097A1 (en) 2016-09-22

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees