HK1249469A1 - 用RORγ抑制剂治疗癌症的方法 - Google Patents
用RORγ抑制剂治疗癌症的方法 Download PDFInfo
- Publication number
- HK1249469A1 HK1249469A1 HK18109103.5A HK18109103A HK1249469A1 HK 1249469 A1 HK1249469 A1 HK 1249469A1 HK 18109103 A HK18109103 A HK 18109103A HK 1249469 A1 HK1249469 A1 HK 1249469A1
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- Prior art keywords
- cancer
- methods
- inhibitors
- rorgamma
- treating cancer
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biomedical Technology (AREA)
- Biochemistry (AREA)
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- Diabetes (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132465P | 2015-03-12 | 2015-03-12 | |
| US62/132,465 | 2015-03-12 | ||
| US201662280081P | 2016-01-18 | 2016-01-18 | |
| US62/280,081 | 2016-01-18 | ||
| PCT/US2016/021983 WO2016145298A1 (en) | 2015-03-12 | 2016-03-11 | METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1249469A1 true HK1249469A1 (zh) | 2018-11-02 |
Family
ID=56879765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18109103.5A HK1249469A1 (zh) | 2015-03-12 | 2016-03-11 | 用RORγ抑制剂治疗癌症的方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10959984B2 (enExample) |
| EP (1) | EP3268087A4 (enExample) |
| JP (1) | JP2018513123A (enExample) |
| CN (1) | CN107614062A (enExample) |
| HK (1) | HK1249469A1 (enExample) |
| WO (1) | WO2016145298A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107614062A (zh) | 2015-03-12 | 2018-01-19 | 加利福尼亚大学董事会 | 用RORγ抑制剂治疗癌症的方法 |
| JP7027437B2 (ja) * | 2016-10-27 | 2022-03-01 | エスカリア バイオサイエンシーズ,ビーブイ | ROR-γモジュレーター |
| WO2019023651A2 (en) | 2017-07-28 | 2019-01-31 | Massachusetts Institute Of Technology | MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR |
| EP3849556A1 (en) * | 2018-09-13 | 2021-07-21 | Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Modulation of trf1 for brain cancer treatment |
| WO2020061024A1 (en) * | 2018-09-18 | 2020-03-26 | Yale University | Dermatologic topical applications of ror gamma and ror gamma-t inhibitors for the prevention of skin cancer development |
| WO2020065682A1 (en) * | 2018-09-29 | 2020-04-02 | Translational Health Science And Technology Institute | Ror antagonists, their use and method of treatment comprising the said modulators |
| RU2679625C1 (ru) * | 2018-11-08 | 2019-02-12 | Ильясов Шамиль Сионович | ПРИМЕНЕНИЕ 3-О-СУЛЬФАМОИЛОКСИ-6-ОКСА-7β-МЕТИЛ-D-ГОМО-8α-ЭСТРА-1,3,5(10)-ТРИЕН-17а-ОНА ДЛЯ ЛЕЧЕНИЯ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ, ВКЛЮЧАЯ ТРИЖДЫ-НЕГАТИВНУЮ ФОРМУ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
| US20220202811A1 (en) * | 2019-02-20 | 2022-06-30 | The Regents Of The University Of California | Treatment for retinoic acid receptor-related orphan receptor Ɣ (rorƔ)-dependent cancers |
| CN109879784B (zh) * | 2019-03-18 | 2021-06-29 | 中国科学院广州生物医药与健康研究院 | 一种联苯胺类化合物及其应用 |
| AU2020253486A1 (en) * | 2019-04-03 | 2021-11-04 | University Of Florida Research Foundation, Incorporated | Method of inhibiting trem-1 |
| US12467043B2 (en) | 2019-07-12 | 2025-11-11 | Duke University | 3′ UTR CRISPR-DCAS 13 engineering system and methods of using same |
| CN113912563B (zh) * | 2020-07-10 | 2025-05-27 | 中国科学院广州生物医药与健康研究院 | 一种苯并五元氮杂环化合物及其应用 |
| WO2022067185A1 (en) * | 2020-09-27 | 2022-03-31 | Veru Inc. | Methods of treating prostate cancer with minimal side effects |
| WO2022122740A1 (en) * | 2020-12-07 | 2022-06-16 | Diaccurate | Ror-gamma inhibitors for the treatment of ror-gamma-dependent cancer |
| US20240368145A1 (en) | 2021-07-09 | 2024-11-07 | Immunic Ag | Methods for treating cancer |
| WO2023155846A1 (zh) * | 2022-02-18 | 2023-08-24 | 上海醇健医药技术有限公司 | 17-吡啶基-10α-甲基-甾体衍生物及中间体化合物、其制备方法、其用途、以及其药物组合物 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4957735A (en) | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
| US5055303A (en) | 1989-01-31 | 1991-10-08 | Kv Pharmaceutical Company | Solid controlled release bioadherent emulsions |
| US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| US5254342A (en) | 1991-09-30 | 1993-10-19 | University Of Southern California | Compositions and methods for enhanced transepithelial and transendothelial transport or active agents |
| EP0630234B1 (en) | 1992-03-12 | 1997-06-11 | Alkermes Controlled Therapeutics, Inc. | Controlled release acth containing microspheres |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
| US5962318A (en) | 1996-11-15 | 1999-10-05 | St. Jude Children's Research Hospital | Cytotoxic T lymphocyte-mediated immunotherapy |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| JP2008505080A (ja) | 2004-07-01 | 2008-02-21 | ニューヨーク ユニバーシティー | RORγt機能の調節のための組成物および方法 |
| US7993638B2 (en) | 2006-03-01 | 2011-08-09 | Janssen Pharmaceutica Nv | Cancer treatment combining lymphodepleting agent with CTLs and cytokines |
| WO2011115892A1 (en) * | 2010-03-15 | 2011-09-22 | Griffin Patrick R | Modulators of the retinoic acid receptor-related orphan receptors |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012100734A1 (en) | 2011-01-24 | 2012-08-02 | Glaxo Group Limited | Compounds useful as retinoid-related orphan receptor gamma modulators |
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| WO2012129394A2 (en) * | 2011-03-22 | 2012-09-27 | Brigham And Women's Hospital, Inc. | Methods and compositions for the treatment of cancer |
| WO2012158784A2 (en) * | 2011-05-16 | 2012-11-22 | Theodore Mark Kamenecka | Modulators of the nuclear hormone receptor ror |
| WO2013018695A1 (ja) * | 2011-07-29 | 2013-02-07 | 武田薬品工業株式会社 | 複素環化合物 |
| US20140315881A1 (en) * | 2011-07-29 | 2014-10-23 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| CN104379559B (zh) | 2012-04-27 | 2016-11-09 | 葛兰素集团有限公司 | 化合物 |
| WO2014008214A1 (en) | 2012-07-02 | 2014-01-09 | Biogen Idec Ma Inc. | Biaryl-containing compounds as inverse agonists of ror-gamma receptors |
| PL2849736T3 (pl) | 2012-07-05 | 2019-06-28 | Nutramax Laboratories, Inc. | Kompozycje zawierające prekursor sulforafanu glukorafaninę, glukozydazę, kwas askorbinowy i ekstrakt lub proszek z ostropestu plamistego |
| WO2014026328A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
| WO2014026330A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| EP2929350A4 (en) * | 2012-12-04 | 2016-11-16 | Caris Mpi Inc | MOLECULAR PROFILING OF CANCER |
| WO2013171729A2 (en) | 2013-01-08 | 2013-11-21 | Glenmark Pharmaceuticals S.A. | Aryl and heteroaryl amide compounds as rorgamat modulator |
| WO2014179564A1 (en) | 2013-05-01 | 2014-11-06 | Vitae Pharmaceuticals, Inc. | Thiazalopyrrolidine inhibitors of ror-gamma |
| WO2015008234A1 (en) * | 2013-07-17 | 2015-01-22 | Glenmark Pharmaceuticals S.A. | Bicyclic heterocyclic compounds as ror gamma modulators |
| US9550771B2 (en) | 2013-09-11 | 2017-01-24 | Genentech, Inc. | Keto-imidazopyridine derivatives as RORc modulators |
| CA2928537A1 (en) | 2013-10-25 | 2015-04-30 | Glaxosmithkline Llc | Novel compounds |
| AU2014359324B2 (en) | 2013-12-05 | 2019-02-21 | Lead Pharma Holding B.V. | ROR gamma (RORy) modulators |
| WO2015083130A1 (en) | 2013-12-06 | 2015-06-11 | Aurigene Discovery Technologies Limited | Fused pyridine and pyrimidine derivatives as ror gamma modulators |
| CN104530014B (zh) | 2013-12-25 | 2018-03-20 | 中国科学院广州生物医药与健康研究院 | 2‑氧代‑1,2‑二氢苯并[cd]吲哚‑6‑磺酰胺类化合物及其组合物和应用 |
| WO2015101928A1 (en) | 2013-12-31 | 2015-07-09 | Aurigene Discovery Technologies Limited | Fused thiophene and thiazole derivatives as ror gamma modulators |
| EP3527569B1 (en) | 2014-02-03 | 2021-08-25 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma for use in treating drye eye |
| CN105272904B (zh) | 2014-07-18 | 2019-04-09 | 中国科学院广州生物医药与健康研究院 | N-苯基酰胺类化合物及其应用 |
| CN107614062A (zh) | 2015-03-12 | 2018-01-19 | 加利福尼亚大学董事会 | 用RORγ抑制剂治疗癌症的方法 |
| WO2017127442A1 (en) | 2016-01-18 | 2017-07-27 | The Regents Of The University Of California | Methods for treating cancer with rorgamma inhibitors |
-
2016
- 2016-03-11 CN CN201680027763.2A patent/CN107614062A/zh active Pending
- 2016-03-11 WO PCT/US2016/021983 patent/WO2016145298A1/en not_active Ceased
- 2016-03-11 HK HK18109103.5A patent/HK1249469A1/zh unknown
- 2016-03-11 JP JP2017547968A patent/JP2018513123A/ja active Pending
- 2016-03-11 EP EP16762587.0A patent/EP3268087A4/en not_active Withdrawn
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2017
- 2017-09-11 US US15/701,122 patent/US10959984B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US10959984B2 (en) | 2021-03-30 |
| WO2016145298A1 (en) | 2016-09-15 |
| JP2018513123A (ja) | 2018-05-24 |
| CN107614062A (zh) | 2018-01-19 |
| EP3268087A1 (en) | 2018-01-17 |
| US20180085348A1 (en) | 2018-03-29 |
| EP3268087A4 (en) | 2018-08-29 |
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