HK1247926A1 - 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物 - Google Patents
四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物 Download PDFInfo
- Publication number
- HK1247926A1 HK1247926A1 HK18107440.1A HK18107440A HK1247926A1 HK 1247926 A1 HK1247926 A1 HK 1247926A1 HK 18107440 A HK18107440 A HK 18107440A HK 1247926 A1 HK1247926 A1 HK 1247926A1
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- HK
- Hong Kong
- Prior art keywords
- crystalline form
- diphenyl
- dimethyl
- disease
- tetrahydro
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195486P | 2015-07-22 | 2015-07-22 | |
| US62/195,486 | 2015-07-22 | ||
| PCT/IB2016/001181 WO2017013498A2 (en) | 2015-07-22 | 2016-07-19 | Crystal forms of tetra-hydro-n, n-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride, processes for making such forms, and their pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1247926A1 true HK1247926A1 (zh) | 2018-10-05 |
Family
ID=57833871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18107440.1A HK1247926A1 (zh) | 2015-07-22 | 2016-07-19 | 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10413519B2 (enExample) |
| EP (2) | EP4616852A3 (enExample) |
| JP (3) | JP7304043B2 (enExample) |
| CN (2) | CN119390667A (enExample) |
| CA (1) | CA2986349A1 (enExample) |
| HK (1) | HK1247926A1 (enExample) |
| WO (1) | WO2017013498A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4616852A3 (en) * | 2015-07-22 | 2025-10-22 | Anavex Life Sciences Corp. | Crystal forms of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, processes of making such forms, and their pharmaceutical compositions |
| US10426754B2 (en) | 2017-06-14 | 2019-10-01 | Anavex Life Sciences Corp. | Crystalline form of ANAVEX2-73 for the treatment of Alzheimer's disease |
| CN111315375A (zh) * | 2017-06-14 | 2020-06-19 | 阿纳韦克斯生命科学公司 | 用于治疗阿尔茨海默病的anavex2-73 |
| CN112105349A (zh) * | 2018-04-12 | 2020-12-18 | 阿纳韦克斯生命科学公司 | A2-73结晶多晶型物质组合物及其使用方法 |
| US12383526B2 (en) | 2018-05-18 | 2025-08-12 | Anavex Life Sciences Corp. | Optimized sigma-1 agonist method of responder selection and treatment |
| WO2021158586A1 (en) | 2020-02-04 | 2021-08-12 | Teva Pharmaceuticals International Gmbh | Solid state forms of blarcamesine salts |
| JP2025514292A (ja) * | 2022-04-29 | 2025-05-02 | ▲蘇▼州科睿思制▲葯▼有限公司 | 塩酸ブラルカメシンの結晶形、その調製方法およびその使用 |
| US12018005B1 (en) * | 2023-07-25 | 2024-06-25 | Egis Gyógyszergyár Zrt. | Blarcamesine co-crystals for the manufacture of pharmaceutical dosage form |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| GR1002616B (el) * | 1996-02-21 | 1997-02-20 | Συνθεση και μεθοδος συνθεσης μοριου: τετραυδρο-ν,ν-διμεθυλο-2,2-διφαινυλο-3-φουρανομεθαναμινης (αε 37), αντισπασμωδικης, αντικαταθλιπτικης και νοοτροπικης δρασης. | |
| GB9703673D0 (en) | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
| GB9804379D0 (en) | 1998-03-02 | 1998-04-22 | Bradford Particle Design Ltd | Method of particle formation |
| GB9810559D0 (en) | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
| GB9915975D0 (en) | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| TW586963B (en) | 2001-07-20 | 2004-05-11 | Nektar Therapeutics Uk Ltd | Method and apparatus for preparing target substance in particulate form and fluid inlet assembly for said apparatus |
| US7368468B2 (en) | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
| GR1006794B (el) | 2009-02-26 | 2010-06-04 | Αλεξανδρος Βαμβακιδης | Προσδετες των σιγμα υποδοχεων, αντι-αποπτωτικες και προ-αποπτωτικες ιδιοτητες επι των κυτταρικων μηχανισμων, και με πρωτοτυπη κυτταρο-προστατευτικη αλλα και αντικαρκινικη δραση |
| GB201005623D0 (en) * | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
| GR1007686B (el) | 2011-07-08 | 2012-09-12 | Αλεξανδρος Δημητριου Βαμβακιδης | Συνθεση των (+) και (-) 1-(5,5-διφαινυλοτετραϋδροφουραν-3-υλ)-ν,ν-διμεθυλομεθυλαμινης, (+) και (-) 1-(2,2-διφαινυλοτετραϋδροφουραν-3-υλ)-ν,ν-διμεθυλομεθυλαμινης και (+) και (-) 1-(2,2-διφαινυλοτετραϋδροφουραν-3-υλ)-ν-μεθυλομεθυλαμινης |
| CN103539783A (zh) | 2012-07-12 | 2014-01-29 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法 |
| GR1008233B (el) * | 2013-03-28 | 2014-06-23 | Αλεξανδρος Δημητριου Βαμβακιδης | Βελτιωση και θεραπευτικη αξιοποιηση της συμπτωματικης αντιμετωπισης της ασθενειας του alzheimer με rivastigmine, galantamine ή donepezil, δια επιλεγμενων αμινοτετραϋδροφουρανιων που δρουν σαν μικτοι σιγμα-1/ μουσκαρινικοι προσδετες |
| EP4616852A3 (en) * | 2015-07-22 | 2025-10-22 | Anavex Life Sciences Corp. | Crystal forms of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, processes of making such forms, and their pharmaceutical compositions |
| US11617734B2 (en) | 2015-07-22 | 2023-04-04 | Anavex Life Sciences Corp. | Enantiomers of A2-73, analogues, and sigma agonist activity |
| US10426754B2 (en) | 2017-06-14 | 2019-10-01 | Anavex Life Sciences Corp. | Crystalline form of ANAVEX2-73 for the treatment of Alzheimer's disease |
-
2016
- 2016-07-19 EP EP25193445.1A patent/EP4616852A3/en active Pending
- 2016-07-19 CN CN202411518463.7A patent/CN119390667A/zh active Pending
- 2016-07-19 HK HK18107440.1A patent/HK1247926A1/zh unknown
- 2016-07-19 US US15/579,705 patent/US10413519B2/en active Active
- 2016-07-19 EP EP16827324.1A patent/EP3325456B1/en active Active
- 2016-07-19 WO PCT/IB2016/001181 patent/WO2017013498A2/en not_active Ceased
- 2016-07-19 CA CA2986349A patent/CA2986349A1/en active Pending
- 2016-07-19 CN CN201680033152.9A patent/CN108026059A/zh active Pending
- 2016-07-19 JP JP2017564733A patent/JP7304043B2/ja active Active
-
2019
- 2019-07-29 US US16/525,319 patent/US10966952B2/en active Active
-
2021
- 2021-02-08 JP JP2021018132A patent/JP2021073300A/ja active Pending
- 2021-04-05 US US17/222,611 patent/US11661405B2/en active Active
-
2023
- 2023-04-24 JP JP2023070740A patent/JP7492781B2/ja active Active
- 2023-05-08 US US18/313,723 patent/US20230278973A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2986349A1 (en) | 2017-01-26 |
| EP3325456A4 (en) | 2019-01-23 |
| JP2018524307A (ja) | 2018-08-30 |
| US10966952B2 (en) | 2021-04-06 |
| CN119390667A (zh) | 2025-02-07 |
| JP2023083528A (ja) | 2023-06-15 |
| US20180169060A1 (en) | 2018-06-21 |
| US10413519B2 (en) | 2019-09-17 |
| US20210220321A1 (en) | 2021-07-22 |
| EP3325456B1 (en) | 2025-09-03 |
| EP4616852A2 (en) | 2025-09-17 |
| JP2021073300A (ja) | 2021-05-13 |
| US20190350892A1 (en) | 2019-11-21 |
| US20230278973A1 (en) | 2023-09-07 |
| WO2017013498A2 (en) | 2017-01-26 |
| JP7492781B2 (ja) | 2024-05-30 |
| JP7304043B2 (ja) | 2023-07-06 |
| EP4616852A3 (en) | 2025-10-22 |
| WO2017013498A3 (en) | 2017-03-02 |
| CN108026059A (zh) | 2018-05-11 |
| US11661405B2 (en) | 2023-05-30 |
| EP3325456A2 (en) | 2018-05-30 |
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