HK1246395A1 - 通過競爭分析的小分子的納米孔隙檢測 - Google Patents

通過競爭分析的小分子的納米孔隙檢測

Info

Publication number
HK1246395A1
HK1246395A1 HK18105650.0A HK18105650A HK1246395A1 HK 1246395 A1 HK1246395 A1 HK 1246395A1 HK 18105650 A HK18105650 A HK 18105650A HK 1246395 A1 HK1246395 A1 HK 1246395A1
Authority
HK
Hong Kong
Prior art keywords
small molecules
competition assays
nanopore detection
nanopore
detection
Prior art date
Application number
HK18105650.0A
Other languages
English (en)
Inventor
T‧J‧莫林
Original Assignee
奧特拉公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 奧特拉公司 filed Critical 奧特拉公司
Publication of HK1246395A1 publication Critical patent/HK1246395A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK18105650.0A 2015-03-11 2018-05-02 通過競爭分析的小分子的納米孔隙檢測 HK1246395A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131693P 2015-03-11 2015-03-11
PCT/US2016/022210 WO2016145415A1 (en) 2015-03-11 2016-03-11 Nanopore detection of small molecules through competition assays

Publications (1)

Publication Number Publication Date
HK1246395A1 true HK1246395A1 (zh) 2018-09-07

Family

ID=56878896

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105650.0A HK1246395A1 (zh) 2015-03-11 2018-05-02 通過競爭分析的小分子的納米孔隙檢測

Country Status (9)

Country Link
US (1) US10837954B2 (zh)
EP (1) EP3268732A4 (zh)
JP (1) JP6568949B2 (zh)
KR (2) KR20190012278A (zh)
CN (1) CN107430107B (zh)
CA (1) CA2978202A1 (zh)
HK (1) HK1246395A1 (zh)
MX (1) MX2017011489A (zh)
WO (1) WO2016145415A1 (zh)

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EP3254109A4 (en) * 2015-02-02 2018-07-04 Two Pore Guys, Inc. Labile linkers for biomarker detection
KR20180085742A (ko) * 2015-11-23 2018-07-27 투 포어 가이즈, 인코포레이티드 추적 및 검출을 위한 표적 변형
CN107014791B (zh) * 2017-03-29 2019-10-29 郑州轻工业学院 一种荧光传感器及其制备方法和应用
CN108181358B (zh) * 2017-11-15 2020-02-11 华东理工大学 基于气单胞菌溶素纳米通道检测氨基酸的方法
DE102018210484A1 (de) 2018-06-27 2020-01-02 Robert Bosch Gmbh Sensor zum Detektieren von Ionen in einem Fluid sowie Verfahren zum Detektieren von Ionen in einem Fluid mit einem solchen Sensor
CN109239140B (zh) * 2018-08-16 2021-04-13 广东第二师范学院 一种纳米孔功能性控制方法及系统
CN109078628B (zh) * 2018-08-27 2021-06-11 西北大学 一种以苄胺为配基的高效疏水相互作用色谱介质、制备方法及其在蛋白质复性与纯化的应用
US20210310988A1 (en) * 2018-09-07 2021-10-07 Ontera Inc. Sensing compositions, methods, and devices for the detection of molecules using a nanopore device
KR102127111B1 (ko) 2019-01-31 2020-06-26 경희대학교 산학협력단 나노포어의 제조 방법 및 이를 통해 제조된 나노포어 구조체
CN111999490B (zh) * 2019-12-19 2021-07-30 瑞芯智造(深圳)科技有限公司 一种检测样品体系中微量蛋白的方法

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EP1252335A4 (en) * 2000-02-03 2005-03-02 Res Dev Foundation SIGNAL-TREATING APTAMERS THAT TRANSMIT MOLECULAR DETECTION TO A DIFFERENTIAL SIGNAL
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US20030022150A1 (en) 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
AU2002361642A1 (en) 2001-11-16 2003-06-10 The University Of Tennessee Research Corporation Recombinant antibody fusion proteins and methods for detection of apoptotic cells
WO2004046687A2 (en) * 2002-11-14 2004-06-03 Qtl Biosystems, Llc Methods of biosensing using fluorescent polymers and quencher-tether-ligand bioconjugates
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AU2011238582A1 (en) 2010-03-30 2012-10-25 Trustees Of Boston University Tools and method for nanopores unzipping-dependent nucleic acid sequencing
CN103328973B (zh) 2011-07-20 2015-04-01 加利福尼亚大学董事会 双孔装置
JP6170508B2 (ja) * 2012-01-31 2017-07-26 ザ・ユニバーシティ・オブ・トレド 分析物の検出および測定のための方法および装置
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JP5951527B2 (ja) * 2013-03-07 2016-07-13 株式会社東芝 検体検出装置及び検出方法
EP2994751B1 (en) 2013-05-06 2018-10-10 Two Pore Guys, Inc. A method of biological target detection using a nanopore and a fusion protein binding agent
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WO2018093976A1 (en) 2016-11-16 2018-05-24 Nanopore Diagnostics, Llc Analysis of nucleic acids using probe with non-linear tag

Also Published As

Publication number Publication date
US20180313814A1 (en) 2018-11-01
KR20190012278A (ko) 2019-02-08
KR101945366B1 (ko) 2019-02-07
JP6568949B2 (ja) 2019-08-28
CN107430107A (zh) 2017-12-01
EP3268732A1 (en) 2018-01-17
US10837954B2 (en) 2020-11-17
JP2018508023A (ja) 2018-03-22
WO2016145415A1 (en) 2016-09-15
CA2978202A1 (en) 2016-09-15
EP3268732A4 (en) 2018-07-25
CN107430107B (zh) 2019-08-30
MX2017011489A (es) 2018-01-23
KR20170118229A (ko) 2017-10-24

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