HK1246180A1 - 使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法 - Google Patents

使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法 Download PDF

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Publication number
HK1246180A1
HK1246180A1 HK18105719.9A HK18105719A HK1246180A1 HK 1246180 A1 HK1246180 A1 HK 1246180A1 HK 18105719 A HK18105719 A HK 18105719A HK 1246180 A1 HK1246180 A1 HK 1246180A1
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Hong Kong
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natural killer
killer cells
methods
infectious diseases
solid tumors
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HK18105719.9A
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English (en)
Chinese (zh)
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康琳
张小葵
杰佛瑞‧哈里斯
張小葵
弗拉基米尔‧扬科维奇
傑佛瑞‧哈裡斯
弗拉基米爾‧揚科維奇
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Celgene Corporation
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Publication of HK1246180A1 publication Critical patent/HK1246180A1/zh

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HK18105719.9A 2014-12-31 2015-12-30 使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法 HK1246180A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462098547P 2014-12-31 2014-12-31
US62/098,547 2014-12-31
US201562139952P 2015-03-30 2015-03-30
US62/139,952 2015-03-30
PCT/US2015/068069 WO2016109668A1 (en) 2014-12-31 2015-12-30 Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

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HK1246180A1 true HK1246180A1 (zh) 2018-09-07

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HK18104846.8A HK1245140A1 (zh) 2014-12-31 2015-12-30 使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法

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US (2) US20180021378A1 (https=)
EP (1) EP3240551A4 (https=)
JP (2) JP6797803B2 (https=)
KR (1) KR20170100653A (https=)
CN (1) CN107249604A (https=)
AU (2) AU2015374062B2 (https=)
CA (1) CA2972806A1 (https=)
HK (2) HK1246180A1 (https=)
WO (1) WO2016109668A1 (https=)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
JP6493692B2 (ja) 2013-03-15 2019-04-10 セルジーン コーポレイション 修飾されたｔリンパ球
DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
AU2015305449B2 (en) * 2014-08-22 2021-05-06 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
UA124450C2 (uk) 2014-12-01 2021-09-22 Самма Хелт Спосіб індукції відновлення серця або міокарда або поліпшення функції вказаного серця або міокарда пацієнта
CA2973878A1 (en) 2015-01-22 2016-07-28 University Of Massachusetts Cancer immunotherapy
MA53355A (fr) 2015-05-29 2022-03-16 Agenus Inc Anticorps anti-ctla-4 et leurs procédés d'utilisation
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
EP3439675A4 (en) 2016-04-08 2019-12-18 Purdue Research Foundation METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
JP7158104B2 (ja) * 2016-07-15 2022-10-21 ビラクタ セラピューティクス，インク． Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤
JP7066696B2 (ja) 2016-10-11 2022-05-13 アジェナス インコーポレイテッド 抗ｌａｇ－３抗体及びその使用方法
US11459568B2 (en) 2016-10-31 2022-10-04 University Of Massachusetts Targeting microRNA-101-3p in cancer therapy
CN110300599B (zh) 2016-12-07 2024-07-02 艾吉纳斯公司 抗体和其使用方法
DK3551660T5 (da) 2016-12-07 2024-09-02 Agenus Inc Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf
WO2018104562A1 (en) 2016-12-09 2018-06-14 Onkimmune Limited Engineered natural killer cells and uses thereof
WO2018121679A1 (zh) * 2016-12-30 2018-07-05 四川大学 表达cxcr4的嵌合抗原受体修饰的淋巴细胞及制备方法和用途
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
US12129487B2 (en) * 2017-03-27 2024-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to obtain lymphoid progenitors
CA3056591A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
EP3630144A4 (en) * 2017-05-25 2021-03-31 University of Central Florida Research Foundation, Inc. NEW ONCOLYTIC VIRUSES TO SENSITIZE TUMOR CELLS TO DESTRUCTION BY NATURAL KILLER CELLS
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
WO2019067792A1 (en) * 2017-09-28 2019-04-04 Celularity, Inc. TUMOR CONTROL WITH INTERMEDIATE NATURAL KILLER CELLS DERIVED FROM HUMAN PLACENTA (PINK) IN COMBINATION WITH ANTIBODY
US11834677B2 (en) * 2017-10-02 2023-12-05 Gamida Cell Ltd. Expansion and use of expanded NK cell fractions
CA3080109A1 (en) * 2017-11-03 2019-05-09 Sorrento Therapeutics, Inc. Cd38-directed chimeric antigen receptor constructs
KR20200098590A (ko) * 2017-12-12 2020-08-20 마크로제닉스, 인크. 이중특이적 cd16-결합 분자 및 질환 치료에서의 그것의 용도
CN108060137B (zh) * 2017-12-26 2021-07-02 博生吉医药科技(苏州)有限公司 Il7和il21修饰的nk92细胞、制备方法及其应用
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
IL264068B2 (en) * 2018-01-05 2023-07-01 Great Novel Therapeutics Biotech & Medicals Corp Aggregate and pharmaceutical preparation containing an hdac inhibitor and an nsaid aggregate together with an immune checkpoint inhibitor for use in a method for removing immunosuppression in the microenvironment of a tumor or stimulating an immune system against cancer cells
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
US11814623B2 (en) 2018-01-30 2023-11-14 University Of Massachusetts Methods of treating a wound using epigenetic regulation
IL276365B2 (en) 2018-02-01 2023-10-01 Nkmax Co Ltd A method for the production of natural killer cells and a preparation for cancer treatment
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY
US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof
AU2019225174B2 (en) 2018-02-23 2025-11-20 Endocyte, Inc. Sequencing method for CAR T cell therapy
WO2019183094A1 (en) * 2018-03-19 2019-09-26 The Regents Of The University Of Michigan Compositions and methods for t-cell and cytokine activation
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
EP3781182A4 (en) 2018-04-18 2021-11-17 Summa Health COMPOSITIONS AND METHODS OF TREATMENT OF ISCHEMIA AND CARDIOMYOPATHIA
WO2019200586A1 (en) * 2018-04-19 2019-10-24 The Chinese University Of Hong Kong Modified nk cells and uses thereof
GB201807050D0 (en) * 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
KR102373502B1 (ko) * 2018-05-14 2022-03-11 주식회사 금호에이치티 골수유래억제세포 관련 질환의 예방 및 치료 용도
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
KR20210016567A (ko) * 2018-05-30 2021-02-16 글리코스템 떼라퓨틱스 비.브이. Car nk 세포
CN112601546B (zh) 2018-06-12 2024-04-16 湖南远泰生物技术有限公司 Plap-car-效应细胞
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
CA3112788A1 (en) * 2018-09-05 2020-03-12 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic virus platform to treat hematological cancer
CN112912400B (zh) 2018-10-19 2025-05-30 明尼苏达大学董事会 Nk接合子分子及其使用方法
AU2019372673A1 (en) 2018-11-01 2021-05-27 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for T cell engineering
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
KR20210111244A (ko) * 2018-11-30 2021-09-10 셀룰래리티 인코포레이티드 태반-유래 동종이계 car-t 세포 및 이의 용도
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
IL286482B2 (en) * 2019-03-21 2025-01-01 Gamida Cell Ltd Cultured NK cell fractions for use in combination therapy
TW202110873A (zh) 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
US20220273716A1 (en) * 2019-07-25 2022-09-01 Celularity Inc. Populations of natural killer cells comprising a cd38 chimeric antigen receptor
US20220340927A1 (en) * 2019-09-01 2022-10-27 Exuma Biotech Corp. Methods and compositions for the modification and delivery of lymphocytes
AU2020361622A1 (en) * 2019-10-10 2022-04-28 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic viruses that express multi-specific immune cell engagers
WO2021108769A1 (en) * 2019-11-27 2021-06-03 Deverra Therapeutics Inc. Compositions and methods for culturing hematopoietic stem and progenitor cells
WO2021107779A1 (en) * 2019-11-28 2021-06-03 Glycostem Therapeutics B.V. Method for obtaining car-nk cells
CN115243713A (zh) * 2020-03-05 2022-10-25 埃克苏马生物技术公司 用于递送修饰的淋巴细胞聚集体的方法和组合物
CN115461070A (zh) * 2020-03-18 2022-12-09 斯坦福大学托管董事会 组织蛋白酶抑制素基因表达的上调作为疾病的其他治疗的辅助
US20240000937A1 (en) * 2020-09-22 2024-01-04 World Biotech Regenerative Medical Group Limited Methods and compositions of car-expressing natural killer cells with bispecific antigen-binding molecules as cancer therapeutic agents
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
TW202245598A (zh) 2021-02-09 2022-12-01 美商千禧製藥公司 用於冷凍及解凍哺乳動物細胞的方法及組成物
AU2022218710A1 (en) * 2021-02-09 2023-08-10 Takeda Pharmaceutical Company Limited Methods and compositions for freezing and thawing mammalian cells
CN113398264B (zh) * 2021-08-06 2022-04-29 朱有建 Nk细胞及其组合物在治疗癌症中的用途
US20240335472A1 (en) * 2021-08-10 2024-10-10 Gamida Cell Ltd. Anti-her2 car nk cells, methods of their production and uses thereof
CN113577267B (zh) * 2021-09-06 2022-04-08 江西北正干细胞生物科技有限公司 Nk细胞和抗体的药物组合物及其在治疗癌症中的用途
JPWO2023038037A1 (https=) * 2021-09-08 2023-03-16
EP4180049A1 (en) * 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
CN114058584B (zh) * 2022-01-07 2022-07-01 山东省齐鲁干细胞工程有限公司 一种临床用自然杀伤细胞的制备方法
CN115927169B (zh) * 2022-10-11 2023-08-11 再造再生医学科技(杭州)有限公司 用于扩增cd34+造血干细胞的培养液和体外扩增cd34+造血干细胞的方法
CN119082021B (zh) * 2024-09-30 2025-03-28 广东壹加再生医学研究院有限公司 一种增强型nk细胞及其制备方法
CN119280423A (zh) * 2024-10-10 2025-01-10 中南大学 一种联合靶向鼻咽癌治疗的载药体系及其制备方法与应用
CN121426926A (zh) * 2025-10-21 2026-01-30 北京京科信拓生物技术有限公司 基因编辑的免疫细胞及其应用
CN121378506A (zh) * 2025-10-21 2026-01-23 北京京科信拓生物技术有限公司 表达car的免疫细胞及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
US6384105B1 (en) 1999-04-16 2002-05-07 William Marsh Rice University Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol)
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
JP2002045174A (ja) 2000-07-31 2002-02-12 Inst Of Physical & Chemical Res ナチュラルキラー細胞増殖法
DK1349918T3 (da) 2000-12-06 2014-11-10 Anthrogenesis Corp Fremgangsmåde til indsamling af stamceller fra moderkagen
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
CA2861491C (en) * 2012-02-13 2020-08-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
JP2015526088A (ja) * 2012-08-13 2015-09-10 アントフロゲネシス コーポレーション ナチュラルキラー細胞及びその使用
CN113684185A (zh) * 2013-02-26 2021-11-23 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
WO2014164554A1 (en) * 2013-03-10 2014-10-09 Baylor College Of Medicine Chemotherapy-resistant immune cells
WO2014145252A2 (en) * 2013-03-15 2014-09-18 Milone Michael C Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
CN105377897A (zh) * 2013-05-03 2016-03-02 俄亥俄州创新基金会 Cs1-特异性嵌合抗原受体工程化的免疫效应细胞
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells

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