HK1245838A1 - 用於體外病毒基因組工程的組合物和方法 - Google Patents
用於體外病毒基因組工程的組合物和方法Info
- Publication number
- HK1245838A1 HK1245838A1 HK18105318.4A HK18105318A HK1245838A1 HK 1245838 A1 HK1245838 A1 HK 1245838A1 HK 18105318 A HK18105318 A HK 18105318A HK 1245838 A1 HK1245838 A1 HK 1245838A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- compositions
- methods
- viral genome
- genome engineering
- vitro viral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462092707P | 2014-12-16 | 2014-12-16 | |
US201562102362P | 2015-01-12 | 2015-01-12 | |
US201562242811P | 2015-10-16 | 2015-10-16 | |
PCT/US2015/065891 WO2016100389A1 (en) | 2014-12-16 | 2015-12-15 | Compositions of and methods for in vitro viral genome engineering |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1245838A1 true HK1245838A1 (zh) | 2018-08-31 |
Family
ID=56127485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18105318.4A HK1245838A1 (zh) | 2014-12-16 | 2018-04-24 | 用於體外病毒基因組工程的組合物和方法 |
Country Status (9)
Country | Link |
---|---|
US (4) | US10221398B2 (zh) |
EP (1) | EP3234136B1 (zh) |
JP (2) | JP6842417B2 (zh) |
CN (2) | CN107278227B (zh) |
AU (2) | AU2015362618B2 (zh) |
CA (1) | CA2971205A1 (zh) |
EA (1) | EA038595B1 (zh) |
HK (1) | HK1245838A1 (zh) |
WO (1) | WO2016100389A1 (zh) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0811530B1 (pt) | 2007-05-14 | 2019-01-02 | Research Foundation Of State Univ Of New York | composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície |
CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
CA2953499C (en) | 2014-06-23 | 2023-10-24 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated dna assembly |
US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
CN107278227B (zh) | 2014-12-16 | 2021-05-28 | C3J治疗公司 | 用于体外病毒基因组工程的组合物和方法 |
US20160362667A1 (en) * | 2015-06-10 | 2016-12-15 | Caribou Biosciences, Inc. | CRISPR-Cas Compositions and Methods |
US10513732B2 (en) * | 2015-07-13 | 2019-12-24 | New York University | Sequencing methods and kits |
IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and their uses |
US11433260B2 (en) | 2015-12-21 | 2022-09-06 | Gholam A. Peyman | Cancer treatment methods using thermotherapy and/or enhanced immunotherapy |
US10136820B2 (en) * | 2015-12-21 | 2018-11-27 | Gholam A. Peyman | Method to visualize very early stage neoplasm or other lesions |
WO2017172644A2 (en) | 2016-03-28 | 2017-10-05 | The Charles Stark Draper Laboratory, Inc. | Bacteria identification and antibiotic susceptibility profiling device |
IL308426A (en) | 2016-08-03 | 2024-01-01 | Harvard College | Adenosine nuclear base editors and their uses |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
DK3503915T5 (da) | 2016-08-26 | 2024-09-02 | Telesis Bio Inc | Genetisk modificerede Vibro natriegen |
SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
US12018250B2 (en) | 2016-10-14 | 2024-06-25 | Fred Hutchinson Cancer Center | Compositions and methods for evading bacterial defense mechanisms |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
WO2018148412A1 (en) | 2017-02-09 | 2018-08-16 | The Charles Stark Draper Laboratory Inc. | Recombinant k1-5 bacteriophages and uses thereof |
US20190070232A1 (en) | 2017-03-06 | 2019-03-07 | Massachusetts Institute Of Technology | Methods of cloning prophages and producing lytic phage particles |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
EP3592777A1 (en) | 2017-03-10 | 2020-01-15 | President and Fellows of Harvard College | Cytosine to guanine base editor |
JP7191388B2 (ja) | 2017-03-23 | 2022-12-19 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸によってプログラム可能なdna結合蛋白質を含む核酸塩基編集因子 |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
WO2018222891A1 (en) * | 2017-06-01 | 2018-12-06 | The Charles Stark Draper Laboratory Inc. | Phage engineering: protection by circularized intermediate |
CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
US10174295B1 (en) * | 2017-08-01 | 2019-01-08 | The Charles Stark Draper Laboratory, Inc. | Composition of matter: engineering of Escherichia coli phage K1E |
US11891630B2 (en) | 2017-08-08 | 2024-02-06 | The Charles Stark Draper Laboratory, Inc. | Bacteriophage engineering via semi-synthesis |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
JP6923862B2 (ja) * | 2018-05-22 | 2021-08-25 | 学校法人自治医科大学 | 抗菌ファージ、治療用組成物、殺菌剤、食品、細菌判別キット、治療用組成物製造方法、細菌除去方法、細菌判別方法、及び動物治療方法 |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
US20220010284A1 (en) * | 2018-11-01 | 2022-01-13 | The Trustees Of Princeton University | System for protein inactivation and recombinant phages for targeted bacterial killing, infection, biodetection, and as a means of protein extraction |
CN113423824A (zh) * | 2018-11-27 | 2021-09-21 | 艾力格生物科技有限公司 | 用于细菌递送媒介物中的嵌合受体结合蛋白 |
JP2022514700A (ja) * | 2018-12-21 | 2022-02-14 | エリゴ・バイオサイエンス | 細菌送達ビヒクルにおける使用のための分岐型受容体結合多サブユニットタンパク質複合体 |
WO2020191243A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
CA3133359C (en) | 2019-04-04 | 2023-04-11 | Regeneron Pharmaceuticals, Inc. | Methods for scarless introduction of targeted modifications into targeting vectors |
DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
CN114540389B (zh) * | 2020-11-26 | 2024-05-14 | 深圳华大生命科学研究院 | 一种制备基因工程病毒的方法及其应用 |
CN112778399A (zh) * | 2021-01-21 | 2021-05-11 | 南开大学 | 一类源自毒性淀粉样纤维纳米抗菌肽的制备及性质表征方法 |
WO2022251644A1 (en) | 2021-05-28 | 2022-12-01 | Lyell Immunopharma, Inc. | Nr4a3-deficient immune cells and uses thereof |
EP4347826A1 (en) | 2021-06-02 | 2024-04-10 | Lyell Immunopharma, Inc. | Nr4a3-deficient immune cells and uses thereof |
CN113755451B (zh) * | 2021-09-03 | 2023-06-06 | 广西大学 | 一株大肠杆菌噬菌体gn6及其应用 |
EP4248987A1 (en) * | 2022-03-21 | 2023-09-27 | Nomad Bioscience GmbH | Chimeric bacteriocins and method for the control of pseudomonas |
WO2023225665A1 (en) | 2022-05-19 | 2023-11-23 | Lyell Immunopharma, Inc. | Polynucleotides targeting nr4a3 and uses thereof |
WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5877279A (en) | 1994-10-13 | 1999-03-02 | Nanoframes, Llc | Materials for the production of nanometer structures and use thereof |
EP1030861A4 (en) * | 1997-10-31 | 2001-09-05 | Maxygen Inc | MODIFICATION OF VIRAL TROPISM AND THE DIVERSITY OF HOST SPECIES BY RECOMBINATION OF THE VIRAL GENOME |
GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
GB9809414D0 (en) * | 1998-05-02 | 1998-07-01 | Scottish Crop Research Inst | Method |
US7019122B1 (en) | 1998-10-30 | 2006-03-28 | Janssen Pharmaceutica N.V. | Unusual retrotransposon from the yeast Candida albicans |
AU2001278003A1 (en) * | 2000-07-25 | 2002-02-05 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Bacteriophage having multiple host range |
WO2006021944A1 (en) | 2004-08-12 | 2006-03-02 | Leanway Automatic Areanas Ltd. | Enhanced database structure configuration |
WO2006137847A2 (en) * | 2004-09-13 | 2006-12-28 | Trustees Of Boston University | Engineered enzymatically active bacteriophages and methods of uses thereof |
NZ555830A (en) * | 2004-12-15 | 2009-01-31 | Univ North Carolina | Chimeric vectors |
WO2007005053A1 (en) | 2005-06-30 | 2007-01-11 | Codon Devices, Inc. | Hierarchical assembly methods for genome engineering |
WO2007074479A1 (en) | 2005-12-29 | 2007-07-05 | Abl Biotechnologies Ltd | Novel strain of schizochytrium limacinum useful in the production of lipids and extracellular polysaccharides and process thereof |
WO2008027472A2 (en) | 2006-08-29 | 2008-03-06 | Danisco Us, Inc., Genencor Division | Compositions and methods for improved protein production |
WO2008141757A1 (en) | 2007-05-23 | 2008-11-27 | Cognis Ip Management Gmbh | Efficient astaxanthin production strains derived from haematococcus pluvialis |
GB0715416D0 (en) | 2007-08-07 | 2007-09-19 | Phico Therapeutics Ltd | Modified bacteriophage |
US9056899B2 (en) * | 2008-01-10 | 2015-06-16 | Trustees Of Boston University | Engineered bacteriophages as adjuvants for antimicrobial agents and compositions and methods of use thereof |
DK3064599T3 (en) | 2008-02-15 | 2019-04-08 | Synthetic Genomics Inc | METHODS IN VITRO FOR COMBINING AND COMBINATORY CONSTRUCTION OF NUCLEIC ACID MOLECULES |
US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
CN101928670B (zh) | 2009-09-24 | 2012-02-22 | 上海天伟生物制药有限公司 | 一种抗生素的高产菌株及其制备方法和用途 |
US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
EP4332217A3 (en) * | 2010-09-17 | 2024-05-22 | Technophage, Investigação e Desenvolvimento em Biotecnologia, SA | Antibacterial phage, phage peptides and methods of use thereof |
US9771576B2 (en) * | 2012-02-01 | 2017-09-26 | Synthetic Genomics, Inc. | Materials and methods for the synthesis of error-minimized nucleic acid molecules |
DK2800811T3 (en) | 2012-05-25 | 2017-07-17 | Univ Vienna | METHODS AND COMPOSITIONS FOR RNA DIRECTIVE TARGET DNA MODIFICATION AND FOR RNA DIRECTIVE MODULATION OF TRANSCRIPTION |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
WO2015035168A1 (en) * | 2013-09-05 | 2015-03-12 | Massachusetts Institute Of Technolgy | Tuning bacteriophage host range |
CN107207614B (zh) * | 2014-10-09 | 2022-01-11 | 利普泰克有限公司 | 嵌合蛋白 |
CN107278227B (zh) | 2014-12-16 | 2021-05-28 | C3J治疗公司 | 用于体外病毒基因组工程的组合物和方法 |
-
2015
- 2015-12-15 CN CN201580076597.0A patent/CN107278227B/zh active Active
- 2015-12-15 JP JP2017532046A patent/JP6842417B2/ja active Active
- 2015-12-15 CA CA2971205A patent/CA2971205A1/en active Pending
- 2015-12-15 EP EP15870907.1A patent/EP3234136B1/en active Active
- 2015-12-15 CN CN202110495059.2A patent/CN113215115B/zh active Active
- 2015-12-15 WO PCT/US2015/065891 patent/WO2016100389A1/en active Application Filing
- 2015-12-15 EA EA201791343A patent/EA038595B1/ru unknown
- 2015-12-15 AU AU2015362618A patent/AU2015362618B2/en active Active
- 2015-12-15 US US14/970,458 patent/US10221398B2/en active Active
-
2018
- 2018-04-24 HK HK18105318.4A patent/HK1245838A1/zh unknown
-
2019
- 2019-01-11 US US16/246,381 patent/US10711253B2/en active Active
- 2019-04-03 US US16/374,646 patent/US10837004B2/en active Active
-
2020
- 2020-11-16 US US17/099,633 patent/US11913032B2/en active Active
-
2021
- 2021-02-19 JP JP2021024982A patent/JP7133671B2/ja active Active
-
2022
- 2022-04-26 AU AU2022202713A patent/AU2022202713A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20160186147A1 (en) | 2016-06-30 |
US20190211312A1 (en) | 2019-07-11 |
US20210087538A1 (en) | 2021-03-25 |
WO2016100389A1 (en) | 2016-06-23 |
US11913032B2 (en) | 2024-02-27 |
US10837004B2 (en) | 2020-11-17 |
AU2015362618B2 (en) | 2022-01-27 |
EA201791343A1 (ru) | 2018-03-30 |
EP3234136B1 (en) | 2024-08-21 |
JP7133671B2 (ja) | 2022-09-08 |
AU2015362618A1 (en) | 2017-07-13 |
CA2971205A1 (en) | 2016-06-23 |
US20190322988A1 (en) | 2019-10-24 |
AU2022202713A1 (en) | 2022-05-19 |
EA038595B1 (ru) | 2021-09-21 |
EP3234136A4 (en) | 2018-10-10 |
US10221398B2 (en) | 2019-03-05 |
JP2021074024A (ja) | 2021-05-20 |
EP3234136A1 (en) | 2017-10-25 |
CN113215115B (zh) | 2024-07-02 |
JP6842417B2 (ja) | 2021-03-17 |
CN107278227A (zh) | 2017-10-20 |
CN113215115A (zh) | 2021-08-06 |
US10711253B2 (en) | 2020-07-14 |
JP2017537643A (ja) | 2017-12-21 |
CN107278227B (zh) | 2021-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1245838A1 (zh) | 用於體外病毒基因組工程的組合物和方法 | |
IL287586A (en) | Methods and preparations for enriching breeding products | |
IL277196A (en) | Methods and preparations for genome engineering | |
ZA201801578B (en) | Methods and compositions for marker-free genome modification | |
HK1256817A1 (zh) | 用於基因組編輯的組合物和方法 | |
HRP20181630T1 (hr) | Postupci i kompoziti za ciljne genetske modifikacije i načini korištenja | |
IL251450A0 (en) | Preparations and methods for silencing hepatitis b virus gene expression | |
IL252970B (en) | Compositions and methods for genome editing in the living body with high efficiency | |
IL247309A0 (en) | Preparations for inhibiting virus replication and methods for their preparation and use | |
IL251576A0 (en) | Methods and compositions for creating or maintaining multifunctional cells | |
IL246352B (en) | Preparations and methods for preparing airway cells | |
HK1252004A1 (zh) | 用於病毒栓塞的組合物和方法 | |
SG11201703569XA (en) | HEPATITIS D VIRUS (HDV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF | |
IL259894A (en) | Improved compositions and improved methods for viral delivery of neoepitopes and their use | |
SI3250550T1 (sl) | Sestave in metode za senzibilizacijo virusov | |
HK1243404A1 (zh) | 色酰胺組合物和使用方法 | |
PL3113774T3 (pl) | Kompozycje grapiprantu i sposoby ich zastosowania | |
ZA201703123B (en) | Combination long acting compositions and methods for hepatitis c | |
GB2537518B (en) | Settable compositions and methods of use |