HK1224203A1 - 含有fc的多肽的稳定化 - Google Patents
含有fc的多肽的稳定化 Download PDFInfo
- Publication number
- HK1224203A1 HK1224203A1 HK16112553.6A HK16112553A HK1224203A1 HK 1224203 A1 HK1224203 A1 HK 1224203A1 HK 16112553 A HK16112553 A HK 16112553A HK 1224203 A1 HK1224203 A1 HK 1224203A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- polypeptides
- stabilization
- containing polypeptides
- region
- inteface
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361860800P | 2013-07-31 | 2013-07-31 | |
| US61/860,800 | 2013-07-31 | ||
| PCT/US2014/048908 WO2015017548A2 (en) | 2013-07-31 | 2014-07-30 | Stabilization of fc-containing polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1224203A1 true HK1224203A1 (zh) | 2017-08-18 |
Family
ID=52432568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16112553.6A HK1224203A1 (zh) | 2013-07-31 | 2014-07-30 | 含有fc的多肽的稳定化 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20160193295A1 (enExample) |
| EP (1) | EP3027647A4 (enExample) |
| JP (2) | JP2016526909A (enExample) |
| KR (3) | KR20160034404A (enExample) |
| CN (1) | CN105658664A (enExample) |
| AU (3) | AU2014296215A1 (enExample) |
| BR (1) | BR112016002219A2 (enExample) |
| CA (1) | CA2919076C (enExample) |
| CL (1) | CL2016000232A1 (enExample) |
| EA (1) | EA035319B1 (enExample) |
| HK (1) | HK1224203A1 (enExample) |
| IL (1) | IL243690B (enExample) |
| MX (2) | MX2016001165A (enExample) |
| SG (1) | SG11201600734YA (enExample) |
| WO (1) | WO2015017548A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2862516C (en) | 2012-03-27 | 2023-02-14 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| WO2014120619A2 (en) | 2013-01-30 | 2014-08-07 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| FR3012453B1 (fr) | 2013-10-31 | 2015-11-13 | Lab Francais Du Fractionnement | Proteine chimerique dans le traitement de l’amylose |
| UA123432C2 (uk) | 2014-07-30 | 2021-04-07 | Нджм Біофармасьютікалз, Інк. | Димер та спосіб його застосування для лікування метаболічних розладів |
| ES2799503T3 (es) * | 2014-10-31 | 2020-12-18 | Ngm Biopharmaceuticals Inc | Composiciones y procedimientos de uso para el tratamiento de trastornos metabólicos |
| WO2016100788A1 (en) | 2014-12-19 | 2016-06-23 | Alkermes, Inc. | Single chain fc fusion proteins |
| IL256989B (en) | 2015-08-07 | 2022-08-01 | Alx Oncology Inc | Constructs with a sirp-alpha site or a variant thereof |
| CA3025162A1 (en) | 2016-05-26 | 2017-11-30 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| CA3026393C (en) | 2016-06-22 | 2023-03-14 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| MX2019007611A (es) * | 2016-12-22 | 2020-07-29 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos t y métodos para su uso. |
| EP3576789B1 (en) * | 2017-02-01 | 2024-12-11 | Zhejiang Shimai Pharmaceutical Co., Ltd. | MONOMERIC HUMAN IgG1 Fc AND BISPECIFIC ANTIBODIES |
| IL271837B2 (en) * | 2017-07-07 | 2024-01-01 | Hanmi Pharm Ind Co Ltd | Novel therapeutic enzyme fusion protein and use thereof |
| CA3071337A1 (en) * | 2017-08-15 | 2019-02-21 | Kindred Biosciences, Inc. | Igg fc variants for veterinary use |
| CN107540748B (zh) * | 2017-09-15 | 2020-07-14 | 北京伟杰信生物科技有限公司 | 长效重组猪fsh融合蛋白及其制备方法与应用 |
| US12435328B2 (en) * | 2017-12-22 | 2025-10-07 | Hanmi Pharm. Co., Ltd. | Therapeutic enzyme fusion protein having a novel structure and use thereof |
| TWI724392B (zh) | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
| CN109021109A (zh) * | 2018-07-20 | 2018-12-18 | 上海交通大学 | 一种牛源性抗金黄色葡萄球菌融合抗体scFv-Fc及其制备方法 |
| KR20210042117A (ko) | 2018-08-03 | 2021-04-16 | 암젠 리서치 (뮌헨) 게엠베하 | Cldn18.2 및 cd3에 대한 항체 작제물 |
| KR102148405B1 (ko) * | 2018-09-19 | 2020-08-27 | 주식회사 바이오앱 | 돼지의 Fc 단편을 포함하는 재조합 벡터 및 상기 벡터를 이용한 재조합 단백질의 제조 방법 |
| KR102200773B1 (ko) * | 2018-09-19 | 2021-01-12 | 주식회사 바이오앱 | 돼지의 Fc 단편과 융합된 항원 및 이를 포함하는 백신 조성물 |
| US10947278B2 (en) * | 2018-09-19 | 2021-03-16 | Bioapplications Inc. | Recombinant vector comprising porcine FC fragment and preparation method of recombinant protein using thereof |
| WO2020167957A1 (en) * | 2019-02-12 | 2020-08-20 | Board Of Regents, The University Of Texas System | High affinity engineered t-cell receptors targeting cmv infected cells |
| KR20220044904A (ko) | 2019-05-31 | 2022-04-12 | 알렉소 온콜로지 인크. | 면역 관문 억제제와 병용하는 sirp 알파 fc 융합으로 암을 치료하는 방법 |
| JP7661245B2 (ja) | 2019-06-07 | 2025-04-14 | アムジエン・インコーポレーテツド | 二重特異性結合構築物 |
| WO2021053556A1 (en) * | 2019-09-18 | 2021-03-25 | Novartis Ag | Nkg2d fusion proteins and uses thereof |
| US11542276B2 (en) | 2019-11-25 | 2023-01-03 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| AU2020400805B2 (en) * | 2019-12-11 | 2024-03-28 | Lg Chem, Ltd. | Fusion polypeptide comprising GDF15 and polypeptide region capable of O-glycosylation |
| US20230093169A1 (en) | 2020-01-22 | 2023-03-23 | Amgen Research (Munch) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
| JP7481856B2 (ja) * | 2020-02-25 | 2024-05-13 | シスメックス株式会社 | 改変抗体及びその製造方法、並びに抗体の熱安定性を向上させる方法 |
| CN111285936A (zh) * | 2020-03-11 | 2020-06-16 | 北京双赢科创生物科技有限公司 | 靶向肿瘤的酸性敏感纳米肽段及其应用 |
| TW202200615A (zh) | 2020-03-12 | 2022-01-01 | 美商安進公司 | 用於治療和預防患者的crs之方法 |
| JP2023527293A (ja) | 2020-05-19 | 2023-06-28 | アムジエン・インコーポレーテツド | Ｍａｇｅｂ２結合構築物 |
| CN116096736A (zh) * | 2020-08-14 | 2023-05-09 | 武汉友微生物技术有限公司 | 新型冠状病毒rbd融合蛋白 |
| US20230322860A1 (en) * | 2020-08-21 | 2023-10-12 | Ajou University Industry-Academic Cooperation Foundation | ANTIBODY FRAGMENT CONSISTING OF HEAVY CHAIN AND LIGHT CHAIN CONSTANT REGIONS IN WHICH GAMMA CONSTANT REGION (Cgamma1) AND EPSILON CONSTANT REGION (CE2-4) ARE FUSED, AND USE THEREOF |
| CN114426974B (zh) * | 2020-10-29 | 2023-11-21 | 洛阳普泰生物技术有限公司 | 特异性结合非洲猪瘟病毒CD2v蛋白的抗体或抗体片段 |
| KR20230097061A (ko) * | 2020-11-02 | 2023-06-30 | 아트라러스, 인크. | Sap fc 융합 단백질 및 사용 방법 |
| TW202233679A (zh) | 2020-11-06 | 2022-09-01 | 德商安美基研究（慕尼黑）公司 | 選擇性地與cldn6和cd3結合的多肽構建體 |
| JP2023552375A (ja) * | 2020-12-06 | 2023-12-15 | エーエルエックス オンコロジー インコーポレイテッド | 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための多量体 |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CA3216908A1 (en) | 2021-05-13 | 2022-11-17 | ALX Oncology Inc. | Combination therapies for treating cancer |
| EP4392461A4 (en) * | 2021-08-24 | 2025-10-15 | Sunshine Lake Pharma Co Ltd | GDF15 FUSION PROTEINS AND THEIR USES |
| CN116064562A (zh) * | 2022-10-28 | 2023-05-05 | 江南大学 | 玉米赤霉烯酮的真核表达单链抗体以及全长抗体的制备方法以及用途 |
| CN116284455B (zh) * | 2023-04-17 | 2024-10-11 | 北京康乐卫士生物技术股份有限公司 | 一种带状疱疹病毒疫苗的嵌合抗原及其应用 |
| WO2025036564A1 (de) * | 2023-08-17 | 2025-02-20 | Gottfried Wilhelm Leibniz Universität Hannover (Luh) | Nukleinsäuresequenz, vektor, screening-verfahren und verfahren zur herstellung von rekombinanten antikörpern |
| WO2025162458A1 (zh) * | 2024-02-04 | 2025-08-07 | 南通壹宸生物医药科技有限公司 | 融合抗体及其制备和应用 |
| CN118344462B (zh) * | 2024-06-18 | 2024-11-08 | 苏州易合医药有限公司 | 一种用于肺部给药的索马鲁肽突变体、融合蛋白及相关产品 |
| CN119613573B (zh) * | 2025-02-14 | 2025-05-30 | 浙江大学 | 一种CD40L-Fc融合蛋白、基因片段、重组质粒、重组细胞以及制备方法和用途 |
| CN119735654B (zh) * | 2025-02-27 | 2025-07-01 | 浙江海隆生物科技股份有限公司 | 一种牛副流感病毒的亚单位hn蛋白制备方法和应用 |
| CN120623322B (zh) * | 2025-08-14 | 2025-12-05 | 成都蓉生药业有限责任公司 | 一种人IgG Fc变体、基因片段、表达载体、宿主细胞、IgG抗体及人IgG Fc变体制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| ES2246069T3 (es) * | 1997-05-02 | 2006-02-01 | Genentech, Inc. | Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos. |
| US20030207346A1 (en) * | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| AU2005282700A1 (en) * | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
| EA016609B1 (ru) * | 2005-11-28 | 2012-06-29 | Генмаб А/С | Рекомбинантные моновалентные антитела и способы их получения |
| JP2013511281A (ja) * | 2009-11-23 | 2013-04-04 | アムジェン インコーポレイテッド | 単量体抗体Ｆｃ |
| MX379481B (es) | 2010-12-06 | 2025-03-11 | Seagen Inc | Anticuerpos humanizados a liv-1 y uso de los mismos para tratar cancer |
-
2014
- 2014-07-30 CA CA2919076A patent/CA2919076C/en active Active
- 2014-07-30 AU AU2014296215A patent/AU2014296215A1/en not_active Abandoned
- 2014-07-30 CN CN201480046222.5A patent/CN105658664A/zh active Pending
- 2014-07-30 KR KR1020167004786A patent/KR20160034404A/ko not_active Ceased
- 2014-07-30 EA EA201690299A patent/EA035319B1/ru not_active IP Right Cessation
- 2014-07-30 MX MX2016001165A patent/MX2016001165A/es unknown
- 2014-07-30 KR KR1020257032842A patent/KR20250152665A/ko active Pending
- 2014-07-30 HK HK16112553.6A patent/HK1224203A1/zh unknown
- 2014-07-30 KR KR1020237032656A patent/KR20230141929A/ko not_active Ceased
- 2014-07-30 WO PCT/US2014/048908 patent/WO2015017548A2/en not_active Ceased
- 2014-07-30 US US14/909,431 patent/US20160193295A1/en not_active Abandoned
- 2014-07-30 IL IL243690A patent/IL243690B/en unknown
- 2014-07-30 JP JP2016531860A patent/JP2016526909A/ja active Pending
- 2014-07-30 EP EP14832297.7A patent/EP3027647A4/en active Pending
- 2014-07-30 SG SG11201600734YA patent/SG11201600734YA/en unknown
- 2014-07-30 BR BR112016002219A patent/BR112016002219A2/pt not_active Application Discontinuation
-
2016
- 2016-01-27 MX MX2022008013A patent/MX2022008013A/es unknown
- 2016-01-28 CL CL2016000232A patent/CL2016000232A1/es unknown
-
2019
- 2019-03-08 US US16/297,494 patent/US20190192628A1/en active Pending
-
2020
- 2020-01-17 AU AU2020200329A patent/AU2020200329A1/en not_active Abandoned
- 2020-09-25 JP JP2020160475A patent/JP7344858B2/ja active Active
-
2022
- 2022-02-22 AU AU2022201204A patent/AU2022201204B2/en active Active
-
2025
- 2025-01-17 US US19/030,935 patent/US20250325631A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190192628A1 (en) | 2019-06-27 |
| WO2015017548A2 (en) | 2015-02-05 |
| CN105658664A (zh) | 2016-06-08 |
| MX2022008013A (es) | 2022-07-27 |
| US20160193295A1 (en) | 2016-07-07 |
| JP7344858B2 (ja) | 2023-09-14 |
| AU2022201204B2 (en) | 2025-01-02 |
| KR20230141929A (ko) | 2023-10-10 |
| CL2016000232A1 (es) | 2016-09-02 |
| IL243690A0 (en) | 2016-04-21 |
| US20250325631A1 (en) | 2025-10-23 |
| SG11201600734YA (en) | 2016-02-26 |
| EA035319B1 (ru) | 2020-05-27 |
| MX2016001165A (es) | 2016-06-29 |
| AU2014296215A1 (en) | 2016-02-11 |
| EP3027647A2 (en) | 2016-06-08 |
| CA2919076A1 (en) | 2015-02-05 |
| CA2919076C (en) | 2024-01-30 |
| KR20160034404A (ko) | 2016-03-29 |
| JP2016526909A (ja) | 2016-09-08 |
| EA201690299A1 (ru) | 2016-11-30 |
| JP2021019598A (ja) | 2021-02-18 |
| WO2015017548A3 (en) | 2015-11-05 |
| BR112016002219A2 (pt) | 2017-09-12 |
| AU2020200329A1 (en) | 2020-02-06 |
| EP3027647A4 (en) | 2017-01-04 |
| KR20250152665A (ko) | 2025-10-23 |
| IL243690B (en) | 2022-09-01 |
| AU2022201204A1 (en) | 2022-03-17 |
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