EA201690299A1 - СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ - Google Patents

СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ

Info

Publication number
EA201690299A1
EA201690299A1 EA201690299A EA201690299A EA201690299A1 EA 201690299 A1 EA201690299 A1 EA 201690299A1 EA 201690299 A EA201690299 A EA 201690299A EA 201690299 A EA201690299 A EA 201690299A EA 201690299 A1 EA201690299 A1 EA 201690299A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polypeptides
amino acid
stabilization
containing polypeptides
region
Prior art date
Application number
EA201690299A
Other languages
English (en)
Other versions
EA035319B1 (ru
Inventor
Гунасекаран Каннан
Дженнифер Лавалле
Фредерик У. Джекобсен
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201690299A1 publication Critical patent/EA201690299A1/ru
Publication of EA035319B1 publication Critical patent/EA035319B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

В настоящем изобретении предложены полипептиды, содержащие Fc-область антитела, которая имеет делецию по меньшей мере одного остатка цистеина в шарнирной области и замену по меньшей мере одной аминокислоты на поверхности домена СН3 на остаток аминокислоты, содержащий сульфгидрильную группу. Также предложены гибридные Fc-белки и антитела, содержащие такие полипептиды, нуклеиновые кислоты и векторы, кодирующие указанные полипептиды, а также клетки-хозяева и способы получения указанных полипептидов.
EA201690299A 2013-07-31 2014-07-30 СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ EA035319B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361860800P 2013-07-31 2013-07-31
PCT/US2014/048908 WO2015017548A2 (en) 2013-07-31 2014-07-30 Stabilization of fc-containing polypeptides

Publications (2)

Publication Number Publication Date
EA201690299A1 true EA201690299A1 (ru) 2016-11-30
EA035319B1 EA035319B1 (ru) 2020-05-27

Family

ID=52432568

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690299A EA035319B1 (ru) 2013-07-31 2014-07-30 СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ

Country Status (15)

Country Link
US (2) US20160193295A1 (ru)
EP (1) EP3027647A4 (ru)
JP (2) JP2016526909A (ru)
KR (2) KR20160034404A (ru)
CN (1) CN105658664A (ru)
AU (3) AU2014296215A1 (ru)
BR (1) BR112016002219A2 (ru)
CA (1) CA2919076C (ru)
CL (1) CL2016000232A1 (ru)
EA (1) EA035319B1 (ru)
HK (1) HK1224203A1 (ru)
IL (1) IL243690B (ru)
MX (2) MX2016001165A (ru)
SG (1) SG11201600734YA (ru)
WO (1) WO2015017548A2 (ru)

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US10947278B2 (en) * 2018-09-19 2021-03-16 Bioapplications Inc. Recombinant vector comprising porcine FC fragment and preparation method of recombinant protein using thereof
KR102148405B1 (ko) * 2018-09-19 2020-08-27 주식회사 바이오앱 돼지의 Fc 단편을 포함하는 재조합 벡터 및 상기 벡터를 이용한 재조합 단백질의 제조 방법
US20220144916A1 (en) * 2019-02-12 2022-05-12 Board Of Regents, The University Of Texas System High affinity engineered t-cell receptors targeting cmv infected cells
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US20230093169A1 (en) 2020-01-22 2023-03-23 Amgen Research (Munch) Gmbh Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
CN113372438A (zh) * 2020-02-25 2021-09-10 希森美康株式会社 改造抗体及其制造方法、以及提高抗体的热稳定性的方法
CN111285936A (zh) * 2020-03-11 2020-06-16 北京双赢科创生物科技有限公司 靶向肿瘤的酸性敏感纳米肽段及其应用
WO2021183861A1 (en) 2020-03-12 2021-09-16 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
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WO2022032660A1 (zh) * 2020-08-14 2022-02-17 武汉友微生物技术有限公司 新型冠状病毒rbd融合蛋白
CN114426974B (zh) * 2020-10-29 2023-11-21 洛阳普泰生物技术有限公司 特异性结合非洲猪瘟病毒CD2v蛋白的抗体或抗体片段
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Also Published As

Publication number Publication date
CA2919076C (en) 2024-01-30
HK1224203A1 (zh) 2017-08-18
JP7344858B2 (ja) 2023-09-14
EP3027647A4 (en) 2017-01-04
JP2016526909A (ja) 2016-09-08
JP2021019598A (ja) 2021-02-18
AU2020200329A1 (en) 2020-02-06
WO2015017548A3 (en) 2015-11-05
KR20160034404A (ko) 2016-03-29
US20190192628A1 (en) 2019-06-27
EP3027647A2 (en) 2016-06-08
KR20230141929A (ko) 2023-10-10
AU2014296215A1 (en) 2016-02-11
EA035319B1 (ru) 2020-05-27
CN105658664A (zh) 2016-06-08
IL243690B (en) 2022-09-01
SG11201600734YA (en) 2016-02-26
AU2022201204A1 (en) 2022-03-17
US20160193295A1 (en) 2016-07-07
BR112016002219A2 (pt) 2017-09-12
CA2919076A1 (en) 2015-02-05
CL2016000232A1 (es) 2016-09-02
IL243690A0 (en) 2016-04-21
WO2015017548A2 (en) 2015-02-05
MX2016001165A (es) 2016-06-29
MX2022008013A (es) 2022-07-27

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