HK1222887A1 - 重編程分化細胞和從重編程的細胞產生動物和胚胎幹細胞的高效方法 - Google Patents

重編程分化細胞和從重編程的細胞產生動物和胚胎幹細胞的高效方法

Info

Publication number
HK1222887A1
HK1222887A1 HK16111146.2A HK16111146A HK1222887A1 HK 1222887 A1 HK1222887 A1 HK 1222887A1 HK 16111146 A HK16111146 A HK 16111146A HK 1222887 A1 HK1222887 A1 HK 1222887A1
Authority
HK
Hong Kong
Prior art keywords
cells
embryonic stem
highly efficient
efficient methods
reprogrammed
Prior art date
Application number
HK16111146.2A
Other languages
English (en)
Inventor
.蘭扎
.程
Original Assignee
Astellas Inst For Regenerative Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Inst For Regenerative Medicine filed Critical Astellas Inst For Regenerative Medicine
Publication of HK1222887A1 publication Critical patent/HK1222887A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0273Cloned animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0604Whole embryos; Culture medium therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657Cardiomyocytes; Heart cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0393Animal model comprising a reporter system for screening tests
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/235Leukemia inhibitory factor [LIF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998Proteins not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/02Coculture with; Conditioned medium produced by embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00Cells related to new breeds of animals
    • C12N2517/04Cells produced using nuclear transfer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
HK16111146.2A 2007-02-23 2016-09-22 重編程分化細胞和從重編程的細胞產生動物和胚胎幹細胞的高效方法 HK1222887A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90297007P 2007-02-23 2007-02-23
US91854307P 2007-03-16 2007-03-16
US99377207P 2007-09-14 2007-09-14
US943207P 2007-12-28 2007-12-28

Publications (1)

Publication Number Publication Date
HK1222887A1 true HK1222887A1 (zh) 2017-07-14

Family

ID=39710674

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111146.2A HK1222887A1 (zh) 2007-02-23 2016-09-22 重編程分化細胞和從重編程的細胞產生動物和胚胎幹細胞的高效方法

Country Status (10)

Country Link
US (2) US8796021B2 (zh)
EP (3) EP2121902A4 (zh)
JP (4) JP2010518857A (zh)
KR (1) KR20100014504A (zh)
CN (2) CN105441385A (zh)
AU (1) AU2008218998A1 (zh)
CA (1) CA2679109C (zh)
HK (1) HK1222887A1 (zh)
IL (1) IL200522A (zh)
WO (1) WO2008103462A2 (zh)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005304978A1 (en) 2004-11-04 2006-05-18 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
EP2302034B1 (en) 2005-08-03 2020-10-14 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
EP2121902A4 (en) 2007-02-23 2010-12-22 Advanced Cell Tech Inc HIGHLY EFFICIENT METHODS OF RENEWING DIFFERENTIATED CELLS AND GENERATING ANIMALS AND EMBRYONIC STEM CELLS FROM NEWLY PROGRAMMED CELLS
US9102920B2 (en) 2008-05-06 2015-08-11 Agency For Science, Technology And Research Method of effecting de-differentiation of a cell
CN101798569B (zh) * 2009-02-09 2012-11-21 北京瑞途之星科技有限公司 以卵裂后的发育胚胎替代卵母细胞的治疗性克隆新方法
JP5909482B2 (ja) * 2010-03-31 2016-04-26 ザ スクリプス リサーチ インスティテュート 細胞の再プログラム
CN101921808B (zh) * 2010-08-18 2012-05-30 东北农业大学 一种提高猪体细胞核移植效率的方法
US20120184035A1 (en) * 2011-01-13 2012-07-19 Sadhana Agarwal Methods and Compositions For Reprogramming Cells
WO2012174086A1 (en) * 2011-06-14 2012-12-20 J. R. Simplot Company A method for identifying a mammal receptive to embryo transfer
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
CN102321571A (zh) * 2011-09-21 2012-01-18 王跃嗣 从分化细胞制备自体造血干细胞的方法
ES2690212T3 (es) 2011-11-30 2018-11-19 Astellas Institute For Regenerative Medicine Células estromales mesenquimales y usos relacionados con las mismas
US9428732B2 (en) * 2011-12-05 2016-08-30 Primorigen Biosciences, Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
WO2013106753A1 (en) * 2012-01-13 2013-07-18 The Board Of Trustees Of The Leland Stanford Junior University Mechanical biomarkers for oocyte and embryo viability
CN102608323A (zh) * 2012-03-26 2012-07-25 西北农林科技大学 一种基于哺乳动物囊胚的分子免疫检测的胚胎质量分析方法
US9896699B2 (en) 2013-03-15 2018-02-20 New York Stem Cell Foundation, Inc. Somatic cell nuclear transfer methods
CA2908443A1 (en) * 2013-04-16 2014-10-23 Koninklijke Nederlandse Akademie Van Wetenschappen Blastoid, cell line based artificial blastocyst
JP2016073207A (ja) * 2014-10-02 2016-05-12 株式会社リプロセル 細胞凍結保存方法、細胞解凍方法、及び細胞
CN107889507B (zh) 2015-03-23 2021-11-26 安斯泰来再生医药协会 改进的人视网膜色素(rpe)细胞和感光祖细胞的效能测定
KR102447145B1 (ko) 2016-03-31 2022-09-23 샌바이오, 인크. 줄기 세포 배양 및 치료를 위한 배지, 방법, 세포 및 분비 인자
EP3555262A4 (en) * 2016-11-07 2020-05-13 K2 Research Holdings, LLC PRODUCTION AND THERAPEUTIC USES OF EPINUL PLURIPOTENT CELLS AND DIFFERENTIATED CELLS DERIVED THEREFROM
CN107099553A (zh) * 2017-06-19 2017-08-29 内蒙古大学 一种小鼠体细胞核移植方法
WO2019060735A1 (en) 2017-09-21 2019-03-28 EMULATE, Inc. PHYSIOLOGY AND PATHOPHYSIOLOGY OF HUMAN INTESTINES: INTESTIN-ON-CHIP
CN108624621B (zh) * 2018-01-17 2019-04-12 中国科学院上海生命科学研究院 非人灵长类的体细胞克隆动物的制备方法
CN110819585B (zh) * 2018-08-09 2022-12-06 山东大学 含有igf2的胚胎体外培育方法和培养基
TWI715874B (zh) * 2018-09-27 2021-01-11 台灣粒線體應用技術股份有限公司 無血清培養液以及使用此無血清培養液分離和放大培養幹細胞方法
EP3870188A1 (en) * 2018-10-23 2021-09-01 The Board of Trustees of the Leland Stanford Junior University Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields
WO2022272042A2 (en) * 2021-06-25 2022-12-29 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Primordial germ cells
CN113925878B (zh) * 2021-10-20 2024-03-08 上海交通大学医学院附属仁济医院 一种细胞外囊泡在治疗神经损伤性勃起功能障碍中的应用
CN114128668A (zh) * 2021-11-24 2022-03-04 华中农业大学 一种提高水牛夏季同期发情-定时输精效果的处理方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4441972A (en) 1983-04-08 1984-04-10 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4664097A (en) 1984-05-09 1987-05-12 The Wistar Institute Of Anatomy & Biology Nuclear transplantation in the mammalian embryo by microsurgery and cell fusion
US4578168A (en) 1984-07-27 1986-03-25 Biotronics Apparatus for fusing live cells with electric fields
US4994384A (en) 1986-12-31 1991-02-19 W. R. Grace & Co.-Conn. Multiplying bovine embryos
US5057420A (en) 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
US5213979A (en) 1987-12-30 1993-05-25 W. R. Grace & Co.-Conn. In vitro culture of bovine embryos
BR8907666A (pt) 1988-09-21 1991-07-30 Cambridge Animal Biotech Derivacao de linhas de celulas embrionarias pluripotenciais de animais domesticos
US4944384A (en) 1989-01-30 1990-07-31 Hay & Forage Industries Trash discharge apparatus for crop transferring conveyor mechanism
JP3375957B2 (ja) 1990-07-09 2003-02-10 アムラド・コーポレイション・リミテッド 白血病抑制因子を用いる胚の増強移植、増殖及び維持
US5096822A (en) 1990-07-26 1992-03-17 W. R. Grace & Co.- Conn. Bovine embryo medium
JP3104995B2 (ja) 1991-01-31 2000-10-30 ワーナー−ランバート・コンパニー 抗炎症剤として有用な4,6−ジ−第三ブチル−5−ヒドロキシ−1,3−ピリミジンの置換されたヘテロアリール類似体
US5173158A (en) 1991-07-22 1992-12-22 Schmukler Robert E Apparatus and methods for electroporation and electrofusion
US5496720A (en) 1993-02-10 1996-03-05 Susko-Parrish; Joan L. Parthenogenic oocyte activation
GB9308271D0 (en) 1993-04-21 1993-06-02 Univ Edinburgh Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
WO1995016770A1 (en) 1993-12-17 1995-06-22 Abs Global, Inc. Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates
EP1149898A2 (en) 1993-12-23 2001-10-31 Infigen, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7696404B2 (en) * 1996-08-19 2010-04-13 Advanced Cell Technology, Inc. Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6011197A (en) * 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
EP0973871A1 (en) 1997-03-06 2000-01-26 Infigen, Inc. Method of cloning animals
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US20040199935A1 (en) 1999-06-30 2004-10-07 Chapman Karen B. Cytoplasmic transfer to de-differentiate recipient cells
US7621606B2 (en) 2001-08-27 2009-11-24 Advanced Cell Technology, Inc. Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
NZ516236A (en) 1999-06-30 2004-12-24 Advanced Cell Tech Inc Altering life span of a recipient cell by transferring cell cytoplasm from a donor cell for use in gene therapy and cloning
MXPA02003732A (es) * 1999-10-14 2004-09-10 Univ Massachusetts Preparacion y seleccion de celulas donadoras para transplante nuclear.
EP1226239A4 (en) * 1999-10-15 2003-02-12 Advanced Cell Tech Inc Process for the preparation of differentiated progenitor cells and embryonic stem cells with line defects
EP1240318A4 (en) 1999-12-20 2004-12-08 Univ Massachusetts EMBRYONAL OR STEM CELL-LIKE CELLS PRODUCED BY CROSS-SPECIES, NUCLEAR TRANSPLANTATION
US20030213008A1 (en) * 1999-12-20 2003-11-13 Perry Anthony C.F. Method to produce cloned embryos and adults from cultured cells
EP1248517A2 (en) * 2000-01-07 2002-10-16 Oregon Health and Science University Clonal propagation of primate offspring by embryo splitting
DE10108412B4 (de) * 2001-02-21 2006-03-09 Cevec Pharmaceuticals Gmbh Pigmentepithelzelle des Auges, ihre Herstellung und Verwendung in der Therapie einer Augen- oder Nervenerkrankung
IL160507A0 (en) 2001-08-24 2004-07-25 Advanced Cell Tech Inc Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
JP2003067271A (ja) * 2001-08-27 2003-03-07 Hitachi Ltd 統合管理システム
US20030044976A1 (en) * 2001-08-27 2003-03-06 Advanced Cell Technology De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
JP2005510232A (ja) * 2001-11-26 2005-04-21 アドバンスド セル テクノロジー、インク. 再プログラムされたヒト体細胞核ならびに自系および同系なヒト幹細胞の製造および使用方法
WO2003057836A2 (en) 2001-12-27 2003-07-17 Advanced Cell Technology, Inc. Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
US7247477B2 (en) 2002-04-16 2007-07-24 Technion Research & Development Foundation Ltd. Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells
WO2003100011A2 (en) 2002-05-23 2003-12-04 Advanced Cell Technology, Inc. Generation of histocompatible tissues using nuclear transplantation
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
CN1708582A (zh) 2002-10-31 2005-12-14 独立行政法人理化学研究所 多能干细胞培养用的组合物及其使用
AU2003296480A1 (en) * 2002-12-10 2004-06-30 The Wistar Institute Method for programmed differentiation of stem cells
JP4613069B2 (ja) 2002-12-16 2011-01-12 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 支持細胞非含有、異種非含有のヒト胚性幹細胞の調製方法およびこれらを使用して調製された幹細胞培養物
US20040229350A1 (en) * 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
US20050118713A1 (en) * 2003-05-12 2005-06-02 Nikolai Strelchenko Morula derived embryonic stem cells
TW200521236A (en) * 2003-12-22 2005-07-01 Animal Technology Inst Taiwan Method for generating non-human mammalian chimeric embryo
EP2438814A3 (en) 2004-01-23 2012-10-03 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
GB2441530B (en) 2004-02-12 2009-09-23 Univ Newcastle Stem Cells
WO2006013519A1 (en) 2004-07-26 2006-02-09 Koninklijke Philips Electronics N.V. Method of storing data in an information carrier, system for reading such an information carrier.
WO2006013573A2 (en) 2004-08-06 2006-02-09 Mendy Erad Ltd. Early detection of harmful agents: method, system and kit
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
AU2005304978A1 (en) 2004-11-04 2006-05-18 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
EP2302034B1 (en) 2005-08-03 2020-10-14 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
US20090271335A1 (en) * 2005-10-20 2009-10-29 Advanced Cell Technology, Inc. Totipotent, Nearly Totipotent or Pluripotent Mammalian Cells Homozygous or Hemizygous for One or More Histocompatibility Antigent Genes
US20080070303A1 (en) 2005-11-21 2008-03-20 West Michael D Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
WO2007058671A1 (en) 2005-11-21 2007-05-24 West Michael D Novel uses of cells with prenatal patterns of gene expression
EP2029724A4 (en) 2006-05-03 2010-03-24 Advanced Cell Tech Inc DERIVATION FROM EMBRYONAL STEM CELLS AND EMBRYO-DERIVED CELLS
CN100465268C (zh) * 2006-05-17 2009-03-04 北京大学 人胚胎干细胞的培养方法及其专用培养基
US20070298496A1 (en) * 2006-06-23 2007-12-27 Hung-Chih Kuo Method of deriving pluripotent stem cells from a single blastomere
EP2121902A4 (en) 2007-02-23 2010-12-22 Advanced Cell Tech Inc HIGHLY EFFICIENT METHODS OF RENEWING DIFFERENTIATED CELLS AND GENERATING ANIMALS AND EMBRYONIC STEM CELLS FROM NEWLY PROGRAMMED CELLS

Also Published As

Publication number Publication date
KR20100014504A (ko) 2010-02-10
US20100240132A1 (en) 2010-09-23
IL200522A0 (en) 2011-08-01
EP2121902A2 (en) 2009-11-25
CN101679942A (zh) 2010-03-24
JP2019004912A (ja) 2019-01-17
US20150175960A1 (en) 2015-06-25
IL200522A (en) 2016-06-30
JP2016163593A (ja) 2016-09-08
AU2008218998A1 (en) 2008-08-28
CN105441385A (zh) 2016-03-30
JP6423386B2 (ja) 2018-11-14
CA2679109A1 (en) 2008-08-28
WO2008103462A2 (en) 2008-08-28
WO2008103462A3 (en) 2008-11-27
EP3190178A1 (en) 2017-07-12
JP5955809B2 (ja) 2016-07-20
US8796021B2 (en) 2014-08-05
EP2121902A4 (en) 2010-12-22
US10584313B2 (en) 2020-03-10
JP2013146280A (ja) 2013-08-01
CA2679109C (en) 2016-07-19
EP2982744A1 (en) 2016-02-10
JP2010518857A (ja) 2010-06-03

Similar Documents

Publication Publication Date Title
HK1222887A1 (zh) 重編程分化細胞和從重編程的細胞產生動物和胚胎幹細胞的高效方法
IL272848B (en) Methods for reprogramming cells and their use
EP1997281A4 (en) METHOD AND SYSTEM FOR RECOGNIZING DESIRABLE E-MAIL
IL212433A0 (en) Pluripotent stem cells obtained by non-viral reprogramming
GB0716313D0 (en) Methods for embryonic stem cell culture
EP2446928A4 (en) METHOD FOR KILLING TUMOR CELLS SELECTIVELY AND APPARATUS FOR THE METHOD
EP2155859A4 (en) FORMULATIONS AND METHODS FOR CULTIVATING EMBRYONIC STEM CELLS
SI2240572T1 (sl) Uporaba RNA za reprogramiranje somatskih celic
EP2096169A4 (en) NUCLEAR-NEUPROGRAMMIERUNGSVERFAHREN
EP2283117A4 (en) METHODS FOR THE PURIFICATION OF ENDODERMIC AND PANCREATIC ENDODERM CELLS FROM HUMAN EMBRYONIC STEM CELLS
IL201384A0 (en) Patient - specific stem cell lines derived from human parthenogenetic blastocysts
EP1874191A4 (en) REAL-TIME REPRESENTATION CONTROLLED ELECTROPORATION
IL193883A0 (en) Human embryonic stem cell methods and podxl expression
IL207036A0 (en) Stem cell aggregates and methods for making and using
ZA200908680B (en) Crushing plant and method for controlling the same
EP2133119A4 (en) METHOD FOR CONTROLLING THE HAIR GROWTH AND DEVICE FOR THE PROCEDURE
EP2133120A4 (en) METHOD FOR CONTROLLING HAIR GROWTH, AND APPARATUS ASSOCIATED WITH THE METHOD
EP2021464A4 (en) METHOD FOR CULTURING HUMAN EMBRYONIC STEM CELLS
EP2173310A4 (en) METHODS FOR PROMOTING HAIR GROWTH
ZA200908474B (en) Crushing plant and method for controlling the same
GB0812789D0 (en) Materials and methods for cell growth
EP2513297A4 (en) MATERIALS AND METHODS FOR THE PRODUCTION OF PLURIPOTENT STEM CELLS
IL178480A0 (en) Methods for generating neuronal cells from human embryonic stem cells and uses thereof
IL201346A0 (en) Newcompositions and methods for cell killing
EP2446020A4 (en) RE-PROGRAMMING OF DENTAL STEM CELLS