HK121293A - Desulfatohirudine,process for its preparation and pharmaceutical agent - Google Patents

Desulfatohirudine,process for its preparation and pharmaceutical agent

Info

Publication number
HK121293A
HK121293A HK1212/93A HK121293A HK121293A HK 121293 A HK121293 A HK 121293A HK 1212/93 A HK1212/93 A HK 1212/93A HK 121293 A HK121293 A HK 121293A HK 121293 A HK121293 A HK 121293A
Authority
HK
Hong Kong
Prior art keywords
preparation
desulfatohirudine
pharmaceutical agent
desulfatohirudins
hirudin
Prior art date
Application number
HK1212/93A
Other languages
English (en)
Inventor
Ursula Dr Seemueller
Johannes Dipl-Chem Dodt
Hans Prof Dr Fritz
Ernst Prof Dr Dr Fink
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6214920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK121293(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of HK121293A publication Critical patent/HK121293A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
HK1212/93A 1983-11-22 1993-11-04 Desulfatohirudine,process for its preparation and pharmaceutical agent HK121293A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833342139 DE3342139A1 (de) 1983-11-22 1983-11-22 Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel

Publications (1)

Publication Number Publication Date
HK121293A true HK121293A (en) 1993-11-12

Family

ID=6214920

Family Applications (1)

Application Number Title Priority Date Filing Date
HK1212/93A HK121293A (en) 1983-11-22 1993-11-04 Desulfatohirudine,process for its preparation and pharmaceutical agent

Country Status (19)

Country Link
US (3) US4654302A (es)
EP (1) EP0142860B1 (es)
JP (1) JP2551551B2 (es)
AT (1) ATE56021T1 (es)
AU (1) AU578050B2 (es)
CA (1) CA1239606A (es)
CY (1) CY1737A (es)
DD (1) DD232498A5 (es)
DE (3) DE3342139A1 (es)
DK (1) DK165696C (es)
HK (1) HK121293A (es)
IE (1) IE57885B1 (es)
IL (1) IL73570A (es)
LU (1) LU90192I2 (es)
MX (1) MX9203370A (es)
NL (1) NL970045I2 (es)
NZ (1) NZ210275A (es)
PH (1) PH23831A (es)
ZA (1) ZA849068B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
FR2562088B1 (fr) * 1984-03-27 1987-11-13 Transgene Sa Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
ATE64956T1 (de) * 1984-06-14 1991-07-15 Ciba Geigy Ag Verfahren zur herstellung von thrombininhibitoren.
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
JPS6229997A (ja) * 1985-04-08 1987-02-07 Sankyo Co Ltd Ｃ末端にプロリンアミドを有するペプチドの製法
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
WO1990003391A1 (en) * 1988-09-29 1990-04-05 Biogen, Inc. Hirudin peptides
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
WO1990006128A1 (en) * 1988-12-05 1990-06-14 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
US4861865A (en) * 1989-01-23 1989-08-29 Washington University Novel antithrombin peptide
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US6239101B1 (en) * 1989-07-05 2001-05-29 Oklahoma Medical Research Foundation Thrombin binding polypeptides
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2035917C (en) * 1990-02-13 2001-10-02 John L. Krstenansky Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
DE4209110A1 (de) * 1991-11-26 1993-05-27 Basf Ag Neue thrombininhibitorische proteine aus landblutegeln
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
GB9401447D0 (en) * 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
NZ336793A (en) * 1997-01-20 2000-08-25 Japan Energy Corp Method for stabilizing peptides by adding an organic acid and then lyophilizing the peptide mixture
DE19755682A1 (de) * 1997-12-15 1999-06-17 Knoll Ag Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE10149678A1 (de) 2001-10-09 2009-03-12 Novel Science International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

Also Published As

Publication number Publication date
US4745177A (en) 1988-05-17
CA1239606A (en) 1988-07-26
IE57885B1 (en) 1993-05-05
DE19775096I2 (de) 2002-07-04
DK552684A (da) 1985-05-23
DK165696B (da) 1993-01-04
US4801576A (en) 1989-01-31
JPS60136597A (ja) 1985-07-20
DE3342139A1 (de) 1985-05-30
EP0142860B1 (de) 1990-08-29
JP2551551B2 (ja) 1996-11-06
IE842979L (en) 1985-05-22
EP0142860A3 (en) 1987-03-11
MX9203370A (es) 1992-09-01
US4654302A (en) 1987-03-31
NL970045I2 (nl) 1998-08-03
AU3575984A (en) 1985-05-30
PH23831A (en) 1989-11-23
NZ210275A (en) 1988-08-30
CY1737A (en) 1995-10-20
AU578050B2 (en) 1988-10-13
DK165696C (da) 1993-05-24
EP0142860A2 (de) 1985-05-29
NL970045I1 (nl) 1998-03-02
ATE56021T1 (de) 1990-09-15
IL73570A0 (en) 1985-02-28
DD232498A5 (de) 1986-01-29
DK552684D0 (da) 1984-11-21
LU90192I2 (fr) 1998-03-02
DE3483085D1 (de) 1990-10-04
IL73570A (en) 1988-05-31
ZA849068B (en) 1985-07-31

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Legal Events

Date Code Title Description
AS Change of ownership

Owner name: NOVARTIS AG

Free format text: FORMER OWNER(S): UCP GEN-PHARMA AG, CIBA-GEIGY AG

Owner name: 93

Free format text: FORMER OWNER(S): UCP GEN-PHARMA AG, CIBA-GEIGY AG

Owner name: UCP GEN-PHARMA AG

Free format text: FORMER OWNER(S): NOVARTIS AG, UCP GEN-PHARMA AG

CHPA Change of a particular in the register (except of change of ownership)
PE Patent expired
PE Patent expired

Effective date: 20041119