HK1212921A1 - 用於神經成像的包括與病毒組分結合的熒光染料的成像法和組合物 - Google Patents

用於神經成像的包括與病毒組分結合的熒光染料的成像法和組合物

Info

Publication number
HK1212921A1
HK1212921A1 HK16100998.4A HK16100998A HK1212921A1 HK 1212921 A1 HK1212921 A1 HK 1212921A1 HK 16100998 A HK16100998 A HK 16100998A HK 1212921 A1 HK1212921 A1 HK 1212921A1
Authority
HK
Hong Kong
Prior art keywords
imaging
compositions
fluorescent dyes
nerve
viral components
Prior art date
Application number
HK16100998.4A
Other languages
English (en)
Inventor
Robert W Flower
Original Assignee
Novadaq Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novadaq Technologies Inc filed Critical Novadaq Technologies Inc
Publication of HK1212921A1 publication Critical patent/HK1212921A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK16100998.4A 2008-05-14 2016-01-29 用於神經成像的包括與病毒組分結合的熒光染料的成像法和組合物 HK1212921A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12765908P 2008-05-14 2008-05-14
US8298108P 2008-07-23 2008-07-23

Publications (1)

Publication Number Publication Date
HK1212921A1 true HK1212921A1 (zh) 2016-06-24

Family

ID=40810868

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16100998.4A HK1212921A1 (zh) 2008-05-14 2016-01-29 用於神經成像的包括與病毒組分結合的熒光染料的成像法和組合物

Country Status (10)

Country Link
US (4) US8361775B2 (zh)
EP (2) EP2285417B1 (zh)
JP (2) JP2011520907A (zh)
KR (2) KR101406506B1 (zh)
CN (2) CN104800863A (zh)
BR (1) BRPI0908612A2 (zh)
HK (1) HK1212921A1 (zh)
MX (1) MX2010012035A (zh)
RU (1) RU2475537C2 (zh)
WO (1) WO2009140510A1 (zh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US8498695B2 (en) 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
JP5231625B2 (ja) 2008-03-18 2013-07-10 ノヴァダク テクノロジーズ インコーポレイテッド Ｎｉｒ画像およびフルカラー画像を獲得するための画像化システムおよびその作動方法
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2285421B1 (en) 2008-05-02 2018-04-11 Novadaq Technologies ULC Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics
US8554579B2 (en) 2008-10-13 2013-10-08 Fht, Inc. Management, reporting and benchmarking of medication preparation
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
CA2829306C (en) 2011-03-08 2017-02-14 Novadaq Technologies Inc. Full spectrum led illuminator
EP2804523B1 (en) * 2012-01-18 2016-09-28 University of Utah Research Foundation Devices and systems for fluorescence imaging of tissue
JP6028096B2 (ja) 2012-06-21 2016-11-16 ノバダック テクノロジーズ インコーポレイテッド 血管造影及びかん流の定量化並びに解析手法
JP2015536181A (ja) 2012-10-26 2015-12-21 バクスター・コーポレーション・イングルウッドＢａｘｔｅｒ Ｃｏｒｐｏｒａｔｉｏｎ Ｅｎｇｌｅｗｏｏｄ 医学的用量調製システムのためのワーク・ステーションの改善
KR102078768B1 (ko) * 2012-10-26 2020-02-19 백스터 코포레이션 잉글우드 의료 투여분 조제 시스템을 위한 개선된 이미지 취득
US9040019B2 (en) 2012-11-30 2015-05-26 General Electric Company Methods of detecting myelin basic protein
RU2664595C2 (ru) * 2013-05-23 2018-08-21 Конинклейке Филипс Н.В. Устройство для воздействия на кожу с адаптивной обратной связью по движению
US9625386B2 (en) * 2014-09-10 2017-04-18 Iwasaki Electric Co., Ltd. Imaging system
CN107209118B (zh) * 2014-09-29 2021-05-28 史赛克欧洲运营有限公司 在自体荧光存在下生物材料中目标荧光团的成像
US11107574B2 (en) 2014-09-30 2021-08-31 Baxter Corporation Englewood Management of medication preparation with formulary management
KR102012880B1 (ko) 2014-10-09 2019-08-22 노바다크 테크놀러지즈 유엘씨 형광-조정 광전용적맥파 측정기를 사용한 조직 내의 절대적인 혈류의 정량화
AU2015358483A1 (en) 2014-12-05 2017-06-15 Baxter Corporation Englewood Dose preparation data analytics
CA2975295A1 (en) * 2015-02-02 2016-08-11 Novadaq Technologies Inc. Methods and systems for characterizing tissue of a subject
US10869592B2 (en) 2015-02-23 2020-12-22 Uroviu Corp. Handheld surgical endoscope
CA2978455A1 (en) 2015-03-03 2016-09-09 Baxter Corporation Englewood Pharmacy workflow management with integrated alerts
USD790727S1 (en) 2015-04-24 2017-06-27 Baxter Corporation Englewood Platform for medical dose preparation
AU2016351730B2 (en) 2015-11-13 2019-07-11 Novadaq Technologies Inc. Systems and methods for illumination and imaging of a target
EP4155716A1 (en) 2016-01-26 2023-03-29 Stryker European Operations Limited Image sensor assembly
US10744212B2 (en) * 2016-03-14 2020-08-18 General Electric Company Topical application of nerve labeling dyes for image-guided surgery
USD916294S1 (en) 2016-04-28 2021-04-13 Stryker European Operations Limited Illumination and imaging device
EP3469420A4 (en) 2016-06-14 2020-02-12 Novadaq Technologies ULC ADAPTIVE IMAGING METHODS AND SYSTEMS FOR IMPROVING LOW LIGHT SIGNALS IN MEDICAL VISUALIZATION
WO2018018160A1 (en) 2016-07-29 2018-02-01 Novadaq Technologies ULC Methods and systems for characterizing tissue of a subject utilizing machine learning
CN106190841B (zh) * 2016-08-30 2018-12-18 刘长亮 一种神经网络电活动检测系统以及基于此系统的神经精神类药物的筛选方法
US11832797B2 (en) 2016-09-25 2023-12-05 Micronvision Corp. Endoscopic fluorescence imaging
US11350816B2 (en) 2020-09-13 2022-06-07 Micron Vision Corp. Portable and ergonomic endoscope with disposable cannula
WO2018058013A1 (en) * 2016-09-25 2018-03-29 Xiaolong Ouyang Endoscopic fluorescence imaging
US11684248B2 (en) 2017-09-25 2023-06-27 Micronvision Corp. Endoscopy/stereo colposcopy medical instrument
US11330973B2 (en) 2017-09-25 2022-05-17 Micronvision Corp Portable and ergonomic endoscope with disposable cannula
KR101911725B1 (ko) * 2017-01-16 2018-12-28 주식회사 코어파마 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법
KR102306048B1 (ko) * 2017-01-30 2021-09-29 메디비콘 아이엔씨. 확산 반사 보정을 갖는 형광 추적제의 비침습 모니터링 방법
JP6931705B2 (ja) 2017-02-10 2021-09-08 ノバダック テクノロジーズ ユーエルシー オープンフィールドハンドヘルド蛍光イメージングシステムおよび方法
KR101970664B1 (ko) 2017-06-12 2019-04-19 (주)계림건축사사무소 탈부착식 패널 어셈블리
US11980342B2 (en) 2020-11-12 2024-05-14 Micronvision Corp. Minimally invasive endoscope
US11771304B1 (en) 2020-11-12 2023-10-03 Micronvision Corp. Minimally invasive endoscope
CN109628415A (zh) * 2018-12-13 2019-04-16 中国科学院深圳先进技术研究院 三级神经环路操纵组合物及动物三级神经环路操纵方法
WO2021016626A1 (en) 2019-07-25 2021-01-28 Uroviu Corp. Disposable endoscopy cannula with integrated grasper

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1707499A1 (ru) * 1989-06-22 1992-01-23 Институт Физиологии Им.И.П.Павлова Способ окрашивани перехватов Ранвье
JP3896176B2 (ja) * 1996-05-21 2007-03-22 浜松ホトニクス株式会社 近赤外線蛍光トレーサーおよび蛍光イメージング方法
US6013265A (en) * 1996-10-22 2000-01-11 University Of Maryland, Baltimore Vaccine composition for herpes simplex virus and methods of using
US6054131A (en) 1998-01-16 2000-04-25 University Of Maryland Baltimore Vaccine composition for herpes simplex virus and method of using
US6399354B1 (en) * 1998-07-31 2002-06-04 President And Fellows Of Harvard College Replication-competent virus expressing a detectable fusion protein
US6915154B1 (en) 1999-09-24 2005-07-05 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
AU2001247369A1 (en) * 2000-03-10 2001-09-24 Washington University Method for labeling individual cells
AU2002243751A1 (en) * 2001-01-31 2002-08-12 Mayo Foundation For Medical Education And Research Detection of herpes simplex virus
WO2003006658A1 (en) * 2001-07-13 2003-01-23 The General Hospital Corporation Mutant herpes simplex virus that expresses yeast cytosine deaminase
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location

Also Published As

Publication number Publication date
KR20110011655A (ko) 2011-02-08
EP2285417A1 (en) 2011-02-23
RU2011111077A (ru) 2012-09-27
RU2475537C2 (ru) 2013-02-20
US20090285762A1 (en) 2009-11-19
MX2010012035A (es) 2011-02-23
EP2285417B1 (en) 2016-08-10
US20120078093A1 (en) 2012-03-29
US20160199515A1 (en) 2016-07-14
BRPI0908612A2 (pt) 2020-08-18
WO2009140510A1 (en) 2009-11-19
KR20140007976A (ko) 2014-01-20
KR101406506B1 (ko) 2014-06-19
CN104800863A (zh) 2015-07-29
JP2014111614A (ja) 2014-06-19
US8361775B2 (en) 2013-01-29
US20180369426A1 (en) 2018-12-27
JP5806342B2 (ja) 2015-11-10
JP2011520907A (ja) 2011-07-21
EP3124051A1 (en) 2017-02-01
CN102026668A (zh) 2011-04-20

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