HK1210048A1 - Bioerodible silicon-based devices for delivery of therapeutic agents - Google Patents

Bioerodible silicon-based devices for delivery of therapeutic agents Download PDF

Info

Publication number
HK1210048A1
HK1210048A1 HK15110964.4A HK15110964A HK1210048A1 HK 1210048 A1 HK1210048 A1 HK 1210048A1 HK 15110964 A HK15110964 A HK 15110964A HK 1210048 A1 HK1210048 A1 HK 1210048A1
Authority
HK
Hong Kong
Prior art keywords
therapeutic agent
carrier material
certain embodiments
pore
pores
Prior art date
Application number
HK15110964.4A
Other languages
English (en)
Chinese (zh)
Inventor
．阿什通
P．阿什通
．坎漢
L．T．坎汉
．巴奈特
C．巴奈特
Original Assignee
Psi医疗有限公司
视点制药有限公司
视点制药美国有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psi医疗有限公司, 视点制药有限公司, 视点制药美国有限公司 filed Critical Psi医疗有限公司
Publication of HK1210048A1 publication Critical patent/HK1210048A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15110964.4A 2010-11-01 2015-11-06 Bioerodible silicon-based devices for delivery of therapeutic agents HK1210048A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40893410P 2010-11-01 2010-11-01
US61/408,934 2010-11-01
US201161470299P 2011-03-31 2011-03-31
US61/470,299 2011-03-31

Publications (1)

Publication Number Publication Date
HK1210048A1 true HK1210048A1 (en) 2016-04-15

Family

ID=46024803

Family Applications (3)

Application Number Title Priority Date Filing Date
HK15110964.4A HK1210048A1 (en) 2010-11-01 2015-11-06 Bioerodible silicon-based devices for delivery of therapeutic agents
HK15111163.1A HK1210416A1 (en) 2010-11-01 2015-11-12 Bioerodible silicon-based devices for delivery of therapeutic agents
HK15111162.2A HK1210415A1 (en) 2010-11-01 2015-11-12 Bioerodible silicon-based devices for delivery of therapeutic agents

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK15111163.1A HK1210416A1 (en) 2010-11-01 2015-11-12 Bioerodible silicon-based devices for delivery of therapeutic agents
HK15111162.2A HK1210415A1 (en) 2010-11-01 2015-11-12 Bioerodible silicon-based devices for delivery of therapeutic agents

Country Status (11)

Country Link
US (3) US9333173B2 (enExample)
EP (1) EP2635255B1 (enExample)
JP (2) JP6026424B2 (enExample)
CN (4) CN104622789A (enExample)
AU (2) AU2011323524B2 (enExample)
CA (1) CA2816576C (enExample)
HK (3) HK1210048A1 (enExample)
IN (1) IN2013MN00758A (enExample)
RU (1) RU2640918C2 (enExample)
TW (1) TWI615150B (enExample)
WO (1) WO2012061377A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
CA2758607C (en) 2009-05-04 2018-05-15 Psivida Us, Inc. Porous silicon drug-eluting particles
CN104622789A (zh) 2010-11-01 2015-05-20 普西维达公司 用于递送治疗剂的可生物侵蚀的硅基装置
WO2014165108A1 (en) * 2013-03-12 2014-10-09 Psivida Us, Inc. Bioerodible silicon-based delivery vehicles for delivery of therapeutic agents
RU2695536C2 (ru) * 2013-03-12 2019-07-23 Айпоинт Фармасьютикалз Юэс, Инк. Устройство для доставки лекарственных средств, содержащее частицы носителя на основе кремния
HK1216720A1 (zh) 2013-03-15 2016-12-02 Psi医疗有限公司 用於递送治疗剂的可生物蚀解的硅基组合物
US20160075776A1 (en) * 2014-09-16 2016-03-17 Paul Ashton Compositions and Methods for Controlled Release of Agents
JP6883257B2 (ja) * 2017-05-16 2021-06-09 株式会社豊田中央研究所 還元反応用固体触媒
CN112566622A (zh) 2018-06-19 2021-03-26 细胞疗法有限责任公司 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统
CA3104472A1 (en) 2018-06-19 2019-12-26 Cella Therapeutics, Llc Drug delivery systems comprising active pharmaceutical ingredients and a sustained delevery component
CN112218877B (zh) 2018-08-27 2025-07-25 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
EP4049652A1 (en) * 2021-02-26 2022-08-31 Nano Targeting & Therapy Biopharma Inc. Method for delivering an agent to posterior segment of an eye and uses thereof
TWI803092B (zh) * 2021-04-01 2023-05-21 逢甲大學 具負載與釋放活性成分的奈米粒子、其製造方法與眼用裝置之應用

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3832458A (en) 1971-12-06 1974-08-27 River C Foundation Hydrophilic silicone composition and method
US4036979A (en) 1974-01-25 1977-07-19 American Cyanamid Company Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate
US3919723A (en) 1974-05-20 1975-11-18 Friedrichsfeld Gmbh Bone shaft or bone joint prosthesis and process
US3919060A (en) 1974-06-14 1975-11-11 Ibm Method of fabricating semiconductor device embodying dielectric isolation
DE3214667C2 (de) 1982-04-21 1985-07-18 Akzo Gmbh, 5600 Wuppertal Zusammengesetzter Körper für die Langzeitabgabe von Wirkstoffen
JPS59101145A (ja) 1982-11-30 1984-06-11 日本特殊陶業株式会社 薬液含浸多孔質セラミツクス
JPS59131346A (ja) 1983-01-17 1984-07-28 日本特殊陶業株式会社 薬液含浸多孔質セラミツクスの製造法
DE3423667A1 (de) 1984-05-08 1985-11-28 Rüdiger Dipl.-Ing. 5204 Lohmar Scheunemann Implantat fuer knochen- und zahnwurzelersatz mit spezieller uebergangsstruktur zwischen knochen und implantatkern und knochenseitig ganz oder teilweise resorbierbarer matrix
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4608048A (en) 1984-12-06 1986-08-26 Alza Corporation Dispensing device with drug delivery patterns
US5057082A (en) 1988-11-04 1991-10-15 Plastic Injectors, Inc. Trocar assembly
AU634529B2 (en) 1989-03-17 1993-02-25 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US5167625A (en) 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
AU665067B2 (en) * 1992-04-30 1995-12-14 Takeda Pharmaceutical Company Limited Prefilled syringe
US5366454A (en) 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5370630A (en) 1993-11-12 1994-12-06 Smidebush; Michael J. Device for injection of fluidic materials into body tissue
US5489266A (en) * 1994-01-25 1996-02-06 Becton, Dickinson And Company Syringe assembly and method for lyophilizing and reconstituting injectable medication
US5558071A (en) 1994-03-07 1996-09-24 Combustion Electromagnetics, Inc. Ignition system power converter and controller
US5817327A (en) 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5591453A (en) 1994-07-27 1997-01-07 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5665114A (en) 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
US5792099A (en) 1995-02-14 1998-08-11 Decamp; Dennis Syringe and cannula for insertion of viscoelastic material into an eye and method of using same
JP3768536B2 (ja) 1995-04-03 2006-04-19 アボツト・ラボラトリーズ 低温溶融性薬物と制御放出のための添加物との均質混合物
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
GB9611437D0 (en) 1995-08-03 1996-08-07 Secr Defence Biomaterial
US5665428A (en) 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
DE19608423A1 (de) 1996-03-05 1997-09-11 Merck Patent Gmbh Implantate mit phasenweiser Arzneistoffabgabe
FR2749169B1 (fr) * 1996-06-04 1998-08-21 Delab Procede pour constituer une preparation injectable et dispositif pour la mise en oeuvre de ce procede
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5922299A (en) 1996-11-26 1999-07-13 Battelle Memorial Institute Mesoporous-silica films, fibers, and powders by evaporation
JP3217286B2 (ja) * 1996-12-19 2001-10-09 科学技術振興事業団 Ｄｎａ固定化複合体
US6696258B1 (en) 1998-01-20 2004-02-24 Drexel University Mesoporous materials and methods of making the same
AU2460099A (en) 1998-01-20 1999-08-02 Drexel University Mesoporous materials and methods of making the same
US6060036A (en) 1998-02-09 2000-05-09 Implant Sciences Corporation Radioactive seed implants
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
IL143846A0 (en) 1998-12-23 2002-04-21 Alza Corp Dosage forms comprising porous particles
JP2002534139A (ja) * 1999-01-05 2002-10-15 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜と脈絡膜への経強膜徐放性薬剤標的送達
WO2001012221A1 (en) 1999-08-16 2001-02-22 Henceforth Hibernia, Inc. Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them
GB9924334D0 (en) 1999-10-15 1999-12-15 Secr Defence Pharmaceutical products and methods of fabrication therefor
KR20020064299A (ko) 1999-10-18 2002-08-07 퍽스 인코포레이티드 자기 표적화형 캐리어
SE9903958D0 (sv) 1999-11-02 1999-11-02 Boerje Sellergren Porous materials for selective binding or transport of molecular guests
US6521284B1 (en) 1999-11-03 2003-02-18 Scimed Life Systems, Inc. Process for impregnating a porous material with a cross-linkable composition
AUPQ573300A0 (en) 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
CN1424912A (zh) 2000-02-28 2003-06-18 阿文蒂斯药物股份有限公司 用于治疗癌症的含有喜树碱和嘧啶衍生物的组合物
IL134830A0 (en) 2000-03-01 2001-05-20 Chay 13 Medical Res Group N V Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them
EP1267912A2 (en) 2000-03-14 2003-01-02 Burkhard Göke Effects of glucagon-like peptide-1 (7-36) on antro-pyloro-duodenal motility
GB0008494D0 (en) * 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
GB2365769A (en) 2000-08-18 2002-02-27 Secr Defence Skin preparations containing silicon
GB0104383D0 (en) 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
WO2002096389A1 (en) 2001-05-30 2002-12-05 Microchips, Inc. Conformal coated microchip reservoir devices
CA2496736C (en) 2002-08-23 2012-11-13 Mcmaster University Methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes
CN1301692C (zh) 2002-09-18 2007-02-28 阿勒根公司 眼植入物导入的器械
WO2004071949A2 (en) 2003-02-13 2004-08-26 The Regents Of The University Of California Nanostructured casting of organic and bio-polymers in porous silicon templates
US7433811B2 (en) 2003-05-06 2008-10-07 The Regents Of The University Of California Direct patterning of silicon by photoelectrochemical etching
US7563451B2 (en) 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
US20070042046A1 (en) 2003-10-21 2007-02-22 Roghieh Saffie Methods for the treatment of cancer
GB0324483D0 (en) * 2003-10-21 2003-11-19 Psi Medica Ltd Composite material
US20050181049A1 (en) 2003-11-19 2005-08-18 Dong Liang C. Composition and method for enhancing bioavailability
JP2008513127A (ja) 2004-09-17 2008-05-01 オルムコ コーポレイション 医療装置及び針製造方法
US20060067979A1 (en) 2004-09-30 2006-03-30 Bausch & Lomb Incorporated Ophthalmic drug release device for multiple drug release
WO2006037160A1 (en) 2004-10-05 2006-04-13 The University Of Melbourne Porous polyelectrolyte materials
ES2669585T3 (es) 2004-10-29 2018-05-28 The Regents Of The University Of California Micropartículas porosas de silicio para la entrega de fármaco para el ojo
JP4977475B2 (ja) 2004-12-21 2012-07-18 日本電気株式会社 フィルム外装電気デバイス用ケース
JP2007091716A (ja) 2005-08-29 2007-04-12 Kuraray Co Ltd 水中薬剤徐放性微粒子及びその製造方法
GB0526332D0 (en) 2005-12-23 2006-02-01 Psimedica Ltd Pharmaceutical product
US8119394B2 (en) * 2006-03-14 2012-02-21 University Of Rochester Cell culture devices having ultrathin porous membrane and uses thereof
CA2648066C (en) 2006-03-31 2012-07-03 Forsight Labs, Llc Drug delivery methods, structures, and compositions for nasolacrimal system
JP4984644B2 (ja) * 2006-05-19 2012-07-25 株式会社ジェイ・エム・エス 注射装置
US9248121B2 (en) 2006-08-21 2016-02-02 Abbott Laboratories Medical devices for controlled drug release
AU2007302586B2 (en) 2006-09-25 2013-06-27 Archer-Daniels-Midland Company Superabsorbent surface-treated carboxyalkylated polysaccharides and process for producing same
JP5141948B2 (ja) * 2007-07-09 2013-02-13 株式会社豊田中央研究所 バイモダルな細孔構造を有する球状シリカ系メソ多孔体及びその製造方法
KR20100047258A (ko) 2007-07-10 2010-05-07 더 리전트 오브 더 유니버시티 오브 캘리포니아 선택된 조직에 조성물을 전달하는 물질 및 방법
US20130084243A1 (en) 2010-01-27 2013-04-04 Liliane Goetsch Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
MX2011002936A (es) 2008-09-25 2011-04-11 Cephalon Inc Formulaciones liquidas de bendamustina.
GB0817938D0 (en) * 2008-09-30 2008-11-05 Intrinsiq Materials Global Ltd Cosmetic formulations
GB0817936D0 (en) * 2008-09-30 2008-11-05 Intrinsiq Materials Global Ltd Porous materials
JP5369725B2 (ja) 2009-01-30 2013-12-18 株式会社ニコン 撮像装置
US20120045515A1 (en) * 2009-02-04 2012-02-23 Ye Liu Hollow silica particle with a polymer thereon
US20110300222A1 (en) 2009-02-20 2011-12-08 The Regents Of The University Of California Luminescent porous silicon nanoparticles, methods of making and using same
US20100247607A1 (en) 2009-03-26 2010-09-30 Psivida Us, Inc. Implantable formulations of bisphosphonic acids
JP5382700B2 (ja) * 2009-03-27 2014-01-08 独立行政法人産業技術総合研究所 ロッド状多孔質シリカ粒子
CA2758607C (en) 2009-05-04 2018-05-15 Psivida Us, Inc. Porous silicon drug-eluting particles
US20110028412A1 (en) 2009-08-03 2011-02-03 Cappellos, Inc. Herbal enhanced analgesic formulations
DE102010008982A1 (de) 2010-02-24 2011-08-25 Bayer Innovation GmbH, 40225 Siliciumhaltiges, biologisch degradierbares Material zur anti-inflammatorischen Therapie
GB201017048D0 (en) 2010-10-08 2010-11-24 Ucl Business Plc Composition
CN104622789A (zh) 2010-11-01 2015-05-20 普西维达公司 用于递送治疗剂的可生物侵蚀的硅基装置
US20120238994A1 (en) 2010-12-22 2012-09-20 Martin Nazzaro Two-piece injectable drug delivery device with heat-cured seal
RU2013138180A (ru) 2011-02-11 2015-03-20 Псивида Юэс, Инк. Способы лечения макулярного отека с использованием противоотечных лекарственных средств
CA2830654A1 (en) 2011-03-31 2012-10-04 Galderma Research & Development Compositions comprising a filler product and at least one bioresorbable and biodegradable silica-based material
WO2013030679A2 (en) 2011-08-29 2013-03-07 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
WO2014081925A1 (en) 2012-11-21 2014-05-30 Agios Pharmaceuticals, Inc. Glutamase inhibitors and method of use
WO2014165108A1 (en) 2013-03-12 2014-10-09 Psivida Us, Inc. Bioerodible silicon-based delivery vehicles for delivery of therapeutic agents
US10517844B2 (en) 2014-11-13 2019-12-31 Buck Institute For Research On Aging Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications

Also Published As

Publication number Publication date
AU2011323524B2 (en) 2016-12-08
CN103282020B (zh) 2016-10-26
US20160243276A1 (en) 2016-08-25
EP2635255A1 (en) 2013-09-11
TW201306867A (zh) 2013-02-16
US9333173B2 (en) 2016-05-10
JP2016121173A (ja) 2016-07-07
JP6026424B2 (ja) 2016-11-16
JP6189460B2 (ja) 2017-08-30
HK1210416A1 (en) 2016-04-22
WO2012061377A1 (en) 2012-05-10
IN2013MN00758A (enExample) 2015-06-12
RU2640918C2 (ru) 2018-01-12
US9808421B2 (en) 2017-11-07
CA2816576C (en) 2020-06-02
CN104622790A (zh) 2015-05-20
RU2013119438A (ru) 2014-12-10
EP2635255A4 (en) 2016-11-09
AU2016259330B2 (en) 2018-11-08
CN104622789A (zh) 2015-05-20
CA2816576A1 (en) 2012-05-10
US11026885B2 (en) 2021-06-08
US20170035690A1 (en) 2017-02-09
JP2013541562A (ja) 2013-11-14
HK1210415A1 (en) 2016-04-22
EP2635255B1 (en) 2019-08-21
AU2016259330A1 (en) 2016-12-08
CN103282020A (zh) 2013-09-04
TWI615150B (zh) 2018-02-21
US20120177695A1 (en) 2012-07-12
CN104586742A (zh) 2015-05-06
AU2011323524A1 (en) 2013-05-23

Similar Documents

Publication Publication Date Title
CN103282020B (zh) 用于递送治疗剂的可生物侵蚀的硅基装置
US9980911B2 (en) Bioerodible silicon-based compositions for delivery of therapeutic agents
US20160346211A1 (en) Bioerodible silicon-based delivery vehicles for delivery of therapeutic agents
HK1188733A (en) Bioerodible silicon-based devices for delivery of therapeutic agents
HK1188733B (en) Bioerodible silicon-based devices for delivery of therapeutic agents
US20160075776A1 (en) Compositions and Methods for Controlled Release of Agents