HK1209361A1 - Compositions and methods for transmucosal absorption - Google Patents

Compositions and methods for transmucosal absorption

Info

Publication number
HK1209361A1
HK1209361A1 HK15110186.6A HK15110186A HK1209361A1 HK 1209361 A1 HK1209361 A1 HK 1209361A1 HK 15110186 A HK15110186 A HK 15110186A HK 1209361 A1 HK1209361 A1 HK 1209361A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
transmucosal absorption
transmucosal
absorption
Prior art date
Application number
HK15110186.6A
Other languages
English (en)
Chinese (zh)
Inventor
Harry Brittain
Seth Lederman
Giorgio Reiner
Original Assignee
Tonix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tonix Pharmaceuticals Inc filed Critical Tonix Pharmaceuticals Inc
Publication of HK1209361A1 publication Critical patent/HK1209361A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
HK15110186.6A 2012-06-15 2015-10-16 Compositions and methods for transmucosal absorption HK1209361A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261660593P 2012-06-15 2012-06-15
US201261667774P 2012-07-03 2012-07-03
US201261725402P 2012-11-12 2012-11-12
US201361792900P 2013-03-15 2013-03-15
PCT/US2013/046023 WO2013188847A1 (fr) 2012-06-15 2013-06-14 Compositions et procédés pour l'absorption transmucosale

Publications (1)

Publication Number Publication Date
HK1209361A1 true HK1209361A1 (en) 2016-04-01

Family

ID=49758769

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110186.6A HK1209361A1 (en) 2012-06-15 2015-10-16 Compositions and methods for transmucosal absorption

Country Status (26)

Country Link
US (1) US20140171515A1 (fr)
EP (1) EP2861223B1 (fr)
JP (5) JP6259452B2 (fr)
CN (2) CN104684550A (fr)
AR (1) AR092330A1 (fr)
AU (2) AU2013274003B2 (fr)
BR (1) BR112014031394B1 (fr)
CA (2) CA2876902C (fr)
DK (1) DK2861223T3 (fr)
ES (1) ES2929133T3 (fr)
HK (1) HK1209361A1 (fr)
HR (1) HRP20221325T1 (fr)
HU (1) HUE060175T2 (fr)
IL (1) IL236268B (fr)
LT (1) LT2861223T (fr)
MX (2) MX2014015436A (fr)
MY (1) MY194495A (fr)
NZ (2) NZ726488A (fr)
PL (1) PL2861223T3 (fr)
PT (1) PT2861223T (fr)
RS (1) RS63822B1 (fr)
SG (2) SG10201605407TA (fr)
SI (1) SI2861223T1 (fr)
TW (3) TWI590820B (fr)
WO (1) WO2013188847A1 (fr)
ZA (1) ZA201500288B (fr)

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LT2501234T (lt) 2009-11-20 2017-12-11 Tonix Pharma Holdings Limited Būdai ir kompozicijos, skirti simptomų, susijusių su potrauminiu streso sutrikimu, gydymui naudojant ciklobenzapriną
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
HRP20240648T1 (hr) 2013-03-15 2024-08-02 Tonix Pharma Holdings Limited Eutektičke formulacije ciklobenzaprin hidroklorida i manitola
CA2961822A1 (fr) * 2014-09-18 2016-03-24 Tonix Pharma Holdings Limited Formulation d'eutectique de l'hydrochlorure de cyclobenzaprine
EP3322412B1 (fr) * 2015-07-15 2021-04-07 Theranexus Utilisation de l'amitriptyline pour le blocage des demi-canaux du cerveau et procédé de potentialisation de son effet in vivo
WO2018045367A1 (fr) * 2016-09-02 2018-03-08 Nova Southeastern University Comprimés sublinguaux à désintégration rapide de sulfate d'atropine pour le traitement de l'intoxication aiguë par les organophosphorés
CA3069699A1 (fr) * 2017-07-13 2019-01-17 Tonix Pharmaceuticals Holding Corp. Analogues de cyclobenzaprine et d'amitryptilene
CN107519142B (zh) * 2017-08-24 2021-02-26 正大制药（青岛）有限公司 一种盐酸环苯扎林舌下片及其制备方法
CN107496355B (zh) * 2017-08-24 2021-04-30 正大制药（青岛）有限公司 一种盐酸环苯扎林舌下喷雾剂及其制备方法
IL275144B1 (en) * 2017-12-08 2024-08-01 Hoffmann La Roche Pharmacy preparation
CN118267382A (zh) 2017-12-11 2024-07-02 通尼克斯制药控股有限公司 用于痴呆和神经变性病况中的激越、精神病和认知衰退的环苯扎林治疗
CN108721240A (zh) * 2018-06-08 2018-11-02 华益药业科技(安徽)有限公司 一种25mg阿米替林薄膜包衣片处方和工艺规程
CA3109258A1 (fr) * 2018-08-20 2020-02-27 Tonix Pharma Holdings Limited Procedes de traitement de trouble de stress aigus et de trouble de stress post-traumatique
WO2021064589A1 (fr) * 2019-09-30 2021-04-08 Cadila Healthcare Limited Compositions pharmaceutiques intranasales de cyclobenzaprine
WO2021207561A1 (fr) 2020-04-08 2021-10-14 Tonix Pharmaceuticals Holding Corp. Traitement par cyclobenzaprine pour traiter une dysfonction sexuelle
WO2022109218A1 (fr) * 2020-11-20 2022-05-27 Tonix Pharmaceuticals Holding Corp. Traitement à base de cyclobenzaprine pour un trouble de consommation d'alcool
CN116940340A (zh) 2020-12-07 2023-10-24 通尼克斯医药控股公司 纤维肌痛的环苯扎林治疗
WO2022170107A2 (fr) 2021-02-04 2022-08-11 Tonix Pharmaceuticals Holding Corp. Procédé amélioré d'évaluation de la réponse clinique dans le traitement de symptômes du trouble de stress post-traumatique
WO2023059728A1 (fr) 2021-10-06 2023-04-13 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine pour le traitement ou la prévention d'un dysfonctionnement sexuel associé à des états de santé mentaux chez des patients femelles
US20230414536A1 (en) 2022-06-21 2023-12-28 Tonix Pharmaceuticals Holding Corp. CYCLOBENZAPRINE TREATMENT FOR POST-ACUTE SEQUELAE OF (SARS)-CoV-2 INFECTION (PASC)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968507A (en) * 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
WO1999018937A1 (fr) * 1997-10-16 1999-04-22 Merck & Co., Inc. Nouvelle composition contenant de la cyclobenzaprine
PT1077683E (pt) * 1998-05-14 2003-04-30 Alza Corp Terapia anti-depressiva
AR025110A1 (es) 1999-08-13 2002-11-06 Vela Pharmaceuticals Inc Metodos y composiciones para tratar o prevenir alteraciones del sueno y enfermedades asociadas usando dosis muy bajas de ciclobenzaprina
BR0013122A (pt) 1999-08-13 2002-04-30 Vela Pharmaceuticals Inc Ciclobenzaprina para tratamento de distúrbio de ansiedade generalizado e composições de ciclobenzaprina
AU2001261744A1 (en) * 2000-05-19 2001-12-03 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
WO2002094229A1 (fr) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Administration de myorelaxants par voie respiratoire
JP2006516963A (ja) * 2003-02-04 2006-07-13 クリサリス テクノロジーズ インコーポレイテッド エアロゾル製剤及びブスピロン、ブプレノルフィン、トリアゾラム、シクロベンザプリン及びゾルピデムのエアロゾル送出
US20090117054A1 (en) * 2005-03-29 2009-05-07 University Of Kentucky Research Foundation Sublingual spray for the treatment of pain
US20090148532A1 (en) * 2007-12-06 2009-06-11 Venkatesh Gopi M Preparation of controlled release skeletal muscle relaxant dosage forms
JP2009079060A (ja) * 2008-10-15 2009-04-16 Novadel Pharma Inc 極性または非極性の、バッカルスプレーまたはカプセル
US20100266682A1 (en) * 2008-12-10 2010-10-21 Nipun Davar Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
LT2501234T (lt) * 2009-11-20 2017-12-11 Tonix Pharma Holdings Limited Būdai ir kompozicijos, skirti simptomų, susijusių su potrauminiu streso sutrikimu, gydymui naudojant ciklobenzapriną
US20110319389A1 (en) * 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
ITMI20110558A1 (it) * 2011-04-06 2012-10-07 Campiglio Consulting Srl Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale
HRP20240648T1 (hr) * 2013-03-15 2024-08-02 Tonix Pharma Holdings Limited Eutektičke formulacije ciklobenzaprin hidroklorida i manitola

Also Published As

Publication number Publication date
WO2013188847A8 (fr) 2015-02-05
HUE060175T2 (hu) 2023-02-28
CA2876902A1 (fr) 2013-12-19
AR092330A1 (es) 2015-04-15
JP2024032964A (ja) 2024-03-12
NZ631144A (en) 2016-12-23
BR112014031394A8 (pt) 2021-11-03
BR112014031394B1 (pt) 2022-10-18
ZA201500288B (en) 2022-05-25
CA2876902C (fr) 2021-07-13
CA3118913A1 (fr) 2013-12-19
IL236268A0 (en) 2015-02-26
TWI642429B (zh) 2018-12-01
CN111388430A (zh) 2020-07-10
LT2861223T (lt) 2022-12-12
AU2018241128A1 (en) 2018-10-25
CA3118913C (fr) 2024-04-30
NZ726488A (en) 2018-10-26
TWI683660B (zh) 2020-02-01
BR112014031394A2 (pt) 2017-06-27
JP2019123757A (ja) 2019-07-25
JP2017222726A (ja) 2017-12-21
AU2013274003A1 (en) 2015-02-05
SG10201605407TA (en) 2016-08-30
JP6259452B2 (ja) 2018-01-10
PL2861223T3 (pl) 2022-12-12
SG11201408318RA (en) 2015-01-29
EP2861223B1 (fr) 2022-08-03
EP2861223A4 (fr) 2016-01-27
WO2013188847A1 (fr) 2013-12-19
TWI590820B (zh) 2017-07-11
TW201408281A (zh) 2014-03-01
SI2861223T1 (sl) 2023-01-31
MY194495A (en) 2022-11-30
AU2013274003B2 (en) 2018-07-05
PT2861223T (pt) 2022-11-07
MX2021005317A (es) 2022-12-16
TW201731494A (zh) 2017-09-16
CN104684550A (zh) 2015-06-03
HRP20221325T1 (hr) 2022-12-23
DK2861223T3 (da) 2022-11-07
RS63822B1 (sr) 2023-01-31
IL236268B (en) 2022-03-01
JP2021138765A (ja) 2021-09-16
MX2014015436A (es) 2015-07-14
AU2018241128B2 (en) 2020-05-21
TW201842903A (zh) 2018-12-16
ES2929133T3 (es) 2022-11-25
EP2861223A1 (fr) 2015-04-22
JP2015519404A (ja) 2015-07-09
US20140171515A1 (en) 2014-06-19

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