HK1208453A1 - Substituted pyridopyrimidine compounds and their use as flt3 inhibitors flt3 - Google Patents

Substituted pyridopyrimidine compounds and their use as flt3 inhibitors flt3

Info

Publication number
HK1208453A1
HK1208453A1 HK15109075.2A HK15109075A HK1208453A1 HK 1208453 A1 HK1208453 A1 HK 1208453A1 HK 15109075 A HK15109075 A HK 15109075A HK 1208453 A1 HK1208453 A1 HK 1208453A1
Authority
HK
Hong Kong
Prior art keywords
flt3
inhibitors
substituted pyridopyrimidine
pyridopyrimidine compounds
compounds
Prior art date
Application number
HK15109075.2A
Other languages
English (en)
Chinese (zh)
Inventor
金宏宇
李希奎
宋浩俊
李宰奎
高鐘盛
金政浩
金世園
李任勇
Original Assignee
Genosco
Oscotec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genosco, Oscotec Inc filed Critical Genosco
Publication of HK1208453A1 publication Critical patent/HK1208453A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/305—Mercury compounds
    • A61K31/31—Mercury compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15109075.2A 2012-03-22 2015-09-16 Substituted pyridopyrimidine compounds and their use as flt3 inhibitors flt3 HK1208453A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261614274P 2012-03-22 2012-03-22
PCT/US2013/032575 WO2013142382A1 (en) 2012-03-22 2013-03-15 Substituted pyridopyrimidine compounds and their use as flt3 inhibitors

Publications (1)

Publication Number Publication Date
HK1208453A1 true HK1208453A1 (en) 2016-03-04

Family

ID=49223277

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15109075.2A HK1208453A1 (en) 2012-03-22 2015-09-16 Substituted pyridopyrimidine compounds and their use as flt3 inhibitors flt3

Country Status (22)

Country Link
US (1) US8877763B2 (tr)
EP (1) EP2828259B1 (tr)
JP (1) JP6101341B2 (tr)
KR (1) KR102011770B1 (tr)
CN (1) CN104428298B (tr)
AU (1) AU2013235344B2 (tr)
BR (1) BR112014023460B1 (tr)
CA (1) CA2868156C (tr)
CL (1) CL2014002505A1 (tr)
EA (1) EA031267B1 (tr)
ES (1) ES2694223T3 (tr)
HK (1) HK1208453A1 (tr)
IL (1) IL234802B (tr)
IN (1) IN2014MN02082A (tr)
MX (1) MX360912B (tr)
MY (1) MY184858A (tr)
NZ (1) NZ700283A (tr)
PL (1) PL2828259T3 (tr)
SG (1) SG11201405942RA (tr)
TR (1) TR201816480T4 (tr)
WO (1) WO2013142382A1 (tr)
ZA (1) ZA201407588B (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6434506B2 (ja) * 2013-10-21 2018-12-05 ジェノスコ 置換ピリミジン化合物およびｓｙｋ阻害剤としてのそれらの使用
US10065934B2 (en) * 2014-07-17 2018-09-04 Sunshine Lake Pharma Co., Ltd. Substituted urea derivatives and pharmaceutical uses thereof
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
JP6836989B2 (ja) 2014-11-17 2021-03-03 ロード アイランド ホスピタル ナノ材料組成物、合成方法、およびアセンブリ
MX2020013805A (es) * 2018-06-27 2021-03-09 Oscotec Inc Derivados de piridopirimidinona para uso como inhibidores de axl.
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
KR102230721B1 (ko) 2019-02-01 2021-03-22 주식회사 오스코텍 피리도피리미딘계 염산염을 포함하는 경구용 고형제제 및 이의 제조방법
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CN110327347B (zh) * 2019-08-16 2021-06-01 陕西科技大学 G-749在制备抗真菌药物中的应用
TWI759829B (zh) * 2019-08-23 2022-04-01 財團法人生物技術開發中心 作為第iii型受體酪胺酸激酶抑制劑之雜環吡唑衍生物
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
WO2023225005A1 (en) 2022-05-17 2023-11-23 Biomea Fusion, Inc. Flt3 combination therapy for cancer and compositions therefor
KR102440707B1 (ko) 2022-07-10 2022-09-05 이우미 공장 추천 시스템

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK10772002A3 (sk) * 2000-01-27 2004-01-08 Warner-Lambert Company Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení
CN1275964C (zh) * 2000-08-31 2006-09-20 霍夫曼-拉罗奇有限公司 作为细胞增殖抑制剂的7－氧代吡啶并嘧啶
BR0113590A (pt) * 2000-08-31 2003-07-22 Hoffmann La Roche 7-oxo-piridopirimidinas
EP2025678A1 (en) * 2007-08-17 2009-02-18 Oncalis AG Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase
TW200938542A (en) * 2008-02-01 2009-09-16 Irm Llc Compounds and compositions as kinase inhibitors
US8383635B2 (en) * 2008-08-12 2013-02-26 Glaxosmithkline Llc Chemical compounds
US8338481B2 (en) * 2009-01-28 2012-12-25 Ramot At Tel-Aviv University Ltd. Alkoxyalkyl S-prenylthiosalicylates for treatment of cancer
KR20120059558A (ko) * 2009-08-19 2012-06-08 암비트 바이오사이언시즈 코포레이션 바이아릴 화합물 및 이의 사용 방법
TR201802464T4 (tr) * 2009-10-29 2018-03-21 Genosco Ki̇naz i̇nhi̇bi̇törleri̇

Also Published As

Publication number Publication date
AU2013235344B2 (en) 2017-03-16
KR102011770B1 (ko) 2019-08-19
CN104428298A (zh) 2015-03-18
US20130274274A1 (en) 2013-10-17
CA2868156A1 (en) 2013-09-26
JP6101341B2 (ja) 2017-03-22
MX360912B (es) 2018-11-22
ZA201407588B (en) 2015-11-25
EP2828259A1 (en) 2015-01-28
PL2828259T3 (pl) 2019-02-28
EA201491747A1 (ru) 2015-10-30
EP2828259B1 (en) 2018-08-08
IL234802B (en) 2018-10-31
SG11201405942RA (en) 2014-10-30
AU2013235344A1 (en) 2014-10-09
CA2868156C (en) 2020-07-28
IN2014MN02082A (tr) 2015-08-21
KR20140144709A (ko) 2014-12-19
CN104428298B (zh) 2017-03-01
NZ700283A (en) 2016-08-26
BR112014023460B1 (pt) 2020-09-01
WO2013142382A1 (en) 2013-09-26
MY184858A (en) 2021-04-27
EP2828259A4 (en) 2015-08-19
ES2694223T3 (es) 2018-12-19
EA031267B1 (ru) 2018-12-28
US8877763B2 (en) 2014-11-04
JP2015510942A (ja) 2015-04-13
MX2014011354A (es) 2014-12-05
CL2014002505A1 (es) 2015-10-02
TR201816480T4 (tr) 2018-11-21

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