HK1207115A1 - 用於調節 活性的微小 化合物及方法 - Google Patents

用於調節 活性的微小 化合物及方法

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Publication number
HK1207115A1
HK1207115A1 HK15107699.2A HK15107699A HK1207115A1 HK 1207115 A1 HK1207115 A1 HK 1207115A1 HK 15107699 A HK15107699 A HK 15107699A HK 1207115 A1 HK1207115 A1 HK 1207115A1
Authority
HK
Hong Kong
Prior art keywords
mir
rna
methods
modulating
activity
Prior art date
Application number
HK15107699.2A
Other languages
English (en)
Inventor
Balkrishen Bhat
Eric Marcusson
Original Assignee
Regulus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1207115(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of HK1207115A1 publication Critical patent/HK1207115A1/zh

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
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  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
HK15107699.2A 2012-04-25 2015-08-10 用於調節 活性的微小 化合物及方法 HK1207115A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261741783P 2012-04-25 2012-04-25
US201261717927P 2012-10-24 2012-10-24
US201361779913P 2013-03-13 2013-03-13
PCT/US2013/037913 WO2013163258A1 (en) 2012-04-25 2013-04-24 Microrna compounds and methods for modulating mir-21 activity

Publications (1)

Publication Number Publication Date
HK1207115A1 true HK1207115A1 (zh) 2016-01-22

Family

ID=48289681

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107699.2A HK1207115A1 (zh) 2012-04-25 2015-08-10 用於調節 活性的微小 化合物及方法

Country Status (29)

Country Link
US (5) US8969317B2 (zh)
EP (1) EP2841579B1 (zh)
JP (1) JP6322189B2 (zh)
KR (4) KR20220028183A (zh)
CN (1) CN104254607B (zh)
AR (1) AR090825A1 (zh)
AU (1) AU2013251696B2 (zh)
BR (1) BR112014026639A8 (zh)
CA (1) CA2869639A1 (zh)
CL (3) CL2014002844A1 (zh)
CO (1) CO7111303A2 (zh)
CR (1) CR20140524A (zh)
DO (1) DOP2014000233A (zh)
EA (1) EA030211B1 (zh)
EC (1) ECSP14028612A (zh)
GT (1) GT201400221A (zh)
HK (1) HK1207115A1 (zh)
IL (1) IL234904B (zh)
IN (1) IN2014DN09134A (zh)
MX (1) MX353562B (zh)
MY (1) MY173600A (zh)
NZ (1) NZ630591A (zh)
PE (1) PE20142404A1 (zh)
PH (1) PH12014502387A1 (zh)
SG (1) SG11201406931XA (zh)
TW (1) TWI647235B (zh)
UA (1) UA117098C2 (zh)
WO (1) WO2013163258A1 (zh)
ZA (1) ZA201407228B (zh)

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DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
SG194636A1 (en) 2011-04-25 2013-12-30 Regulus Therapeutics Inc Microrna compounds and methods for modulating mir-21 activity
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JP6113737B2 (ja) 2011-10-03 2017-04-12 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法
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US9193971B2 (en) * 2012-04-10 2015-11-24 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for the treatment of nonalcoholic steatohepatitis
KR20220028183A (ko) 2012-04-25 2022-03-08 사노피 마이크로rna 화합물 및 mir-21 활성 조절 방법
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
DK2906256T3 (en) * 2012-10-12 2018-11-19 Ionis Pharmaceuticals Inc SELECTIVE ANTISENSE COMPOUNDS AND APPLICATIONS THEREOF
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US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
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US20160289678A1 (en) * 2013-11-22 2016-10-06 Dcb-Usa Llc Use of microrna 146-a in the diagnosis, treatment and prevention of picornavirus infection and microrna 146-a antagonists
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CN105087477A (zh) * 2015-05-21 2015-11-25 王松灵 miR-21反义核苷酸修饰的骨髓间充质干细胞的用途
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
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