HK1206339A1 - N-aryltriazole compounds as lpar antagonists lpar n- - Google Patents
N-aryltriazole compounds as lpar antagonists lpar n-Info
- Publication number
- HK1206339A1 HK1206339A1 HK15106924.1A HK15106924A HK1206339A1 HK 1206339 A1 HK1206339 A1 HK 1206339A1 HK 15106924 A HK15106924 A HK 15106924A HK 1206339 A1 HK1206339 A1 HK 1206339A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lpar
- antagonists
- aryltriazole
- compounds
- aryltriazole compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661953P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062463 WO2013189865A1 (fr) | 2012-06-20 | 2013-06-17 | Composés n-aryltriazole utilisés comme antagonistes de lpar |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1206339A1 true HK1206339A1 (en) | 2016-01-08 |
Family
ID=48628669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15106924.1A HK1206339A1 (en) | 2012-06-20 | 2015-07-21 | N-aryltriazole compounds as lpar antagonists lpar n- |
Country Status (22)
Country | Link |
---|---|
US (1) | US20150133512A1 (fr) |
EP (1) | EP2864301A1 (fr) |
JP (1) | JP2015520203A (fr) |
KR (1) | KR20150011389A (fr) |
CN (1) | CN104395299A (fr) |
AU (1) | AU2013279513A1 (fr) |
BR (1) | BR112014030674A2 (fr) |
CA (1) | CA2869564A1 (fr) |
CL (1) | CL2014003241A1 (fr) |
CO (1) | CO7131357A2 (fr) |
EA (1) | EA201492281A1 (fr) |
HK (1) | HK1206339A1 (fr) |
IL (1) | IL236087A0 (fr) |
IN (1) | IN2014DN09352A (fr) |
MA (1) | MA37762B1 (fr) |
MX (1) | MX2014014711A (fr) |
PE (1) | PE20142305A1 (fr) |
PH (1) | PH12014502363A1 (fr) |
SG (1) | SG11201407228PA (fr) |
UA (1) | UA110310C2 (fr) |
WO (1) | WO2013189865A1 (fr) |
ZA (1) | ZA201408167B (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG2014011555A (en) | 2011-08-15 | 2014-08-28 | Intermune Inc | Lysophosphatidic acid receptor antagonists |
TW201437200A (zh) * | 2013-01-15 | 2014-10-01 | Intermune Inc | 溶血磷脂酸受體拮抗劑 |
EA033923B1 (ru) | 2013-03-15 | 2019-12-10 | Эпиджен Байосайенсиз, Инк. | Гетероциклические соединения, применимые в лечении заболеваний |
UY36060A (es) | 2014-04-02 | 2015-10-30 | Bayer Pharma AG | Compuestos de azol sustituidos con amida |
CA2953472C (fr) | 2014-06-27 | 2022-08-02 | Ube Industries, Ltd. | Sel d'un compose heterocyclique substitue par un groupe halogeno |
WO2017055316A1 (fr) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Composés azole à substitution amido |
WO2017055313A1 (fr) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Composés azole amido-substitués |
AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
WO2018078005A1 (fr) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Dérivés d'azaspiro à substitution amido en tant qu'inhibiteurs de tankyrase |
WO2018078009A1 (fr) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Dérivés de cyclohexane à substitution amido |
WO2018087126A1 (fr) | 2016-11-09 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Dérivés de cyclohexane à substitution amido en tant qu'inhibiteurs de tankyrase |
CN107721984A (zh) * | 2017-11-07 | 2018-02-23 | 大连理工大学 | 一种新型5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑的制备方法 |
CN107827829A (zh) * | 2017-11-07 | 2018-03-23 | 大连理工大学 | 5‑酰胺基‑1,4,5‑三取代的1,2,3‑三氮唑在水相及生物介质中的制备方法 |
JP7280881B2 (ja) | 2017-12-19 | 2023-05-24 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸トリアゾールアゾール |
CN112041316A (zh) * | 2017-12-19 | 2020-12-04 | 百时美施贵宝公司 | 作为lpa拮抗剂的异噁唑o-连接的氨基甲酰基环己基酸 |
KR20200100723A (ko) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 피라졸 아진 |
ES2962367T3 (es) | 2017-12-19 | 2024-03-18 | Bristol Myers Squibb Co | Acidos carbamoil ciclohexílicos N-enlazados a pirazol como antagonistas de receptores del ácido lisofosfatídico (LPA) |
ES2942767T3 (es) * | 2017-12-19 | 2023-06-06 | Bristol Myers Squibb Co | Isoxazol azoles del ácido ciclohexílico como antagonistas del LPA |
WO2019126103A1 (fr) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Acides pyrazoles azoles cyclohexyliques utilisés en tant qu'antagonistes de lpa |
US11447475B2 (en) | 2017-12-19 | 2022-09-20 | Bristol-Myers Squibb Company | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
KR20200100752A (ko) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 피라졸 o-연결된 카르바모일 시클로헥실 산 |
MX2020005323A (es) | 2017-12-19 | 2020-08-13 | Bristol Myers Squibb Co | Triazol azinas de acido ciclohexilo como antagonistas de acido lisofosfatidico (lpa). |
CN111479807A (zh) | 2017-12-19 | 2020-07-31 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸异噁唑吖嗪 |
CN111434653A (zh) * | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 三氮唑类化合物及其制备方法与用途 |
AU2020384883B2 (en) | 2019-11-15 | 2023-11-16 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof |
CR20220609A (es) | 2020-06-03 | 2023-05-04 | Gilead Sciences Inc | Antagonistas del receptor de lpa y usos de los mismos |
JP2023529369A (ja) | 2020-06-03 | 2023-07-10 | ギリアード サイエンシーズ, インコーポレイテッド | Lpa受容体アンタゴニスト及びそれらの使用 |
US11980609B2 (en) | 2021-05-11 | 2024-05-14 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011159550A2 (fr) * | 2010-06-14 | 2011-12-22 | Amidra Pharmaceuticals, Inc. | Antagoniste du récepteur de l'acide lysophosphatidique et ses utilisations |
WO2011159633A1 (fr) * | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Formulations inhalables d'antagonistes de récepteur d'acide lysophosphatidique |
MX2013006040A (es) * | 2010-12-07 | 2013-08-26 | Amira Pharmaceuticals Inc | Antagonistas del receptor de acido lisofosfatidico y su uso en el tratamiento de fibrosis. |
WO2012138648A1 (fr) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions et procédés pour la modulation de récepteurs au lpa |
SG2014011555A (en) * | 2011-08-15 | 2014-08-28 | Intermune Inc | Lysophosphatidic acid receptor antagonists |
EA201492285A1 (ru) * | 2012-06-20 | 2015-04-30 | Ф. Хоффманн-Ля Рош Аг | Соединения n-алкилтриазола в качестве антагонистов лизофосфатидной кислоты (lpar) |
-
2013
- 2013-06-17 EP EP13729332.0A patent/EP2864301A1/fr not_active Withdrawn
- 2013-06-17 US US14/403,261 patent/US20150133512A1/en not_active Abandoned
- 2013-06-17 PE PE2014002213A patent/PE20142305A1/es not_active Application Discontinuation
- 2013-06-17 MA MA37762A patent/MA37762B1/fr unknown
- 2013-06-17 CA CA2869564A patent/CA2869564A1/fr not_active Abandoned
- 2013-06-17 WO PCT/EP2013/062463 patent/WO2013189865A1/fr active Application Filing
- 2013-06-17 CN CN201380031806.0A patent/CN104395299A/zh active Pending
- 2013-06-17 IN IN9352DEN2014 patent/IN2014DN09352A/en unknown
- 2013-06-17 AU AU2013279513A patent/AU2013279513A1/en not_active Abandoned
- 2013-06-17 UA UAA201500426A patent/UA110310C2/uk unknown
- 2013-06-17 BR BR112014030674A patent/BR112014030674A2/pt not_active Application Discontinuation
- 2013-06-17 MX MX2014014711A patent/MX2014014711A/es unknown
- 2013-06-17 EA EA201492281A patent/EA201492281A1/ru unknown
- 2013-06-17 KR KR1020147035551A patent/KR20150011389A/ko not_active Application Discontinuation
- 2013-06-17 SG SG11201407228PA patent/SG11201407228PA/en unknown
- 2013-06-17 JP JP2015517705A patent/JP2015520203A/ja active Pending
-
2014
- 2014-10-22 PH PH12014502363A patent/PH12014502363A1/en unknown
- 2014-11-07 ZA ZA2014/08167A patent/ZA201408167B/en unknown
- 2014-11-20 CO CO14255124A patent/CO7131357A2/es unknown
- 2014-11-28 CL CL2014003241A patent/CL2014003241A1/es unknown
- 2014-12-04 IL IL236087A patent/IL236087A0/en unknown
-
2015
- 2015-07-21 HK HK15106924.1A patent/HK1206339A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2015520203A (ja) | 2015-07-16 |
UA110310C2 (uk) | 2015-12-10 |
MA37762A1 (fr) | 2017-07-31 |
CL2014003241A1 (es) | 2015-03-20 |
KR20150011389A (ko) | 2015-01-30 |
IN2014DN09352A (fr) | 2015-07-17 |
PH12014502363A1 (en) | 2015-01-12 |
CN104395299A (zh) | 2015-03-04 |
SG11201407228PA (en) | 2014-12-30 |
EP2864301A1 (fr) | 2015-04-29 |
ZA201408167B (en) | 2015-12-23 |
CA2869564A1 (fr) | 2013-12-27 |
US20150133512A1 (en) | 2015-05-14 |
PE20142305A1 (es) | 2015-01-16 |
CO7131357A2 (es) | 2014-12-01 |
BR112014030674A2 (pt) | 2017-06-27 |
MA37762B1 (fr) | 2018-04-30 |
IL236087A0 (en) | 2015-02-01 |
EA201492281A1 (ru) | 2015-04-30 |
MX2014014711A (es) | 2015-03-04 |
WO2013189865A1 (fr) | 2013-12-27 |
AU2013279513A1 (en) | 2014-10-16 |
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