HK1205742A1 - 6- (4- (1 -amino- 3 -hydroxycyclobutyl) phenyl) - 5 - phenyl (furo, thieno or pyrrolo) [2, 3-d]pyrimidin- 4 - one derivatives for the treatment of cancer 6-(4-(1--3-))-5-()[23- d]-4- - Google Patents

6- (4- (1 -amino- 3 -hydroxycyclobutyl) phenyl) - 5 - phenyl (furo, thieno or pyrrolo) [2, 3-d]pyrimidin- 4 - one derivatives for the treatment of cancer 6-(4-(1--3-))-5-()[23- d]-4-

Info

Publication number
HK1205742A1
HK1205742A1 HK15106340.7A HK15106340A HK1205742A1 HK 1205742 A1 HK1205742 A1 HK 1205742A1 HK 15106340 A HK15106340 A HK 15106340A HK 1205742 A1 HK1205742 A1 HK 1205742A1
Authority
HK
Hong Kong
Prior art keywords
phenyl
hydroxycyclobutyl
furo
thieno
pyrrolo
Prior art date
Application number
HK15106340.7A
Other languages
English (en)
Chinese (zh)
Inventor
Timothy Harrison
Colin Odowd
Steven Shepherd
Graham Trevitt
Lixin Zhang
Frank Burkamp
Original Assignee
Almac Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almac Discovery Ltd filed Critical Almac Discovery Ltd
Publication of HK1205742A1 publication Critical patent/HK1205742A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15106340.7A 2012-03-23 2015-07-03 6- (4- (1 -amino- 3 -hydroxycyclobutyl) phenyl) - 5 - phenyl (furo, thieno or pyrrolo) [2, 3-d]pyrimidin- 4 - one derivatives for the treatment of cancer 6-(4-(1--3-))-5-()[23- d]-4- HK1205742A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1205164.5A GB201205164D0 (en) 2012-03-23 2012-03-23 Pharmaceutical compounds
PCT/GB2013/050771 WO2013140189A1 (en) 2012-03-23 2013-03-25 6- (4- (1 -amino- 3 -hydroxycyclobutyl) phenyl) - 5 - phenyl (furo, thieno or pyrrolo) [2, 3-d] pyrimidin- 4 - one derivatives for the treatment of cancer

Publications (1)

Publication Number Publication Date
HK1205742A1 true HK1205742A1 (en) 2015-12-24

Family

ID=46087031

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15106340.7A HK1205742A1 (en) 2012-03-23 2015-07-03 6- (4- (1 -amino- 3 -hydroxycyclobutyl) phenyl) - 5 - phenyl (furo, thieno or pyrrolo) [2, 3-d]pyrimidin- 4 - one derivatives for the treatment of cancer 6-(4-(1--3-))-5-()[23- d]-4-

Country Status (16)

Country Link
US (1) US9156853B2 (xx)
EP (1) EP2838901B1 (xx)
JP (1) JP6118890B2 (xx)
KR (1) KR20140139023A (xx)
CN (1) CN104245705A (xx)
AU (1) AU2013237184A1 (xx)
CA (1) CA2867632A1 (xx)
GB (1) GB201205164D0 (xx)
HK (1) HK1205742A1 (xx)
IL (1) IL234772A0 (xx)
MX (1) MX2014011326A (xx)
NZ (1) NZ630580A (xx)
RU (1) RU2014142633A (xx)
SG (1) SG11201405580WA (xx)
WO (1) WO2013140189A1 (xx)
ZA (1) ZA201406788B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
AR103297A1 (es) 2014-12-30 2017-05-03 Forma Therapeutics Inc Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina
EP3253738A1 (en) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
EP3253765A1 (en) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
JP2018504432A (ja) 2015-02-05 2018-02-15 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的プロテアーゼ７阻害物質としてのイソチアゾロピリミジノン、ピラゾロピリミジノン及びピロロピリミジノン
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
KR102133569B1 (ko) * 2018-06-28 2020-07-13 한국과학기술연구원 신규한 피롤로[2,3-d]피리미딘-4-온 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
CN113444110B (zh) * 2020-03-25 2023-05-12 江苏恒瑞医药股份有限公司 四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505084A (ja) 2004-06-29 2008-02-21 アムゲン インコーポレイティッド フラノピリミジン
AU2007327992A1 (en) 2006-12-06 2008-06-12 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
CA2726317A1 (en) 2008-06-03 2009-12-10 Merck Sharp & Dohme Corp. Inhibitors of akt activity
CA2726358A1 (en) 2008-06-03 2009-12-10 Merck Sharp & Dohme Corp. Inhibitors of akt activity
JP2012516847A (ja) * 2009-02-02 2012-07-26 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
WO2010104933A1 (en) 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibitors of akt activity
EP2413932A4 (en) * 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
GB0919380D0 (en) * 2009-11-04 2009-12-23 Almac Discovery Ltd Pharmaceutical compouds
GB0922589D0 (en) * 2009-12-23 2010-02-10 Almac Discovery Ltd Pharmaceutical compounds
WO2011133733A1 (en) * 2010-04-23 2011-10-27 Merck Sharp & Dohme Corp. Inhibitors of akt activity

Also Published As

Publication number Publication date
WO2013140189A1 (en) 2013-09-26
US20150045377A1 (en) 2015-02-12
NZ630580A (en) 2016-01-29
ZA201406788B (en) 2016-05-25
US9156853B2 (en) 2015-10-13
RU2014142633A (ru) 2016-05-20
MX2014011326A (es) 2015-03-20
EP2838901A1 (en) 2015-02-25
KR20140139023A (ko) 2014-12-04
CN104245705A (zh) 2014-12-24
SG11201405580WA (en) 2014-10-30
JP2015510923A (ja) 2015-04-13
IL234772A0 (en) 2014-11-30
JP6118890B2 (ja) 2017-04-19
CA2867632A1 (en) 2013-09-26
EP2838901B1 (en) 2016-11-02
AU2013237184A1 (en) 2014-09-25
GB201205164D0 (en) 2012-05-09

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