HK1205461A1 - 用於眼部传输治疗剂的组合物和方法 - Google Patents

用於眼部传输治疗剂的组合物和方法 Download PDF

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Publication number
HK1205461A1
HK1205461A1 HK15106047.3A HK15106047A HK1205461A1 HK 1205461 A1 HK1205461 A1 HK 1205461A1 HK 15106047 A HK15106047 A HK 15106047A HK 1205461 A1 HK1205461 A1 HK 1205461A1
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HK
Hong Kong
Prior art keywords
compositions
methods
therapeutic agent
ocular delivery
ocular
Prior art date
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HK15106047.3A
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English (en)
Chinese (zh)
Inventor
L. Kaplan David
L. Lovett Michael
Wang Xiaoqin
Yucel Tuna
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Trustees Of Tufts College
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Publication of HK1205461A1 publication Critical patent/HK1205461A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
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  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15106047.3A 2012-02-22 2013-02-22 用於眼部传输治疗剂的组合物和方法 HK1205461A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261601924P 2012-02-22 2012-02-22
US61/601,924 2012-02-22
PCT/US2013/027465 WO2013126799A1 (en) 2012-02-22 2013-02-22 Compositions and methods for ocular delivery of a therapeutic agent

Publications (1)

Publication Number Publication Date
HK1205461A1 true HK1205461A1 (zh) 2015-12-18

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US (2) US20150037422A1 (enExample)
EP (1) EP2817031A4 (enExample)
JP (1) JP2015508104A (enExample)
CA (1) CA2865132A1 (enExample)
HK (1) HK1205461A1 (enExample)
WO (1) WO2013126799A1 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3240136A1 (en) 2012-11-08 2014-05-15 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
WO2014138085A1 (en) 2013-03-05 2014-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery
SG11201507316UA (en) 2013-03-14 2015-10-29 Panoptica Inc Ocular formulations for drug-delivery to the posterior segment of the eye
AU2014233480B2 (en) 2013-03-15 2018-08-09 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
US9492474B2 (en) 2013-07-10 2016-11-15 Matrix Biology Institute Compositions of hyaluronan with high elasticity and uses thereof
US20150164882A1 (en) * 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
US20150129457A1 (en) * 2013-07-22 2015-05-14 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
CN104667287B (zh) * 2013-11-27 2018-02-06 山东博士伦福瑞达制药有限公司 用于治疗眼后房新生血管增生的眼用组合物及其用途
CN103656746A (zh) * 2013-12-13 2014-03-26 无锡合众信息科技有限公司 一种可自愈水凝胶玻璃体填充物及其制备方法
WO2015106005A1 (en) * 2014-01-08 2015-07-16 Circuit Therapeutics, Inc. Method for therapeutic management of ocular hypertension
WO2015108787A2 (en) * 2014-01-16 2015-07-23 Retinal Therapies LLC Compositions and methods for the treatment of intraocular neovascularization and/or leakage
EP3102250B1 (en) * 2014-02-04 2020-05-13 AMSilk GmbH Coated silk films, methods for the production thereof and uses thereof
CN104027847B (zh) * 2014-06-20 2015-08-26 西安交通大学 一种附带血管网流道的人工软组织体的制造方法
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
DK3182985T3 (da) 2014-08-20 2020-04-06 Silk Tech Ltd Fibroinafledt proteinsammensætning
MA56220A (fr) * 2014-09-17 2022-04-20 Panoptica Inc Formulations oculaires permettant l'administration de médicament et la protection du segment antérieur de l'oeil
CN104368046B (zh) * 2014-11-10 2016-01-13 四川大学 一种纤维增强型载药水凝胶人工角膜裙边支架及其制备方法
EP3858329A1 (en) * 2014-12-10 2021-08-04 Incept, LLC Hydrogel drug delivery implants
CN104587531B (zh) * 2014-12-25 2016-05-04 南京臻泉医药科技有限公司 一种修复关节软骨损伤的凝胶支架的制备方法
US20160303281A1 (en) * 2015-04-17 2016-10-20 Rochal Industries, Llc Composition and kits for pseudoplastic microgel matrices
US10816823B2 (en) 2015-05-04 2020-10-27 École Polytechnique Fédérale de Lausanne Ophthalmic contact lens with compressible affinity matrix
WO2016200688A1 (en) 2015-06-06 2016-12-15 Cloudbreak Therapeutics, Llc Compositions and methods for treating pterygium
TWI700085B (zh) 2015-06-22 2020-08-01 新源生物科技股份有限公司 酪胺酸激酶抑制劑之眼用調配物的用途
CN105169476B (zh) * 2015-09-15 2018-06-22 王岩松 一种医用原位凝胶的制备方法及其应用
PT3842047T (pt) 2015-09-24 2024-09-19 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e processos para o seu uso
WO2017053686A1 (en) * 2015-09-24 2017-03-30 Massachusetts Eye And Ear Infirmary Drug delivery system and methods of use
CN106692977A (zh) * 2015-11-11 2017-05-24 陶虎 一种蚕丝蛋白胶囊及其制备方法
WO2017117464A1 (en) 2015-12-30 2017-07-06 Kodiak Sciences Inc. Antibodies and conjugates thereof
EP3400014A1 (en) * 2016-01-08 2018-11-14 Clearside Biomedical, Inc. Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics
WO2017165449A1 (en) * 2016-03-22 2017-09-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery
JP2019519596A (ja) 2016-04-08 2019-07-11 コーネル・ユニバーシティーCornell University シルク由来タンパク質を使用して創傷治癒を増進する方法
DK3245988T3 (da) 2016-05-18 2024-01-29 Sonikure Holdings Ltd System til ultralydsforstærket transskleral levering af lægemidler
KR102408596B1 (ko) 2016-06-02 2022-06-13 에이디에스 테라퓨틱스 엘엘씨 비정상적 신생혈관이 있는 안구 질환 치료를 위한, 닌테다닙을 사용하는 조성물 및 방법
US11395853B2 (en) 2016-06-23 2022-07-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions
US11278546B2 (en) * 2016-07-22 2022-03-22 Aiviva Biopharma, Inc. Multikinase inhibitors and uses in ocular fibrosis
WO2018031973A1 (en) 2016-08-12 2018-02-15 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
JP2019529400A (ja) * 2016-09-09 2019-10-17 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 硝子体小胞中の核酸、タンパク質及び小分子の送達方法
DK3513809T3 (da) 2016-09-13 2022-05-02 Kyowa Kirin Co Ltd Medicinsk sammensætning, som omfatter tivozanib
WO2019055594A1 (en) 2017-09-13 2019-03-21 North Carolina State University BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY
WO2019094702A1 (en) * 2017-11-10 2019-05-16 Cocoon Biotech Inc. Ocular applications of silk-based products
CN108310618A (zh) * 2018-02-12 2018-07-24 南通纺织丝绸产业技术研究院 一种多层复合针壁丝素蛋白微针及其制备方法
CN108392728A (zh) * 2018-02-12 2018-08-14 南通纺织丝绸产业技术研究院 一种丝素蛋白多层复合微针及其制备方法
CN108079431A (zh) * 2018-02-12 2018-05-29 南通纺织丝绸产业技术研究院 一种多层丝素蛋白复合针壁微针
EP3758677A1 (en) * 2018-02-26 2021-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Drug delivery systems
BR112020017872A2 (pt) 2018-03-02 2020-12-22 Kodiak Sciences Inc. Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos
JP2021521173A (ja) * 2018-04-11 2021-08-26 オハイオ・ステイト・イノベーション・ファウンデーション 眼内薬物送達用の持続放出微粒子のための方法及び組成物
US20200085979A1 (en) 2018-09-11 2020-03-19 Stanley Satz Precision medicine theranostics and diagnostics a combination thereof
EP3852608A4 (en) 2018-09-21 2022-09-28 Aufbau Medical Innovations Limited COMPOSITIONS AND METHODS FOR TREATING GLAUCOMA
AU2020219436A1 (en) * 2019-02-08 2021-10-07 Ohio State Innovation Foundation Drug delivery compositions for ocular administration of therapeutics and methods of use thereof
JP7570342B2 (ja) * 2019-03-05 2024-10-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼の疾患又は障害を治療するための医薬組成物
US11883525B2 (en) 2019-05-31 2024-01-30 Dose Medical Corporation Bioerodible polyester polymer axitinib ocular implants and related methods of use
AU2020288624B2 (en) 2019-06-04 2025-09-25 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
WO2021072265A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
US20210127976A1 (en) * 2019-11-01 2021-05-06 Koninklijke Philips N.V. System and method for assessing preparedness for imaging procedures
WO2021141672A2 (en) * 2019-11-15 2021-07-15 Silk Technologies, Ltd. Stable formulations of silk-derived protein
FI3884929T3 (fi) * 2020-03-25 2023-08-07 Ocular Therapeutix Inc Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti
WO2021205471A1 (en) * 2020-04-06 2021-10-14 Jawaharlal Nehru Centre For Advanced Scientific Research Composition, injectable hydrogel and methods thereof
CN113440604B (zh) * 2021-06-24 2022-05-31 浙江泽瑞生物医药有限公司 一种有效抑制血糖的索马鲁肽的口服缓释片剂及其制备方法
WO2023039168A1 (en) * 2021-09-09 2023-03-16 The Board Of Trustees Of The Leland Stanford Junior University Use of verteporfin to modulate wound healing after an ocular surgical procedure or ocular injury
KR20250022114A (ko) 2022-06-07 2025-02-14 애드베룸 바이오테크놀로지스, 인코포레이티드 시력 회복을 위한 멜라놉신 변이체
CN120897764A (zh) 2023-04-11 2025-11-04 视尔普斯眼科公司 包含阿西替尼多晶型物iv的眼部植入物
CN116687840B (zh) * 2023-08-03 2023-10-20 四川省医学科学院·四川省人民医院 一种用于治疗眼部病状的凝胶制剂及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1505542A1 (ru) * 1988-01-13 1989-09-07 А. И. Иголкин Медицинска пипетка А.И.Иголкина дл глазных капель
AUPQ496500A0 (en) * 2000-01-06 2000-02-03 University Of Sydney, The Kit
PL375024A1 (en) * 2002-08-05 2005-11-14 Alcon, Inc. Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration
US20070026043A1 (en) * 2003-11-20 2007-02-01 Angiotech International Ag Medical devices combined with diblock copolymer compositions
US8067031B2 (en) * 2004-04-28 2011-11-29 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
JP2008502739A (ja) * 2004-06-11 2008-01-31 トラスティーズ オブ タフツ カレッジ 絹に基づく薬物送達システム
JP2009540011A (ja) * 2006-06-12 2009-11-19 エクセジェニックス、インク．ディー／ビー／エー オプコ ヘルス、インク． 血管新生のｓｉＲＮＡ阻害のための組成物及び方法
DK2211876T3 (en) * 2007-05-29 2015-01-12 Tufts College PROCESS FOR silk fibroin-GELATION USING sonication
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
US8420077B2 (en) * 2009-04-20 2013-04-16 Allergan, Inc. Silk fibroin hydrogels and uses thereof
US20110111031A1 (en) * 2009-04-20 2011-05-12 Guang-Liang Jiang Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof
WO2011109691A2 (en) * 2010-03-05 2011-09-09 Trustees Of Tufts College Silk-based ionomeric compositions
EP2558104A4 (en) * 2010-04-12 2013-12-11 R Tech Ueno Ltd METHOD AND OPHTHALMIC COMPOSITION FOR TREATING RETINAL DISEASE

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