HK1205122A1 - 用於治療老花眼及白內障之膽鹼酯 - Google Patents
用於治療老花眼及白內障之膽鹼酯Info
- Publication number
- HK1205122A1 HK1205122A1 HK15105868.1A HK15105868A HK1205122A1 HK 1205122 A1 HK1205122 A1 HK 1205122A1 HK 15105868 A HK15105868 A HK 15105868A HK 1205122 A1 HK1205122 A1 HK 1205122A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cataract
- choline esters
- treating presbyopia
- presbyopia
- treating
- Prior art date
Links
- 208000002177 Cataract Diseases 0.000 title 1
- 229940055076 parasympathomimetics choline ester Drugs 0.000 title 1
- 201000010041 presbyopia Diseases 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D343/00—Heterocyclic compounds containing rings having sulfur and selenium or sulfur and tellurium atoms as the only ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18700509P | 2009-06-15 | 2009-06-15 | |
US22493009P | 2009-07-13 | 2009-07-13 | |
US24223209P | 2009-09-14 | 2009-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1205122A1 true HK1205122A1 (zh) | 2015-12-11 |
Family
ID=43306962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15105868.1A HK1205122A1 (zh) | 2009-06-15 | 2015-06-19 | 用於治療老花眼及白內障之膽鹼酯 |
Country Status (8)
Country | Link |
---|---|
US (7) | US8410162B2 (zh) |
EP (2) | EP2442645B1 (zh) |
DK (2) | DK2442645T3 (zh) |
ES (2) | ES2579173T3 (zh) |
HK (1) | HK1205122A1 (zh) |
PL (2) | PL2442645T3 (zh) |
PT (2) | PT2442645E (zh) |
WO (1) | WO2010147962A1 (zh) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
US8697109B2 (en) | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
DK2442647T3 (en) | 2009-06-15 | 2016-05-30 | Encore Health Llc | Dithiolforbindelser, derivatives thereof, and the uses of these |
PL2442645T3 (pl) | 2009-06-15 | 2015-02-27 | Encore Health Llc | Estry choliny |
ES2640474T3 (es) * | 2010-11-18 | 2017-11-03 | Ischemix Llc | Compuestos lipoílicos y su uso para el tratamiento de la lesión isquémica |
TWI588560B (zh) | 2012-04-05 | 2017-06-21 | 布萊恩荷登視覺協會 | 用於屈光不正之鏡片、裝置、方法及系統 |
US9201250B2 (en) | 2012-10-17 | 2015-12-01 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
US9541773B2 (en) | 2012-10-17 | 2017-01-10 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
BR112016020181A8 (pt) | 2014-03-03 | 2021-06-29 | Encore Vision Inc | composições de ácido lipoico éster colina e métodos de uso. |
US10449209B2 (en) | 2015-04-29 | 2019-10-22 | Arterez, Llc | Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage |
EP3352739B1 (en) * | 2015-09-24 | 2021-10-27 | Novartis AG | Lipoic acid choline ester compositions and methods to generate biocompatible ophthalmic formulations |
JOP20190057A1 (ar) * | 2016-09-23 | 2019-03-24 | Encore Vision Inc | تركيبات استر كولين حمض الليبويك وطرق تثبيتها إلى منتجات عقار ذات صلة دوائية |
ES2952834T3 (es) | 2017-04-25 | 2023-11-06 | Ischemix Llc | Lipoil-Glu-Ala para el tratamiento de daño neurodegenerativo producido por traumatismo craneoencefálico |
CN106967044B (zh) * | 2017-05-12 | 2019-02-22 | 苏州富士莱医药股份有限公司 | 制备r-硫辛酸胆碱酯卤化物的方法 |
WO2019150341A1 (en) * | 2018-02-05 | 2019-08-08 | Cellixbio Private Limited | Combination of an antimuscarinic or an anticholinergic agent and lipoic acid and uses thereof |
JP2022516796A (ja) * | 2019-01-12 | 2022-03-02 | セリックス バイオ プライヴェート リミテッド | 選択的αアドレナリン受容体作用薬又は抗コリン作動薬及びリポ酸の組合せ物並びにその使用 |
CN113710320A (zh) * | 2019-04-17 | 2021-11-26 | 参天制药株式会社 | 硫辛酸前药 |
CA3170063A1 (en) * | 2020-02-05 | 2021-08-12 | Vtv Therapeutics Llc | Substituted fused imidazole derivatives and methods of treating refractive ocular disorders |
CN113387923A (zh) | 2020-03-13 | 2021-09-14 | 诺华股份有限公司 | 硫辛酸胆碱酯盐的药物组合物及使用其的治疗方法 |
TW202210066A (zh) * | 2020-05-26 | 2022-03-16 | 日商參天製藥股份有限公司 | 對老花眼之治療或預防有用之含硫化合物 |
EP4232157A4 (en) * | 2020-10-22 | 2024-08-28 | Xequel Bio Inc | PEPTIDE FORMULATIONS AND THEIR OPHTHALMIC USE |
KR102595126B1 (ko) * | 2022-09-27 | 2023-10-30 | 하나제약 주식회사 | 콜린알포세레이트 에스테르 유도체의 제조방법과 그 용도 |
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UA86441C2 (ru) * | 2007-03-30 | 2009-04-27 | Акционерное Общество Открытого Типа "Галичфарм" | (2-гидроксиэтил)триметиламмония тиоктат (холина тиоктат), имеющий гепатопротекторное, гипоаммониемическое и детоксицирующее действие, способ его получения, фармацевтическая композиция на его основе |
US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
DK2442647T3 (en) | 2009-06-15 | 2016-05-30 | Encore Health Llc | Dithiolforbindelser, derivatives thereof, and the uses of these |
PL2442645T3 (pl) | 2009-06-15 | 2015-02-27 | Encore Health Llc | Estry choliny |
-
2010
- 2010-06-15 PL PL10790043T patent/PL2442645T3/pl unknown
- 2010-06-15 EP EP20100790043 patent/EP2442645B1/en active Active
- 2010-06-15 PT PT10790043T patent/PT2442645E/pt unknown
- 2010-06-15 US US12/815,526 patent/US8410162B2/en active Active
- 2010-06-15 DK DK10790043T patent/DK2442645T3/en active
- 2010-06-15 PL PL14181820T patent/PL2821405T3/pl unknown
- 2010-06-15 WO PCT/US2010/038642 patent/WO2010147962A1/en active Application Filing
- 2010-06-15 EP EP14181820.3A patent/EP2821405B1/en active Active
- 2010-06-15 DK DK14181820.3T patent/DK2821405T3/en active
- 2010-06-15 ES ES14181820.3T patent/ES2579173T3/es active Active
- 2010-06-15 ES ES10790043.3T patent/ES2524706T3/es active Active
- 2010-06-15 PT PT141818203T patent/PT2821405E/pt unknown
-
2013
- 2013-03-27 US US13/851,355 patent/US20140121266A1/en not_active Abandoned
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2014
- 2014-10-28 US US14/525,471 patent/US9326970B2/en active Active
-
2015
- 2015-06-19 HK HK15105868.1A patent/HK1205122A1/zh not_active IP Right Cessation
-
2016
- 2016-04-05 US US15/091,389 patent/US20160287557A1/en not_active Abandoned
-
2017
- 2017-12-11 US US15/837,171 patent/US20180228767A1/en not_active Abandoned
-
2020
- 2020-02-14 US US16/791,265 patent/US20200352903A1/en not_active Abandoned
-
2022
- 2022-02-04 US US17/592,700 patent/US20220151988A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2010147962A1 (en) | 2010-12-23 |
ES2524706T3 (es) | 2014-12-11 |
EP2442645A1 (en) | 2012-04-25 |
DK2821405T3 (en) | 2016-07-25 |
US8410162B2 (en) | 2013-04-02 |
US9326970B2 (en) | 2016-05-03 |
US20200352903A1 (en) | 2020-11-12 |
EP2821405B1 (en) | 2016-04-13 |
PT2821405E (pt) | 2016-06-14 |
US20180228767A1 (en) | 2018-08-16 |
DK2442645T3 (en) | 2014-11-24 |
EP2442645A4 (en) | 2013-03-06 |
PL2442645T3 (pl) | 2015-02-27 |
EP2821405A1 (en) | 2015-01-07 |
US20140121266A1 (en) | 2014-05-01 |
US20160287557A1 (en) | 2016-10-06 |
ES2579173T3 (es) | 2016-08-05 |
US20100317725A1 (en) | 2010-12-16 |
PL2821405T3 (pl) | 2017-08-31 |
US20220151988A1 (en) | 2022-05-19 |
EP2442645B1 (en) | 2014-08-27 |
PT2442645E (pt) | 2014-11-05 |
US20150111959A1 (en) | 2015-04-23 |
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