HK1203501A1 - 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4]nonane- 6 -one compound as voltage-gated sodium channels modulator - Google Patents

2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4]nonane- 6 -one compound as voltage-gated sodium channels modulator Download PDF

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Publication number
HK1203501A1
HK1203501A1 HK15104075.3A HK15104075A HK1203501A1 HK 1203501 A1 HK1203501 A1 HK 1203501A1 HK 15104075 A HK15104075 A HK 15104075A HK 1203501 A1 HK1203501 A1 HK 1203501A1
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Hong Kong
Prior art keywords
voltage
spiro
diaza
nonane
pyridin
Prior art date
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HK15104075.3A
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English (en)
Chinese (zh)
Inventor
David R. Witty
David T. Macpherson
Gerard M.P. GIBLIN
Steven J. Stanway
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Convergence Pharmaceuticals Limited
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Publication date
Application filed by Convergence Pharmaceuticals Limited filed Critical Convergence Pharmaceuticals Limited
Publication of HK1203501A1 publication Critical patent/HK1203501A1/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems

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  • Psychiatry (AREA)
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  • Diabetes (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15104075.3A 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4]nonane- 6 -one compound as voltage-gated sodium channels modulator HK1203501A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161579613P 2011-12-22 2011-12-22
GBGB1122113.2A GB201122113D0 (en) 2011-12-22 2011-12-22 Novel compounds
GB201122113 2011-12-22
US201161579613P 2011-12-22
PCT/GB2012/053233 WO2013093496A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4] nonane- 6 -one compound as voltage-gated sodium channels modulator

Publications (1)

Publication Number Publication Date
HK1203501A1 true HK1203501A1 (en) 2015-10-30

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Application Number Title Priority Date Filing Date
HK15104075.3A HK1203501A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4]nonane- 6 -one compound as voltage-gated sodium channels modulator
HK15103930.0A HK1203492A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4]nonane- 6 -one compounds as voltage - gated sodium channels modulators

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HK15103930.0A HK1203492A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4]nonane- 6 -one compounds as voltage - gated sodium channels modulators

Country Status (18)

Country Link
US (3) US9303032B2 (cs)
EP (2) EP2794612B1 (cs)
JP (2) JP2015502395A (cs)
KR (1) KR20140113692A (cs)
CN (1) CN104271581B (cs)
AU (1) AU2012356386A1 (cs)
BR (1) BR112014014940A2 (cs)
CA (1) CA2858938C (cs)
EA (1) EA026500B1 (cs)
ES (1) ES2581327T3 (cs)
GB (1) GB201122113D0 (cs)
HK (2) HK1203501A1 (cs)
IL (1) IL233215A0 (cs)
IN (1) IN2014MN01469A (cs)
MX (1) MX2014007637A (cs)
SG (1) SG11201403356YA (cs)
WO (2) WO2013093496A1 (cs)
ZA (1) ZA201404269B (cs)

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GB201122113D0 (en) * 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
RU2650523C1 (ru) 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
SG11202002707VA (en) * 2017-10-10 2020-04-29 Biogen Inc Process for preparing spiro derivatives
RU2761436C1 (ru) 2017-11-17 2021-12-08 Целликс Био Прайвет Лимитед Композиции и способы лечения нарушений со стороны органа зрения
CN113563258A (zh) * 2021-07-29 2021-10-29 派普医药(江苏)有限公司 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors
JP2024534573A (ja) * 2021-09-24 2024-09-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ナトリウムチャネル活性化剤としてのピリジニル誘導体

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Also Published As

Publication number Publication date
ZA201404269B (en) 2016-06-29
CA2858938A1 (en) 2013-06-27
CA2858938C (en) 2020-03-10
BR112014014940A2 (pt) 2017-06-13
US20150225400A1 (en) 2015-08-13
US9376436B2 (en) 2016-06-28
US20140350040A1 (en) 2014-11-27
WO2013093496A1 (en) 2013-06-27
US20160185758A1 (en) 2016-06-30
IL233215A0 (en) 2014-08-31
EP2794612A1 (en) 2014-10-29
WO2013093497A1 (en) 2013-06-27
HK1203492A1 (en) 2015-10-30
JP2015502395A (ja) 2015-01-22
EA201491251A1 (ru) 2014-11-28
US9303032B2 (en) 2016-04-05
CN104271581B (zh) 2016-08-31
KR20140113692A (ko) 2014-09-24
AU2012356386A1 (en) 2014-07-10
ES2581327T3 (es) 2016-09-05
IN2014MN01469A (cs) 2015-04-17
SG11201403356YA (en) 2014-07-30
EA026500B1 (ru) 2017-04-28
MX2014007637A (es) 2014-09-26
EP2794612B1 (en) 2016-04-06
GB201122113D0 (en) 2012-02-01
CN104271581A (zh) 2015-01-07
JP2015502394A (ja) 2015-01-22
EP2797922A1 (en) 2014-11-05
EP2797922B1 (en) 2016-04-06

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