HK1203082A1 - 使用具有對水解酶抗性的衣殼的 的方法 - Google Patents
使用具有對水解酶抗性的衣殼的 的方法Info
- Publication number
- HK1203082A1 HK1203082A1 HK15103603.6A HK15103603A HK1203082A1 HK 1203082 A1 HK1203082 A1 HK 1203082A1 HK 15103603 A HK15103603 A HK 15103603A HK 1203082 A1 HK1203082 A1 HK 1203082A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- vlps
- vlp
- hydrolases
- processes
- capsids
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/123—Hepatitis delta
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/128—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes processing or releasing ribozyme
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18141—Use of virus, viral particle or viral elements as a vector
- C12N2795/18142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161578706P | 2011-12-21 | 2011-12-21 | |
US201261607900P | 2012-03-07 | 2012-03-07 | |
US201261661688P | 2012-06-19 | 2012-06-19 | |
PCT/US2012/071419 WO2013096866A2 (en) | 2011-12-21 | 2012-12-21 | Processes using vlps with capsids resistant to hydrolases |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1203082A1 true HK1203082A1 (zh) | 2015-10-16 |
Family
ID=48655925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15103603.6A HK1203082A1 (zh) | 2011-12-21 | 2015-04-14 | 使用具有對水解酶抗性的衣殼的 的方法 |
Country Status (13)
Country | Link |
---|---|
US (2) | US20130167267A1 (zh) |
EP (2) | EP4019636A1 (zh) |
JP (3) | JP6041896B2 (zh) |
CN (2) | CN107164376B (zh) |
AR (1) | AR089440A1 (zh) |
AU (2) | AU2012358267B2 (zh) |
BR (1) | BR112014012162B1 (zh) |
CA (1) | CA2860310C (zh) |
HK (1) | HK1203082A1 (zh) |
IL (1) | IL232662B (zh) |
MX (1) | MX358762B (zh) |
SG (1) | SG11201402657WA (zh) |
WO (1) | WO2013096866A2 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107164376B (zh) | 2011-12-21 | 2021-03-30 | 阿普斯有限责任公司 | 使用具有对水解酶抗性的衣壳的vlp的方法 |
BR112015029559A2 (pt) | 2013-06-19 | 2017-12-12 | Apse Llc | partícula similar a vírus, ácido nucleico e métodos para produzir rna de fita dupla e sirna, shrna, sshrna, 1shrna e mirna |
WO2015038746A1 (en) * | 2013-09-11 | 2015-03-19 | Georgia Tech Research Corporation | Compositions and methods for inhibiting gene expression |
WO2015038915A2 (en) * | 2013-09-12 | 2015-03-19 | Apse, Llc | Compositions and methods using capsids resistant to hydrolases |
WO2017059277A1 (en) * | 2015-10-01 | 2017-04-06 | Apse, Llc | Methods and compositions comprising apse knots |
CA3040110A1 (en) | 2015-10-13 | 2017-04-20 | Daniel C. Carter | Nsp10 self-assembling fusion proteins for vaccines, therapeutics, diagnostics and other nanomaterial applications |
SG11201805124VA (en) * | 2015-12-31 | 2018-07-30 | Apse Inc | Methods and compositions of insect control |
SG11201807478QA (en) * | 2016-03-15 | 2018-09-27 | Apse Inc | Methods and compositions for increased double stranded rna production |
CN110325540A (zh) | 2016-11-07 | 2019-10-11 | 纳诺索尔公司 | 转录后化学修饰的双链rna |
CN108795961A (zh) * | 2018-05-31 | 2018-11-13 | 中华人民共和国大榭出入境检验检疫局 | 肠道病毒pcr质控品装甲rna及制备方法 |
WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
EP4141110A1 (en) | 2020-04-24 | 2023-03-01 | Obshchestvo S Ogranichennoy Otvetstvennost'yu "Ingenik" | Method for producing particles of bacteriophages of the genus levivirus |
CN113045631B (zh) * | 2021-03-10 | 2022-11-08 | 湖北大学 | 一种表达病毒样颗粒的质体转化的转基因植物的制备方法及其在抵抗棉铃虫中的应用 |
EP4166672A1 (en) * | 2021-10-15 | 2023-04-19 | NEUWAY Pharma GmbH | A novel method for purification of protein- or peptide-based capsules |
WO2024006433A1 (en) * | 2022-06-30 | 2024-01-04 | Carnegie Mellon University | Method for production of virus-like particles for gene delivery |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS501B1 (zh) | 1970-05-19 | 1975-01-06 | ||
US5443969A (en) | 1992-10-29 | 1995-08-22 | Rutgers University | RNA packaging system |
US6066318A (en) | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
CA2274584A1 (en) * | 1996-12-03 | 1998-06-11 | Medical University Of South Carolina | Tissue specific and target rna-specific ribozymes as antimicrobial therapeutics against microbial pathogens |
GB9925459D0 (en) | 1999-10-27 | 1999-12-29 | Plant Bioscience Ltd | Gene silencing |
US7264810B2 (en) | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
CA2460269C (en) * | 2001-09-06 | 2013-01-15 | Alphavax, Inc. | Alphavirus replicon vector systems |
JP4516748B2 (ja) | 2001-09-14 | 2010-08-04 | サイトス バイオテクノロジー アーゲー | ウィルス様粒子中への免疫賦活物質のパッケージ化:調製法および使用法 |
NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
WO2005001039A2 (en) * | 2003-05-29 | 2005-01-06 | Creighton University | Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof |
US20080207539A1 (en) * | 2003-09-01 | 2008-08-28 | Patrick Arbuthnot | Self-Processing Rna Expression Cassette |
EP1512742A1 (en) * | 2003-09-08 | 2005-03-09 | Margarete Odenthal | Conditional modification of sirnas expression |
WO2005086667A2 (en) | 2004-02-27 | 2005-09-22 | The Dow Chemical Company | High efficiency peptide production in plant cells |
US20080171361A1 (en) | 2007-01-11 | 2008-07-17 | The Board Of Regents For Oklahoma State University | CAP-Independent Translational Enhancer for Protein Synthesis in Wheat Germ Extract and Transgenic Cereals |
CA2685308A1 (en) * | 2007-04-27 | 2009-01-29 | Dow Global Technologies Inc. | Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
EP2085479A1 (en) * | 2008-01-31 | 2009-08-05 | Institut Pasteur | Reverse genetics of negative-strand rna viruses in yeast |
US20110250675A1 (en) * | 2008-03-26 | 2011-10-13 | Life Technologies Corporaiton | Virus-Like Particle Mediated Cellular Delivery |
US8324149B2 (en) * | 2008-11-18 | 2012-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Encapsidation of heterologous entities into virus-like particles |
US8906862B2 (en) | 2009-02-27 | 2014-12-09 | The Regents Of The University Of California | Multiple antigen delivery system using hepatitis E virus-like particle |
US8906863B2 (en) | 2009-02-27 | 2014-12-09 | The Regents Of The University Of California | Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector |
CA2765357A1 (en) | 2009-06-15 | 2010-12-23 | Plant Bioscience Limited | Production of viral capsids |
PL2480658T3 (pl) * | 2009-09-22 | 2017-12-29 | Medicago Inc. | Sposób otrzymywania VLP pochodzenia roślinnego |
HUE033056T2 (hu) | 2010-03-08 | 2017-11-28 | Monsanto Technology Llc | Polinukleotid molekulák génszabályozáshoz növényekben |
US20130245102A1 (en) | 2010-10-12 | 2013-09-19 | Research Foundation Of The City University Of New York | Novel dna templates for small rna production in mammalian cells |
US20130224828A1 (en) * | 2010-11-01 | 2013-08-29 | Qapsule Technologies, Inc. | RNA-Directed Packaging of Enzymes Within Protein Particles |
CN107164376B (zh) | 2011-12-21 | 2021-03-30 | 阿普斯有限责任公司 | 使用具有对水解酶抗性的衣壳的vlp的方法 |
CN102533831B (zh) * | 2012-02-16 | 2013-09-11 | 郑州大学 | 一种包含自剪切位点的组织特异性双基因沉默RNAi表达载体 |
BR112015029559A2 (pt) * | 2013-06-19 | 2017-12-12 | Apse Llc | partícula similar a vírus, ácido nucleico e métodos para produzir rna de fita dupla e sirna, shrna, sshrna, 1shrna e mirna |
WO2015038915A2 (en) * | 2013-09-12 | 2015-03-19 | Apse, Llc | Compositions and methods using capsids resistant to hydrolases |
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2012
- 2012-12-21 CN CN201710382239.3A patent/CN107164376B/zh active Active
- 2012-12-21 BR BR112014012162-1A patent/BR112014012162B1/pt active IP Right Grant
- 2012-12-21 WO PCT/US2012/071419 patent/WO2013096866A2/en active Application Filing
- 2012-12-21 AR ARP120104949A patent/AR089440A1/es active IP Right Grant
- 2012-12-21 EP EP21197081.9A patent/EP4019636A1/en active Pending
- 2012-12-21 JP JP2014548974A patent/JP6041896B2/ja active Active
- 2012-12-21 EP EP12860313.1A patent/EP2798059B1/en active Active
- 2012-12-21 CA CA2860310A patent/CA2860310C/en active Active
- 2012-12-21 US US13/725,184 patent/US20130167267A1/en not_active Abandoned
- 2012-12-21 SG SG11201402657WA patent/SG11201402657WA/en unknown
- 2012-12-21 MX MX2014007516A patent/MX358762B/es active IP Right Grant
- 2012-12-21 AU AU2012358267A patent/AU2012358267B2/en active Active
- 2012-12-21 CN CN201280062447.0A patent/CN104114696B/zh active Active
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2014
- 2014-05-16 US US14/279,793 patent/US9181531B2/en active Active
- 2014-05-18 IL IL232662A patent/IL232662B/en active IP Right Grant
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2015
- 2015-04-14 HK HK15103603.6A patent/HK1203082A1/zh unknown
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2016
- 2016-11-08 JP JP2016218086A patent/JP6332879B2/ja active Active
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2017
- 2017-11-16 AU AU2017261590A patent/AU2017261590B2/en active Active
- 2017-12-18 JP JP2017241444A patent/JP2018038437A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2013096866A3 (en) | 2013-10-03 |
EP2798059A4 (en) | 2015-07-29 |
AU2012358267B2 (en) | 2017-10-26 |
EP2798059A2 (en) | 2014-11-05 |
US20130167267A1 (en) | 2013-06-27 |
JP2015500662A (ja) | 2015-01-08 |
IL232662A0 (en) | 2014-07-31 |
US20140302593A1 (en) | 2014-10-09 |
JP6041896B2 (ja) | 2016-12-14 |
US9181531B2 (en) | 2015-11-10 |
CA2860310C (en) | 2023-03-21 |
JP2017035109A (ja) | 2017-02-16 |
EP2798059B1 (en) | 2021-09-29 |
CN107164376B (zh) | 2021-03-30 |
AU2017261590B2 (en) | 2019-12-12 |
BR112014012162A2 (pt) | 2019-08-13 |
CA2860310A1 (en) | 2013-06-27 |
CN107164376A (zh) | 2017-09-15 |
AU2012358267A1 (en) | 2014-06-05 |
IL232662B (en) | 2019-05-30 |
MX2014007516A (es) | 2014-09-22 |
CN104114696B (zh) | 2017-05-03 |
AR089440A1 (es) | 2014-08-20 |
SG11201402657WA (en) | 2014-09-26 |
JP6332879B2 (ja) | 2018-05-30 |
MX358762B (es) | 2018-09-03 |
EP4019636A1 (en) | 2022-06-29 |
WO2013096866A2 (en) | 2013-06-27 |
CN104114696A (zh) | 2014-10-22 |
JP2018038437A (ja) | 2018-03-15 |
AU2017261590A1 (en) | 2017-12-07 |
BR112014012162B1 (pt) | 2021-09-08 |
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