HK1198697A1 - Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands - Google Patents

Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

Info

Publication number
HK1198697A1
HK1198697A1 HK14112124.8A HK14112124A HK1198697A1 HK 1198697 A1 HK1198697 A1 HK 1198697A1 HK 14112124 A HK14112124 A HK 14112124A HK 1198697 A1 HK1198697 A1 HK 1198697A1
Authority
HK
Hong Kong
Prior art keywords
pyrazole
receptor ligands
urea derivatives
vanilloid receptor
substituted heteroaromatic
Prior art date
Application number
HK14112124.8A
Other languages
English (en)
Chinese (zh)
Inventor
Robert Frank-Foltyn
Gregor Bahrenberg
Thomas Christoph
Bernhard Lesch
Jeewoo Lee
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46640622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1198697(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HK1198697A1 publication Critical patent/HK1198697A1/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
HK14112124.8A 2011-07-26 2014-12-02 Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands HK1198697A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11006114 2011-07-26
PCT/EP2012/003135 WO2013013815A1 (fr) 2011-07-26 2012-07-25 Dérivés de carboxamide et d'urée contenant un pyrazole hétéroaromatique substitués en tant que ligands de récepteur de vanilloïde

Publications (1)

Publication Number Publication Date
HK1198697A1 true HK1198697A1 (en) 2015-05-29

Family

ID=46640622

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112124.8A HK1198697A1 (en) 2011-07-26 2014-12-02 Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

Country Status (17)

Country Link
US (1) US20130029962A1 (fr)
EP (1) EP2736900A1 (fr)
JP (1) JP2014521616A (fr)
KR (1) KR20140049026A (fr)
CN (1) CN103842357A (fr)
AR (1) AR087301A1 (fr)
BR (1) BR112014001880A2 (fr)
CA (1) CA2842916A1 (fr)
CL (1) CL2013003816A1 (fr)
CO (1) CO6940410A2 (fr)
EA (1) EA201400161A1 (fr)
EC (1) ECSP14013164A (fr)
HK (1) HK1198697A1 (fr)
MX (1) MX2014000779A (fr)
PE (1) PE20140836A1 (fr)
WO (1) WO2013013815A1 (fr)
ZA (1) ZA201400085B (fr)

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BR112014001908A2 (pt) * 2011-07-26 2017-02-21 Gruenenthal Gmbh derivados aza heterocíclicos substituídos
CA2843022C (fr) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Quinoleines substituees et leur utilisation comme medicaments
US9816022B2 (en) 2013-05-31 2017-11-14 Halliburton Energy Services, Inc. Ampholyte polymeric compounds in subterranean applications
ES2660760T3 (es) * 2013-12-19 2018-03-26 Grünenthal GmbH Pirrolocarboxamidas fluorometil-sustituidas como bloqueantes del canal de Ca CaV2.2
AU2014365740A1 (en) 2013-12-19 2016-05-26 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides iv
EP3083612A1 (fr) * 2013-12-19 2016-10-26 Grünenthal GmbH Pyrrole carboxamides substitués par un groupe fluorométhyle, utilisés comme inhibiteurs des canaux calciques cav2.2
DK3154947T3 (en) * 2014-06-11 2018-06-18 Bayer Cropscience Ag PROCEDURE FOR PREPARING 3,5-BIS (HALOGENAL COOL) PYRAZOLES BY ACYLATION OF KETIMINES
CA2965467A1 (fr) * 2014-10-24 2016-04-28 Ono Pharmaceutical Co., Ltd. Activateur des canaux kcnq2-5
AU2015353073B2 (en) * 2014-11-24 2018-04-19 Medifron Dbt Inc. Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II
CN104478911A (zh) * 2014-12-19 2015-04-01 成都安斯利生物医药有限公司 一种制备3-三氟甲基吡咯硼酸的方法
PT3319959T (pt) 2015-07-06 2021-12-06 Alkermes Inc Inibidores hetero-halo de histona desacetilase
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
CN105523995A (zh) * 2015-12-17 2016-04-27 浙江汇能生物股份有限公司 一种咯萘啶中间体2-甲氧基-5-氨基吡啶的制备方法
CN105753783B (zh) * 2016-04-08 2017-12-15 李文淏 一种合成塞来昔布的方法
JP6197971B1 (ja) * 2016-04-22 2017-09-20 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
EP3241830A1 (fr) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Derivés de bicycles condensés hétérocycliques utilisés comme pesticides
WO2018125983A1 (fr) 2016-12-30 2018-07-05 Mitobridge, Inc. Dérivés d'oxopyridine utiles en tant qu'inhibiteurs de la semialdéhyde décarboxylase d'aminocarboxymuconate (acmsd)
SI3570834T1 (sl) 2017-01-11 2022-05-31 Alkermes, Inc. Biciklični inhibitorji histonske deacetilaze
CN111032040B (zh) 2017-08-07 2023-08-29 罗丹疗法公司 组蛋白去乙酰酶的双环抑制剂
WO2022030589A1 (fr) * 2020-08-05 2022-02-10 国立大学法人北海道大学 Ligand contenant un composé de coordination monodenté d'urée et catalyseur de borylation le contenant
WO2022263498A1 (fr) * 2021-06-15 2022-12-22 Grünenthal GmbH Amides de pyrazole substitués
WO2024036243A2 (fr) * 2022-08-10 2024-02-15 Vettore, LLC Sels d'inhibiteurs hétérocycliques du transporteur 4 de monocarboxylate pour le traitement d'une maladie
PL442982A1 (pl) * 2022-11-29 2024-06-03 Uniwersytet Medyczny W Lublinie N-podstawione pochodne 1-(1-fenylo-3-arylo)-1H-pirazol-4-ylo)metanaminy, sposób ich wytwarzania i ich zastosowanie

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JP2010083763A (ja) * 2008-09-29 2010-04-15 Mitsui Chemicals Inc ピラゾール誘導体およびその製造方法、ならびに殺菌剤
JP5745505B2 (ja) 2009-05-07 2015-07-08 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング バニロイド受容体リガンドとしての置換フェニル尿素および置換フェニルアミド
TWI504589B (zh) 2009-05-07 2015-10-21 作為香草類化合物受體之配體之經取代芳香族羧醯胺及尿素衍生物

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AR087301A1 (es) 2014-03-12
BR112014001880A2 (pt) 2017-02-21
CL2013003816A1 (es) 2014-06-20
PE20140836A1 (es) 2014-08-03
EA201400161A1 (ru) 2014-06-30
MX2014000779A (es) 2014-03-27
CA2842916A1 (fr) 2013-01-31
WO2013013815A1 (fr) 2013-01-31
KR20140049026A (ko) 2014-04-24
US20130029962A1 (en) 2013-01-31
CN103842357A (zh) 2014-06-04
ECSP14013164A (es) 2014-11-28
CO6940410A2 (es) 2014-05-09
JP2014521616A (ja) 2014-08-28

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