HK1179964A1 - 稠合的吡啶化合物 - Google Patents

稠合的吡啶化合物

Info

Publication number
HK1179964A1
HK1179964A1 HK13107236.4A HK13107236A HK1179964A1 HK 1179964 A1 HK1179964 A1 HK 1179964A1 HK 13107236 A HK13107236 A HK 13107236A HK 1179964 A1 HK1179964 A1 HK 1179964A1
Authority
HK
Hong Kong
Prior art keywords
pyridine compounds
anellated
anellated pyridine
compounds
pyridine
Prior art date
Application number
HK13107236.4A
Other languages
English (en)
Inventor
羅卡．戈比
羅莎‧瑪麗亞．羅德里格斯薩爾米恩托
于爾根．維希曼
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1179964A1 publication Critical patent/HK1179964A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK13107236.4A 2010-07-06 2013-06-21 稠合的吡啶化合物 HK1179964A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10168490 2010-07-06
PCT/EP2011/061167 WO2012004206A1 (en) 2010-07-06 2011-07-04 Anellated pyridine compounds

Publications (1)

Publication Number Publication Date
HK1179964A1 true HK1179964A1 (zh) 2013-10-11

Family

ID=44546276

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13107236.4A HK1179964A1 (zh) 2010-07-06 2013-06-21 稠合的吡啶化合物

Country Status (14)

Country Link
US (1) US8470828B2 (zh)
EP (1) EP2590984B1 (zh)
JP (1) JP2013533872A (zh)
KR (1) KR20130097149A (zh)
CN (1) CN102958936B (zh)
AR (1) AR082111A1 (zh)
BR (1) BR112013000189A2 (zh)
CA (1) CA2801583A1 (zh)
ES (1) ES2533063T3 (zh)
HK (1) HK1179964A1 (zh)
MX (1) MX2012014135A (zh)
RU (1) RU2013102401A (zh)
TW (1) TW201206938A (zh)
WO (1) WO2012004206A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CN101945848A (zh) 2007-12-20 2011-01-12 英维沃医药有限公司 四取代的苯
US8586579B2 (en) * 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
UY35420A (es) 2013-03-15 2014-10-31 Abbvie Inc Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3
AR095264A1 (es) 2013-03-15 2015-09-30 Abbvie Deutschland Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3
CN106518841B (zh) * 2015-09-15 2019-03-05 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
WO2017045599A1 (zh) * 2015-09-15 2017-03-23 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
JP7015092B2 (ja) 2016-07-28 2022-02-02 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
KR20200112910A (ko) 2018-01-26 2020-10-05 시오노기 앤드 컴파니, 리미티드 도파민 d3 수용체 길항 작용을 갖는 축환 화합물
JP7250405B2 (ja) 2018-01-26 2023-04-03 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物
CN113754580B (zh) * 2020-06-05 2023-04-25 上海中泽医药科技有限公司 一种吡啶吗啉类化合物、其制备方法及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
HUP0500170A3 (en) * 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
EP1987019B1 (en) 2006-02-17 2012-11-28 F. Hoffmann-La Roche AG Benzoyl-piperidine derivatives as 5ht2/d3 modulators
EP1870405A1 (en) 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
JP5502733B2 (ja) * 2007-07-26 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ２ａ及びｄ３受容体の二重のモジュレーター
CN101778820B (zh) 2007-08-09 2012-12-05 弗·哈夫曼-拉罗切有限公司 作为5-ht2a和d3受体双重调节剂的苯甲酰基-哌啶衍生物
CA2735400A1 (en) 2008-09-22 2010-03-25 F. Hoffmann-La Roche Ag Piperazine d3 and 5-ht2a receptor modulators
JP2012502948A (ja) 2008-09-23 2012-02-02 エフ．ホフマン−ラ ロシュ アーゲー ドーパミンｄ３受容体の調節剤として有用なイソオキサゾロ［４，５］ピリジン−３−イル−ピペラジン誘導体
AU2009296047A1 (en) 2008-09-23 2010-04-01 F. Hoffmann-La Roche Ag Pyridinylpiperazin derivatives useful as modulators of dopamine D3 receptors
KR20110059649A (ko) 2008-09-23 2011-06-02 에프. 호프만-라 로슈 아게 도파민 ｄ3 수용체의 조절제로서 유용한 벤조〔ｄ〕이속사졸-3-일-피페라진 유도체
US8586579B2 (en) * 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds

Also Published As

Publication number Publication date
AR082111A1 (es) 2012-11-14
JP2013533872A (ja) 2013-08-29
EP2590984B1 (en) 2015-01-28
CN102958936A (zh) 2013-03-06
MX2012014135A (es) 2013-01-29
US8470828B2 (en) 2013-06-25
EP2590984A1 (en) 2013-05-15
RU2013102401A (ru) 2014-08-20
KR20130097149A (ko) 2013-09-02
US20120010201A1 (en) 2012-01-12
ES2533063T3 (es) 2015-04-07
BR112013000189A2 (pt) 2016-05-24
CA2801583A1 (en) 2012-01-12
CN102958936B (zh) 2015-10-21
TW201206938A (en) 2012-02-16
WO2012004206A1 (en) 2012-01-12

Similar Documents

Publication Publication Date Title
HRP20181788T1 (hr) Supstituirani spojevi piridinon-piridinil
EP2590647A4 (en) PRO-NEUROGENIC COMPOUNDS
GB201008134D0 (en) Compounds
HK1179964A1 (zh) 稠合的吡啶化合物
ZA201300032B (en) Tetrahydrocarboline derivative
EP2605658A4 (en) SPIROXAZOLIDINONVERBINDUNGEN
GB201007347D0 (en) Compounds
EP2649050A4 (en) LINKS
GB201002563D0 (en) Compounds
GB201008209D0 (en) Compounds
GB201001688D0 (en) Compounds
HK1185082A1 (zh) 醯基苯衍生物
EP2795032A4 (en) DRILLING WITH INCREASED RANGE
EP2599775A4 (en) ETHINYLPYRAZOLDERIVAT
HK1183877A1 (zh) 取代的吡啶化合物
ZA201303887B (en) 2-carboxamide-4-piperazinyl-benzofuran derivative
GB201002216D0 (en) Compounds
GB201015537D0 (en) Compounds
GB201008210D0 (en) Compounds
GB201001796D0 (en) Compounds
GB201015145D0 (en) Compounds
GB201014392D0 (en) Compounds
GB201014052D0 (en) Compounds
GB201013507D0 (en) Compounds
GB201013508D0 (en) Compounds

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190704