HK1178889A1 - Morphinan compounds - Google Patents

Morphinan compounds

Info

Publication number
HK1178889A1
HK1178889A1 HK13105601.5A HK13105601A HK1178889A1 HK 1178889 A1 HK1178889 A1 HK 1178889A1 HK 13105601 A HK13105601 A HK 13105601A HK 1178889 A1 HK1178889 A1 HK 1178889A1
Authority
HK
Hong Kong
Prior art keywords
morphinan compounds
morphinan
compounds
Prior art date
Application number
HK13105601.5A
Other languages
English (en)
Chinese (zh)
Inventor
Robert Tung
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Publication of HK1178889A1 publication Critical patent/HK1178889A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Ecology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
HK13105601.5A 2007-05-01 2010-07-22 Morphinan compounds HK1178889A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91513007P 2007-05-01 2007-05-01
US91666207P 2007-05-08 2007-05-08
US97604407P 2007-09-28 2007-09-28

Publications (1)

Publication Number Publication Date
HK1178889A1 true HK1178889A1 (en) 2013-09-19

Family

ID=51894365

Family Applications (5)

Application Number Title Priority Date Filing Date
HK13105154.6A HK1178154A1 (en) 2007-05-01 2010-07-22 Morphinan compounds
HK11109620.6A HK1155442A1 (en) 2007-05-01 2010-07-22 Morphinan compounds
HK15101294.4A HK1201058A1 (zh) 2007-05-01 2010-07-22 嗎啡烷化合物
HK13105601.5A HK1178889A1 (en) 2007-05-01 2010-07-22 Morphinan compounds
HK19101064.8A HK1259133A1 (zh) 2007-05-01 2017-05-02 嗎啡烷化合物

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HK13105154.6A HK1178154A1 (en) 2007-05-01 2010-07-22 Morphinan compounds
HK11109620.6A HK1155442A1 (en) 2007-05-01 2010-07-22 Morphinan compounds
HK15101294.4A HK1201058A1 (zh) 2007-05-01 2010-07-22 嗎啡烷化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK19101064.8A HK1259133A1 (zh) 2007-05-01 2017-05-02 嗎啡烷化合物

Country Status (15)

Country Link
US (6) US9314440B2 (da)
EP (5) EP2792662B1 (da)
BR (1) BRPI0811478B8 (da)
CA (3) CA2945581C (da)
CY (1) CY1117826T1 (da)
DK (4) DK3825306T3 (da)
ES (5) ES2577477T3 (da)
FI (1) FI3825306T3 (da)
HK (5) HK1178154A1 (da)
HR (5) HRP20230745T3 (da)
HU (3) HUE063526T2 (da)
LT (1) LT3825306T (da)
PL (3) PL2792662T3 (da)
PT (5) PT3825306T (da)
SI (2) SI3825306T1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX341177B (es) * 2007-05-01 2016-08-10 Concert Pharmaceuticals Inc Compuestos de morfina.
PT3825306T (pt) * 2007-05-01 2023-07-24 Sun Pharmaceutical Ind Inc Compostos de morfinano
US20180243289A1 (en) * 2015-07-30 2018-08-30 Concert Pharmaceuticals, Inc. Deuterated morphinan compounds for treating agitation
CA2994153A1 (en) * 2015-07-30 2017-02-02 Concert Pharmaceuticals, Inc. Deuterated morphinan compounds for use in treating agitation
WO2017064876A1 (ja) 2015-10-14 2017-04-20 学校法人 久留米大学 グレリンを有効成分として含有するレット症候群（ｒｔｔ）の予防・治療剤
WO2018136654A1 (en) * 2017-01-19 2018-07-26 Donald Danforth Plant Science Center Morphinan n-demethylase isolated from the methylobacterium thebainfresser and methods of use thereof

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Also Published As

Publication number Publication date
DK2792662T3 (da) 2016-07-25
EP3093290A1 (en) 2016-11-16
HRP20160521T1 (hr) 2016-08-12
HUE025569T2 (en) 2016-02-29
DK2357183T3 (da) 2015-09-07
HK1155442A1 (en) 2012-05-18
FI3825306T3 (fi) 2023-08-23
BRPI0811478B1 (pt) 2020-12-29
SI2792662T1 (sl) 2016-10-28
DK3825306T3 (da) 2023-09-11
EP3357923A1 (en) 2018-08-08
PL2792662T3 (pl) 2016-10-31
US20180327809A1 (en) 2018-11-15
US20240093265A1 (en) 2024-03-21
BRPI0811478A2 (pt) 2014-11-04
EP2357183B1 (en) 2015-07-01
PT2522667E (pt) 2014-11-11
US11473123B2 (en) 2022-10-18
PT2522668E (pt) 2015-06-09
ES2577477T3 (es) 2016-07-15
US9868976B2 (en) 2018-01-16
CA3056205C (en) 2023-09-26
LT3825306T (lt) 2023-08-10
US20240117407A1 (en) 2024-04-11
EP2792662A1 (en) 2014-10-22
EP3093290B1 (en) 2018-01-24
EP3825306B1 (en) 2023-06-07
EP2357183A1 (en) 2011-08-17
EP3357923B1 (en) 2019-11-13
HRP20150809T1 (hr) 2016-02-12
HRP20150848T1 (hr) 2015-09-25
HRP20230745T3 (hr) 2023-10-27
HUE063526T2 (hu) 2024-01-28
HK1178154A1 (en) 2013-09-06
EP2792662B1 (en) 2016-04-06
US20170037449A1 (en) 2017-02-09
BRPI0811478A8 (pt) 2019-10-15
ES2545617T3 (es) 2015-09-14
HRP20140903T1 (hr) 2014-11-21
SI3825306T1 (sl) 2023-10-30
US20210348208A1 (en) 2021-11-11
BRPI0811478B8 (pt) 2021-05-25
CY1117826T1 (el) 2017-05-17
HK1259133A1 (zh) 2019-11-29
ES2523286T3 (es) 2014-11-24
CA2945581A1 (en) 2008-11-13
PT2357183E (pt) 2015-09-28
PT2792662T (pt) 2016-07-07
EP3825306A1 (en) 2021-05-26
CA3056205A1 (en) 2008-11-13
HK1201058A1 (zh) 2015-08-21
PL2357183T3 (pl) 2015-12-31
ES2951028T3 (es) 2023-10-17
EP3825306B8 (en) 2023-08-02
US20140329846A1 (en) 2014-11-06
US9314440B2 (en) 2016-04-19
ES2536984T3 (es) 2015-06-01
PL3825306T3 (pl) 2023-09-11
PT3825306T (pt) 2023-07-24
HRP20160521T8 (hr) 2016-10-07
CA3208128A1 (en) 2008-11-13
CA2945581C (en) 2021-11-16
DK2522668T3 (da) 2015-05-26
HUE029782T2 (en) 2017-04-28

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