HK1178511A1 - N-alkoxyamide conjugates as imaging agents n- - Google Patents
N-alkoxyamide conjugates as imaging agents n-Info
- Publication number
- HK1178511A1 HK1178511A1 HK13105302.7A HK13105302A HK1178511A1 HK 1178511 A1 HK1178511 A1 HK 1178511A1 HK 13105302 A HK13105302 A HK 13105302A HK 1178511 A1 HK1178511 A1 HK 1178511A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- imaging agents
- alkoxyamide
- conjugates
- alkoxyamide conjugates
- imaging
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22394609P | 2009-07-08 | 2009-07-08 | |
PCT/US2010/001926 WO2011005322A2 (fr) | 2009-07-08 | 2010-07-08 | Conjugués n-alkoxyamides en tant qu'agents d'imagerie |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1178511A1 true HK1178511A1 (en) | 2013-09-13 |
Family
ID=43429724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13105302.7A HK1178511A1 (en) | 2009-07-08 | 2013-05-02 | N-alkoxyamide conjugates as imaging agents n- |
Country Status (8)
Country | Link |
---|---|
US (2) | US8877157B2 (fr) |
EP (1) | EP2451776B1 (fr) |
JP (1) | JP5676600B2 (fr) |
CN (1) | CN102781909B (fr) |
AU (1) | AU2010271097B2 (fr) |
CA (1) | CA2803520C (fr) |
HK (1) | HK1178511A1 (fr) |
WO (1) | WO2011005322A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI549692B (zh) | 2006-12-26 | 2016-09-21 | 藍瑟斯醫學影像公司 | 使心臟神經分布顯像之配位體 |
CN103965128B (zh) | 2008-01-08 | 2018-04-03 | 兰休斯医疗成像公司 | 作为显像剂的n‑烷氧基酰胺共轭物 |
CA2803520C (fr) | 2009-07-08 | 2019-10-22 | Lantheus Medical Imaging, Inc. | Conjugues n-alkoxyamides en tant qu'agents d'imagerie |
KR102136503B1 (ko) | 2010-05-11 | 2020-07-21 | 랜티우스 메디컬 이메징, 인크. | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 |
GB201102189D0 (en) | 2011-02-08 | 2011-03-23 | King S College London | Materials and methods relating to cardiovascular imaging |
BR122019017259B1 (pt) | 2011-09-09 | 2022-05-10 | Lantheus Medical Imaging, Inc | Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento |
ES2748940T3 (es) | 2011-11-11 | 2020-03-18 | Univ Yale | Evaluación de la presencia de una fibrilación auricular y de la vulnerabilidad a ésta, y otras indicaciones sobre la base de la toma de imágenes basada en metaloproteinasas de matriz |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
UA126388C2 (uk) | 2016-11-18 | 2022-09-28 | Астеллас Фарма Інк. | Fab-фрагмент антитіла до muc1 людини |
TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類CEACAM5抗體Fab片段 |
KR20210113201A (ko) * | 2019-01-07 | 2021-09-15 | 아스텔라스세이야쿠 가부시키가이샤 | 배위자 및 CEACAM5 항체 Fab 프래그먼트를 포함하는 복합체 |
Family Cites Families (33)
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JPS5122885A (en) | 1974-08-13 | 1976-02-23 | Sagami Chem Res | Ashiru ll aminosan oo chikanhidorokisamidono seizohoho |
JPS5910322B2 (ja) | 1975-07-30 | 1984-03-08 | 三井東圧化学株式会社 | 殺草剤 |
US4859777A (en) | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
WO1987002893A1 (fr) | 1985-11-18 | 1987-05-21 | Board Of Regents, The University Of Texas System | Agents polychelateurs pour l'amelioration de l'image et du spectre (et pour derive spectrale) |
DE3768523D1 (de) | 1986-02-18 | 1991-04-18 | Squibb & Sons Inc | ((2,2,2-trichloroethoxy)methoxy)amin. |
US5064956A (en) | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
IT1224627B (it) | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
JP2927532B2 (ja) * | 1989-11-09 | 1999-07-28 | 塩野義製薬株式会社 | 含窒素異項環オキシーフェノキシ酢酸誘導体およびその除草剤としての用途 |
JPH0491070A (ja) | 1990-08-06 | 1992-03-24 | Kanebo Ltd | カリックスアレーン誘導体 |
US5274129A (en) | 1991-06-12 | 1993-12-28 | Idaho Research Foundation, Inc. | Hydroxamic acid crown ethers |
GB9115375D0 (en) | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
US5639746A (en) | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
TW319763B (fr) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
US5874573A (en) | 1995-06-26 | 1999-02-23 | Concat, Inc. | Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy |
DE19914101C1 (de) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik |
US6461587B1 (en) | 1999-03-22 | 2002-10-08 | Schering Aktiengesellschaft | Perfluoroalkylamides, their production and their use in diagnosis |
US6989139B2 (en) | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
US6656448B1 (en) * | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
US20020002152A1 (en) | 2000-04-14 | 2002-01-03 | Craig Richard A. | Hydrazide and alkoxyamide angiogenesis inhibitors |
AU2002254000A1 (en) | 2001-02-23 | 2002-09-12 | Bristol-Myers Squibb Pharma Company | Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque |
US20040146964A1 (en) | 2001-03-21 | 2004-07-29 | Maxwell Patrick Henry | Assays, methods and means |
TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
CN1795015A (zh) | 2003-05-23 | 2006-06-28 | 埃匹克斯医药品股份有限公司 | 螯合配位体和造影剂的光学纯和光学富集异构体 |
WO2005020973A2 (fr) | 2003-08-29 | 2005-03-10 | The University Of Houston System | Compositions a activite antimycobacterienne comprenant un hydroxamate ou un hydroxamate et une hydroxylamine |
US20050106100A1 (en) | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
WO2005084179A2 (fr) * | 2003-12-01 | 2005-09-15 | Immunomedics, Inc. | Procedes ameliores pour la preparation de conjugues de proteines et d'agents de chelation |
US20070142417A1 (en) | 2005-05-11 | 2007-06-21 | Aventis Pharmaceuticals Inc | Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor |
CN101252954A (zh) | 2005-06-30 | 2008-08-27 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为显像剂的酰肼偶联物 |
US7618957B2 (en) | 2005-07-15 | 2009-11-17 | Bayer Schering Pharma Aktiengesellschaft | Perfluoroalkyl-containing complexes, process for their production as well as their use |
CN103965128B (zh) * | 2008-01-08 | 2018-04-03 | 兰休斯医疗成像公司 | 作为显像剂的n‑烷氧基酰胺共轭物 |
CA2803520C (fr) | 2009-07-08 | 2019-10-22 | Lantheus Medical Imaging, Inc. | Conjugues n-alkoxyamides en tant qu'agents d'imagerie |
-
2010
- 2010-07-08 CA CA2803520A patent/CA2803520C/fr not_active Expired - Fee Related
- 2010-07-08 AU AU2010271097A patent/AU2010271097B2/en not_active Ceased
- 2010-07-08 CN CN201080040596.8A patent/CN102781909B/zh not_active Expired - Fee Related
- 2010-07-08 JP JP2012519544A patent/JP5676600B2/ja not_active Expired - Fee Related
- 2010-07-08 EP EP10797455.2A patent/EP2451776B1/fr active Active
- 2010-07-08 US US13/382,689 patent/US8877157B2/en active Active
- 2010-07-08 WO PCT/US2010/001926 patent/WO2011005322A2/fr active Application Filing
-
2013
- 2013-05-02 HK HK13105302.7A patent/HK1178511A1/xx not_active IP Right Cessation
-
2014
- 2014-09-22 US US14/492,896 patent/US9393329B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN102781909B (zh) | 2015-06-17 |
US20120328514A1 (en) | 2012-12-27 |
CN102781909A (zh) | 2012-11-14 |
WO2011005322A2 (fr) | 2011-01-13 |
EP2451776A4 (fr) | 2015-04-15 |
US8877157B2 (en) | 2014-11-04 |
JP2012532868A (ja) | 2012-12-20 |
EP2451776A2 (fr) | 2012-05-16 |
US9393329B2 (en) | 2016-07-19 |
AU2010271097A1 (en) | 2012-03-01 |
CA2803520A1 (fr) | 2011-01-13 |
JP5676600B2 (ja) | 2015-02-25 |
WO2011005322A3 (fr) | 2011-04-21 |
AU2010271097B2 (en) | 2015-12-10 |
EP2451776B1 (fr) | 2019-09-18 |
CA2803520C (fr) | 2019-10-22 |
US20150078997A1 (en) | 2015-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20210710 |