HK1174063A1 - Method for determining the presence or absence of different aneuploidies in a sample - Google Patents

Method for determining the presence or absence of different aneuploidies in a sample

Info

Publication number
HK1174063A1
HK1174063A1 HK12110738.2A HK12110738A HK1174063A1 HK 1174063 A1 HK1174063 A1 HK 1174063A1 HK 12110738 A HK12110738 A HK 12110738A HK 1174063 A1 HK1174063 A1 HK 1174063A1
Authority
HK
Hong Kong
Prior art keywords
absence
sample
determining
different aneuploidies
aneuploidies
Prior art date
Application number
HK12110738.2A
Other languages
English (en)
Inventor
Richard P Rava
David A Comstock
Brian K Rhees
Original Assignee
Verinata Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verinata Health Inc filed Critical Verinata Health Inc
Publication of HK1174063A1 publication Critical patent/HK1174063A1/xx

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Physiology (AREA)
  • Pathology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Artificial Intelligence (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK12110738.2A 2011-07-26 2012-10-26 Method for determining the presence or absence of different aneuploidies in a sample HK1174063A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/045412 WO2013015793A1 (fr) 2011-07-26 2011-07-26 Procédé de détermination de la présence ou de l'absence d'aneuploïdes différents dans un échantillon

Publications (1)

Publication Number Publication Date
HK1174063A1 true HK1174063A1 (en) 2013-05-31

Family

ID=44838718

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12110738.2A HK1174063A1 (en) 2011-07-26 2012-10-26 Method for determining the presence or absence of different aneuploidies in a sample

Country Status (9)

Country Link
EP (1) EP2563937A1 (fr)
JP (1) JP6161607B2 (fr)
KR (1) KR101974492B1 (fr)
CN (1) CN103003447B (fr)
AU (1) AU2011373694A1 (fr)
CA (1) CA2840418C (fr)
GB (1) GB2485635B (fr)
HK (1) HK1174063A1 (fr)
WO (1) WO2013015793A1 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
US20110245085A1 (en) 2010-01-19 2011-10-06 Rava Richard P Methods for determining copy number variations
CA2786565C (fr) 2010-01-19 2017-04-25 Verinata Health, Inc. Procedes de detection definis par des partitions
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US10662474B2 (en) 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
WO2011090556A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Procédés pour déterminer une fraction d'acide nucléique fœtal dans des échantillons maternels
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
PL3456844T3 (pl) 2011-04-12 2020-11-16 Verinata Health, Inc. Rozdzielanie frakcji genomowych z wykorzystaniem zliczeń polimorfizmów
US9411937B2 (en) * 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
AU2019200162B2 (en) * 2012-07-20 2021-10-07 Verinata Health, Inc. Detecting and classifying copy number variation
AU2013204615A1 (en) * 2012-07-20 2014-02-06 Verinata Health, Inc. Detecting and classifying copy number variation in a fetal genome
AU2013204536A1 (en) * 2012-07-20 2014-02-06 Verinata Health, Inc. Detecting and classifying copy number variation in a cancer genome
CN104736725A (zh) 2012-08-13 2015-06-24 加利福尼亚大学董事会 用于检测生物组分的方法和系统
GB201215449D0 (en) * 2012-08-30 2012-10-17 Zoragen Biotechnologies Llp Method of detecting chromosonal abnormalities
JP6426162B2 (ja) * 2013-06-13 2018-11-21 アリオサ ダイアグノスティックス インコーポレイテッドＡｒｉｏｓａ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． 非侵襲的に胎児の性染色体異数性のリスクを計算する方法
AU2014281635B2 (en) * 2013-06-17 2020-05-28 Verinata Health, Inc. Method for determining copy number variations in sex chromosomes
CN104520437B (zh) * 2013-07-17 2016-09-14 深圳华大基因股份有限公司 一种染色体非整倍性检测方法及装置
ES2968644T3 (es) * 2013-10-04 2024-05-13 Sequenom Inc Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas
CA2928185C (fr) * 2013-10-21 2024-01-30 Verinata Health, Inc. Procede destine a l'amelioration de la sensibilite de detection dans la detemrination des variations du nombre de copies
CN105765076B (zh) * 2013-12-17 2019-07-19 深圳华大基因股份有限公司 一种染色体非整倍性检测方法及装置
US10318704B2 (en) 2014-05-30 2019-06-11 Verinata Health, Inc. Detecting fetal sub-chromosomal aneuploidies
US10697007B2 (en) 2014-06-27 2020-06-30 The Regents Of The University Of California PCR-activated sorting (PAS)
WO2016045106A1 (fr) * 2014-09-26 2016-03-31 深圳华大基因股份有限公司 Procédé d'analyse de la variation du nombre de copies pour des chromosomes de cellule unique et dispositif de détection
EP3209419A4 (fr) 2014-10-22 2018-10-03 The Regents of The University of California Imprimante à microgouttelettes haute définition
EP3567120B1 (fr) * 2014-12-12 2020-08-19 Verinata Health, Inc. Utilisation de la taille de fragments d'adn acellulaire pour déterminer les variations du nombre de copies
ES2923602T3 (es) * 2014-12-31 2022-09-28 Guardant Health Inc Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas
US10319463B2 (en) * 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
EP4112744A1 (fr) 2015-02-04 2023-01-04 The Regents of the University of California Séquençage d'acides nucléiques contenus dans des entités individuelles par marquage par code barre
WO2016127944A1 (fr) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Détection de mutations utilisées pour le dépistage du cancer et l'analyse fœtale
CN104745718B (zh) * 2015-04-23 2018-02-16 北京中仪康卫医疗器械有限公司 一种检测人类胚胎染色体微缺失和微重复的方法
US10844428B2 (en) * 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
WO2017031125A1 (fr) * 2015-08-17 2017-02-23 The Regents Of The University Of California Procédés d'amplification par déplacement multiple (mda) à base de microgouttelettes et compositions associées
WO2017044609A1 (fr) 2015-09-08 2017-03-16 Cold Spring Harbor Laboratory Détermination du nombre de copies génétiques au moyen d'un séquençage multiplex à haut débit de nucléotides smash
WO2017083828A1 (fr) * 2015-11-12 2017-05-18 Samuel Williams Séquençage rapide de fragments d'adn court à l'aide de la technologie des nanopores
CN108475301A (zh) * 2015-12-04 2018-08-31 绿十字基因组公司 用于确定包含核酸的混合物的样品中的拷贝数变异的方法
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
WO2018009723A1 (fr) * 2016-07-06 2018-01-11 Guardant Health, Inc. Procédés de profilage d'un fragmentome d'acides nucléiques sans cellule
CN110088290A (zh) 2016-08-10 2019-08-02 加利福尼亚大学董事会 在乳液微滴中结合多重置换扩增和pcr
TWI603082B (zh) * 2016-09-30 2017-10-21 有勁生物科技股份有限公司 非侵入式胎兒性徵異常檢測系統及其方法與非侵入式胎兒性徵檢測系統及其方法
CN110462053A (zh) 2016-12-21 2019-11-15 加利福尼亚大学董事会 使用基于水凝胶的液滴进行单细胞基因组测序
EP3574108A4 (fr) 2017-01-25 2020-12-23 The Chinese University Of Hong Kong Applications diagnostiques mettant en oeuvre des fragments d'acide nucléique
US11342047B2 (en) * 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
JP2018183095A (ja) * 2017-04-26 2018-11-22 株式会社エンプラス 胎児由来造血前駆細胞の単離方法、および胎児の染色体異常の可能性を試験する方法
US10501739B2 (en) 2017-10-18 2019-12-10 Mission Bio, Inc. Method, systems and apparatus for single cell analysis
SG11202110655UA (en) * 2019-03-28 2021-10-28 Phase Genomics Inc Systems and methods for karyotyping by sequencing

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007100911A2 (fr) * 2006-02-28 2007-09-07 University Of Louisville Research Foundation Détection d'anomalies chromosomiques à l'aide de polymorphismes mononucléotidiques tandem
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
PL2557520T3 (pl) * 2007-07-23 2021-10-11 The Chinese University Of Hong Kong Określanie zaburzenia równowagi sekwencji kwasu nukleinowego
US20100112590A1 (en) * 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
CA2701726A1 (fr) 2007-10-04 2009-04-09 Halcyon Molecular Sequencage de polymeres d'acides nucleiques par microscopie electronique
PT2334812T (pt) * 2008-09-20 2017-03-29 Univ Leland Stanford Junior ¿diagnóstico não invasivo de aneuploidia fetal por sequenciação
EP2494065B1 (fr) * 2009-10-26 2015-12-23 Lifecodexx AG Moyens et procédés destinés au diagnostic non invasif d'une aneuploïdie chromosomale
US20110245085A1 (en) * 2010-01-19 2011-10-06 Rava Richard P Methods for determining copy number variations
US10662474B2 (en) * 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
CA2786565C (fr) * 2010-01-19 2017-04-25 Verinata Health, Inc. Procedes de detection definis par des partitions

Also Published As

Publication number Publication date
GB201114713D0 (en) 2011-10-12
KR101974492B1 (ko) 2019-05-02
KR20140050032A (ko) 2014-04-28
JP6161607B2 (ja) 2017-07-12
CN103003447B (zh) 2020-08-25
CA2840418A1 (fr) 2013-01-31
EP2563937A1 (fr) 2013-03-06
CN103003447A (zh) 2013-03-27
GB2485635B (en) 2012-11-28
AU2011373694A1 (en) 2013-05-02
CA2840418C (fr) 2019-10-29
GB2485635A (en) 2012-05-23
WO2013015793A1 (fr) 2013-01-31
JP2014521334A (ja) 2014-08-28

Similar Documents

Publication Publication Date Title
GB2485635B (en) Method for determining the presence or absence of different aneuploidies in a sample
EP3425063C0 (fr) Procédés de détection d'analyte
HK1199761A1 (en) Method for detecting nucleosomes
EP2779649A4 (fr) Procédé et dispositif pour partager une liste de candidats
HK1202624A1 (en) Adrenomedullin assays and methods for determining mature adrenomedullin
EP2673631A4 (fr) Procédés et systèmes pour la détermination de la présence de testostérone ou d'une quantité de testostérone dans un échantillon
EP2763872A4 (fr) Procédé de réalisation de composants éclairés et composants formés par le procédé
HK1198705A1 (en) Apparatus and methods for detecting analytes
EP2637017A4 (fr) Procédé de mesure de la capacité de remplissage
HK1168649A1 (en) Method and device for assay determination
EP2782023A4 (fr) Procédé d'analyse automatisée de documents textuels
HK1178601A1 (en) Method for detecting -specific ntibodies in biological sample
EP2791653A4 (fr) Techniques de diffusométrie optimisée
EP2759839A4 (fr) Appareil d'analyse automatisé
AP3303A (en) A method for identifying bacteria in a sample
PL2780464T3 (pl) Sposób wykrywania w próbce obecności bakterii wytwarzających ß-laktamazy o szerokim spektrum działania
EP2685257A4 (fr) Méthode d'analyse
GB201213102D0 (en) Method for determining the size and the position of objects
HK1201074A1 (en) Method for determining an analyte concentration
SG11201401345RA (en) Methods of detecting the presence of microorganisms in a sample
IL232355A0 (en) A method for determining calcification tendency
ZA201402881B (en) Method for processing fischer-tropsch off-gas
AP2013007021A0 (en) Method for assaying hydrocarbons
ZA201402882B (en) Method for processing fischer-tropsch off-gas
EP2757373A4 (fr) Procédé de mesure d'anticorps anti-wt1