HK1171375A1 - Igf-i poly (ethylene glycol) conjugates igf-i - Google Patents
Igf-i poly (ethylene glycol) conjugates igf-iInfo
- Publication number
- HK1171375A1 HK1171375A1 HK12112189.2A HK12112189A HK1171375A1 HK 1171375 A1 HK1171375 A1 HK 1171375A1 HK 12112189 A HK12112189 A HK 12112189A HK 1171375 A1 HK1171375 A1 HK 1171375A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- igf
- conjugates
- poly
- ethylene glycol
- glycol
- Prior art date
Links
- 229920001223 polyethylene glycol Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10153275 | 2010-02-11 | ||
PCT/EP2011/051631 WO2011098400A1 (en) | 2010-02-11 | 2011-02-04 | Igf-i poly (ethylene glycol) conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1171375A1 true HK1171375A1 (en) | 2013-03-28 |
Family
ID=42199427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12112189.2A HK1171375A1 (en) | 2010-02-11 | 2012-11-28 | Igf-i poly (ethylene glycol) conjugates igf-i |
Country Status (12)
Country | Link |
---|---|
US (2) | US9587006B2 (de) |
EP (1) | EP2533813B1 (de) |
JP (2) | JP5749744B2 (de) |
KR (1) | KR101485646B1 (de) |
CN (1) | CN102740896B (de) |
BR (1) | BR112012019992A2 (de) |
CA (1) | CA2786340C (de) |
ES (1) | ES2587574T3 (de) |
HK (1) | HK1171375A1 (de) |
MX (1) | MX339559B (de) |
RU (1) | RU2584572C2 (de) |
WO (1) | WO2011098400A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112018006263A2 (pt) | 2015-10-02 | 2018-10-16 | Memorial Sloan Kettering Cancer Center | inibidor de tonsl, molécula pequena, uso de uma molécula pequena ou de um inibidor, cristal tridimensional, métodos para selecionar ou desenhar uma molécula pequena, para identificar um inibidor de ligação de ard de tonsl à histona h4, para predizer o efeito de inibição de tonsl e para identificar um inibidor de tonsl e/ou determinar o efeito inibitório de um inibidor putativo de tonsl, sequência de polinucleotídeo ou sequência de aminoácidos isolada, e, polipeptídeo mutante de tonsl. |
EP3650541A1 (de) * | 2018-11-08 | 2020-05-13 | BioPharma Translationsinstitut Dessau Forschungs GmbH | Trypsin-mutante zur c- und n-terminalen modifizierung von polypeptiden |
CN112546228A (zh) * | 2019-09-10 | 2021-03-26 | 中国科学院上海营养与健康研究所 | 非igf1r结合型的物质在预防和/或治疗炎症性疾病中的应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3051145B2 (ja) | 1990-08-28 | 2000-06-12 | 住友製薬株式会社 | 新規なポリエチレングリコール誘導体修飾ペプチド |
ATE119916T1 (de) | 1990-12-10 | 1995-04-15 | Hoffmann La Roche | Verfahren zur enzymatischen herstellung von grf(1-44)nh2. |
ATE225801T1 (de) | 1992-07-13 | 2002-10-15 | Bionebraska Inc | Verfahren zur modifizierung rekombinanter polypeptide |
AU6048294A (en) * | 1992-11-25 | 1994-06-22 | Amgen Boulder Inc. | Modified insulin-like growth factors |
CA2190752A1 (en) | 1994-05-24 | 1995-11-30 | George N. Cox | Modified insulin-like growth factors |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
DK1157037T3 (da) | 1999-01-29 | 2003-11-24 | Hoffmann La Roche | GCSF-konjugater |
US6303337B1 (en) * | 1999-08-25 | 2001-10-16 | Amber Gen. Inc. | N-terminal and C-terminal markers in nascent proteins |
DE10049673A1 (de) | 2000-10-07 | 2002-04-25 | Univ Leipzig | Verfahren zur Herstellung von Peptiden, Peptidmimetika und Proteinen |
DE10205091B4 (de) * | 2002-02-07 | 2007-04-19 | Biomax Informatics Ag | Verfahren zur Vorhersage der Expressionseffizienz in zellfreien Expressionssystemen |
CN101010425B (zh) * | 2004-08-13 | 2010-05-26 | 霍夫曼-拉罗奇有限公司 | 多肽的c-末端修饰 |
EP1674113A1 (de) * | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Konjugate von insulinähnlichem Wachstumfaktor-1 und Poly(Ethylenglykol) |
PL1767545T3 (pl) * | 2005-09-22 | 2010-04-30 | Biocompatibles Uk Ltd | Polipeptydy fuzyjne GLP-1 (glukagonopodobny peptyd-1) o zwiększonej odporności na peptydazy |
DE102005046113A1 (de) * | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
CL2007002502A1 (es) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
JP2009207449A (ja) * | 2008-03-06 | 2009-09-17 | Univ Nagoya | ラミニンコイルドコイル(lcc)ドメインヘテロ多量体を含むタンパク質会合体の調製方法 |
-
2011
- 2011-02-04 JP JP2012552344A patent/JP5749744B2/ja active Active
- 2011-02-04 KR KR1020127023645A patent/KR101485646B1/ko not_active IP Right Cessation
- 2011-02-04 ES ES11702211.1T patent/ES2587574T3/es active Active
- 2011-02-04 BR BR112012019992-7A patent/BR112012019992A2/pt not_active IP Right Cessation
- 2011-02-04 US US13/577,284 patent/US9587006B2/en active Active
- 2011-02-04 MX MX2012008148A patent/MX339559B/es active IP Right Grant
- 2011-02-04 WO PCT/EP2011/051631 patent/WO2011098400A1/en active Application Filing
- 2011-02-04 CN CN201180008318.9A patent/CN102740896B/zh active Active
- 2011-02-04 RU RU2012138553/10A patent/RU2584572C2/ru not_active IP Right Cessation
- 2011-02-04 CA CA2786340A patent/CA2786340C/en not_active Expired - Fee Related
- 2011-02-04 EP EP11702211.1A patent/EP2533813B1/de active Active
-
2012
- 2012-11-28 HK HK12112189.2A patent/HK1171375A1/xx unknown
-
2015
- 2015-04-02 JP JP2015076201A patent/JP6014194B2/ja active Active
-
2017
- 2017-01-20 US US15/411,824 patent/US20170267736A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR112012019992A2 (pt) | 2020-08-18 |
JP2013518922A (ja) | 2013-05-23 |
KR101485646B1 (ko) | 2015-01-22 |
US20120309679A1 (en) | 2012-12-06 |
CN102740896B (zh) | 2014-08-27 |
RU2584572C2 (ru) | 2016-05-20 |
US9587006B2 (en) | 2017-03-07 |
WO2011098400A1 (en) | 2011-08-18 |
JP2015145402A (ja) | 2015-08-13 |
MX339559B (es) | 2016-05-31 |
MX2012008148A (es) | 2012-08-03 |
CA2786340C (en) | 2017-08-22 |
ES2587574T3 (es) | 2016-10-25 |
RU2012138553A (ru) | 2014-03-20 |
EP2533813B1 (de) | 2016-06-01 |
CA2786340A1 (en) | 2011-08-18 |
JP6014194B2 (ja) | 2016-10-25 |
KR20120137364A (ko) | 2012-12-20 |
JP5749744B2 (ja) | 2015-07-15 |
EP2533813A1 (de) | 2012-12-19 |
US20170267736A1 (en) | 2017-09-21 |
CN102740896A (zh) | 2012-10-17 |
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