HK1168088A1 - Pyrimidine substituted purine compounds as kinase (s) inhibitors - Google Patents
Pyrimidine substituted purine compounds as kinase (s) inhibitorsInfo
- Publication number
- HK1168088A1 HK1168088A1 HK12106992.1A HK12106992A HK1168088A1 HK 1168088 A1 HK1168088 A1 HK 1168088A1 HK 12106992 A HK12106992 A HK 12106992A HK 1168088 A1 HK1168088 A1 HK 1168088A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kinase
- inhibitors
- substituted purine
- purine compounds
- pyrimidine substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01137—Phosphatidylinositol 3-kinase (2.7.1.137)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SG2009/000124 WO2010114484A1 (en) | 2009-04-03 | 2009-04-03 | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1168088A1 true HK1168088A1 (en) | 2012-12-21 |
Family
ID=41136924
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12106992.1A HK1168088A1 (en) | 2009-04-03 | 2012-07-17 | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
HK16104906.7A HK1217017A1 (zh) | 2009-04-03 | 2016-04-28 | 作為激酶抑制劑的嘧啶取代的嘌呤化合物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16104906.7A HK1217017A1 (zh) | 2009-04-03 | 2016-04-28 | 作為激酶抑制劑的嘧啶取代的嘌呤化合物 |
Country Status (13)
Country | Link |
---|---|
US (4) | US8754080B2 (de) |
EP (1) | EP2414362B1 (de) |
JP (1) | JP5465318B2 (de) |
CN (1) | CN102428085B (de) |
BR (1) | BRPI0925059A2 (de) |
CA (2) | CA2950529C (de) |
DK (1) | DK2414362T3 (de) |
ES (1) | ES2500643T3 (de) |
HK (2) | HK1168088A1 (de) |
MX (1) | MX2011010332A (de) |
RU (1) | RU2506264C2 (de) |
TW (1) | TWI474822B (de) |
WO (1) | WO2010114484A1 (de) |
Families Citing this family (32)
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BRPI0817503B8 (pt) | 2007-10-05 | 2021-05-25 | Sstarbio Pte Ltd | derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa |
WO2009146406A1 (en) * | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
CA2730271A1 (en) * | 2008-07-07 | 2010-01-14 | Xcovery Holding Company Llc | Pi3k isoform selective inhibitors |
ES2500643T3 (es) | 2009-04-03 | 2014-09-30 | Verastem, Inc. | Compuestos de purina sustituidos con pirimidina como inhibidores de las cinasas |
TWI579274B (zh) * | 2012-04-20 | 2017-04-21 | 龍馬躍公司 | 製備1-芳基-5-烷基吡唑化合物的改良方法 |
US20150258127A1 (en) * | 2012-10-31 | 2015-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
MX2016004964A (es) * | 2013-10-16 | 2016-07-11 | Shanghai Yingli Pharm Co Ltd | Compuesto heterociclico fusionado, metodo de preparacion del mismo, composicion farmaceutica, y usos del mismo. |
US20150140036A1 (en) | 2013-11-13 | 2015-05-21 | Novartis Institutes For Biomedical Research, Inc. | Low, immune enhancing, dose mtor inhibitors and uses thereof |
CN116478927A (zh) | 2013-12-19 | 2023-07-25 | 诺华股份有限公司 | 人间皮素嵌合抗原受体及其用途 |
EP3087101B1 (de) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulierbarer chimärer antigenrezeptor |
EP3593812A3 (de) | 2014-03-15 | 2020-05-27 | Novartis AG | Behandlung von krebs mithilfe eines chimären antigenrezeptors |
SG10202109752XA (en) | 2014-04-07 | 2021-10-28 | Novartis Ag | Treatment of cancer using anti-cd19 chimeric antigen receptor |
EP3193915A1 (de) | 2014-07-21 | 2017-07-26 | Novartis AG | Kombinationen aus niedrigen, immunfördernden dosen von mtor-inhibitoren und cars |
US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
WO2016014576A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
EP4205749A1 (de) | 2014-07-31 | 2023-07-05 | Novartis AG | Subset-optimierte chimäre antigenrezeptorhaltige zellen |
JP6919118B2 (ja) | 2014-08-14 | 2021-08-18 | ノバルティス アーゲー | GFRα−4キメラ抗原受容体を用いる癌の治療 |
RU2724999C2 (ru) | 2014-08-19 | 2020-06-29 | Новартис Аг | Химерный антигенный рецептор (car) против cd123 для использования в лечении злокачественных опухолей |
WO2016044605A1 (en) | 2014-09-17 | 2016-03-24 | Beatty, Gregory | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
WO2016057705A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
WO2016109426A1 (en) * | 2014-12-29 | 2016-07-07 | Verastem, Inc. | Oral dosing regimen of a dual mtor and pi3 inhibitor |
US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
AU2016249005B2 (en) | 2015-04-17 | 2022-06-16 | Novartis Ag | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
US20180298068A1 (en) | 2015-04-23 | 2018-10-18 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
CA3031542A1 (en) | 2016-07-20 | 2018-01-25 | University Of Utah Research Foundation | Cd229 car t cells and methods of use thereof |
TW202340473A (zh) | 2016-10-07 | 2023-10-16 | 瑞士商諾華公司 | 利用嵌合抗原受體之癌症治療 |
EP3615055A1 (de) | 2017-04-28 | 2020-03-04 | Novartis AG | Zellen, die einen auf bcma abzielenden chimären antigenrezeptor exprimieren, und kombinationsbehandlung mit einem gamma-sekretase-inhibitor |
US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
EP3788369A1 (de) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarker zur auswertung von car-t-zellen zur vorhersage des klinischen ergebnisses |
IL279329B1 (en) | 2018-06-15 | 2024-09-01 | Navitor Pharm Inc | Rapamycin analogs and their uses |
US11819476B2 (en) | 2019-12-05 | 2023-11-21 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
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US4617304A (en) | 1984-04-10 | 1986-10-14 | Merck & Co., Inc. | Purine derivatives |
US4772606A (en) | 1985-08-22 | 1988-09-20 | Warner-Lambert Company | Purine derivatives |
JP3415865B2 (ja) | 1991-11-25 | 2003-06-09 | 武田薬品工業株式会社 | 光学活性アゾール化合物およびその用途 |
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-
2009
- 2009-04-03 ES ES09788615.4T patent/ES2500643T3/es active Active
- 2009-04-03 CA CA2950529A patent/CA2950529C/en not_active Expired - Fee Related
- 2009-04-03 US US13/262,544 patent/US8754080B2/en not_active Expired - Fee Related
- 2009-04-03 RU RU2011141792/04A patent/RU2506264C2/ru not_active IP Right Cessation
- 2009-04-03 CN CN200980159441.3A patent/CN102428085B/zh not_active Expired - Fee Related
- 2009-04-03 CA CA2757485A patent/CA2757485C/en not_active Expired - Fee Related
- 2009-04-03 EP EP09788615.4A patent/EP2414362B1/de not_active Not-in-force
- 2009-04-03 JP JP2012503377A patent/JP5465318B2/ja not_active Expired - Fee Related
- 2009-04-03 WO PCT/SG2009/000124 patent/WO2010114484A1/en active Application Filing
- 2009-04-03 MX MX2011010332A patent/MX2011010332A/es active IP Right Grant
- 2009-04-03 BR BRPI0925059-0A patent/BRPI0925059A2/pt not_active Application Discontinuation
- 2009-04-03 DK DK09788615.4T patent/DK2414362T3/da active
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2010
- 2010-04-02 TW TW099110426A patent/TWI474822B/zh not_active IP Right Cessation
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2012
- 2012-07-17 HK HK12106992.1A patent/HK1168088A1/xx not_active IP Right Cessation
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2014
- 2014-05-07 US US14/271,486 patent/US9138437B2/en not_active Expired - Fee Related
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2015
- 2015-08-18 US US14/828,886 patent/US20160207927A1/en not_active Abandoned
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- 2016-04-28 HK HK16104906.7A patent/HK1217017A1/zh not_active IP Right Cessation
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- 2017-01-09 US US15/401,690 patent/US20170121332A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2500643T3 (es) | 2014-09-30 |
DK2414362T3 (da) | 2014-09-22 |
TW201039828A (en) | 2010-11-16 |
US8754080B2 (en) | 2014-06-17 |
US20170121332A1 (en) | 2017-05-04 |
US20120142683A1 (en) | 2012-06-07 |
BRPI0925059A2 (pt) | 2015-07-28 |
CA2757485C (en) | 2017-01-17 |
RU2011141792A (ru) | 2013-05-10 |
EP2414362A1 (de) | 2012-02-08 |
MX2011010332A (es) | 2011-11-29 |
JP2012522769A (ja) | 2012-09-27 |
TWI474822B (zh) | 2015-03-01 |
CA2950529C (en) | 2019-04-30 |
JP5465318B2 (ja) | 2014-04-09 |
WO2010114484A1 (en) | 2010-10-07 |
CA2757485A1 (en) | 2010-10-07 |
US9138437B2 (en) | 2015-09-22 |
CN102428085A (zh) | 2012-04-25 |
US20150105382A1 (en) | 2015-04-16 |
HK1217017A1 (zh) | 2016-12-16 |
CN102428085B (zh) | 2015-07-15 |
EP2414362B1 (de) | 2014-06-11 |
US20160207927A1 (en) | 2016-07-21 |
RU2506264C2 (ru) | 2014-02-10 |
CA2950529A1 (en) | 2010-10-07 |
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200401 |