HK1168086A1 - Improved method for manufacturing dipeptidyl peptidase-iv inhibitor and intermediate -iv - Google Patents
Improved method for manufacturing dipeptidyl peptidase-iv inhibitor and intermediate -ivInfo
- Publication number
- HK1168086A1 HK1168086A1 HK12108818.9A HK12108818A HK1168086A1 HK 1168086 A1 HK1168086 A1 HK 1168086A1 HK 12108818 A HK12108818 A HK 12108818A HK 1168086 A1 HK1168086 A1 HK 1168086A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitor
- improved method
- dipeptidyl peptidase
- manufacturing
- manufacturing dipeptidyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20090027106 | 2009-03-30 | ||
| PCT/KR2010/001948 WO2010114292A2 (fr) | 2009-03-30 | 2010-03-30 | Procédé amélioré de fabrication d'inhibiteur de dipeptidyl peptidase-iv et d'intermédiaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1168086A1 true HK1168086A1 (en) | 2012-12-21 |
Family
ID=42828846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12108818.9A HK1168086A1 (en) | 2009-03-30 | 2012-09-10 | Improved method for manufacturing dipeptidyl peptidase-iv inhibitor and intermediate -iv |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8598347B2 (fr) |
| EP (2) | EP2669266B1 (fr) |
| JP (1) | JP5475864B2 (fr) |
| KR (1) | KR101152898B1 (fr) |
| CN (1) | CN102378752B (fr) |
| AU (1) | AU2010232086B2 (fr) |
| BR (1) | BRPI1014070B8 (fr) |
| CA (1) | CA2756915C (fr) |
| ES (1) | ES2571443T3 (fr) |
| HK (1) | HK1168086A1 (fr) |
| HU (1) | HUE029168T2 (fr) |
| IL (1) | IL215289A (fr) |
| MX (1) | MX2011010205A (fr) |
| NZ (1) | NZ595543A (fr) |
| RU (1) | RU2498976C9 (fr) |
| SG (1) | SG174973A1 (fr) |
| WO (1) | WO2010114292A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800245C (fr) * | 2009-03-30 | 2015-03-24 | Dong-A Pharmaceutical Co., Ltd. | Procede ameliore d'elaboration d'inhibiteur de dipeptidyl peptidase-iv et d'intermediaire |
| CN104257437B (zh) * | 2014-10-20 | 2016-01-06 | 谢杨 | 一种动物脊髓损伤造模装置 |
| KR101709127B1 (ko) | 2015-06-16 | 2017-02-22 | 경동제약 주식회사 | Dpp-iv 억제제의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 dpp-iv 억제제의 제조방법 |
| CN105017081B (zh) * | 2015-07-08 | 2017-03-08 | 和鼎（南京）医药技术有限公司 | 一种西他列汀中间体的制备方法 |
| WO2019241574A1 (fr) | 2018-06-14 | 2019-12-19 | Astrazeneca Uk Limited | Procédés pour abaisser la glycémie avec une composition pharmaceutique d'inhibiteur de la dipeptidylpeptidase-4 |
| CN116554060A (zh) * | 2023-05-23 | 2023-08-08 | 江苏八巨药业有限公司 | 一种Boc-(R)-3-氨基-4-（2,4,5-三氟苯基)丁酸的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2781221B1 (fr) * | 1998-07-17 | 2000-10-13 | Lafon Labor | Piperazinones substituees en alpha |
| KR20000065816A (ko) * | 1999-04-09 | 2000-11-15 | 성재갑 | 파라 및/또는 메타-치환 시아노페닐알라닌 유도체의 새로운 합성방법 |
| ES2257555T3 (es) | 2001-06-20 | 2006-08-01 | MERCK & CO., INC. | Inhibidores de dipeptidilpeptidasa para el tratamiento de la diabetes. |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| ATE373660T1 (de) | 2002-03-25 | 2007-10-15 | Merck & Co Inc | Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes |
| CA2490818A1 (fr) | 2002-07-15 | 2004-01-22 | Merck & Co., Inc. | Inhibiteurs de piperidino pyrimidine dipeptidyl peptidase utilises dans le traitement du diabete |
| ES2291680T3 (es) | 2002-10-07 | 2008-03-01 | MERCK & CO., INC. | Antidiabeticos beta-amino heterociclicos inhibidores de la dipeptidil peptidasa. |
| US20060178370A1 (en) | 2003-03-18 | 2006-08-10 | Mark Bock | Ketopiperazine derivatives as bradykinin antagonists |
| WO2004087650A2 (fr) | 2003-03-27 | 2004-10-14 | Merck & Co. Inc. | Procede et intermediaires pour la preparation d'inhibiteurs d'amide d'acide beta-amino de dipeptidyle peptidase-iv |
| CA2533893A1 (fr) * | 2003-07-31 | 2005-02-10 | Merck & Co., Inc. | Hexahydrodiazepinones utilises en tant qu'inhibiteurs de la dipeptidyl peptidase iv pour le traitement ou la prevention du diabete |
| WO2006098342A1 (fr) * | 2005-03-16 | 2006-09-21 | Astellas Pharma Inc. | Composes de la piperazinyle |
| EP1702916A1 (fr) | 2005-03-18 | 2006-09-20 | Santhera Pharmaceuticals (Schweiz) GmbH | Inhibiteurs de DPP-IV |
| WO2007063928A1 (fr) | 2005-11-30 | 2007-06-07 | Toray Industries, Inc. | Nouveau derive non cyclique d’amine carboxamide et sel de celui-ci |
| US20090156465A1 (en) | 2005-12-30 | 2009-06-18 | Sattigeri Jitendra A | Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors |
| WO2008028662A1 (fr) | 2006-09-07 | 2008-03-13 | Santhera Pharmaceuticals (Schweiz) Ag | N-[1-(3-amino-4-phenyl-butyryl)-4-hydroxy-pyrrolidin-2-ylmethyl}-propionamide et composés associés utilisés en tant qu'inhibiteurs dpp-iv pour le traitement du diabète sucré de type 2 |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JP5148686B2 (ja) | 2007-04-19 | 2013-02-20 | ドン・ア・ファーム・カンパニー・リミテッド | β−アミノ基を含むＤＰＰ−ＩＶ阻害剤、その製造方法及びそれを有効成分として含む糖尿または肥満予防及び治療用医薬組成物 |
| KR100904426B1 (ko) | 2007-09-11 | 2009-06-26 | 주식회사 하이닉스반도체 | 내부 전압 생성 회로 |
-
2010
- 2010-03-30 NZ NZ595543A patent/NZ595543A/xx unknown
- 2010-03-30 EP EP13182084.7A patent/EP2669266B1/fr active Active
- 2010-03-30 JP JP2012503325A patent/JP5475864B2/ja active Active
- 2010-03-30 CN CN201080015011.7A patent/CN102378752B/zh active Active
- 2010-03-30 KR KR1020100028476A patent/KR101152898B1/ko active Protection Beyond IP Right Term
- 2010-03-30 SG SG2011070885A patent/SG174973A1/en unknown
- 2010-03-30 HU HUE13182084A patent/HUE029168T2/hu unknown
- 2010-03-30 EP EP10759017A patent/EP2415754A4/fr not_active Withdrawn
- 2010-03-30 MX MX2011010205A patent/MX2011010205A/es active IP Right Grant
- 2010-03-30 CA CA2756915A patent/CA2756915C/fr active Active
- 2010-03-30 RU RU2011141209/04A patent/RU2498976C9/ru active
- 2010-03-30 WO PCT/KR2010/001948 patent/WO2010114292A2/fr active Application Filing
- 2010-03-30 ES ES13182084T patent/ES2571443T3/es active Active
- 2010-03-30 BR BRPI1014070A patent/BRPI1014070B8/pt active IP Right Grant
- 2010-03-30 US US13/260,179 patent/US8598347B2/en active Active
- 2010-03-30 AU AU2010232086A patent/AU2010232086B2/en active Active
-
2011
- 2011-09-21 IL IL215289A patent/IL215289A/en active IP Right Grant
-
2012
- 2012-09-10 HK HK12108818.9A patent/HK1168086A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2498976C2 (ru) | 2013-11-20 |
| MX2011010205A (es) | 2011-10-17 |
| KR101152898B1 (ko) | 2012-06-05 |
| US20120016126A1 (en) | 2012-01-19 |
| IL215289A (en) | 2015-10-29 |
| IL215289A0 (en) | 2011-11-30 |
| NZ595543A (en) | 2013-05-31 |
| WO2010114292A2 (fr) | 2010-10-07 |
| EP2669266B1 (fr) | 2016-02-24 |
| KR20100109493A (ko) | 2010-10-08 |
| RU2011141209A (ru) | 2013-05-10 |
| CN102378752B (zh) | 2014-08-20 |
| ES2571443T3 (es) | 2016-05-25 |
| US8598347B2 (en) | 2013-12-03 |
| EP2415754A4 (fr) | 2012-08-22 |
| JP5475864B2 (ja) | 2014-04-16 |
| EP2415754A2 (fr) | 2012-02-08 |
| BRPI1014070B8 (pt) | 2021-05-25 |
| CA2756915A1 (fr) | 2010-10-07 |
| SG174973A1 (en) | 2011-11-28 |
| BRPI1014070A2 (pt) | 2016-04-12 |
| RU2498976C9 (ru) | 2014-02-27 |
| EP2669266A1 (fr) | 2013-12-04 |
| HUE029168T2 (hu) | 2017-02-28 |
| JP2012522045A (ja) | 2012-09-20 |
| CA2756915C (fr) | 2015-06-02 |
| AU2010232086B2 (en) | 2013-02-28 |
| WO2010114292A3 (fr) | 2011-01-20 |
| BRPI1014070B1 (pt) | 2020-10-20 |
| AU2010232086A1 (en) | 2011-11-03 |
| CN102378752A (zh) | 2012-03-14 |
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