HK1166791A1 - Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications 1-()-5--2-(1h) - Google Patents

Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications 1-()-5--2-(1h)

Info

Publication number
HK1166791A1
HK1166791A1 HK12107432.7A HK12107432A HK1166791A1 HK 1166791 A1 HK1166791 A1 HK 1166791A1 HK 12107432 A HK12107432 A HK 12107432A HK 1166791 A1 HK1166791 A1 HK 1166791A1
Authority
HK
Hong Kong
Prior art keywords
trifluoromethyl
salts
applications
preparation
substituted benzyl
Prior art date
Application number
HK12107432.7A
Other languages
English (en)
Chinese (zh)
Inventor
胡高云
陶立堅
陳軍
Original Assignee
中南大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 中南大學 filed Critical 中南大學
Publication of HK1166791A1 publication Critical patent/HK1166791A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HK12107432.7A 2009-05-25 2012-07-30 Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications 1-()-5--2-(1h) HK1166791A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200910043502 2009-05-25
PCT/CN2010/073131 WO2010135976A1 (zh) 2009-05-25 2010-05-24 1-（取代苄基）-5-三氟甲基-2-（1h）吡啶酮化合物及其盐，其制备方法及其用途

Publications (1)

Publication Number Publication Date
HK1166791A1 true HK1166791A1 (en) 2012-11-09

Family

ID=43222161

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12107432.7A HK1166791A1 (en) 2009-05-25 2012-07-30 Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications 1-()-5--2-(1h)

Country Status (10)

Country Link
US (1) US8377932B2 (xx)
EP (1) EP2474533B1 (xx)
JP (1) JP5722883B2 (xx)
KR (1) KR101478133B1 (xx)
CN (1) CN102149683B (xx)
AU (1) AU2010252451B2 (xx)
DK (1) DK2474533T3 (xx)
ES (1) ES2536200T3 (xx)
HK (1) HK1166791A1 (xx)
WO (1) WO2010135976A1 (xx)

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JP5924984B2 (ja) * 2012-03-06 2016-05-25 国立大学法人東京農工大学 トリフルオロメチルピリジノン化合物およびその製造方法
ES2716008T3 (es) 2012-07-18 2019-06-07 Sunshine Lake Pharma Co Ltd Derivados heterocíclicos nitrogenados y su aplicación en fármacos
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
KR20150018127A (ko) * 2013-08-09 2015-02-23 삼성전자주식회사 디스플레이 장치 및 그 방법
US9902712B2 (en) 2013-12-19 2018-02-27 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in drugs
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
CN106466318B (zh) * 2015-08-21 2019-01-01 中南大学 1-杂环取代苄基吡啶酮类化合物在制备治疗糖尿病肾病药物中的应用
CN107663167A (zh) * 2016-10-19 2018-02-06 广州南新制药有限公司 1‑（取代苄基）‑5‑三氟甲基‑2(1h)‑吡啶酮盐酸盐的晶型及制备方法
CN107652228B (zh) * 2016-10-28 2020-04-14 广州南新制药有限公司 抗肾纤维化药物1-（取代苄基）-5-三氟甲基-2(1h)-吡啶酮盐酸盐的合成方法
CN113456642B (zh) * 2021-07-09 2022-09-06 中南大学 一种美氟尼酮在制备治疗急性肾损伤药物中的应用
WO2023168650A1 (zh) * 2022-03-10 2023-09-14 广州南新制药有限公司 一种美氟尼酮晶型的制备方法
WO2023168649A1 (zh) * 2022-03-10 2023-09-14 广州南新制药有限公司 一种美氟尼酮盐酸盐的制备方法

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Also Published As

Publication number Publication date
AU2010252451A1 (en) 2011-12-15
US8377932B2 (en) 2013-02-19
KR20120060785A (ko) 2012-06-12
JP5722883B2 (ja) 2015-05-27
KR101478133B1 (ko) 2014-12-31
CN102149683B (zh) 2013-10-02
ES2536200T3 (es) 2015-05-21
JP2012527488A (ja) 2012-11-08
WO2010135976A1 (zh) 2010-12-02
EP2474533A4 (en) 2012-11-14
EP2474533B1 (en) 2015-02-25
AU2010252451B2 (en) 2014-04-03
US20120129859A1 (en) 2012-05-24
CN102149683A (zh) 2011-08-10
DK2474533T3 (en) 2015-05-18
EP2474533A1 (en) 2012-07-11

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220520