HK1164165A1 - Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan cd38 - Google Patents
Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan cd38Info
- Publication number
- HK1164165A1 HK1164165A1 HK12105154.7A HK12105154A HK1164165A1 HK 1164165 A1 HK1164165 A1 HK 1164165A1 HK 12105154 A HK12105154 A HK 12105154A HK 1164165 A1 HK1164165 A1 HK 1164165A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- melphalan
- containing antibodies
- antibodies recognizing
- combinations containing
- recognizing specifically
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title 1
- 229960001924 melphalan Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08291116A EP2191840A1 (fr) | 2008-11-28 | 2008-11-28 | Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et melphalan |
| PCT/IB2009/055389 WO2010061357A1 (fr) | 2008-11-28 | 2009-11-27 | Associations antitumorales contenant des anticorps reconnaissant spécifiquement cd38 et du melphalan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1164165A1 true HK1164165A1 (en) | 2012-09-21 |
Family
ID=40578382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12105154.7A HK1164165A1 (en) | 2008-11-28 | 2012-05-25 | Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan cd38 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US9259406B2 (fr) |
| EP (2) | EP2191840A1 (fr) |
| JP (3) | JP2012510461A (fr) |
| KR (1) | KR101733252B1 (fr) |
| CN (1) | CN102264385B (fr) |
| AR (1) | AR074219A1 (fr) |
| AU (1) | AU2009321249B2 (fr) |
| BR (1) | BRPI0921864B1 (fr) |
| CA (1) | CA2744990C (fr) |
| CL (1) | CL2011001254A1 (fr) |
| CO (1) | CO6440557A2 (fr) |
| CR (1) | CR20110280A (fr) |
| EA (1) | EA026867B1 (fr) |
| EC (1) | ECSP11011062A (fr) |
| HK (1) | HK1164165A1 (fr) |
| HN (1) | HN2011001417A (fr) |
| IL (1) | IL213116B (fr) |
| MA (1) | MA32896B1 (fr) |
| ME (1) | ME01136B (fr) |
| MX (1) | MX342625B (fr) |
| MY (1) | MY164577A (fr) |
| NI (1) | NI201100105A (fr) |
| NZ (1) | NZ593027A (fr) |
| PA (1) | PA8850101A1 (fr) |
| PE (1) | PE20120340A1 (fr) |
| SG (1) | SG171820A1 (fr) |
| SV (1) | SV2011003924A (fr) |
| TN (1) | TN2011000232A1 (fr) |
| TW (1) | TWI454260B (fr) |
| UA (1) | UA107069C2 (fr) |
| UY (1) | UY32263A (fr) |
| WO (1) | WO2010061357A1 (fr) |
| ZA (1) | ZA201103925B (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2191840A1 (fr) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et melphalan |
| CA2796464C (fr) | 2010-04-16 | 2021-08-03 | Immune Disease Institute, Inc. | Expression de polypeptide prolongee a partir d'arn synthetiques modifies et utilisations de celle-ci |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK2621531T3 (en) | 2010-09-27 | 2017-02-27 | Morphosys Ag | ANTI-CD38 ANTIBODY AND LENALIDOMIDE OR BORTEZOMIB FOR TREATMENT OF MULTIPLE MYELOM AND NHL |
| AU2011308496A1 (en) | 2010-10-01 | 2013-05-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| UA112170C2 (uk) * | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2013052523A1 (fr) | 2011-10-03 | 2013-04-11 | modeRNA Therapeutics | Nucléosides, nucléotides et acides nucléiques modifiés, et leurs utilisations |
| CA2859387A1 (fr) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Nucleoside, nucleotide, et compositions d'acide nucleique modifies |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151669A1 (fr) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Polynucléotides modifiés pour la production de protéines cytoplasmiques et cytosquelettiques |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| EP2900232B1 (fr) * | 2012-09-25 | 2017-11-15 | MorphoSys AG | Combinaisons et leurs utilisations |
| US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
| US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
| UA118255C2 (uk) * | 2012-12-07 | 2018-12-26 | Санофі | Композиція, яка містить антитіло до cd38 і леналідомід |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (fr) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucléotides codant pour un récepteur de lipoprotéines de faible densité |
| NZ719784A (en) | 2013-10-31 | 2022-02-25 | Sanofi Sa | Specific anti-cd38 antibodies for treating human cancers |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| US10617757B2 (en) | 2014-08-08 | 2020-04-14 | The Regents Of The University Of California | Methods for treating multiple myeloma |
| EP3191187B1 (fr) | 2014-09-09 | 2021-07-28 | Janssen Biotech, Inc. | Polythérapies avec des anticorps anti-cd38 |
| BR112017011749A2 (pt) | 2014-12-04 | 2018-05-15 | Janssen Biotech Inc | anticorpos anti-cd38 para o tratamento de leucemia mieloide aguda |
| KR102602754B1 (ko) | 2015-05-20 | 2023-11-14 | 얀센 바이오테크 인코포레이티드 | 경쇄 아밀로이드증 및 다른 cd38-양성 혈액학적 악성종양을 치료하기 위한 항-cd38 항체 |
| MY192978A (en) | 2015-06-22 | 2022-09-20 | Janssen Biotech Inc | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| RS63210B1 (sr) | 2015-11-03 | 2022-06-30 | Janssen Biotech Inc | Potkožne formulacije anti-cd38 antitela i njihova upotreba |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| WO2019035938A1 (fr) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | Molécules multispécifiques se liant à bcma et leurs utilisations |
| WO2019089832A1 (fr) | 2017-10-31 | 2019-05-09 | Janssen Biotech, Inc. | Méthodes de traitement du myélome multiple à haut risque |
| WO2019130228A1 (fr) * | 2018-01-01 | 2019-07-04 | Orbicular Pharmaceutical Technologies Pvt. Ltd., | Compositions liquides stables de melphalan |
| AU2020242228A1 (en) | 2019-03-15 | 2021-07-22 | Morphosys Ag | Anti-CD38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease |
| US11655302B2 (en) | 2019-06-10 | 2023-05-23 | Sanofi | Anti-CD38 antibodies and formulations |
| WO2021113739A1 (fr) | 2019-12-05 | 2021-06-10 | Thomas Ballet | Formulations d'anticorps anti-cd38 pour administration sous-cutanée |
| US20240109977A1 (en) | 2021-01-14 | 2024-04-04 | Morphosys Ag | Anti-cd38 antibodies and their uses |
| TW202302642A (zh) | 2021-03-01 | 2023-01-16 | 德商莫菲西斯公司 | 用於治療抗體介導移植物排斥用途之抗ｃｄ３８抗體 |
| TW202321303A (zh) | 2021-07-19 | 2023-06-01 | 德商莫菲西斯公司 | 抗pla2r自體抗體媒介膜性腎病變之治療 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB750155A (en) | 1953-03-17 | 1956-06-13 | Nat Res Dev | Substituted alanines |
| US3032585A (en) | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| EP0519596B1 (fr) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | Procédé pour réduire l'immunogénicité des domaines variables d'anticorps |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| CA2219361C (fr) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Anticorps humains derives d'une xenosouris immunisee |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| KR100942002B1 (ko) | 1996-12-03 | 2010-02-12 | 암젠 프레몬트 인코포레이티드 | 복수의 ｖｈ 및 ｖｋ 부위를 함유하는 사람 면역글로불린 유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된 항체 |
| BRPI9809391B8 (pt) | 1997-04-14 | 2021-05-25 | Amgen Res Munich Gmbh | processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| JP2003524587A (ja) * | 1998-06-05 | 2003-08-19 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | 多発性骨髄腫を処置するための、ｃｄ３８に対する、遺伝子操作した抗体の使用 |
| US7223397B1 (en) | 1999-01-07 | 2007-05-29 | Research Development Foundation | Potentiation of anti-CD38-Immunotoxin cytotoxicity |
| GB0221574D0 (en) | 2002-09-17 | 2002-10-23 | Isis Innovation | Treatments |
| SG142330A1 (en) | 2004-02-06 | 2008-05-28 | Morphosys Ag De | Anti-cd38 human antibodies and uses therefor |
| SI2567976T1 (sl) * | 2005-03-23 | 2017-11-30 | Genmab A/S | Protitelesa usmerjena proti cd38 za zdravljenje multiplega mieloma |
| EA034877B1 (ru) | 2006-09-26 | 2020-04-01 | Генмаб А/С | Способ комбинированной терапии опухолей, экспрессирующих cd38, и терапевтическая комбинация для применения в указанном способе |
| US20080092384A1 (en) * | 2006-10-16 | 2008-04-24 | Schaake Mark D | Installation of Middle Bearing for a Crankshaft |
| EP1914242A1 (fr) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Nouveau anticorps Anti-CD38 pour le traitement du cancer |
| EP2191841A1 (fr) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et vincristine |
| EP2191843A1 (fr) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et cyclophosphamide |
| EP2191840A1 (fr) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Combinaisons antitumorales contenant des anticorps reconnaissant spécifiquement les CD38 et melphalan |
-
2008
- 2008-11-28 EP EP08291116A patent/EP2191840A1/fr not_active Ceased
-
2009
- 2009-11-25 PA PA20098850101A patent/PA8850101A1/es unknown
- 2009-11-25 TW TW098140158A patent/TWI454260B/zh active
- 2009-11-25 UY UY0001032263A patent/UY32263A/es not_active Application Discontinuation
- 2009-11-25 AR ARP090104545A patent/AR074219A1/es not_active Application Discontinuation
- 2009-11-27 ME MEP-2011-93A patent/ME01136B/me unknown
- 2009-11-27 CN CN200980148094.4A patent/CN102264385B/zh active Active
- 2009-11-27 UA UAA201108006A patent/UA107069C2/uk unknown
- 2009-11-27 JP JP2011538092A patent/JP2012510461A/ja not_active Withdrawn
- 2009-11-27 PE PE2011001107A patent/PE20120340A1/es active IP Right Grant
- 2009-11-27 EA EA201100864A patent/EA026867B1/ru not_active IP Right Cessation
- 2009-11-27 BR BRPI0921864-5A patent/BRPI0921864B1/pt active IP Right Grant
- 2009-11-27 KR KR1020117014746A patent/KR101733252B1/ko active IP Right Grant
- 2009-11-27 MY MYPI2011002367A patent/MY164577A/en unknown
- 2009-11-27 EP EP09775302A patent/EP2370094A1/fr not_active Withdrawn
- 2009-11-27 AU AU2009321249A patent/AU2009321249B2/en active Active
- 2009-11-27 WO PCT/IB2009/055389 patent/WO2010061357A1/fr active Application Filing
- 2009-11-27 SG SG2011037967A patent/SG171820A1/en unknown
- 2009-11-27 NZ NZ593027A patent/NZ593027A/xx unknown
- 2009-11-27 US US13/130,862 patent/US9259406B2/en active Active
- 2009-11-27 MX MX2011005670A patent/MX342625B/es active IP Right Grant
- 2009-11-27 CA CA2744990A patent/CA2744990C/fr not_active Expired - Fee Related
-
2011
- 2011-05-11 TN TN2011000232A patent/TN2011000232A1/fr unknown
- 2011-05-19 EC EC2011011062A patent/ECSP11011062A/es unknown
- 2011-05-24 IL IL213116A patent/IL213116B/en active IP Right Grant
- 2011-05-26 CR CR20110280A patent/CR20110280A/es unknown
- 2011-05-27 CL CL2011001254A patent/CL2011001254A1/es unknown
- 2011-05-27 HN HN2011001417A patent/HN2011001417A/es unknown
- 2011-05-27 ZA ZA2011/03925A patent/ZA201103925B/en unknown
- 2011-05-27 NI NI201100105A patent/NI201100105A/es unknown
- 2011-05-27 CO CO11065644A patent/CO6440557A2/es unknown
- 2011-05-27 SV SV2011003924A patent/SV2011003924A/es unknown
- 2011-06-13 MA MA33937A patent/MA32896B1/fr unknown
-
2012
- 2012-05-25 HK HK12105154.7A patent/HK1164165A1/xx unknown
-
2015
- 2015-05-27 JP JP2015107404A patent/JP6148696B2/ja active Active
-
2017
- 2017-03-01 JP JP2017037860A patent/JP2017141233A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1164165A1 (en) | Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan cd38 | |
| ZA201104064B (en) | Antitumor combinations containing antibodies recognizing specifically cd38 and cytarabine | |
| HK1164154A1 (en) | Antitumor combinations containing antibodies recognizing specifically cd38 and cylophosphamide cd38 | |
| HRP20181787T1 (hr) | Antitumorske kombinacije koje sadržavaju protutijela koja specifično prepoznaju cd38 i bortezomib | |
| HK1164153A1 (en) | Antitumor combinations containing antibodies recognizing specifically cd38 and vincristine cd38 | |
| GB2462709B (en) | Compound gesture recognition | |
| ZA201102119B (en) | Improved antibody libraies | |
| IL209309A0 (en) | Anti-fn14 antibodies and uses thereof | |
| EP3064512C0 (fr) | Anticorps contre cldn6 | |
| IL216731A (en) | And antibodies against p95 – her2 and their uses | |
| HRP20150133T1 (hr) | Instant napitak na bazi žitarica | |
| EP2291957A4 (fr) | Traitement de flux multimédia | |
| HK1129282A1 (en) | Magnetic clasp | |
| GB201103446D0 (en) | Compound gesture recognition | |
| GB0911770D0 (en) | Antibody | |
| TWM347415U (en) | Band recognition structure | |
| GB0817622D0 (en) | Antibody | |
| GB0817621D0 (en) | Antibody |