HK1158623A1 - }- 合成 -雙- 三氟甲基 苯基 -乙氧基}-甲基 -苯基- -二氮雜-螺環 -癸酮化合物的中間體 - Google Patents

}- 合成 -雙- 三氟甲基 苯基 -乙氧基}-甲基 -苯基- -二氮雜-螺環 -癸酮化合物的中間體

Info

Publication number
HK1158623A1
HK1158623A1 HK11112887.811112887.8A HK11112887A HK1158623A1 HK 1158623 A1 HK1158623 A1 HK 1158623A1 HK 11112887 A HK11112887 A HK 11112887A HK 1158623 A1 HK1158623 A1 HK 1158623A1
Authority
HK
Hong Kong
Prior art keywords
phenyl
decan
diaza
spiro
intermediates
Prior art date
Application number
HK11112887.811112887.8A
Other languages
English (en)
Inventor
George G Wu
Gerald Werne
Xiaoyong Fu
Robert K Orr
Frank Xing Chen
Jian Cui
Victoria M Sprague
Fucheng Zhang
Ji Xie
Liansheng Zeng
Louis Peter Castellanos
Yuyin Chen
Marc Poirier
Ingrid Mergelsberg
Original Assignee
Opko Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Health Inc filed Critical Opko Health Inc
Publication of HK1158623A1 publication Critical patent/HK1158623A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Pyrrole Compounds (AREA)
HK11112887.811112887.8A 2008-09-05 2011-11-28 }- 合成 -雙- 三氟甲基 苯基 -乙氧基}-甲基 -苯基- -二氮雜-螺環 -癸酮化合物的中間體 HK1158623A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9447408P 2008-09-05 2008-09-05
PCT/US2009/056020 WO2010028232A1 (en) 2008-09-05 2009-09-04 Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

Publications (1)

Publication Number Publication Date
HK1158623A1 true HK1158623A1 (zh) 2012-07-20

Family

ID=41402490

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11112887.811112887.8A HK1158623A1 (zh) 2008-09-05 2011-11-28 }- 合成 -雙- 三氟甲基 苯基 -乙氧基}-甲基 -苯基- -二氮雜-螺環 -癸酮化合物的中間體

Country Status (14)

Country Link
US (2) US9249144B2 (zh)
EP (2) EP3034493A1 (zh)
JP (2) JP5736313B2 (zh)
KR (1) KR101719004B1 (zh)
CN (2) CN104496988B (zh)
AU (1) AU2009289598B2 (zh)
CA (1) CA2736195C (zh)
ES (1) ES2552322T3 (zh)
HK (1) HK1158623A1 (zh)
HU (1) HUE026148T2 (zh)
MX (1) MX2011002475A (zh)
PL (1) PL2346823T3 (zh)
PT (1) PT2346823E (zh)
WO (1) WO2010028232A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8178550B2 (en) 2006-04-05 2012-05-15 Opko Health, Inc. Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
KR20080108319A (ko) 2006-04-05 2008-12-12 쉐링 코포레이션 약제학적 제형: 8-［｛1-（3,5-비스-（트리플루오로메틸）페닐）-에톡시｝-메틸］-8-페닐-1,7-디아자-스피로［4,5］데칸-2-온의 염 및이를 사용한 치료 방법
AR066191A1 (es) 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
WO2010028232A1 (en) 2008-09-05 2010-03-11 Schering Corporation Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
MX336071B (es) 2009-08-14 2016-01-06 Opko Health Inc Formulaciones intravenosas de antagonistas de neurocinina 1.
CN105017251B (zh) * 2015-06-30 2018-06-29 齐鲁制药有限公司 一种nk-1受体拮抗剂的制备方法及其中间体
EA201792513A1 (ru) * 2015-07-15 2018-06-29 Опко Хелс, Инк. Гетероарильные карбонитрилы для лечения заболевания
CN106866669A (zh) * 2017-04-19 2017-06-20 成都百特万合医药科技有限公司 一种合成罗拉吡坦中间体的方法

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US8178550B2 (en) 2006-04-05 2012-05-15 Opko Health, Inc. Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
PE20080353A1 (es) * 2006-04-05 2008-04-25 Schering Corp Sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona y proceso de preparacion de las mismas
AR066191A1 (es) 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
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WO2010028232A1 (en) 2008-09-05 2010-03-11 Schering Corporation Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
MX336071B (es) 2009-08-14 2016-01-06 Opko Health Inc Formulaciones intravenosas de antagonistas de neurocinina 1.

Also Published As

Publication number Publication date
MX2011002475A (es) 2011-08-03
US20160145256A1 (en) 2016-05-26
CN102203062B (zh) 2014-12-17
HUE026148T2 (en) 2016-05-30
US20140031549A1 (en) 2014-01-30
US9822116B2 (en) 2017-11-21
KR101719004B1 (ko) 2017-03-22
PL2346823T3 (pl) 2016-01-29
US9249144B2 (en) 2016-02-02
EP2346823A1 (en) 2011-07-27
EP3034493A1 (en) 2016-06-22
AU2009289598A1 (en) 2010-03-11
JP2012502053A (ja) 2012-01-26
WO2010028232A1 (en) 2010-03-11
CA2736195A1 (en) 2010-03-11
ES2552322T3 (es) 2015-11-27
EP2346823B1 (en) 2015-08-19
CN102203062A (zh) 2011-09-28
AU2009289598B2 (en) 2014-09-11
CN104496988A (zh) 2015-04-08
PT2346823E (pt) 2015-11-26
KR20110067117A (ko) 2011-06-21
CN104496988B (zh) 2017-04-12
JP5736313B2 (ja) 2015-06-17
CA2736195C (en) 2017-05-16
JP2015143265A (ja) 2015-08-06

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200901